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SCIENTIFIC REPORTS, ISSN 2045-2322, 05/2019, Volume 9, Issue 1, pp. 7906 - 13
Drug-target binding kinetics are suggested to be important parameters for the prediction of in vivo drug-efficacy. For G protein-coupled receptors (GPCRs), the... 
MOLECULAR-MECHANISM | DRUG-DISCOVERY | IN-VITRO | MEPYRAMINE | AFFINITY | MULTIDISCIPLINARY SCIENCES | BIOCHEMICAL-MECHANISMS | ANTAGONIST BINDING | HISTAMINE H-1 RECEPTOR | ASSOCIATION | TARGET RESIDENCE TIME | Histamine H1 receptors | Radioisotopes | Gold | Ligands | G protein-coupled receptors | Kinetics
Journal Article
Injury epidemiology, ISSN 2197-1714, 2019, Volume 6, Issue 1, pp. 14 - 8
This paper describes a protocol for determining the incidence of serious fall injuries for Strategies to Reduce Injuries and Develop Confidence in Elders... 
Falls | Older people | Medical records | Clinical trials | Primary care | Injuries | Health informatics | Adjudication
Journal Article
BBA - Biomembranes, ISSN 0005-2736, 10/2019, Volume 1861, Issue 10, p. 182977
Antimicrobial peptides (AMPs) are a promising class of innate host defense molecules for next-generation antibiotics, as they uniquely target and permeabilize... 
Atomic force microscopy | Isothermal titration calorimetry | Membrane properties | Cholesterol | Antimicrobial peptides | Membrane disruption
Journal Article
Addictive behaviors, 08/2019, Volume 100, p. 106107
Perceived social support and smoking cues, such as cigarette availability, are important factors that affect smoking cessation outcomes. However, very few... 
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 07/2019, Volume 62, Issue 14, pp. 6630 - 6644
Drug–target binding kinetics are an important predictor of in vivo drug efficacy, yet the relationship between ligand structures and their binding kinetics is... 
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 07/2019, Volume 62, Issue 14, pp. 6630 - 6644
Drug-target binding kinetics are an important predictor of in vivo drug efficacy, yet the relationship between ligand structures and their binding kinetics is... 
DRUG | CHEMISTRY, MEDICINAL | INDUCED WHEAL | BINDING-KINETICS | FLARE RESPONSES | BIOCHEMICAL-MECHANISMS | PLATELET-ACTIVATING-FACTOR | TARGET BINDING | LIGAND | DUAL ANTAGONISTS | ASSOCIATION
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 11/2018, Volume 13, Issue 11, pp. 3131 - 3141
B-cell lymphoma 6 (BCL6) inhibition is a promising mechanism for treating hematological cancers but high quality chemical probes are necessary to evaluate its... 
REPRESSION | ROLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | N-COR | DEGRADATION | INHIBITOR | EXPRESSION | EZH2
Journal Article
Journal of Orthopaedic Surgery, ISSN 1022-5536, 6/2019, Volume 27, Issue 2, p. 230949901985716
Background: Prosthetic joint infection is a rare, but devastating complication of primary total hip arthroplasty (THA). Postoperative wound discharge and deep... 
staples | total hip arthroplasty | infection | wound discharge | wound closure | barbed suture | REPLACEMENT | SURGERY | ORTHOPEDICS
Journal Article
Journal of Health and Social Behavior, ISSN 0022-1465, 6/2019, Volume 60, Issue 2, pp. 188 - 203
Journal Article
by Peden, Carol and Peden, Carol J and Stephens, Tim and Martin, Michael and Martin, Graham and Kahan, Brennan and Kahan, Brennan C and Thomson, Ann and Rivett, Kate and Wells, Duncan and Wells, John and Richardson, Peter and Richardson, Gerry and Kerry, Sally and Bion, Julian and Pearse, Rupert M and Pearse, Rupert and Brett, Stephen and Ackland, Gareth and Grocott, Mike and Holt, Peter and Robert, Glenn and Ukoumunne, Obioha and Waring, Justin and Everingham, Kirsty and Phull, Mandeep and Cromwell, David and Evley, Rachel and Lilford, Richard and Kocman, David and Asaria, Miqdad and Tarrant, Carolyn and Yang, Fan and Abraham, Ajit and Bothma, Pieter and Conway, Daniel and Stapleton, Clare and Edwards, Jennifer and Edwards, Mark and Minto, Gary and Saunders, David and Owen, Tom and Waldmann, Carl and Hayden, Paul and Gillies, Michael and Tighe, Sean and Smith, Hannah and Smith, Neil and Mythen, Monty and Murray, Therese and Murray, Dave and Murray, Diane and Murray, David and Lobo, Dileep and Leuwer, Martin and Kirk-Bayley, Justin and Howell, Simon and Gordon, Anthony and Anderson, Iain and Lourtie, Jose and Walker, Simon and Drake, Sharon and Watson, Geoff and Watson, Nick and Watson, Nicholas and Watson, Mark and Szakmany, Tamas and Sutcliffe, Robert and Mahajan, Ravi and Girling, Alan and Forbes, Gordon and Faiz, Omar and Blunt, Mark and Singh, Jagdeep and Singh, Satish and Singh, Surjait and Steel, Alistair and Wong, Kate and Cabreros, Leilani and Chitre, Vivek and Obideyi, Ayodele and Ali, Dhiraj and Blenk, Karl and Broad, Dan and Brodbeck, Andreas and Dumpala, Rajesh and Engel, Arnth and Ganepola, Ranjit and Garg, Sudha and Gay, Mike and Karlikowsk, Michael and Lams, Edward and Millican, Dean and Misane, Inga and Mull, Ajaya and Naik, Veena and Pushpa, Nathan and Nutt, Chris and Sagadai, Saravanna and Stuart, Hazel and ... and Enhanced Peri-Operative Care for High-risk patients (EPOCH) trial group
The Lancet, ISSN 0140-6736, 06/2019, Volume 393, Issue 10187, pp. 2213 - 2221
Emergency abdominal surgery is associated with poor patient outcomes. We studied the effectiveness of a national quality improvement (QI) programme to... 
Intervention | Medical personnel | Abdominal surgery | Systemic diseases | Health | Decision making | Health services | Mortality | Health care policy | Critical care | Clinical trials | Emergency medical care | Survival | Patients | Clinical outcomes | Abdomen | Randomization | Hospitals | Motivation | Surgery | Quality control | Clusters | Emergency medical services | Quality of care
Journal Article