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Human Genetics, ISSN 0340-6717, 6/2019, Volume 138, Issue 6, pp. 547 - 561
Air pollution is recognized as causal factor for cardiovascular disease (CVD) and is associated with multiple CVD risk factors. Substantial research effort has... 
Human Genetics | Gene Function | Molecular Medicine | Biomedicine | Metabolic Diseases | MiRNA | Detoxification | Cardiovascular disease | Genomes | Genetic diversity | GSTM1 protein | GSTT1 protein | Risk factors | Literature reviews | Interleukin 6 | Pollution | Reviews | Particulate matter | Biomarkers | Air pollution | Gene loci | Pollutants | Cardiovascular diseases
Journal Article
Environmental Research, ISSN 0013-9351, 02/2016, Volume 145, p. 9
Epidemiological studies have identified associations between long-term PM.sub.2.5 exposure and cardiovascular events, though most have relied on concentrations... 
Medicine, Experimental | Medical research | Air quality | Coronary heart disease | Environmental health | Catheterization | Epidemiology | Analysis | Cardiac patients
Journal Article
by Peters, Marjolein and Joehanes, Roby and Pilling, Luke and Schurmann, Claudia and Conneely, Karen N and Powell, Joseph and Reinmaa, Eva and Sutphin, George L and Zhernakova, Alexana and Schramm, Katharina and Wilson, Yana A and Kobes, Sayuko and Tukiainen, Taru and Ramos, Yolande and Göring, Harald H and Fornage, Myriam and Liu, Yongmei and Gharib, Sina and Stranger, Barbara and Jager, Philip and Aviv, Abraham and Levy, Daniel and Murabito, Joanne and Munson, Peter J and Huan, Tianxiao and Hofman, Albert and Uitterlinden, Ané and Rivadeneira Ramirez, Fernando and van Rooij, Jeroen and Stolk, Lisette and Broer, Linda and Verbiest, Michael and Jhamai, Mila and Arp, Pascal and Metspalu, Anes and Tserel, Liina and Milani, Lili and Samani, Nilesh and Peterson, Pärt and Kasela, Silva and Codd, Veryan and Peters, Annette and Ward-Caviness, Cavin K and Herder, Christian and Waldenberger, Melanie and Roden, Michael and Singmann, Paula and Zeilinger, Sonja and Illig, Thomas and Homuth, Georg and Grabe, Hans Jörgen and Völzke, Henry and Steil, Leif and Kocher, Thomas and Murray, Anna and Melzer, David and Yaghootkar, Hanieh and Bandinelli, S and Moses, Eric and Kent, Jack and Curran, Joanne and Johnson, Matthew and Williams-Blangero, Sarah and Westra, Harm-Jan and McRae, Allan F and Smith, Jennifer A and Kardia, Sharon and Hovatta, Iiris and Perola, Markus and Ripatti, Samuli and Salomaa, Veikko and Henders, Anjali and Martin, Nicholas and Smith, Alicia K and Mehta, Divya and Binder, Elisabeth B and Nylocks, K. Maria and Kennedy, Elizabeth M and Klengel, Torsten and Ding, Jingzhong and Suchy-Dicey, Astrid and Enquobahrie, D and Brody, Jennifer and Rotter, Jerome I and Chen, Yii-Der I and Houwing-Duistermaat, Jeanine and Kloppenburg, Margreet and Slagboom, Eline and Helmer, Quinta and Hollander, Wouter and Bean, Shannon and Raj, Towfique and Bakhshi, Noman and Wang, Qiao Ping and Oyston, Lisa J and Psaty, Bruce and Tracy, Russell and Montgomery, Grant and Turner, Stephen and Blangero, John and ... and NABEC UKBEC Consortium and NABEC/UKBEC Consortium
Nature Communications, ISSN 2041-1723, 10/2015, Volume 6, Issue 1, p. 8570
textabstractDisease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately... 
LIFE-SPAN | OXIDATIVE STRESS | METHYLATION | PROFILES | GLYCOSAMINOGLYCANS | HUMAN LONGEVITY | DROSOPHILA-MELANOGASTER | MULTIDISCIPLINARY SCIENCES | PATTERNS | GENE-EXPRESSION CHANGES | GENOME-WIDE ASSOCIATION | Aging - blood | DNA Methylation | Humans | Transcriptome | European Continental Ancestry Group | Gene Expression Profiling | Biomarkers - blood
Journal Article
by Ligthart, Symen and Marzi, C and Aslibekyan, S and Mendelson, M.M and Conneely, Karen N and Tanaka, Toshiko and Colicino, E and Waite, Lindsay and Joehanes, Roby and Guan, Weihua and Brody, Jennifer and Elks, Cathy and Marioni, Riccardo and Jhun, Min A and Agha, G and Bressler, Jan and Ward-Caviness, Cavin K and Chen, Brian and Huan, Tianxiao and Bakulski, Kelly M and Salfati, Elias and Fiorito, G and Wahl, Simone and Schramm, Katharina and Sha, J and Hernandez, Dena and Just, A.C and Smith, Jennifer A and Sotoodehnia, Nona and Pilling, Luke and Pankow, James and Tsao, P.S and Liu, C and Zhao, Wei and Guarrera, Simonetta and Michopoulos, V.J and Smith, A.K and Peters, Marjolein and Melzer, David and Vokonas, P and Fornage, Myriam and Prokisch, Holger and Bis, Joshua and Chu, Auey and Herder, Christian and Grallert, Harald and Yao, Chen and Shah, Sonia and McRae, Allan F and Lin, H and Horvath, Steve and Fallin, D and Hofman, Albert and Wareham, Nick and Wiggins, Kerri and Feinberg, Anew P and Starr, John and Visscher, Peter and Murabito, Joanne and Kardia, S.L.R and Absher, Devin and Binder, Elisabeth and Singleton, Anew and Bandinelli, Stefania and Peters, Annette and Waldenberger, Melanie and Matullo, G and Schwartz, J.D and Demerath, Ellen and Uitterlinden, Ané and Meurs, J.B.J and Franco, Oscar and Chen, Y and Levy, Daniel and Turner, Stephen and Deary, Ian J and Ressler, Kerry and Dupuis, Josée and Ferrucci, Luigi and Ong, K.K and Assimes, Themistocles and Boerwinkle, Eric and Koenig, Wolfgang and Arnett, Donna and Baccarelli, Anea A and Benjamin, Emelia and Dehghan, Abbas and CHARGE Epigenetics Coronary Heart and WHI-EMPC Invest Giovanni Fiorito and CHARGE epigenetics of Coronary Heart Disease and WHI-EMPC Investigators
Genome Biology, ISSN 1474-7596, 12/2016, Volume 17, Issue 1, p. 255
Journal Article
PLOS ONE, ISSN 1932-6203, 04/2019, Volume 14, Issue 4, pp. e0207834 - e0207834
DNA methylation age (DNAm age) has become a widely utilized epigenetic biomarker for the aging process. The Horvath method for determining DNAm age is perhaps... 
MULTIDISCIPLINARY SCIENCES | WIDE ASSOCIATION | Epigenetic inheritance | DNA microarrays | Research | Methylation | Analysis | DNA | Pediatrics | Laboratories | Genomes | Datasets | Mathematical analysis | DNA methylation | Aging | Physiology | Bioindicators | Chronology | Cardiology | Probes | Age | Deoxyribonucleic acid--DNA | DNA probes | Gene expression | Loci | Medicine | Epigenetics | Biomarkers | Intubation | Arrays | Cancer | Environmental protection | Deoxyribonucleic acid
Journal Article
Aging, ISSN 1945-4589, 01/2016, Volume 8, Issue 9, pp. 1844 - 1865
textabstractEstimates of biological age based on DNA methylation patterns, often referred to as "epigenetic age", "DNAm age", have been shown to be robust... 
DNA methylation | Epigenetics | All-cause mortality | Epigenetic clock | Lifespan | Mortality | lifespan | CANCER | epigenetics | CELL BIOLOGY | all-cause mortality | DISEASE | mortality | COHORT | EPIDEMIOLOGY | BRAIN | epigenetic clock | BLOOD | LIFE
Journal Article
Environmental Health Perspectives, ISSN 0091-6765, 02/2018, Volume 126, Issue 2, p. 027004
BACKGROUND: Long-term air pollution exposure is negatively associated with lung function, yet the mechanisms underlying this association not fully clear.... 
ACTIVATION | EPIGENETIC MEDIATION | ASSOCIATIONS | PHOSPHOLIPASE-D | USE REGRESSION-MODELS | ESCAPE | DENSITY | ENVIRONMENTAL SCIENCES | OBSTRUCTIVE PULMONARY-DISEASE | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | TOXICOLOGY | FINE PARTICULATE MATTER | NITROGEN-DIOXIDE | Particulate Matter - toxicity | Air Pollutants - analysis | Genome-Wide Association Study | Humans | Middle Aged | Air Pollution - adverse effects | Linear Models | Male | DNA Methylation - genetics | Environmental Exposure - analysis | Environmental Exposure - adverse effects | Nitrogen Dioxide - analysis | Particulate Matter - analysis | Time Factors | CpG Islands - genetics | Adult | Female | Nitrogen Dioxide - toxicity | Respiratory Function Tests | Air Pollutants - toxicity | Cohort Studies | Respiratory insufficiency | Environmental aspects | Causes of | Air pollution | Development and progression | Genetic aspects | Nitrogen dioxide | Methylation | Health aspects | Analysis | Lung diseases | Genes | Genomics | DNA | Genomes | B cells | Respiratory function | Airborne particulates | Human exposure | Particulates | Exposure | Regression analysis | Land use | Regression models | Pollution | Carbon content | Robustness (mathematics) | Lungs | Respiratory diseases | Particulate matter | DNA methylation | Replication | Particulate emissions | Deoxyribonucleic acid--DNA | CpG islands
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 4, p. e0152670
There is a growing literature indicating that genetic variants modify many of the associations between environmental exposures and clinical outcomes,... 
SPERMATOGENESIS | AIR-POLLUTION | INHIBITION | DNA METHYLATION | RISK-FACTOR | MULTIDISCIPLINARY SCIENCES | VASCULAR CALCIFICATION | CARDIOVASCULAR-DISEASE | ATHEROSCLEROSIS | CORONARY-HEART-DISEASE | PROGRESSION | Genetic Predisposition to Disease | Genome-Wide Association Study | Humans | Middle Aged | Transportation | Air Pollution - adverse effects | Male | Environmental Exposure - analysis | Housing | Gene-Environment Interaction | Environmental Exposure - adverse effects | Peripheral Arterial Disease - genetics | Peripheral Arterial Disease - chemically induced | Female | Air Pollution - analysis | Polymorphism, Single Nucleotide | Bone Morphogenetic Proteins - genetics | Physiological aspects | Bone morphogenetic proteins | Genetic aspects | Single nucleotide polymorphisms | Research | Peripheral vascular diseases | Risk factors | Calcification (ectopic) | Laboratories | Pathogenesis | Genes | Traffic | Critical care | Cardiovascular disease | Genomes | Single-nucleotide polymorphism | Access routes | Epidemiology | Proteins | Highways | Pollution | Vascular diseases | Atherosclerosis | DNA methylation | Physiology | Deoxyribonucleic acid--DNA | Genotypes | Tibial nerve | Bone morphogenetic protein 2 | Mortality | Health risks | Exposure | Thrombosis | Medicine | Studies | Genetic variance | MicroRNAs | Arteriosclerosis | Epigenetics | Calcification | Air pollution | Intubation | Bone | Environmental protection | Deoxyribonucleic acid | DNA
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2019, Volume 14, Issue 5, pp. e0216222 - e0216222
Journal Article