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Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 4, pp. 734 - 745
The eukaryotic RNA exosome is an essential and conserved 3′-to-5′ exoribonuclease complex that degrades or processes nearly every class of cellular RNA. The... 
X-ray crystallography | RNA | RNA decay | click chemistry | exoribonuclease | nuclear | exosome | multi-subunit complex | structure | Saccharomyces cerevisiae - genetics | Allosteric Regulation | Substrate Specificity | Crystallography, X-Ray | Protein Subunits - metabolism | Saccharomyces cerevisiae - metabolism | Thermodynamics | Cell Nucleus - metabolism | Exosome Multienzyme Ribonuclease Complex - chemistry | Cloning, Molecular | Escherichia coli - metabolism | Exosome Multienzyme Ribonuclease Complex - metabolism | Protein Interaction Domains and Motifs | RNA, Fungal - genetics | Exosome Multienzyme Ribonuclease Complex - genetics | Binding Sites | Exosome Multienzyme Ribonuclease Complex - ultrastructure | Protein Subunits - genetics | Recombinant Proteins - metabolism | Protein Conformation, alpha-Helical | Gene Expression | RNA, Fungal - chemistry | Models, Molecular | Recombinant Proteins - chemistry | RNA Cleavage | Recombinant Proteins - genetics | Saccharomyces cerevisiae Proteins - genetics | Amino Acid Motifs | RNA, Fungal - metabolism | Cell Nucleus - genetics | Protein Conformation, beta-Strand | Escherichia coli - genetics | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Protein Subunits - chemistry | Saccharomyces cerevisiae Proteins - chemistry | Phosphates | Structure | Crystals
Journal Article
Journal Article
Molecular cell, ISSN 1097-2765, 10/2012, Volume 48, Issue 1, pp. 133 - 144
The RNA exosome is an essential multi-subunit ribonuclease (RNase) that contributes to cytoplasmic and nuclear RNA decay and quality control. The nine-subunit... 
Journal Article
Nature, ISSN 0028-0836, 7/2014, Volume 511, Issue 7510, pp. 435 - 439
The eukaryotic RNA exosome processes and degrades RNA by directing substrates to the distributive or processive 3′ to 5′ exoribonuclease activities of Rrp6 or... 
Journal Article
eLife, ISSN 2050-084X, 07/2017, Volume 6, Issue 7, 2017
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7660, pp. 671 - 675
Journal Article
2012, ISBN 0124047408, Volume 31
The composition of the multisubunit eukaryotic RNA exosome was described more than a decade ago, and structural studies conducted since that time have... 
3′-to-5′ RNA decay | Hydrolytic | S1 domain | PIN domain | Cold-shock domain | RNA degradation | Phosphorolytic | Exosome | Multisubunit | Exoribonuclease | KH domain | RNA processing | Structure | Endoribonuclease | RNA binding | PH domain | RNase | 3'-to-5' RNA decay
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