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The New England Journal of Medicine, ISSN 0028-4793, 12/2016, Volume 375, Issue 24, pp. 2321 - 2334
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2011, Volume 46, Issue 5, pp. 1892 - 1896
Expansion of the 6-membered ring and subsequent fine-tuning of the newly obtained 7-membered spiropiperidine structure resulted in the discovery of a series of... 
SCD1 inhibitor | Spiropiperidine | Pyridazine | Benzoxazepine
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 12/2008, Volume 130, Issue 50, pp. 16854 - 16855
The efficient total synthesis of (-)-serotobenine (1) has been achieved by constructing an optically active dihydrobenzofuran ring via a rhodium carbenoid... 
RING-SYSTEM | C-H ACTIVATION | CHEMISTRY, MULTIDISCIPLINARY | INSERTION REACTION | INDOLES | Benzofurans - chemistry | Indoles - chemical synthesis | Molecular Structure | Indoles - chemistry | Isomerism | Alkaloids | Rhodium | Analysis | Substitution reactions | Chemical properties | Catalysis | Structure
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 12053 - 8
Glassiness is ubiquitous and diverse in characteristics in nature. Understanding their differences and classification remains a major scientific challenge.... 
FRUSTRATION | TRANSITION | MULTIDISCIPLINARY SCIENCES | EQUILIBRIUM | DYNAMICS | SPIN-GLASSES | SYSTEMS | RELAXATION | FERROMAGNET | HIGH-TEMPERATURE SUPERCONDUCTORS | QUANTUM FLUCTUATIONS | High temperature superconductors | Scaling | Magnetism | Alloys
Journal Article
Organic Letters, ISSN 1523-7060, 03/2014, Volume 16, Issue 6, pp. 1646 - 1649
Journal Article
Science, ISSN 0036-8075, 01/2015, Volume 347, Issue 6219, pp. 273 - 277
Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination... 
GLIOBLASTOMA | REPEAT-CONTAINING RNA | PROTEIN-KINASE | MULTIDISCIPLINARY SCIENCES | POLYMERASE | CHROMOSOME ENDS | SINGLE-STRANDED-DNA | HOMOLOGOUS RECOMBINATION | MUTATIONS | TUMORS | DISCOVERY | Osteosarcoma - drug therapy | Ataxia Telangiectasia Mutated Proteins - metabolism | RNA, Untranslated - metabolism | Humans | Homologous Recombination | X-linked Nuclear Protein | Telomere - drug effects | Sulfones - pharmacology | RNA, Untranslated - genetics | Gene Knockdown Techniques | Glioma - genetics | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Telomerase - metabolism | Antineoplastic Agents - pharmacology | Telomere - metabolism | Nuclear Proteins - genetics | DNA Helicases - genetics | Telomere - genetics | Tumor Suppressor Proteins - metabolism | Nuclear Proteins - metabolism | Replication Protein A - metabolism | Telomere Homeostasis | Transcription Factors - metabolism | DNA Helicases - metabolism | Cell Cycle | Cell Line, Tumor | Telomeric Repeat Binding Protein 2 - metabolism | HeLa Cells | Osteosarcoma - genetics | Pyrazines - pharmacology | Glioma - drug therapy | Promyelocytic Leukemia Protein | Apoptosis | Telomeres | Protein research | Cell research | Cancer cells | Cell cycle | Genetic aspects | Research | Health aspects | Enzymes | Deoxyribonucleic acid--DNA | Cancer | Index Medicus | Proteins | Inhibitors | Deoxyribonucleic acid | Kinases | Chromosomes | Telomerase | Tumors
Journal Article
Journal Article
by Aaberg-Jessen, C and Fogh, L and Halle, B and Jensen, V and Brunner, N and Kristensen, B. W and Abe, T and Momii, Y and Watanabe, J and Morisaki, I and Natsume, A and Wakabayashi, T and Fujiki, M and Aldaz, B and Fabius, A. W. M and Silber, J and Harinath, G and Chan, T. A and Huse, J. T and Anai, S and Hide, T and Nakamura, H and Makino, K and Yano, S and Kuratsu, J.-i and Balyasnikova, I. V and Prasol, M. S and Kanoija, D. K and Aboody, K. S and Lesniak, M. S and Barone, T and Burkhart, C and Purmal, A and Gudkov, A and Gurova, K and Plunkett, R and Barton, K and Misuraca, K and Cordero, F and Dobrikova, E and Min, H and Gromeier, M and Kirsch, D and Becher, O and Pont, L. B and Kloezeman, J and van den Bent, M and Kanaar, R and Kremer, A and Swagemakers, S and French, P and Dirven, C and Lamfers, M and Leenstra, S and Balvers, R and Kleijn, A and Lawler, S and Gong, X and Andres, A and Hanson, J and Delashaw, J and Bota, D and Chen, C.-C and Yao, N.-W and Chuang, W.-J and Chang, C and Chen, P.-Y and Huang, C.-Y and Wei, K.-C and Cheng, Y and Dai, Q and Morshed, R and Han, Y and Auffinger, B and Wainwright, D and Zhang, L and Tobias, A and Rincon, E and Thaci, B and Ahmed, A and He, C and Lesniak, M and Choi, Y. A and Pandya, H and Gibo, D. M and Fokt, I and Priebe, W and Debinski, W and Chornenkyy, Y and Agnihotri, S and Buczkowicz, P and Rakopoulos, P and Morrison, A and Barszczyk, M and Hawkins, C and Chung, S and Decollogne, S and Luk, P and Shen, H and Ha, W and ...
Neuro-Oncology, ISSN 1522-8517, 11/2013, Volume 15, Issue suppl 3, pp. iii37 - iii61
Journal Article
by Ishikura, Kazuki and Obara, Taku and Kato, Tetsuo and Kikuya, Masahiro and Shibamiya, Taku and Shinki, Takahiro and Ikeda, Urara and Kobayashi, Yuka and Metoki, Hirohito and Mano, Nariyasu and Kuriyama, Shinichi and Ohkubo, Takayoshi and Imai, Yutaka and Yoshida, Makoto and Aoki, S and Ido, H and Ito, K and Kikuchi, K and Maeda, I and Mito, T and Nunokawa, A and Oda, K and Suzuki, N and Takagawa, Y and Tateda, K and Tateda, S and Akimot, M and Tashima, G and Fujii, Y and Onodera, G and Onodera, T and Sugiuchi, N and Suzuki, Y and Domon, R and Hayashi, T and Ishibashi, K and Ito, K and Kataoka, S and Kyogoku, S and Mashiko, H and Matsuo, K and Metoki, H and Otake, Y and Saito, J and Shishido, Y and Takayama, A and Tanno, Y and Toyota, S and Uchida, N and Yambe, M and Fujioka, M and Kimura, Y and Matsuoka, H and Sasaki, K and Wada, M and Yamamoto, H and Goto, T and Kamimura, Y and Kitamura, H and Matsuura, Y and Nakayama, Y and Araki, F and Miyazaki, Y and Sakata, T and Sakuma, H and Sato, T and Shimizu, K and Yoshida, M and Deguchi, Y and Kano, T and Nishiyama, A and Shinotsuka, I and Kobayashi, T and Kumakura, S and Masuda, T and Watanabe, T and Honzawa, T and Kubo, H and Aoki, H and Kanozawa, S and Koide, H and Nishiyama, K and Sakamoto, K and Suda, J and Tagaya, T and Yamada, A and Yamanaka, K and Hasegawa, R and Hirai, S and Horibe, K and Jujo, A and Suzuki, M and Tamiya, N and Ueda, T and Umimura, T and Aoki, N and Arai, S and Himeno, T and Ikeda, T and Inoue, H and ...
Clinical and Experimental Hypertension, ISSN 1064-1963, 07/2012, Volume 34, Issue 4, pp. 297 - 304
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 498, Issue 7453, pp. 220 - 223
Journal Article
by Acar-Perk, B and Weimer, J and Koch, K and Salmassi, A and Arnold, N and Mettler, L and Schmutzler, A. G and Ottolini, C. S and Griffin, D. K and Handyside, A. H and Summers, M. C and Thornhill, A. R and Montjean, D and Benkhalifa, M and Cohen-Bacrie, P and Siffroi, J. P and Mandelbaum, J and Berthaut, I and Bashamboo, A and Ravel, C and McElreavey, K and Ao, A and Zhang, X. Y and Yilmaz, A and Chung, J. T and Demirtas, E and Son, W. Y and Dahan, M and Buckett, W and Holzer, H and Tan, S. L and Perheentupa, A and Vierula, M and Jorgensen, N and Skakkebaek, N. E and Chantot-Bastaraud, S and Toppari, J and Muzii, L and Magli, M. C and Gioia, L and Mattioli, M and Ferraretti, A. P and Gianaroli, L and Koscinski, I and Elinati, E and Fossard, C and Kuentz, P and Kilani, Z and Demirol, A and Gurgan, T and Schmitt, F and Velez de la Calle, J and Iqbal, N and Louanjli, N and Pasquier, M and Carre-Pigeon, F and Muller, J and Barratt, C and Viville, S and Magli, C and Grugnetti, C and Castelletti, E and Paviglianiti, B and Pepas, L and Braude, P and Grace, J and Bolton, V and Khalaf, Y and El-Toukhy, T and Galeraud-Denis, I and Bouraima, H and Sibert, L and Rives, N and Carreau, S and Janse, F and de With, L. M and Fauser, B. C. J. M and Lambalk, C. B and Laven, J. S. E and Goverde, A. J and Giltay, J. C and De Leo, V and Governini, L and Quagliariello, A and Margollicci, M. A and Piomboni, P and Luddi, A and Miyamura, H and Nishizawa, H and Ota, S and Suzuki, M and Inagaki, A and Egusa, H and Nishiyama, S and Kato, T and Nakanishi, I and Fujita, T and Imayoshi, Y and Markoff, A and Yanagihara, I and ...
Human Reproduction, ISSN 0268-1161, 07/2011, Volume 26, Issue suppl_1, pp. i278 - i296
Journal Article
Nature, ISSN 0028-0836, 2017, Volume 552, Issue 7683, pp. 110 - 115
Fibrosis is a common pathology in cardiovascular disease(1). In the heart, fibrosis causes mechanical and electrical dysfunction(1,2) and in the kidney, it... 
MYOCARDIAL-INFARCTION | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | MUTATION | MYOFIBROBLASTS | INTERLEUKIN-11 | MECHANISMS | CYTOKINE | CARDIAC FIBROSIS | FAILURE | FIBROBLASTS | Heart | Protein Biosynthesis | Kidney - pathology | Humans | Middle Aged | Transforming Growth Factor beta1 - metabolism | Male | Fibrosis - metabolism | Myocardium - metabolism | Female | Interleukin-11 Receptor alpha Subunit - genetics | Transforming Growth Factor beta1 - pharmacology | Fibroblasts - metabolism | Interleukin-11 - antagonists & inhibitors | Autocrine Communication | Fibrosis - chemically induced | Interleukin-11 Receptor alpha Subunit - deficiency | Transgenes - genetics | Cells, Cultured | Interleukin-11 - genetics | Interleukin-11 - metabolism | Myocardium - pathology | Fibroblasts - pathology | Mice, Knockout | Cardiovascular System - pathology | Animals | Cardiovascular System - metabolism | Fibroblasts - drug effects | Organ Dysfunction Scores | Mice | Fibrosis - pathology | Physiological aspects | Interleukins | Cardiovascular diseases | Health aspects | Fibrosis | Transcription | Toxicity | Syngeneic grafts | Downstream effects | Transforming growth factor | Genomics | Interleukin | Cardiovascular disease | Proteins | Clonal deletion | Interleukin 1 | Fibroblasts | Deletion | Inhibition | Autocrine signalling | Heart diseases | Immunoglobulins | Kidneys | Cytokines | Organs | Extracellular signal-regulated kinase | Interleukin 11 | Protein biosynthesis | Gene expression | Coronary artery disease | Studies | Side effects | Protein synthesis | Renal failure | Ligands | Kidney transplantation
Journal Article
Neuro-Oncology, ISSN 1522-8517, 11/2013, Volume 15, Issue suppl 3, pp. iii206 - iii216
Journal Article
by Yang, F. H and Zhang, B and Zhou, D. J and Bie, L and Tom, M. W and Drummond, D. C and Nicolaides, T and Mueller, S and Banerjee, A and Park, J. W and Prados, M. D and James, D. C and Gupta, N and Hashizume, R and Strohbehn, G. W and Zhou, J and Fu, M and Patel, T. R and Piepmeier, J. M and Saltzman, W. M and Xie, Q and Johnson, J and Bradley, R and Ascierto, M. L and Kang, L and Koeman, J and Marincola, F. M and Briggs, M and Tanner, K and Vande Woude, G. F and Tanaka, S and Klofas, L. K and Wakimoto, H and Borger, D. R and Iafrate, A. J and Batchelor, T. T and Chi, A. S and Madhankumar, A. B and Slagle-Webb, B and Rizk, E and Harbaugh, K and Connor, J. R and Sarkar, G and Curran, G. L and Jenkins, R. B and Kurozumi, K and Ichikawa, T and Onishi, M and Fujii, K and Ishida, J and Shimazu, Y and Date, I and Ebsworth, K and Walters, M. J and Ertl, L. S and Wang, Y and Berahovich, R. D and Zhang, P and Powers, J. P and Liu, S.-C and Al Omran, R and Sullivan, T. J and Jaen, J. C and Brown, M and Schall, T. J and Yusuke, N and Shimizu, S and Shishido-Hara, Y and Shiokawa, Y and Nagane, M and Wang, J and Sai, K and Chen, F.-R and Chen, Z.-P and Shi, Z and Zhang, J and Zhang, K and Han, L and Chen, L and Qian, X and Zhang, A and Wang, G and Jia, Z and Pu, P and Kang, C and Kong, L.-Y and Doucette, T. A and Ferguson, S. D and Hachem, J and Yang, Y and Wei, J and Priebe, W and Fuller, G. N and Qiao, W and Rao, G and Heimberger, A. B and Chen, P.-Y and Ozawa, T and Drummond, D and Santos, R and ...
Neuro-Oncology, ISSN 1522-8517, 10/2012, Volume 14, Issue suppl 6, pp. vi25 - vi37
Journal Article
NATURE CELL BIOLOGY, ISSN 1465-7392, 08/2019, Volume 21, Issue 8, pp. 1003 - 1003
Journal Article