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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Nature Genetics, ISSN 1061-4036, 2013, Volume 45, Issue 9, pp. 984 - 994
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across...
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | CROHNS-DISEASE | DEFICIT HYPERACTIVITY DISORDER | COMMON SNPS | GENETICS & HEREDITY | SCHIZOPHRENIA | RISK | AUTISM SPECTRUM DISORDERS | BIPOLAR DISORDER | ASSOCIATION | HERITABILITY | Usage | Genetic aspects | Research | Single nucleotide polymorphisms | Psychoses | Genomics | Life Sciences | Biochemistry, Molecular Biology
ATTENTION-DEFICIT/HYPERACTIVITY DISORDER | CROHNS-DISEASE | DEFICIT HYPERACTIVITY DISORDER | COMMON SNPS | GENETICS & HEREDITY | SCHIZOPHRENIA | RISK | AUTISM SPECTRUM DISORDERS | BIPOLAR DISORDER | ASSOCIATION | HERITABILITY | Usage | Genetic aspects | Research | Single nucleotide polymorphisms | Psychoses | Genomics | Life Sciences | Biochemistry, Molecular Biology
Journal Article
Nature: international weekly journal of science, ISSN 0028-0836, 04/2015, Volume 520, Issue 7546, pp. 224 - 229
textabstractThe highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical...
EVOLUTION | CHROMATIN | BASAL GANGLIA | MULTIDISCIPLINARY SCIENCES | HIPPOCAMPAL | DYNAMICS | IDENTIFICATION | EXPRESSION | KINECTIN | STRIATUM | GENOME-WIDE ASSOCIATION | Caudate Nucleus - anatomy & histology | Brain - anatomy & histology | Humans | Middle Aged | Genetic Loci - genetics | Gene Expression Regulation, Developmental - genetics | Apoptosis - genetics | Male | Young Adult | Putamen - anatomy & histology | Aging - genetics | Organ Size - genetics | Aged, 80 and over | Adult | Female | Child | Genome-Wide Association Study | Membrane Proteins - genetics | Sex Characteristics | Magnetic Resonance Imaging | Skull - anatomy & histology | Adolescent | Aged | Genetic Variation - genetics | Hippocampus - anatomy & histology | Genetic research | Brain | Genetic aspects | Brain research | Research | Genetic variation | Genomics | Genomes | Epigenetics | Genes | Neuroscience | Cognitive science | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
EVOLUTION | CHROMATIN | BASAL GANGLIA | MULTIDISCIPLINARY SCIENCES | HIPPOCAMPAL | DYNAMICS | IDENTIFICATION | EXPRESSION | KINECTIN | STRIATUM | GENOME-WIDE ASSOCIATION | Caudate Nucleus - anatomy & histology | Brain - anatomy & histology | Humans | Middle Aged | Genetic Loci - genetics | Gene Expression Regulation, Developmental - genetics | Apoptosis - genetics | Male | Young Adult | Putamen - anatomy & histology | Aging - genetics | Organ Size - genetics | Aged, 80 and over | Adult | Female | Child | Genome-Wide Association Study | Membrane Proteins - genetics | Sex Characteristics | Magnetic Resonance Imaging | Skull - anatomy & histology | Adolescent | Aged | Genetic Variation - genetics | Hippocampus - anatomy & histology | Genetic research | Brain | Genetic aspects | Brain research | Research | Genetic variation | Genomics | Genomes | Epigenetics | Genes | Neuroscience | Cognitive science | Biological Sciences | Naturvetenskap | Natural Sciences | Biologiska vetenskaper
Journal Article
Nature communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, p. 13624
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural...
BRAIN-REGIONS | COMMON VARIANTS | METAANALYSIS | TEMPORAL-LOBE EPILEPSY | MEMORY | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | BIPOLAR DISORDER | SUBFIELDS | GENOME-WIDE ASSOCIATION | Glycoproteins - genetics | Alzheimer Disease - physiopathology | Genetic Predisposition to Disease | Genome-Wide Association Study | Microtubule-Associated Proteins - genetics | Humans | Middle Aged | Protein-Serine-Threonine Kinases - genetics | Organ Size | Dipeptidyl Peptidase 4 - genetics | Male | Genetic Loci | Methionine Sulfoxide Reductases - genetics | Nerve Tissue Proteins - genetics | Young Adult | Adolescent | Aged, 80 and over | Adult | Female | Aged | Alzheimer Disease - genetics | Child | Hippocampus - growth & development | Cohort Studies | Neuroscience | Cognitive science | Basic Medicine | Medical Genetics | Medicinsk genetik | Biological Sciences | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Natural Sciences | Bioinformatik och systembiologi | Bioinformatics and Systems Biology
BRAIN-REGIONS | COMMON VARIANTS | METAANALYSIS | TEMPORAL-LOBE EPILEPSY | MEMORY | ALZHEIMERS-DISEASE | MULTIDISCIPLINARY SCIENCES | SUSCEPTIBILITY LOCI | BIPOLAR DISORDER | SUBFIELDS | GENOME-WIDE ASSOCIATION | Glycoproteins - genetics | Alzheimer Disease - physiopathology | Genetic Predisposition to Disease | Genome-Wide Association Study | Microtubule-Associated Proteins - genetics | Humans | Middle Aged | Protein-Serine-Threonine Kinases - genetics | Organ Size | Dipeptidyl Peptidase 4 - genetics | Male | Genetic Loci | Methionine Sulfoxide Reductases - genetics | Nerve Tissue Proteins - genetics | Young Adult | Adolescent | Aged, 80 and over | Adult | Female | Aged | Alzheimer Disease - genetics | Child | Hippocampus - growth & development | Cohort Studies | Neuroscience | Cognitive science | Basic Medicine | Medical Genetics | Medicinsk genetik | Biological Sciences | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Natural Sciences | Bioinformatik och systembiologi | Bioinformatics and Systems Biology
Journal Article
Nature Neuroscience, ISSN 1097-6256, 2016, Volume 19, Issue 12, pp. 1569 - 1582
Intracranial volume reflects the maximally attained brain size during development, and remains stable with loss of tissue in late life. It is highly heritable,...
CONSORTIUM | COMMON VARIANTS | IGF-I | METAANALYSIS | ALZHEIMERS-DISEASE | 17Q21.31 MICRODELETION | BRAIN SIZE | HEIGHT | NEUROSCIENCES | HEAD CIRCUMFERENCE | PARKINSONS-DISEASE | Genetic Predisposition to Disease | Humans | Genetic Loci - genetics | European Continental Ancestry Group | Brain - growth & development | Parkinson Disease - genetics | Phosphatidylinositol 3-Kinases - genetics | Phenotype | Oncogene Protein v-akt - genetics | Brain - pathology | Cognition - physiology | Polymorphism, Single Nucleotide - genetics | Genome-Wide Association Study - methods | Research | Genetic variation | Genomics | Analysis | Neurophysiology | Neuroscience | Cognitive science | Neurosciences & Neurology | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
CONSORTIUM | COMMON VARIANTS | IGF-I | METAANALYSIS | ALZHEIMERS-DISEASE | 17Q21.31 MICRODELETION | BRAIN SIZE | HEIGHT | NEUROSCIENCES | HEAD CIRCUMFERENCE | PARKINSONS-DISEASE | Genetic Predisposition to Disease | Humans | Genetic Loci - genetics | European Continental Ancestry Group | Brain - growth & development | Parkinson Disease - genetics | Phosphatidylinositol 3-Kinases - genetics | Phenotype | Oncogene Protein v-akt - genetics | Brain - pathology | Cognition - physiology | Polymorphism, Single Nucleotide - genetics | Genome-Wide Association Study - methods | Research | Genetic variation | Genomics | Analysis | Neurophysiology | Neuroscience | Cognitive science | Neurosciences & Neurology | Basic Medicine | Medical Genetics | Medicinsk genetik | Medical and Health Sciences | Medicin och hälsovetenskap | Medicinska och farmaceutiska grundvetenskaper
Journal Article
The American Journal of Human Genetics, ISSN 0002-9297, 02/2015, Volume 96, Issue 2, pp. 283 - 294
Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a...
POPULATION | DISEASES | GENETIC RISK | GENETICS & HEREDITY | LOCI | ALGORITHMS | TRAIT | SELECTION | GENOME-WIDE ASSOCIATION | Mental Disorders - genetics | Multifactorial Inheritance - genetics | Multivariate Analysis | Risk Assessment - methods | Genetics, Medical - methods | Schizophrenia - genetics | Depressive Disorder, Major - genetics | Humans | Polymorphism, Single Nucleotide - genetics | Linear Models | Bipolar Disorder - genetics | Genetic Testing - methods | Schizophrenia | Bipolar disorder | Risk factors | Major depressive disorder | Life Sciences | Neurons and Cognition | Report | INFORMATION | Genetics & Heredity | Klinisk medicin | IDENTIFICATION | RESTRICTED MAXIMUM-LIKELIHOOD | Clinical Medicine | MODELS | AVERAGE | TRAITS
POPULATION | DISEASES | GENETIC RISK | GENETICS & HEREDITY | LOCI | ALGORITHMS | TRAIT | SELECTION | GENOME-WIDE ASSOCIATION | Mental Disorders - genetics | Multifactorial Inheritance - genetics | Multivariate Analysis | Risk Assessment - methods | Genetics, Medical - methods | Schizophrenia - genetics | Depressive Disorder, Major - genetics | Humans | Polymorphism, Single Nucleotide - genetics | Linear Models | Bipolar Disorder - genetics | Genetic Testing - methods | Schizophrenia | Bipolar disorder | Risk factors | Major depressive disorder | Life Sciences | Neurons and Cognition | Report | INFORMATION | Genetics & Heredity | Klinisk medicin | IDENTIFICATION | RESTRICTED MAXIMUM-LIKELIHOOD | Clinical Medicine | MODELS | AVERAGE | TRAITS
Journal Article
Nature neuroscience, ISSN 1097-6256, 2016, Volume 19, Issue 3, pp. 420 - +
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia...
INDIVIDUALS | METAANALYSIS | PERSPECTIVE | RELATIVES | VARIANTS | DISORDERS | PHENOTYPES | NEUROSCIENCES | ENDOPHENOTYPE | DISCOVERY | GENOME-WIDE ASSOCIATION | Neuroimaging | Magnetic Resonance Imaging | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Schizophrenia - genetics | Endophenotypes | Humans | Brain - pathology | Organ Size | Polymorphism, Single Nucleotide - genetics | Schizophrenia - pathology | Linkage Disequilibrium | Genome-wide association studies | Phenotype | Schizophrenia | Disease susceptibility | Genetic aspects | Identification and classification | Health aspects | Methods | Neuroscience | Cognitive science
INDIVIDUALS | METAANALYSIS | PERSPECTIVE | RELATIVES | VARIANTS | DISORDERS | PHENOTYPES | NEUROSCIENCES | ENDOPHENOTYPE | DISCOVERY | GENOME-WIDE ASSOCIATION | Neuroimaging | Magnetic Resonance Imaging | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Schizophrenia - genetics | Endophenotypes | Humans | Brain - pathology | Organ Size | Polymorphism, Single Nucleotide - genetics | Schizophrenia - pathology | Linkage Disequilibrium | Genome-wide association studies | Phenotype | Schizophrenia | Disease susceptibility | Genetic aspects | Identification and classification | Health aspects | Methods | Neuroscience | Cognitive science
Journal Article