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1. Full Text Long-term effectiveness of dopamine agonists and monoamine oxidase B inhibitors compared with levodopa as initial treatment for Parkinson's disease (PD MED): a large, open-label, pragmatic randomised trial
by PD MED Collaborative Group and PD Med Collaborative Group
The Lancet (British edition), ISSN 0140-6736, 2014, Volume 384, Issue 9949, pp. 1196 - 1205
Internal Medicine | Neurology | Organic mental disorders. Neuropsychology | General aspects | Psychology. Psychoanalysis. Psychiatry | Adult and adolescent clinical studies | Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases | Psychopathology. Psychiatry | Biological and medical sciences | Medical sciences | Monoamine Oxidase Inhibitors - therapeutic use | Levodopa - therapeutic use | Humans | Middle Aged | Monoamine Oxidase - drug effects | Dopamine Agonists - therapeutic use | Male | Treatment Outcome | Parkinson Disease - drug therapy | Antiparkinson Agents - therapeutic use | Animals | Aged, 80 and over | Female | Aged | Drug Therapy, Combination | Parkinson's disease | Enzyme inhibitors | Dopamine | Agonists | Drug therapy | Comparative analysis | Dopa | Studies | Inhibitor drugs | Mortality | Older people | Parkinsons disease | Index Medicus | Abridged Index Medicus
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2. Full Text Newly identified genetic risk variants for celiac disease related to the immune response
by Hunt, Karen A and Zhernakova, Alexana and Turner, Graham and Heap, Graham A. R and Franke, Lude and Bruinenberg, Marcel and Romanos, Jihane and Dinesen, Lotte C and Ryan, Anthony W and Panesar, Davinder and Gwilliam, Rhian and Takeuchi, Fumihiko and McLaren, William M and Holmes, Geoffrey K. T and Howdle, Peter D and Walters, Julian R. F and Sanders, David S and Playford, Raymond J and Trynka, Gosia and Mulder, Chris J. J and Mearin, M. Luisa and Verbeek, Wieke H. M and Trimble, Valerie and Stevens, Fiona M and O'Morain, Colm and Kennedy, Nicholas P and Kelleher, Dermot and Pennington, Daniel J and Strachan, David P and McArdle, Wendy L and Mein, Charles A and Wapenaar, Martin C and Deloukas, Panos and McGinnis, Ralph and McManus, Ross and Wijmenga, Cisca and van Heel, David A
Nature genetics, ISSN 1061-4036, 04/2008, Volume 40, Issue 4, pp. 395 - 402
RHEUMATOID-ARTHRITIS | B-LYMPHOCYTES | POPULATION | ACTIVATION | REPLICATION | PROTEIN | MOUSE | EXPRESSION | UMCG Approved | GENOME-WIDE ASSOCIATION | REGION | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Gastroenterology. Liver. Pancreas. Abdomen | Stomach. Duodenum. Small intestine. Colon. Rectum. Anus | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Other diseases. Semiology | RGS Proteins - genetics | HLA-DQ Antigens - metabolism | Humans | Male | RNA, Messenger - metabolism | Case-Control Studies | Tissue Distribution | Interleukin-18 Receptor beta Subunit - genetics | Celiac Disease - immunology | Receptors, CCR3 - genetics | Polymerase Chain Reaction | Female | Genetic Predisposition to Disease | Celiac Disease - genetics | RNA, Messenger - genetics | Risk Factors | Diabetes Mellitus, Type 1 - genetics | Chromosome Mapping | Interleukin-12 Subunit p35 - genetics | Linkage Disequilibrium | Animals | Genetic Markers - genetics | Biomarkers | Interleukin-18 Receptor beta Subunit - blood | Mice | Polymorphism, Single Nucleotide | Genome, Human | Cohort Studies | Celiac disease | Care and treatment | Genetic variation | Genotype | Genetic aspects | Research | Identification and classification | Genotype & phenotype | Immunology | Genomics | Risk factors | Index Medicus
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3. Full Text Replication of Genome-Wide Association Signals in UK Samples Reveals Risk Loci for Type 2 Diabetes
by Eleftheria Zeggini and Michael N. Weedon and Cecilia M. Lindgren and Timothy M. Frayling and Katherine S. Elliott and Hana Lango and Nicholas J. Timpson and John R. B. Perry and Nigel W. Rayner and Rachel M. Freathy and Jeffrey C. Barrett and Beverley Shields and Andrew P. Morris and Sian Ellard and Christopher J. Groves and Lorna W. Harries and Jonathan L. Marchini and Katharine R. Owen and Beatrice Knight and Lon R. Cardon and Mark Walker and Graham A. Hitman and Andrew D. Morris and Alex S. F. Doney and Mark I. McCarthy and Andrew T. Hattersley and WTCCC and Wellcome Trust Case Control Consortium (WTCCC) and The Wellcome Trust Case Control Consortium (WTCCC)
Science (American Association for the Advancement of Science), ISSN 0036-8075, 6/2007, Volume 316, Issue 5829, pp. 1336 - 1341
Medical research | Forestry research | Hospital buildings | Medical genetics | Genetic research | Hospital units | Genetic loci | Reports | Type 2 diabetes mellitus | Human genetics | Research universities | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Biological and medical sciences | Endocrinopathies | Etiopathogenesis. Screening. Investigations. Target tissue resistance | Diabetes. Impaired glucose tolerance | Medical sciences | Endocrine pancreas. Apud cells (diseases) | Insulin-Like Growth Factor Binding Proteins - genetics | Genetic Predisposition to Disease | Meta-Analysis as Topic | Oligonucleotide Array Sequence Analysis | Introns | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Male | United Kingdom | Chromosome Mapping | Transcription Factors - genetics | Genes, p16 | Case-Control Studies | Homeodomain Proteins - genetics | Adult | Female | Aged | Polymorphism, Single Nucleotide | Genome, Human | Type 2 diabetes | Genetic aspects | Research | Risk factors | Biomedical research | Cellular biology | Genomics | Diabetes | Molecular biology | Pancreas | Population genetics | Index Medicus
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4. Full Text Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
by Burton, Paul R and Clayton, David G and Cardon, Lon R and Craddock, Nick and Deloukas, Panos and Duncanson, Audrey and Kwiatkowski, Dominic P and McCarthy, Mark I and Ouwehand, Willem H and Samani, Nilesh J and Todd, John A and Donnelly, Peter and Barrett, Jeffrey C and Davison, Dan and Easton, Doug and Evans, David and Leung, Hin-Tak and Marchini, Jonathan L and Morris, Andrew P and Spencer, Chris C. A and Tobin, Martin D and Attwood, Antony P and Boorman, James P and Cant, Barbara and Everson, Ursula and Hussey, Judith M and Jolley, Jennifer D and Knight, Alexandra S and Koch, Kerstin and Meech, Elizabeth and Nutland, Sarah and Prowse, Christopher V and Stevens, Helen E and Taylor, Niall C and Walters, Graham R and Walker, Neil M and Watkins, Nicholas A and Winzer, Thilo and Jones, Richard W and McArdle, Wendy L and Ring, Susan M and Strachan, David P and Pembrey, Marcus and Breen, Gerome and St. Clair, David and Caesar, Sian and Gordon-Smith, Katherine and Jones, Lisa and Fraser, Christine and Green, Elaine K and Grozeva, Detelina and Hamshere, Marian L and Holmans, Peter A and Jones, Ian R and Kirov, George and Moskvina, Valentina and Nikolov, Ivan and O'Donovan, Michael C and Owen, Michael J and Collier, David A and Elkin, Amanda and Farmer, Anne and Williamson, Richard and McGuffin, Peter and Young, Allan H and Ferrier, I. Nicol and Ball, Stephen G and Balmforth, Anthony J and Barrett, Jennifer H and Bishop, D. Timothy and Iles, Mark M and Maqbool, Azhar and Yuldasheva, Nadira and Hall, Alistair S and Braund, Peter S and Dixon, Richard J and Mangino, Massimo and Stevens, Suzanne and Thompson, John R and Bredin, Francesca and Tremelling, Mark and Parkes, Miles and Drummond, Hazel and Lees, Charles W and Nimmo, Elaine R and Satsangi, Jack and Fisher, Sheila A and Forbes, Alastair and Lewis, Cathryn M and Onnie, Clive M and Prescott, Natalie J and Sanderson, Jeremy and Mathew, Christopher G and Barbour, Jamie and Mohiuddin, M. Khalid and Todhunter, Catherine E and Mansfield, John C and Ahmad, Tariq and Cummings, Fraser R and Jewell, Derek P and ... and Breast Canc Susceptib Collaborat and Wellcome Trust Case Control Cons and Biol RA Genet & Genom Study and Wellcome Trust Case Control Consortium and The Wellcome Trust Case Control Consortium
Nature (London), ISSN 0028-0836, 06/2007, Volume 447, Issue 7145, pp. 661 - 678
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Fundamental and applied biological sciences. Psychology | Classical genetics, quantitative genetics, hybrids | Human | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | Geography | Crohn Disease - genetics | Genetics, Population | Genetic Predisposition to Disease - genetics | Diabetes Mellitus - genetics | Chromosomes, Human - genetics | Gene Frequency | Humans | United Kingdom | Bipolar Disorder - genetics | Case-Control Studies | Genome, Human - genetics | Arthritis, Rheumatoid - genetics | Genetic Markers - genetics | Coronary Artery Disease - genetics | Hypertension - genetics | Data analysis | Disease | Genomics | Data collection | Gene loci | Epidemiology | Risk factors | Index Medicus
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5. Full Text Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
by Burton, Paul R and Clayton, David G and Cardon, Lon R and Craddock, Nick and Deloukas, Panos and Duncanson, Audrey and Kwiatkowski, Dominic P and McCarthy, Mark I and Ouwehand, Willem H and Samani, Nilesh J and Todd, John A and Donnelly, Peter and Barrett, Jeffrey C and Davison, Dan and Easton, Doug and Evans, David M and Leung, Hin-Tak and Marchini, Jonathan L and Morris, Andrew P and Spencer, Chris C.A and Tobin, Martin D and Attwood, Antony P and Boorman, James P and Cant, Barbara and Everson, Ursula and Hussey, Judith M and Jolley, Jennifer D and Knight, Alexandra S and Koch, Kerstin and Meech, Elizabeth and Nutland, Sarah and Prowse, Christopher V and Stevens, Helen E and Taylor, Niall C and Walters, Graham R and Walker, Neil M and Watkins, Nicholas A and Winzer, Thilo and Jones, Richard W and McArdle, Wendy L and Ring, Susan M and Strachan, David P and Pembrey, Marcus and Breen, Gerome and Clair, David St and Caesar, Sian and Gordon-Smith, Katharine and Jones, Lisa and Fraser, Christine and Green, Elaine K and Grozeva, Detelina and Hamshere, Marian L and Holmans, Peter A and Jones, Ian R and Kirov, George and Moskivina, Valentina and Nikolov, Ivan and O'Donovan, Michael C and Owen, Michael J and Collier, David A and Elkin, Amanda and Farmer, Anne and Williamson, Richard and McGuffin, Peter and Young, Allan H and Ferrier, I. Nicol and Ball, Stephen G and Balmforth, Anthony J and Barrett, Jennifer H and Bishop, Timothy D and Iles, Mark M and Maqbool, Azhar and Yuldasheva, Nadira and Hall, Alistair S and Braund, Peter S and Dixon, Richard J and Mangino, Massimo and Stevens, Suzanne and Thompson, John R and Bredin, Francesca and Tremelling, Mark and Parkes, Miles and Drummond, Hazel and Lees, Charles W and Nimmo, Elaine R and Satsangi, Jack and Fisher, Sheila A and Forbes, Alastair and Lewis, Cathryn M and Onnie, Clive M and Prescott, Natalie J and Sanderson, Jeremy and Matthew, Christopher G and Barbour, Jamie and Mohiuddin, M. Khalid and Todhunter, Catherine E and Mansfield, John C and Ahmad, Tariq and Cummings, Fraser R and Jewell, Derek P and ... and Breast Cancer Susceptibility Collaboration (UK) and Wellcome Trust Case Control Consortium and Biologics in RA Genetics and Genomics Study Syndicate (BRAGGS) Steering Committee and Australo-Anglo-American Spondylitis Consortium (TASC) and The Australo-Anglo-American Spondylitis Consortium (TASC)
Nature genetics, ISSN 1061-4036, 11/2007, Volume 39, Issue 11, pp. 1329 - 1337
Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Genetics, Population | Aminopeptidases - genetics | Spondylitis, Ankylosing - genetics | Minor Histocompatibility Antigens | Thyroiditis, Autoimmune - epidemiology | Humans | Autoimmunity - genetics | Genotype | Multiple Sclerosis - genetics | Chromosome Mapping | Multiple Sclerosis - epidemiology | Receptors, Interleukin - genetics | Thyroiditis, Autoimmune - genetics | Case-Control Studies | Linkage Disequilibrium | Haplotypes - genetics | Breast Neoplasms - genetics | Polymerase Chain Reaction | Spondylitis, Ankylosing - epidemiology | Polymorphism, Single Nucleotide - genetics | North America - epidemiology | Receptors, Immunologic - genetics | Breast Neoplasms - epidemiology | Histocompatibility antigens | HLA histocompatibility antigens | Physiological aspects | Genetic aspects | Diagnosis | Research | Single nucleotide polymorphisms | Ankylosing spondylitis | Risk factors | Genotype & phenotype | Multiple sclerosis | Genetic research | Genetics | Arthritis | Breast cancer | Autoimmune diseases | Index Medicus
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