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European Journal of Organic Chemistry, ISSN 1434-193X, 03/2013, Volume 2013, Issue 9, pp. 1649 - 1652
Phototryptophan is a new photoactivatable amino acid designed to be incorporated into tryptophan‐containing peptides for photoaffinity labeling. The synthesis... 
Amino acids | Photoaffinity labeling | Chiral resolution | Nitrogen heterocycles | Photochemistry | DIAZIRINES | PHOTOAFFINITY PROBES | CHEMISTRY, ORGANIC | HEMIASTERLIN | INDOLES | CYTOTOXIC PEPTIDES | CHEMISTRY | (-)-HEMIASTERLIN | Tryptophan | Photographic industry | Peptides | Enantiomers
Journal Article
Cellular and molecular life sciences : CMLS, ISSN 1420-682X, 07/2019, pp. 1 - 15
Premature intrapancreatic trypsinogen activation is widely regarded as an initiating event for acute pancreatitis. Previous studies have alternatively... 
LAMP-2 protein | Pancreatitis | Phagosomes | Lysosomes | Fluorescence | Labelling | Autophagy | Western blotting | Membrane proteins | Proteins | Secretory vesicles | Cell activation | Vesicles | Trypsin | Trypsinogen | Proteolysis | Cathepsin B | Mice | Pancreas | Localization | Phagocytosis | Endosomes | Index Medicus
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 09/2014, Volume 2014, Issue 25, pp. 5509 - 5520
The synthesis, thermal stability, and photoreactivity of trifluoromethyl diazirines installed at the heterocyclic section of N ‐methylindole, N... 
Diazirines | DFT calculation | Nitrogen heterocycles | Carbenes | Photochemistry | CARBENE | PHOTOAFFINITY PROBES | ACID | ANALOG | CHEMISTRY, ORGANIC
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 09/2014, Volume 2014, Issue 25, pp. 5509 - 5520
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1019 - 1031
Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis, ALI is also a major... 
C-REACTIVE PROTEIN | INFLAMMATORY-RESPONSE | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis | of STAT3 and production of the neutrophil attractant CXCL1 in pancreatic acinar cells. Examination of human samples revealed expression of IL-6 in combination with soluble IL-6 receptor was a reliable predictor of ALI in SAP. These results demonstrate that IL-6 trans-signaling is an essential mediator of ALI in SAP across | INTERLEUKIN-6 | RESPIRATORY-DISTRESS-SYNDROME | PREDICTION | species and suggest that therapeutic inhibition of IL-6 may prevent SAP-associated ALI | ACUTE-PHASE RESPONSE | ALI is also a major complication in severe acute pancreatitis (SAP). The pathophysiology of SAP-associated ALI is poorly understood, but elevated serum levels of IL-6 is a reliable marker for disease severity. Here, we used a mouse model of acute pancreatitis-associated (AP-associated) ALI to determine the role of IL-6 in ALI lethality. Il6-deficient mice had a lower death rate compared with wild-type mice with AP, while mice injected with IL-6 were more likely to develop lethal ALI. We found that inflammation-associated NF-kappa B induced myeloid cell secretion of IL-6, and the effects of secreted IL-6 were mediated by complexation with soluble IL-6 receptor, a process known as trans-signaling. IL-6 trans-signaling stimulated phosphorylation | BLOCKADE | INHIBITOR | SEVERITY | Phosphorylation | Humans | NF-kappa B - metabolism | Pancreatitis - complications | Receptors, Interleukin-8B - antagonists & inhibitors | Benzenesulfonates - pharmacology | Interleukin-6 - physiology | Pancreatitis - immunology | Acute Lung Injury - metabolism | Chemokine CXCL1 - metabolism | STAT3 Transcription Factor - metabolism | Acinar Cells - metabolism | Aminosalicylic Acids - pharmacology | Signal Transduction | Mice, Inbred C57BL | Pancreas - pathology | Mice, Transgenic | Acute Lung Injury - pathology | Interleukin-6 - secretion | Animals | Myeloid Cells - secretion | Receptors, Interleukin-8B - metabolism | Myeloid Cells - metabolism | Acute Lung Injury - immunology | Pancreatitis - pathology | Mice | Phenylurea Compounds - pharmacology | Protein Processing, Post-Translational | Pancreatitis - metabolism | STAT3 Transcription Factor - antagonists & inhibitors | Acute Lung Injury - etiology | Receptors, Interleukin-6 - metabolism | Lung diseases | Pancreatitis | Genetic aspects | Research | Health aspects | Risk factors | Interleukin-6 | Index Medicus | Abridged Index Medicus | Clinical Medicine | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Surgery | Kirurgi
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 07/2018, Volume 28, Issue 12, pp. 2153 - 2158
Journal Article
Gut, ISSN 0017-5749, 03/2014, Volume 63, Issue 3, pp. 494 - 505
Background Autoimmune pancreatitis (AIP) in humans invariably responds to steroid treatment, but little is known about the underlying pathogenesis and the... 
IMMUNE-RESPONSE | IGG4-RELATED DISEASE | IMMUNOGLOBULIN G4-ASSOCIATED CHOLANGITIS | RITUXIMAB THERAPY | CD152 CTLA-4 DETERMINES | IN-VIVO | CLINICAL PROFILE | MURINE LUPUS | MODEL | DIAGNOSTIC-CRITERIA | GASTROENTEROLOGY & HEPATOLOGY | T-Lymphocytes, Regulatory - metabolism | Azathioprine - therapeutic use | Cyclosporine - pharmacology | Immunosuppressive Agents - therapeutic use | Pancreatitis, Chronic - chemically induced | Flow Cytometry | T-Lymphocyte Subsets - drug effects | Pancreatitis, Chronic - drug therapy | Female | Autoimmune Diseases - pathology | Immunosuppressive Agents - pharmacology | Autoimmune Diseases - drug therapy | Biomarkers - metabolism | Pancreatitis, Chronic - immunology | Sirolimus - therapeutic use | Drug Administration Schedule | Autoimmune Diseases - immunology | Pancreas - drug effects | Pancreas - pathology | Treatment Outcome | Random Allocation | Mice, Inbred Strains | Pancreas - immunology | Sirolimus - pharmacology | Pancreatitis, Chronic - pathology | Cyclosporine - therapeutic use | Dexamethasone - therapeutic use | T-Lymphocytes, Regulatory - drug effects | Animals | Lymphocyte Activation - drug effects | T-Lymphocyte Subsets - metabolism | Cell Proliferation - drug effects | Mice | Autoimmune Diseases - chemically induced | CTLA-4 Antigen - antagonists & inhibitors | Poly I-C | Usage | Care and treatment | Rapamycin | Cyclosporine | Pancreatitis | Proteins | Studies | Antigens | Pathogenesis | Lymphocytes | Rodents | Cell cycle | T cell receptors | Steroids | Index Medicus | Abridged Index Medicus
Journal Article
Aerospace Science and Technology, ISSN 1270-9638, 06/2015, Volume 45, pp. 215 - 227
The DLR project ALLFlight (Assisted Low-Level Flight and Landing on Unprepared Landing Sites) deals with the development of a helicopter pilot assistance... 
Path planning | ACT/FHS | Assistance system | Head-up display | Model-based control | Sidestick | ENGINEERING, AEROSPACE | Analysis | Algorithms | Sensors | Surveys | Obstacles | Aircraft components | Pilots | Landing | Helmet mounted displays
Journal Article
Pancreatology, ISSN 1424-3903, 2017, Volume 17, Issue 3, pp. S47 - S48
Introduction: Development of chronic pancreatitis (CP) is mostly caused by repeated bouts of acute pancreatitis leading to chronic inflammation and pancreatic... 
Endocrinology & Metabolism | Gastroenterology and Hepatology | Chymotrypsin | Rodents | Pancreatitis | Inflammation | Pancreas | Autophagy | Proenzymes
Journal Article
Journal Article
American Journal of Physiology : Gastrointestinal and Liver Physiology, ISSN 0193-1857, 2016, Volume 311, Issue 3, pp. G548 - 60
Journal Article