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Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3906 - 3906
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy and is the most common type of acute leukemia in adults. Although a majority of patients... 
Journal Article
Current Opinion in Hematology, ISSN 1065-6251, 11/2018, Volume 25, Issue 6, pp. 441 - 445
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 2790 - 2790
Abstract Therapy resistance and relapse in acute myeloid leukemia (AML) are driven by leukemia stem cells (LSCs). Recent evidence highlighting functional and... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 259 - 259
Abstract The main barrier to curing acute myeloid leukemia (AML) is disease relapse, which occurs due to therapy resistance and persistence of leukemic stem... 
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 2765 - 2765
Abstract Acute myeloid leukemia (AML) patients with normal cytogenetics, NPM1 mutation, and no FLT3-ITD are considered to be at low molecular risk (LMR). We... 
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 1705 - 1705
Abstract Acute myeloid leukemia (AML) is a hierarchical disease in which the bulk blast population is sustained by a minority population of leukemia stem cells... 
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 3681 - 3681
Abstract Current therapies for acute myeloid leukemia (AML) are able to achieve complete remission in 80-85% of patients; however large portions of these cases... 
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 3932 - 3932
Abstract Current treatments for acute myeloid leukemia (AML) often fail to induce long-term remissions and are also toxic to normal tissues, prompting the need... 
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 2595 - 2595
Abstract Treatment of relapsed acute myeloid leukemia (AML) results in lower complete remission rates compared to treatment of AML at diagnosis.... 
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 506, Issue 7488, pp. 328 - 333
In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly... 
HETEROGENEITY | PATHOGENESIS | ORIGIN | METASTASIS | MULTIDISCIPLINARY SCIENCES | ARCHITECTURE | DNA METHYLTRANSFERASE | CLONAL EVOLUTION | ACUTE MYELOID-LEUKEMIA | DNMT3A MUTATIONS | DIFFERENTIATION | Clone Cells - cytology | Neoplasm Transplantation | Neoplastic Stem Cells - cytology | Neoplastic Stem Cells - drug effects | Humans | Hematopoietic Stem Cells - pathology | DNA (Cytosine-5-)-Methyltransferases - metabolism | Heterografts | Neoplastic Stem Cells - metabolism | T-Lymphocytes - metabolism | Hematopoiesis | Cell Division | Leukemia, Myeloid, Acute - drug therapy | Neoplastic Stem Cells - pathology | Female | Cell Differentiation | T-Lymphocytes - pathology | Nuclear Proteins - genetics | Hematopoietic Stem Cells - drug effects | Leukemia, Myeloid, Acute - pathology | Isocitrate Dehydrogenase - genetics | Hematopoietic Stem Cells - metabolism | Mice, SCID | Mutation - genetics | Clone Cells - metabolism | Remission Induction | Cell Lineage | DNA (Cytosine-5-)-Methyltransferases - genetics | Animals | Clone Cells - pathology | Leukemia, Myeloid, Acute - diagnosis | Hematopoietic Stem Cells - cytology | Mice, Inbred NOD | Mice | Drug Resistance, Neoplasm - drug effects | Leukemia, Myeloid, Acute - genetics | Acute leukemia | Genetic aspects | Diagnosis | Identification and classification | Hematopoietic stem cells
Journal Article
Cancer Cell, ISSN 1535-6108, 2011, Volume 20, Issue 5, pp. 674 - 688
Journal Article
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2015, Volume 27, Issue 6, pp. 864 - 876
Journal Article
Nature Medicine, ISSN 1078-8956, 04/2012, Volume 18, Issue 4, pp. 605 - 611
Journal Article