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Pathobiology of Aging & Age-related Diseases, ISSN 2001-0001, 03/2019, Volume 9, Issue sup1, p. 1591258
Journal Article
Pathobiology of Aging & Age-related Diseases, ISSN 2001-0001, 01/2019, Volume 9, Issue 1, p. 1593786
Journal Article
Pathobiology of Aging & Age-related Diseases, ISSN 2001-0001, 01/2018, Volume 8, Issue 1, pp. 1444939 - 20
Because serotonin plays many critical roles in early brain development, we also hypothesized that a dietary supplementation of the essential amino acid... 
TOR protein | Senescence | Conferences | Cardiomyopathy | Stem cell transplantation | Amino acids | Proteins | Immunology | Neurodegeneration | Aging | Supplementation | Stroke | Cytokines | Serotonin | Fluoxetine | Dietary supplements | Tryptophan | Inflammation | Gene expression | Nitric-oxide synthase | Studies | Brain research | Insects | Protein expression | Alzheimers disease
Journal Article
Pathobiology of Aging & Age-related Diseases, ISSN 2001-0001, 01/2017, Volume 7, Issue 1, pp. 1304005 - 3
[...]the Geropathology Research Network was formed, consisting of various working groups composed of experts in anatomic pathology, molecular pathology, and... 
Medicine | Intervention | Medical research | Pathology | Committees | Aging | Workshops | Gene expression | Age
Journal Article
Pathobiology of Aging & Age-related Diseases, ISSN 2001-0001, 01/2016, Volume 6, Issue 1, pp. 31478 - 4
The Geropathology Research Network has established a plan to identify and use pathology-based surrogate endpoints for aging intervention in preclinical drug... 
geropathology | translational research | anti-aging drugs | Studies | Proteins | Medicine | Heart | Pathology | Signal transduction | Funding | Rodents | Aging | Physiology | Bioinformatics | Age | Clinical trials | Translation | Life span
Journal Article
Pathobiology of Aging & Age-related Diseases, ISSN 2001-0001, 01/2015, Volume 5, Issue 1, p. 30765
  METABOLIC SIGNATURES OF AGING AND AGE-RELATED DISEASES Circulating microRNAs profile associates with metabolites and inflammatory molecules as biomarkers of... 
Women | Senescence | Dopamine | Licenses | Inflammation | Metabolism | Gene expression | Studies | Autism | Metabolites | MicroRNAs | Aging | Insulin resistance | Physiology | Behavior | Diabetes | Age | Open access
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e80123
Journal Article
Science, ISSN 0036-8075, 6/2005, Volume 308, Issue 5730, pp. 1909 - 1911
To determine the role of reactive oxygen species in mammalian longevity, we generated transgenic mice that overexpress human catalase localized to the... 
Antioxidants | Pathology | Mitochondria | Reactive oxygen species | Life span | Standardized tests | Transgenic animals | Reports | Mice | Longevity | Skeletal muscle | HEART | LONGEVITY | OXIDATIVE STRESS | CAENORHABDITIS-ELEGANS | DROSOPHILA-MELANOGASTER | THIOREDOXIN | INCREASE | MULTIDISCIPLINARY SCIENCES | SUPEROXIDE DISMUTASE/CATALASE MIMETICS | IN-VIVO | EXPRESSION | Aconitate Hydratase - metabolism | Mitochondria - enzymology | Superoxide Dismutase - genetics | Mitochondria, Heart - metabolism | Reactive Oxygen Species - metabolism | Myocardium - chemistry | Oxidative Stress | Humans | Cataract - pathology | Male | Deoxyguanosine - analysis | Cell Nucleus - enzymology | Cell Nucleus - metabolism | Muscle, Skeletal - chemistry | Aging | Female | Deoxyguanosine - analogs & derivatives | Superoxide Dismutase - metabolism | Free Radicals | Oxidation-Reduction | Signal Transduction | Catalase - genetics | Mitochondria, Heart - enzymology | Mice, Transgenic | Myocardium - pathology | Mitochondria - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Hydrogen Peroxide - metabolism | Catalase - metabolism | DNA - chemistry | Animals | Peroxisomes - enzymology | Arteriosclerosis - pathology | Heart Diseases - pathology | Psychological aspects | Peroxisomes | Physiological aspects | Genetic aspects | Research | Properties | Health aspects | Molecules | Oxygen | Life expectancy | Rodents
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2010, Volume 5, Issue 2, p. e9135
Background: The familial and sporadic forms of Alzheimer's disease (AD) have an identical pathology with a severe disparity in the time of onset [1]. The... 
BETA-SECRETASE | ALPHA-SECRETASE | GAMMA-SECRETASE COMPLEX | ALZHEIMERS-DISEASE | ER STRESS | MOUSE MODEL | IN-VIVO | BIOLOGY | PRESENILIN MUTATIONS | AMYLOID PRECURSOR PROTEIN | INTRACELLULAR DOMAIN | Immunohistochemistry | Amyloid Precursor Protein Secretases - genetics | Neurons - pathology | Apoptosis - drug effects | Endoplasmic Reticulum - metabolism | Brefeldin A - pharmacology | Green Fluorescent Proteins - genetics | Protein Transport - drug effects | Recombinant Fusion Proteins - metabolism | Dose-Response Relationship, Drug | Transfection | Amyloid beta-Peptides - genetics | Endoplasmic Reticulum - drug effects | Amyloid beta-Peptides - metabolism | Phenylbutyrates - pharmacology | Antineoplastic Agents - pharmacology | Neurons - metabolism | Neurons - drug effects | Green Fluorescent Proteins - metabolism | Blotting, Western | Amyloid Precursor Protein Secretases - metabolism | Animals | Tunicamycin - pharmacology | Cell Line, Tumor | Recombinant Fusion Proteins - genetics | Thapsigargin - pharmacology | Anti-Bacterial Agents - pharmacology | Prevention | Epigenetic inheritance | Advertising executives | Neurons | Proteolysis | Genetic aspects | Alzheimer's disease | Apoptosis | Brain | Pathogenesis | Trafficking | Brefeldin A | Tunicamycin | Presenilin | Activation | Neuroblastoma | Neuroblastoma cells | Defects | Proteins | Thapsigargin | Ischemia | Protein folding | Cleavage | Physiology | Localization | Stresses | Neurodegenerative diseases | Pharmacology | Biophysics | Stress | Pathology | Signaling | Mutation | Alzheimers disease | Endoplasmic reticulum | Viability | Secretase | Phenylbutyric acid | Cancer | Biochemical markers
Journal Article
Pathobiology of Aging & Age-related Diseases, ISSN 2001-0001, 01/2015, Volume 5, Issue 1, pp. 28866 - 2
  The symposium ended with scientific sessions on 1) Navigating drug development and translation in an academic environment; 2) Aging and health span in... 
Studies | Pathology | Bioenergetics | Working groups | Womens health | Funding | Aging
Journal Article
Journal Article
Journal Article
Aging Cell, ISSN 1474-9718, 06/2011, Volume 10, Issue 3, pp. 418 - 428
Summary Trafficking through the secretory pathway is known to regulate the maturation of the APP‐cleaving secretases and APP proteolysis. The coupling of... 
molecular chaperone | phenylbutyric acid | radial water maze paradigm | Alzheimer’s disease | secretase | aging | endoplasmic reticulum | Radial water maze paradigm | Aging | Alzheimer's disease | Endoplasmic reticulum | Molecular chaperone | Phenylbutyric acid | Secretase | UNFOLDED-PROTEIN RESPONSE | ALZHEIMERS-DISEASE | ER STRESS | TRAFFICKING | ENDOPLASMIC-RETICULUM STRESS | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | MOUSE MODEL | GAMMA-SECRETASE ACTIVITY | PRESENILIN MUTATIONS | PRECURSOR PROTEIN | EXPRESSION | ADAM17 Protein | Memory - drug effects | Amyloid Precursor Protein Secretases - genetics | Neurons - pathology | Phenylbutyrates - therapeutic use | Receptors, Ionotropic Glutamate - genetics | Endoplasmic Reticulum - metabolism | Male | Receptors, Metabotropic Glutamate - metabolism | Hippocampus - drug effects | Alzheimer Disease - pathology | Receptors, Metabotropic Glutamate - genetics | Phenylbutyrates - administration & dosage | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Membrane Proteins - metabolism | Neurons - metabolism | Neurons - drug effects | Disease Models, Animal | Plaque, Amyloid - pathology | Membrane Proteins - genetics | ADAM10 Protein | Alzheimer Disease - drug therapy | Nootropic Agents - therapeutic use | Mice, Transgenic | Hippocampus - pathology | Receptors, Ionotropic Glutamate - metabolism | Cognition - drug effects | Maze Learning - drug effects | Hippocampus - metabolism | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Nootropic Agents - administration & dosage | Alzheimer Disease - metabolism | Plaque, Amyloid - metabolism | Mice | ADAM Proteins - genetics | Alzheimer Disease - genetics | Cognition & reasoning | Alzheimers disease | Protein folding | Rodents
Journal Article