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Journal of Medicinal Chemistry, ISSN 0022-2623, 04/2017, Volume 60, Issue 7, pp. 2819 - 2839
We previously reported the design of spirooxindoles with two identical substituents at the carbon-2 of the pyrrolidine core as potent MDM2 inhibitors. In this... 
TRIALS | ACTIVATION | DESIGN | CHEMISTRY, MEDICINAL | MECHANISM | DOCKING | PROTEIN-PROTEIN INTERACTION | FLUORINE | P53 PATHWAY | HIGHLY POTENT | RG7112 | Neoplasms - metabolism | Osteosarcoma - drug therapy | Bone and Bones - pathology | Leukemia - pathology | Humans | Antineoplastic Agents - therapeutic use | Leukemia - metabolism | Structure-Activity Relationship | Bone Neoplasms - pathology | Bone Neoplasms - metabolism | Bone and Bones - drug effects | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Bridged Bicyclo Compounds - chemistry | Bone and Bones - metabolism | Bridged Bicyclo Compounds - therapeutic use | Indoles - pharmacology | Antineoplastic Agents - pharmacokinetics | Antineoplastic Agents - pharmacology | Bone Neoplasms - drug therapy | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Proto-Oncogene Proteins c-mdm2 - metabolism | Osteosarcoma - metabolism | Bridged Bicyclo Compounds - pharmacology | Pyrrolidines - pharmacokinetics | Leukemia - drug therapy | Rats | Antineoplastic Agents - chemistry | Drug Discovery | Pyrrolidines - chemistry | Neoplasms - drug therapy | Animals | Halogenation | Cell Line, Tumor | Indoles - pharmacokinetics | Indoles - therapeutic use | Mice | Molecular Docking Simulation | Bridged Bicyclo Compounds - pharmacokinetics | Neoplasms - pathology | Indoles - chemistry | Osteosarcoma - pathology
Journal Article
by Aaboud, M and Aad, G and Abbott, B and Abdallah, J and Abdinov, O and Abeloos, B and Aben, R and AbouZeid, O.S and Abraham, N.L and Abramowicz, H and Abreu, H and Abreu, R and Abulaiti, Y and Acharya, B.S and Adamczyk, L and Adams, D.L and Adelman, J and Adersberger, M and Adomeit, S and Adye, T and Affolder, A.A and Agatonovic-Jovin, T and Agricola, J and Aguilar-Saavedra, J.A and Ahlen, S.P and Ahmadov, F and Aielli, G and Akerstedt, H and Åkesson, T.P.A and Akimov, A.V and Alberghi, G.L and Albert, J and Albrand, S and Alconada Verzini, M.J and Aleksa, M and Aleksandrov, I.N and Alexa, C and Alexander, G and Alexopoulos, T and Alhroob, M and Ali, B and Aliev, M and Alimonti, G and Alison, J and Alkire, S.P and Allbrooke, B.M.M and Allen, B.W and Allport, P.P and Aloisio, A and Alonso, A and Alonso, F and Alpigiani, C and Alstaty, M and Alvarez Gonzalez, B and Álvarez Piqueras, D and Alviggi, M.G and Amadio, B.T and Amako, K and Amaral Coutinho, Y and Amelung, C and Amidei, D and Amor Dos Santos, S.P and Amorim, A and Amoroso, S and Amundsen, G and Anastopoulos, C and Ancu, L.S and Andari, N and Andeen, T and Anders, G and Anders, J.K and Anders, C.F and Anderson, K.J and Andreazza, A and Andrei, V and Angelidakis, S and Angelozzi, I and Anger, P and Angerami, A and Anghinolfi, F and Anisenkov, A.V and Anjos, N and Annovi, A and Antel, C and Antonelli, M and Antonov, A and Anulli, F and Aoki, M and Aperio Bella, L and Arabidze, G and Arai, Y and Araque, J.P and Arce, A.T.H and Arduh, F.A and Arguin, J-F and Argyropoulos, S and Arik, M and Armbruster, A.J and Armitage, L.J and Arnaez, O and ... and eSSENCE: The e-Science Collaboration and Lund University and Partikelfysik and Lunds universitet and Particle Physics
Physics Letters B, ISSN 0370-2693, 09/2016, Volume 760, Issue C, pp. 647 - 665
A search for heavy long-lived charged -hadrons is reported using a data sample corresponding to 3.2 fb of proton–proton collisions at collected by the ATLAS... 
Physics | High Energy Physics - Experiment | Fysik | Subatomär fysik | Physical Sciences | Subatomic Physics | Naturvetenskap | Natural Sciences
Journal Article
Studies in Mycology, ISSN 0166-0616, 06/2015, Volume 81, Issue 81, pp. 149 - 189
Most small genera containing yeast species in the ( , ) are monophyletic, whereas larger genera including , , , and are polyphyletic. With the implementation... 
Fungi | Yeasts | Phylogenetic rank boundary optimisation | Molecular phylogeny | Taxonomy | GMYC approach | Pucciniomycotina | D1/D2 | GENUS | SP NOV | MOLECULAR TAXONOMY | BASIDIOMYCETOUS YEASTS | SYSTEMATICS | F.A | MYCOLOGY | HIGHER-LEVEL CLASSIFICATION | Yeast fungi | Identification and classification | Basidiomycota | P. novozealandica (Hamam. & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Microsporomyces Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | K. miscanthi (Nakase & M. Suzuki) Q.M. Wang, M. Groenew., F.Y. Bai & Boekhout | Phenoliferia Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Ballistosporomycessasicola (Nakase & M. Suzuki) F.Y. Bai, Q.M. Wang, M. Groenew. & Boekhout | P. psychrophila (Margesin & J.P. Samp.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Buckleyzymaceae Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Oberwinklerozymasilvestris (Golubev & Scorzetti) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Microsporomycesbloemfonteinensis (Pohl, M.S. Smit & Albertyn) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | C. terpenoidalis (Thanh, M.S. Smit, Moleleki & Fell) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | C. falcata (Nakase, M. Itoh & M. Suzuki) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Buckleyzyma Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | P. dimennae (Hamam. & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | C. retinophila (Thanh, M.S. Smit, Moleleki & Fell) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | S. tsugae (Phaff & do Carmo-Sousa) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Rhodosporidiobolus fluvialis (Fell, Kurtzman, Tallman & J.D. Buck) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | K. yuccicola (Nakase & M. Suzuki) Q.M. Wang, M. Groenew., F.Y. Bai & Boekhout | S. johnsonii (Nyland) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Trigonosporomyceshylophilus (van der Walt, van der Klift & D.B. Scott) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | P. linderae (Nakase, M. Takash. & Hamam.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Spencerozymacrocea (Shifrine & Phaff) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | H. singularis (Phaff & do Carmo-Sousa) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | S. meli (Libkind, van Broock & J.P. Samp.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Chrysozyma Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Yamadamycesrosulatus (Golubev & Scorzetti) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Sampaiozymaingeniosa (Di Menna) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Cystobasidiopsislactophilus (Nakase, M. Itoh, M. Suzuki & Bandoni) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Phyllozymacoprosmicola (Hamam. & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | S. vanillica (J.P. Samp.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. sphaerocarpa (S.Y. Newell & Fell) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. odoratus (J.P. Samp., Á. Fonseca & Valério) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Rhodosporidiobolus Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | P. himalayensis (Shivaji, Bhadra & Rao) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. diospyroris (Nakase, Tsuzuki, F.L. Lee, Jindam. & M. Takash.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | C. philyla (van der Walt, Klift & D.B. Scott) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. poonsookiae (M. Takash. & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Chrysozymaceae Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Pseudobensingtoniaingoldii (Nakase & Itoh.) F.Y. Bai, Q.M. Wang, M. Groenew. & Boekhout | Symmetrosporacoprosmae (Hamam. & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Slooffia cresolica (Middelhoven & Spaaij) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Microsporomycetaceae Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | B. syzygii (Hamam., Thanh & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Yunzhangia Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Sporobolomyceslongiusculus (Libkind, van Broock & J.P. Samp.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Bannoabischofiae (Hamam., Thanh & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Symmetrosporaceae Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Ruineniaceae Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | B. phyllomatis (van der Walt & Y. Yamada) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | S. pulcherrima (J.E. Wright) F.Y. Bai, Q.M. Wang, Groenewald & Boekhout | Colacogloeaceae Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Symmetrospora Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Sterigmatomyceshyphaenes (Har. & Pat.) F.Y. Bai, Q.M. Wang, Groenewald & Boekhout | Jianyuniasakaguchii (Sugita, M. Takash., Hamam. & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. nylandii (M. Takash. & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | B. taupoensis (Hamam. & Nakase) F.Y. Bai, Q.M. Wang, M. Groenew. & Boekhout | Udeniozymaferulica (J.P. Samp. & van Uden) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Y. sonckii (Hopsu-Havu, Tunnela & Yarrow) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Hasegawazyma Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | C. lophatheri (Nakase, Tsuzuki, F.L. Lee, Jindam. & M. Takash.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. diobovata (S.Y. Newell & I.L. Hunter) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. babjevae (Golubev) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | P. producta (N. Furuya & M. Takash.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Fellozyma Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Pseudobensingtonia F.Y. Bai, Q.M. Wang, M. Groenew. & Boekhout | Ruinenia Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. ruineniae (Holzschu, Tredick & Phaff) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Yunzhangiaauriculariae (Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | P. buffonii (C. Ramírez) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Ustilentylomagraminis (Rodr. Mir. & Diem) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Vonarxula Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | B. salicina (B.N. Johri & Bandoni) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. microsporus (Higham ex Fell, Blatt & Statzell) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Buckleyzymaarmeniaca (R.G. Shivas & Rodr. Mir.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Vonarxulajavanica (Ruinen) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | M. orientis (Pohl, M.S. Smit & Albertyn) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Udeniozyma Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | K. thailandica (Fungsin, Hamam. & Nakase ) Q.M. Wang, M. Groenew., F.Y. Bai & Boekhout | Yamadamyces Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | S. novozelandica (W.B. Kendr. & X.D. Gong) F.Y. Bai, Q.M. Wang, Groenewald & Boekhout | R. kratochvilovae (Hamam., Sugiy. & Komag.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Chrysozymafushanensis (Nakase, F.L. Lee & M. Takash.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Bannozyma Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | E. yunnanense (F.Y. Bai, M. Takash., Hamam. & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. paludigena (Fell & Tallman) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | K. sorbi (F.Y. Bai & Q.M. Wang) Q.M. Wang, M. Groenew., F.Y. Bai & Boekhout | P. musae (M. Takash., S.O. Suh & Nakase) F.Y. Bai, Q.M. Wang, M. Groenew. & Boekhout | Sakaguchiacladiensis (Fell, Statzell & Scorzetti) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Fellozymainositophila (Nakase & M. Suzuki) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | C. diffluens (Ruinen) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | M. pini (Pohl, M.S. Smit & Albertyn) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Spiculogloeomycetes Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Colacogloeacycloclastica (Thanh, M.S. Smit, Moleleki & Fell) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | K. phyllada (van der Walt & Y. Yamada) Q.M. Wang, M. Groenew., F.Y. Bai & Boekhout | Ruineniaclavata (F.Y. Bai & Q.M. Wang) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | C. griseoflava (Nakase & M. Suzuki) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | S. pilati (F.H. Jacob, Faure-Raynaud & Berton) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | B. kluyveri-nielii (van der Walt) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | O. yarrowii (Á. Fonseca & van Uden) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | O. straminea (Golubev & Scorzetti) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Phenoliferiapsychrophenolica (Margesin & J.P. Samp.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Hamamotoa Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. colostri (T. Castelli) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Sakaguchiaceae Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Spencerozyma Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. dracophylli (Hamam. & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | P. corallina (N. Furuya & M. Takash.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Bannozymaarctica (Vishniac & M. Takash.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | C. eucalyptica (C.H. Pohl, M.S. Smit & Albertyn) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Kondoachangbaiensis (F.Y. Bai & Q.M. Wang) Q.M. Wang, M. Groenew., F.Y. Bai & Boekhout | S. oryzae (F.Y. Bai & Y.M. Cai) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Jianyunia Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | S. lamellibrachiae (Nagah., Hamam., Nakase & Horikoshi) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. pyrrosiae (Nakase, Tsuzuki, F.L. Lee, Jindam. & M. Takash.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Hasegawazymalactosa (Hasegawa) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Hamamotoalignophila (Dill, C. Ramírez & González) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | B. yamatoana (Nakase, M. Suzuki & M. Itoh) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Phyllozyma Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Sampaiozyma Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | B. ogasawarensis (Hamam., Thanh & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. azoricus (J.P. Samp. & Gadanho) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | S. marina (Phaff, Mrak & Williams) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | S. symmetrica (F.Y. Bai & Q.M. Wang) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | S. gracilis (Derx) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. rubra (Nakase, Oakada & Sugiy.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | K. subrosea (Nakase & M. Suzuki) Q.M. Wang, M. Groenew., F.Y. Bai & Boekhout | Trigonosporomyces Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | M. magnisporus (Nakase, Tsuzuki, F.L. Lee, Sugita, Jindam. & M. Takash.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. lusitaniae (Á. Fonseca & J.P. Samp.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | R. toruloides (I. Banno) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | S. foliicola (R.G. Shivas & Rodr. Mir.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | P. pustula (Buhagiar) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Erythrobasidiumelongatum (R.G. Shivas & Rodr. Mir.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | P. subbrunnea (Nakase & M. Suzuki) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | P. glacialis (Margesin & J.P. Samp.) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | B. aurantiaca (Saito) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | C. foliorum (Ruinen) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Oberwinklerozyma Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Cystobasidiumportillonense (F. Laich, I. Vaca & R. Chávez) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Pseudohyphozymabogoriensis (Deinema) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Rhodotorulaalborubescens (Derx) Q.M. Wang, F.Y. Bai, Groenew. & Boekhout | S. vermiculata (M. Takash. & Nakase) Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Pseudohyphozyma Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout | Slooffia Q.M. Wang, F.Y. Bai, M. Groenew. & Boekhout
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