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Journal of Cellular Biochemistry, ISSN 0730-2312, 08/2018, Volume 119, Issue 8, pp. 6633 - 6643
Protein phosphatase 2A (PP2A) is an important enzyme within various signal transduction pathways. The present study was investigated PP2A mediates JS‐K‐induced... 
apoptosis | JS‐K | nitric oxide | protein phosphatase 2A | hepatocellular carcinoma | JS-K | ACTIVATION | NITRIC-OXIDE PRODRUG | DONOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | PP2A | CIP2A | CELL BIOLOGY | BAX | NITRATION | LIFE | Cell Survival - drug effects | Liver Neoplasms - genetics | Apoptosis - drug effects | Humans | Liver Neoplasms - drug therapy | Protein Phosphatase 2 - genetics | bcl-X Protein - genetics | Piperazines - pharmacology | Proto-Oncogene Proteins c-bcl-2 - biosynthesis | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Hep G2 Cells | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - biosynthesis | Protein Phosphatase 2 - metabolism | Liver Neoplasms - pathology | bcl-X Protein - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | Azo Compounds - pharmacology | Proto-Oncogene Proteins c-bcl-2 - genetics | Carcinoma, Hepatocellular - metabolism | Proteins | Phosphatases | Apoptosis | Cytochrome | Bax protein | Phosphoprotein phosphatase | Toxicity | Caspase | Cytotoxicity | Hepatocellular carcinoma | Activation | siRNA | Phosphatase | BAK protein | Cytochrome c | Time dependence | Signal transduction | Reduction | Mitochondria | Cell lines | Transduction | Protein phosphatase | Membrane potential | Viability | BIM protein
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2006, Volume 49, Issue 14, pp. 4356 - 4366
The literature provides evidence that metabolic nitric oxide (NO) release mediates the cytotoxic activities (against human leukemia and prostate cancer... 
S-TRANSFERASE | ACTIVATION | CHEMISTRY, MEDICINAL | PHOSPHORYLATION | GLUTATHIONE | KINASE | NITRIC-OXIDE | GROWTH-FACTOR | CELL GROWTH | PHOSPHATASES
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 11/2018, Volume 107, pp. 1385 - 1392
JS-K, (O -(2, 4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-yl] diazen 1-ium-1, 2-diolate), is a novel diazeniumdiolate-based nitric oxide donor prodrug.... 
Reactive oxygen species | JS-K | Apoptosis | Mitochondrial membrane motential | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | VIVO | LUNG-CANCER CELLS | RELEASE | DAMAGE | IN-VITRO | HEPATOCELLULAR-CARCINOMA | PRODRUG | PHARMACOLOGY & PHARMACY
Journal Article
Journal of Biochemical and Molecular Toxicology, ISSN 1095-6670, 04/2016, Volume 30, Issue 4, pp. 192 - 199
ABSTRACT Hepatocellular carcinoma is one of the most common and deadly forms of human malignancies. JS‐K, O2‐(2, 4‐dinitrophenyl) 1‐ [(4‐ethoxycarbonyl)... 
JS‐K | Nitric Oxide | Ca2 | Hepatocellular Carcinoma | Apoptosis | JS-K | PATHWAYS | VIVO | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | LUNG-CANCER CELLS | PERMEABILITY TRANSITION | IN-VITRO | DEPOLARIZATION | TOXICOLOGY | Cytochrome c | Mitochondrial DNA | Hepatoma | Nitric oxide | Liver cancer | Rodents
Journal Article
Journal of Biochemical and Molecular Toxicology, ISSN 1095-6670, 04/2016, Volume 30, Issue 4, pp. 192 - 199
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 07/2018, Volume 37, Issue 1, pp. 142 - 15
Background: JS-K is a nitric oxide (NO) donor and could generate intracellularly high levels of NO. The study explores PP2A as a tumor suppressor is a major... 
Hepatocellular carcinoma | JS-K | Nitric oxide | Apoptosis | Protein phosphatase 2A | PATHWAYS | NITRIC-OXIDE PRODRUG | PHOSPHORYLATION | DONOR | PP2A | CANCER | REGULATOR | ONCOLOGY | Phosphatases | Physiological aspects | Development and progression | Genetic aspects | Research | Hepatoma | Proteins | Liver cancer | Phosphorylation | Cell growth | Rodents | Cytotoxicity | Physiology | Phosphatase | Kinases | Prostate cancer
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 2017, Volume 88, pp. 367 - 373
Abstract JS-K is a novel anticancer nitric oxide (NO) prodrug effective against a variety of cancer cells, including the inhibition of AM-1 hepatoma cell... 
Internal Medicine | Medical Education | Nitric oxide donor | Hep3B cells | Differentiation | Gene expression | JS-K | Apoptosis | CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | VIVO | MYELOID-LEUKEMIA CELLS | TUMOR ANGIOGENESIS | KINASE PATHWAYS | IN-VITRO | GROWTH | PHARMACOLOGY & PHARMACY | GLUTATHIONE-S-TRANSFERASE | PABA/NO | Humans | Caspase 3 - metabolism | Piperazines - chemistry | Acute-Phase Proteins - genetics | Neovascularization, Pathologic - pathology | Azo Compounds - chemistry | Tissue Inhibitor of Metalloproteinase-1 - metabolism | Isoenzymes - metabolism | Carcinoma, Hepatocellular - genetics | Carcinoma, Hepatocellular - blood supply | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Cell Death - drug effects | Gene Expression Regulation, Neoplastic - drug effects | Liver Neoplasms - enzymology | Azo Compounds - pharmacology | Liver Neoplasms - genetics | Acute-Phase Proteins - metabolism | Glutathione Transferase - metabolism | Carcinoma, Hepatocellular - enzymology | Antineoplastic Agents - chemistry | Piperazines - pharmacology | Liver Neoplasms - blood supply | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Matrix Metalloproteinases - metabolism | Nitric Oxide - metabolism | Prodrugs - pharmacology | Thrombospondins - metabolism | Care and treatment | Analysis | Nitric oxide | Genes | Genetic research | Genetic aspects | Hepatoma | Cancer | Index Medicus
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 2017, Volume 92, pp. 989 - 997
Graphical abstract 
Internal Medicine | Medical Education | HCC | Nitric oxide donor | JS-K | HBV | DNA damage | Apoptosis | MEDICINE, RESEARCH & EXPERIMENTAL | S-TRANSFERASE | ACTIVATION | DOUBLE-STRAND BREAKS | PROLIFERATION | MODEL | IN-VITRO | REPAIR | TARGETS | PHARMACOLOGY & PHARMACY | ATM | EXPRESSION | Apoptosis - drug effects | Humans | Piperazines - metabolism | Antiviral Agents - metabolism | Antineoplastic Agents - metabolism | Dose-Response Relationship, Drug | Carcinoma, Hepatocellular - drug therapy | G2 Phase Cell Cycle Checkpoints - drug effects | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Nitric Oxide Donors - pharmacology | Azo Compounds - pharmacology | Hepatitis B virus - immunology | Liver Neoplasms - virology | Antiviral Agents - pharmacology | Nitric Oxide Donors - metabolism | Cell Cycle Proteins - metabolism | Hepatitis B Surface Antigens - metabolism | Liver Neoplasms - drug therapy | Carcinoma, Hepatocellular - virology | Piperazines - pharmacology | Apoptosis Regulatory Proteins - metabolism | Hep G2 Cells | Cell Movement - drug effects | Hepatitis B virus - drug effects | Signal Transduction - drug effects | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Azo Compounds - metabolism | Cell Proliferation - drug effects | DNA Damage | Hepatitis B virus - metabolism | Carcinoma, Hepatocellular - metabolism | Hepatitis B e Antigens - metabolism | Medical colleges | Nitric oxide | DNA | Genetic aspects | Cancer | Hepatitis B | Hepatoma | Monosaccharides | Proteins | Analysis | Genetic research | Health aspects | Sugars
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 11/2018, Volume 107, p. 1385
JS-K, (O.sup.2-(2, 4-dinitrophenyl) 1-[(4-ethoxycarbonyl) piperazin-1-yl] diazen 1-ium-1, 2-diolate), is a novel diazeniumdiolate-based nitric oxide donor... 
Cytochrome c | Antioxidants | Nitric oxide | Apoptosis
Journal Article
Journal Article
Journal of Biochemical and Molecular Toxicology, ISSN 1095-6670, 04/2016, Volume 30, Issue 4, pp. 192 - 199
Hepatocellular carcinoma is one of the most common and deadly forms of human malignancies. JS-K, O super(2)-(2, 4-dinitrophenyl) 1- [(4-ethoxycarbonyl)... 
Journal Article
Chinese Journal of Pharmacology and Toxicology, ISSN 1000-3002, 07/2017, Volume 31, Issue 7, pp. 730 - 735
Journal Article
Zhongguo Yaolixue yu Dulixue Zazhi = Chinese Journal of Pharmacology and Toxicology, ISSN 1000-3002, 01/2017, Volume 31, Issue 10, p. 964
OBJECTIVE To investigate the regulation of {O2 (2,4-dinitrophenyl)1-〔(4-ethoxycarbonyl) piperazin-1-yl〕diazen-1-ium-1,2-diolate}(JS-K), anitric oxide donor, on... 
Energy metabolism | Succinate dehydrogenase | Intravenous administration | Pyruvate kinase | Pyruvic acid | Colorimetry | Hepatoma | Metabolism | Hexokinase | Bearing | Triphosphatase | Nitric oxide | Rodents | Glycolysis | Mice | Oxidation | Lactic acid | Inhibition | ATP | Adenosine triphosphatase | Adenosine triphosphate | Tumors
Journal Article
Zhongguo Yaolixue yu Dulixue Zazhi = Chinese Journal of Pharmacology and Toxicology, ISSN 1000-3002, 01/2017, Volume 31, Issue 7, p. 730
OBJECTIVE To investigate the regulation of{O2 (2,4-dinitrophenyl)1-[(4-ethoxycarbonyl) piperazin-1-yl] diazen-1-ium-1, 2-diolate} (JS-K), a nitric oxide donor,... 
Energy metabolism | Hypoxia-inducible factor 1 | Succinate dehydrogenase | Pyruvic acid | Colorimetry | Hepatoma | Western blotting | Bearing | Thymus | Hypoxia-inducible factor 1a | Oxidation | Phosphofructokinase | Adenosine triphosphate | Hypoxia-inducible factors | Spleen | Pyruvate kinase | Metabolism | Hexokinase | Nitric oxide | Glycolysis | Hypoxia | Mice | Lactic acid | ATP | Adenosine triphosphatase | Tumors | Peritoneum
Journal Article
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 11/2018, Volume 107, p. 1385
Journal Article
无线互联科技, ISSN 1672-6944, 2017, Issue 16, pp. 65 - 66
电商行业想要通过高效的互联网络提高办事效率、降低开销成本、方便管理人员管理,利用软件工程的设计方法和先进的软件开发框架来实现电子商务管理势在必行。文章主要对JS下电商管理系统的设计及实现进行了探讨,以期为电商管理系统的建设提供参考。 
设计 | 电商管理系统 | JS | 实现
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 12/2003, Volume 197, Issue 3, pp. 426 - 434
JS‐K, a non‐ionic diazeniumdiolate derivative, is capable of arylating nucleophiles and spontaneously generating nitric oxide (NO) at physiological pH. This... 
IN-VITRO | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | INDUCED APOPTOSIS | NITRIC-OXIDE DONORS | DIFFERENTIATION | PC12 CELLS | SIGNAL-REGULATED KINASE | ERK PHOSPHORYLATION | AP-1 | NH2-TERMINAL KINASE | CELL BIOLOGY | Transcription Factor AP-1 - drug effects | MAP Kinase Signaling System - physiology | Apoptosis - drug effects | Humans | Transcription Factor AP-1 - metabolism | MAP Kinase Kinase 1 | Mitogen-Activated Protein Kinase Kinases - metabolism | Carcinoma, Hepatocellular - drug therapy | Protein-Serine-Threonine Kinases - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases | Liver Neoplasms - pathology | Nitric Oxide Donors - pharmacology | Phosphorylation - drug effects | Tumor Cells, Cultured | Azo Compounds - pharmacology | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Enzyme Inhibitors - pharmacology | Liver Neoplasms - drug therapy | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-fos - metabolism | Piperazines - pharmacology | Cell Division - drug effects | Proto-Oncogene Proteins c-fos - drug effects | Cell Division - physiology | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins c-jun - metabolism | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Apoptosis - physiology | Nitric Oxide - metabolism | Proto-Oncogene Proteins c-jun - drug effects | Mitogen-Activated Protein Kinases - drug effects | Mitogen-Activated Protein Kinase 3 | Carcinoma, Hepatocellular - metabolism | Drug Screening Assays, Antitumor | Mitogen-Activated Protein Kinases - metabolism
Journal Article