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Nature, ISSN 0028-0836, 12/2010, Volume 468, Issue 7326, pp. 968 - 972
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas(1). Pre-clinical studies have... 
TRANSFORMATION | CELLS | TUMOR PROGRESSION | GENE | SIGNALING PATHWAY | MULTIDISCIPLINARY SCIENCES | BRAF | B-RAF | KAPPA-B | MUTATIONS | CANCER | Allosteric Regulation | Humans | Gene Expression Regulation, Neoplastic | Melanoma - enzymology | Gene Expression Profiling | MAP Kinase Signaling System | Mitogen-Activated Protein Kinase Kinases - metabolism | Melanoma - genetics | Indoles - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Proto-Oncogene Proteins - metabolism | Gene Library | Proto-Oncogene Proteins c-raf - genetics | MAP Kinase Kinase Kinases - genetics | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins - genetics | Clinical Trials as Topic | MAP Kinase Kinase Kinases - metabolism | Enzyme Activation - drug effects | Open Reading Frames - genetics | Sulfonamides - pharmacology | Proto-Oncogene Proteins c-raf - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Drug Resistance, Neoplasm - genetics | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Indoles - therapeutic use | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Protein research | Research | Properties | Protein kinases | Cancer cells | Cell lines | Biochemistry | Mutation | Kinases | Genes | Cancer
Journal Article
The Lancet Oncology, ISSN 1470-2045, 02/2019, Volume 20, Issue 2, pp. e77 - e91
Although novel therapies, including immunotherapy, have dramatically improved outcomes for many patients with cancer, overall outcomes are heterogeneous and... 
IMMUNE | FUSOBACTERIUM-NUCLEATUM | CHECKPOINT-BLOCKADE | ONCOLOGY | INTESTINAL MICROBIOTA | COLORECTAL-CANCER | DOUBLE-BLIND | HOST | PROBIOTICS | GUT MICROBIOTA | CHEMOTHERAPY | Microbiota (Symbiotic organisms) | Immunotherapy | Genomics | Melanoma | Health aspects | Epidemiology | Cancer
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7399, pp. 502 - 506
Journal Article
Nature, ISSN 0028-0836, 11/2012, Volume 491, Issue 7424, pp. 449 - 453
Journal Article
Cancer, ISSN 0008-543X, 04/2017, Volume 123, Issue 8, pp. 1372 - 1381
BACKGROUND BRAFV600, NRAS, TP53, and BRAFNon‐V600 are among the most common mutations detected in non‐acral cutaneous melanoma patients. Although several... 
melanoma | mutations | BRAFV600 | TP53 | BRAFNon‐V600 | Therapy | Demography | Toxicity | p53 Protein | Medical services | Melanoma | Patients | Clinical outcomes | Demographics | Inhibitors | Head and neck | Mutation | Cancer | Geriatrics | Index Medicus | Abridged Index Medicus | BRAFNon-V600
Journal Article
The Lancet Oncology, ISSN 1470-2045, 03/2018, Volume 19, Issue 3, pp. 310 - 322
Journal Article
Pigment Cell & Melanoma Research, ISSN 1755-1471, 03/2019, Volume 32, Issue 2, pp. 280 - 291
The BRAF kinase and the MAPK pathway are targets of current melanoma therapies. However, MAPK pathway inhibition results in dynamic changes of downstream... 
PAX3 | MEK | BRAF | MITF | BRN2 | AXL | Melanoma | Microphthalmia-associated transcription factor | Transcription factors | Control | Inhibitors | Cell survival | Downstream effects | Plasticity | MAP kinase | Plastic properties | Pax3 protein | Tumors | Original
Journal Article
The Lancet Oncology, ISSN 1470-2045, 02/2018, Volume 19, Issue 2, pp. 181 - 193
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1459 - 1470
Journal Article
The Lancet Oncology, ISSN 1470-2045, 07/2019, Volume 20, Issue 7, pp. 892 - 894
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2016, Volume 29, Issue 3, pp. 270 - 284
Journal Article
Cancer Research, ISSN 0008-5472, 08/2015, Volume 75, Issue 15 Supplement, pp. SY26-03 - SY26-03
Journal Article
Cancer Research, ISSN 0008-5472, 07/2015, Volume 75, Issue 14 Supplement, pp. IA31 - IA31
Journal Article