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2001, Methods in enzymology, ISBN 0121822419, Volume 340., xxxiv, 705
This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from... 
Ligand binding (Biochemistry) | Molecular Biology | methods | drug effects | Nucleic acids | RNA-Binding Proteins | Molecular pharmacology | DNA-ligand interactions | DNA-Binding Proteins | DNA-drug interactions
Book
2002, Basic concepts in chemistry, ISBN 9780471549314, vii, 168
Book
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2009, Volume 19, Issue 10, pp. 2844 - 2851
Analysis of a large, structurally diverse Caco-2 permeability dataset using a variety of statistical techniques suggests that log and molecular weight are the... 
Permeability | Caco-2 | Lipophilicity | Molecular weight
Journal Article
1986, Cancer biology and medicine, ISBN 0852009356, vii, 229
Book
11/2018, Topics in medicinal chemistry, ISBN 9783319759241, Volume 28, 482
This book reviews recent breakthroughs in anti-cancer drug discovery. Building on the previous volume in the series, it outlines some of the most significant... 
Cancer-Chemotherapy
eBook
SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9, Issue 1, pp. 7906 - 13
Drug-target binding kinetics are suggested to be important parameters for the prediction of in vivo drug-efficacy. For G protein-coupled receptors (GPCRs), the... 
MOLECULAR-MECHANISM | DRUG-DISCOVERY | IN-VITRO | MEPYRAMINE | AFFINITY | MULTIDISCIPLINARY SCIENCES | BIOCHEMICAL-MECHANISMS | ANTAGONIST BINDING | HISTAMINE H-1 RECEPTOR | ASSOCIATION | TARGET RESIDENCE TIME | Histamine H1 receptors | Radioisotopes | Gold | Ligands | G protein-coupled receptors | Kinetics
Journal Article
2005, Topics in current chemistry, ISBN 3540228357, Volume 253., viii, 209
Book
by Akbani, Rehan and Akdemir, Kadir C and Aksoy, B. Arman and Albert, Monique and Ally, Adrian and Amin, Samirkumar B and Arachchi, Harindra and Arora, Arshi and Auman, J. Todd and Ayala, Brenda and Baboud, Julien and Balasundaram, Miruna and Balu, Saianand and Barnabas, Nandita and Bartlett, John and Bartlett, Pam and Bastian, Boris C and Baylin, Stephen B and Behera, Madhusmita and Belyaev, Dmitry and Benz, Christopher and Bernard, Brady and Beroukhim, Rameen and Bir, Natalie and Black, Aaron D and Bodenheimer, Tom and Boice, Lori and Boland, Genevieve M and Bono, Riccardo and Bootwalla, Moiz S and Bosenberg, Marcus and Bowen, Jay and Bowlby, Reanne and Bristow, Christopher A and Brockway-Lunardi, Laura and Brooks, Denise and Brzezinski, Jakub and Bshara, Wiam and Buda, Elizabeth and Burns, William R and Butterfield, Yaron S.N and Button, Michael and Calderone, Tiffany and Cappellini, Giancarlo Antonini and Carter, Candace and Carter, Scott L and Cherney, Lynn and Cherniack, Andrew D and Chevalier, Aaron and Chin, Lynda and Cho, Juok and Cho, Raymond J and Choi, Yoon-La and Chu, Andy and Chudamani, Sudha and Cibulskis, Kristian and Ciriello, Giovanni and Clarke, Amanda and Coons, Stephen and Cope, Leslie and Crain, Daniel and Curley, Erin and Danilova, Ludmila and D’Atri, Stefania and Davidsen, Tanja and Davies, Michael A and Delman, Keith A and Demchok, John A and Deng, Qixia A and Deribe, Yonathan Lissanu and Dhalla, Noreen and Dhir, Rajiv and DiCara, Daniel and Dinikin, Michael and Dubina, Michael and Ebrom, J. Stephen and Egea, Sophie and Eley, Greg and Engel, Jay and Eschbacher, Jennifer M and Fedosenko, Konstantin V and Felau, Ina and Fennell, Timothy and Ferguson, Martin L and Fisher, Sheila and Flaherty, Keith T and Frazer, Scott and Frick, Jessica and Fulidou, Victoria and Gabriel, Stacey B and Gao, Jianjiong and Gardner, Johanna and Garraway, Levi A and Gastier-Foster, Julie M and Gaudioso, Carmelo and Gehlenborg, Nils and Genovese, Giannicola and Gerken, Mark and Gershenwald, Jeffrey E and Getz, Gad and ... and Canc Genome Atlas Network and Cancer Genome Atlas Network
Cell, ISSN 0092-8674, 06/2015, Volume 161, Issue 7, pp. 1681 - 1696
Journal Article
1995, Cancer biology and medicine, ISBN 0792388860, Volume CABM 04, ix, 221
Book
1990, Cancer biology and medicine., ISBN 9780792389057, ix, 211
Book
1992, Cancer biology and medicine, ISBN 079238959X, Volume CABM 03., vii, 284
Book
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2018, Volume 26, Issue 11, pp. 3006 - 3015
The use of composite metrics that normalise biological potency values in relation to markers of physicochemical properties, such as size or lipophilicity, has... 
Lipophilic ligand efficiency | Ligand efficiency | Lipophilicity | Lead optimisation | DESIGN | CHEMISTRY, MEDICINAL | MACROCYCLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | CHEMISTRY, ORGANIC | RECEPTOR | SOLUBILITY | MEDICINAL CHEMISTRY | POTENT | IN-VIVO | INHIBITORS | CANDIDATES | Ligands | Lipids - chemistry | Drug Discovery - standards | Solubility | Usage | Drug discovery | Index Medicus
Journal Article
Journal Article
Biopolymers, ISSN 0006-3525, 08/2015, Volume 103, Issue 8, pp. 418 - 423
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 14, pp. 6630 - 6644
Drug-target binding kinetics are an important predictor of in vivo drug efficacy, yet the relationship between ligand structures and their binding kinetics is... 
DRUG | CHEMISTRY, MEDICINAL | INDUCED WHEAL | BINDING-KINETICS | FLARE RESPONSES | BIOCHEMICAL-MECHANISMS | PLATELET-ACTIVATING-FACTOR | TARGET BINDING | LIGAND | DUAL ANTAGONISTS | ASSOCIATION
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 10/2019, Volume 1861, Issue 10, pp. 182977 - 182977
Antimicrobial peptides (AMPs) are a promising class of innate host defense molecules for next-generation antibiotics, as they uniquely target and permeabilize... 
Atomic force microscopy | Isothermal titration calorimetry | Membrane properties | Cholesterol | Antimicrobial peptides | Membrane disruption | Index Medicus
Journal Article
Anti-Cancer Agents in Medicinal Chemistry, ISSN 1871-5206, 03/2016, Volume 16, Issue 3, p. 279
Journal Article
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