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Stem Cell Reports, ISSN 2213-6711, 09/2015, Volume 5, Issue 3, pp. 448 - 459
CRISPR/Cas9 protein fused to transactivation domains can be used to control gene expression in human cells. In this study, we demonstrate that a dCas9 fusion... 
SYSTEM | CRISPR | TALE | PROTEIN | REPRESSION | TRANSCRIPTION | CAS9 | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Cellular Reprogramming Techniques | Humans | Adolescent | CRISPR-Cas Systems | Gene Expression Regulation | HEK293 Cells | Female | Male | Aged | Cell Differentiation | Cellular Reprogramming
Journal Article
European Journal of Human Genetics, ISSN 1018-4813, 03/2019, Volume 27, Issue 3, pp. 484 - 487
Clinical trials using somatic gene editing (e.g., CRISPR-Cas9) have started in Europe and the United States and may provide safe and effective treatment and... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | GENETICS & HEREDITY | Clinical trials | Gene therapy | CRISPR
Journal Article
Cell Reports, ISSN 2211-1247, 04/2017, Volume 19, Issue 2, pp. 281 - 294
Journal Article
Stem Cell Research, ISSN 1873-5061, 08/2017, Volume 23, Issue C, pp. 105 - 108
Journal Article
eLife, ISSN 2050-084X, 11/2018, Volume 7
Insulin gene mutations are a leading cause of neonatal diabetes. They can lead to proinsulin misfolding and its retention in endoplasmic reticulum (ER). This... 
Insulin gene mutations | stem cells | beta-cell development | CRISPR-Cas9 | regenerative medicine | induced pluripotent stem cells | human | mTORC1 | endoplasmic reticulum stress | IN-VITRO | UNFOLDED PROTEIN RESPONSE | ER STRESS | BIOLOGY | GENE-EXPRESSION | MUTANT PROINSULIN | GENERATION | ENDOPLASMIC-RETICULUM STRESS | DYSFUNCTION | PANCREATIC PROGENITORS | REVEALS | Diabetes Mellitus - pathology | Proinsulin - chemistry | Diabetes Mellitus - genetics | Induced Pluripotent Stem Cells - chemistry | Humans | Apoptosis - genetics | Male | Endoplasmic Reticulum Stress - genetics | Insulin-Secreting Cells - chemistry | Cell Differentiation - genetics | Insulin-Secreting Cells - metabolism | Female | Single-Cell Analysis | Infant, Newborn | Induced Pluripotent Stem Cells - metabolism | Cell Proliferation - genetics | Endoplasmic Reticulum - genetics | Signal Transduction | Proinsulin - genetics | CRISPR-Cas Systems - genetics | Protein Folding | Animals | Sequence Analysis, RNA | Mice | Mutation | Pancreatic beta cells | Genetic aspects | Gene mutations | Health aspects | Stem cells | Diabetes in children | Cell proliferation | Neonates | Flow cytometry | Stem cell transplantation | Biosynthesis | Glucose | Experiments | Cell growth | CRISPR | Medical research | Secretion | Diabetes mellitus | Ribonucleic acid--RNA | Insulin | Beta cells | Hospitals | Software | Diabetes | Cell size | Electron transport | Endoplasmic reticulum | Pluripotency | Apoptosis | Inhibitory postsynaptic potentials
Journal Article
Bioethics, ISSN 0269-9702, 07/2018
Potential applications of genome editing technology in assisted reproductive technology (ART) raise a vast array of strong opinions, emotional reactions and... 
Samhällsvetenskap | Assisted Reproduction Technology | Privaträtt | Social Sciences | Law | Gene editing | Civil law | Germ line modifications | Juridik
Journal Article
Cell Metabolism, ISSN 1550-4131, 01/2012, Volume 15, Issue 1, pp. 100 - 109
Journal Article
Journal of Neuro-Oncology, ISSN 0167-594X, 4/2010, Volume 97, Issue 2, pp. 217 - 224
Medulloblastomas (MB) and primitive neuroectodermal tumors (PNET) are the most common malignant brain tumors in children. These two tumor types are... 
Amplification | VEGFR2 | Neurology | PDGFRA | Medicine & Public Health | Medulloblastoma | KIT | Oncology | IN-SITU HYBRIDIZATION | MUTATIONAL ANALYSIS | RAS/MAPK PATHWAY | CLINICAL NEUROLOGY | CYTOGENETIC ANALYSIS | ONCOLOGY | CHILDHOOD MEDULLOBLASTOMA | MYCN AMPLIFICATION | GENETIC-HETEROGENEITY | CENTRAL-NERVOUS-SYSTEM | METASTATIC MEDULLOBLASTOMA | COMPARATIVE GENOMIC HYBRIDIZATION | Immunohistochemistry | Neuroectodermal Tumors, Primitive - metabolism | Neuroectodermal Tumors, Primitive - genetics | Neuroectodermal Tumors, Primitive - mortality | Humans | Cerebellar Neoplasms - mortality | Kaplan-Meier Estimate | Brain Neoplasms - genetics | Male | Gene Dosage | Medulloblastoma - metabolism | Stem Cell Factor - genetics | Cerebellar Neoplasms - genetics | Brain Neoplasms - metabolism | Vascular Endothelial Growth Factor Receptor-2 - genetics | In Situ Hybridization | Receptor, Platelet-Derived Growth Factor alpha - genetics | Stem Cell Factor - biosynthesis | Vascular Endothelial Growth Factor Receptor-2 - biosynthesis | Brain Neoplasms - mortality | Medulloblastoma - genetics | Cerebellar Neoplasms - metabolism | Receptor, Platelet-Derived Growth Factor alpha - biosynthesis | Tyrosine | Platelet-derived growth factor | Developmental biology | Gliomas | Brain tumors | Vascular endothelial growth factor | Phosphotransferases | Endothelium | Cancer
Journal Article
PloS one, 2019, Volume 14, Issue 1, p. e0208237
Sickle Cell Disease and ß-thalassemia, which are caused by defective or deficient adult ß-globin (HBB) respectively, are the most common serious genetic blood... 
Journal Article
European journal of human genetics : EJHG, 12/2018
Clinical trials using somatic gene editing (e.g., CRISPR-Cas9) have started in Europe and the United States and may provide safe and effective treatment and... 
Journal Article
Journal Article
BMC Molecular Biology, ISSN 1471-2199, 09/2007, Volume 8, Issue 1, pp. 77 - 77
Background: Most molecular biology experiments, and the techniques associated with this field of study, involve a great deal of engineering in the form of... 
SEQUENCE-ANALYSIS | DNA | BIOCHEMISTRY & MOLECULAR BIOLOGY | Laboratories | Base Sequence | Computer Simulation | Cloning, Molecular - methods | Plasmids - genetics | Polymerase Chain Reaction | Software | Databases, Nucleic Acid | Molecular Biology - methods | Usage | Genetic engineering | Research | Online databases | Nucleotide sequence
Journal Article