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1. Full Text SURG-34. FLUORESCENCE-GUIDED SURGERY WITH 5-AMINOLEVULINIC ACID FOR RESECTION OF PEDIATRIC BRAIN TUMORS
by Wataya, Takafumi
Neuro-Oncology, ISSN 1522-8517, 11/2017, Volume 19, Issue suppl_6, pp. vi242 - vi242
Abstracts
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2. Full Text Self-formation of functional adenohypophysis in three-dimensional culture
by Suga, Hidetaka and Kadoshima, Taisuke and Minaguchi, Maki and Ohgushi, Masatoshi and Soen, Mika and Nakano, Tokushige and Takata, Nozomu and Wataya, Takafumi and Muguruma, Keiko and Miyoshi, Hiroyuki and Yonemura, Shigenobu and Oiso, Yutaka and Sasai, Yoshiki
Nature, ISSN 0028-0836, 12/2011, Volume 480, Issue 7375, pp. 57 - 62
The adenohypophysis (anterior pituitary) is a major centre for systemic hormones. At present, no efficient stem-cell culture for its generation is available,... 
PITUITARY-GLAND | MULTIDISCIPLINARY SCIENCES | CELL LINEAGES | GROWTH | MECHANISMS | DIFFERENTIATION | SPECIFICATION | INDUCTION | EXPRESSION | RATHKES POUCH | ORGANOGENESIS | Ectoderm - embryology | Cell Line | Hypothalamus - embryology | Embryonic Stem Cells - cytology | Cells, Cultured | Endocrine Cells - metabolism | Cell Lineage | Ectoderm - cytology | Animals | Hypothalamus - cytology | Endocrine Cells - cytology | Pituitary Gland, Anterior - cytology | Pituitary Gland, Anterior - embryology | Hypopituitarism - pathology | Mice | Cell Culture Techniques | Pituitary gland | Aggregates | Kinases | Stem cells
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3. Full Text A ROCK inhibitor permits survival of dissociated human embryonic stem cells
by Muguruma, Keiko and Kamiya, Daisuke and Takahashi, Jun B and Watanabe, Kiichi and Matsumura, Michiru and Nishikawa, Shin-ichi and Ueno, Morio and Nishiyama, Ayaka and Wataya, Takafumi and Sasai, Yoshiki and Nishikawa, Satomi
Nature Biotechnology, ISSN 1087-0156, 06/2007, Volume 25, Issue 6, pp. 681 - 686
Poor survival of human embryonic stem (hES) cells after cell dissociation is an obstacle to research, hindering manipulations such as subcloning. Here we show... 
MOTOR-NEURONS | DIRECTED DIFFERENTIATION | ANOIKIS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | RHO-KINASE | EFFICIENT GENERATION | ESTABLISHMENT | SELECTION | ES CELLS | MIDBRAIN | LINES | Cell Survival - drug effects | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Pyridines - administration & dosage | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Cells, Cultured | Intracellular Signaling Peptides and Proteins - metabolism | Dose-Response Relationship, Drug | Animals | Cell Differentiation - drug effects | rho-Associated Kinases | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Mice | Amides - administration & dosage | Protein-Serine-Threonine Kinases - metabolism | Biotechnology | Cell culture | Cloning | Stem cells | Kinases | Embryos | Apoptosis
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4. Full Text Human tail in the cervical region
by Takemori, Chiaki and Nakano, Reiji and Wataya, Takafumi
Pediatrics International, ISSN 1328-8067, 07/2018, Volume 60, Issue 7, pp. 673 - 674
human tail | neuroectodermal appendage | cervical | CORD | PEDIATRICS
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5. Full Text Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells
by Akaike, Akinori and Takahashi, Masayo and Yoshimura, Nagahisa and Wataya, Takafumi and Ikeda, Hanako and Watanabe, Kiichi and Sasai, Yoshiki and Osakada, Fumitaka and Mandai, Michiko
Nature Biotechnology, ISSN 1087-0156, 02/2008, Volume 26, Issue 2, pp. 215 - 224
We previously reported the differentiation of mouse embryonic stem (ES) cells into retinal progenitors. However, these progenitors rarely differentiate into... 
MAMMALIAN EYE | PIGMENT EPITHELIAL-CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | IN-VIVO | DIFFERENTIATION | RETINAL PROGENITOR CELLS | HOMEOBOX GENE | EYE DEVELOPMENT | ES CELLS | PRECURSORS | EXPRESSION | Embryonic Stem Cells - cytology | Tissue Engineering - methods | Photoreceptor Cells - cytology | Species Specificity | Humans | Cells, Cultured | Embryonic Stem Cells - physiology | Haplorhini | Stem Cell Transplantation - methods | Animals | Retinal Diseases - pathology | Mice | Photoreceptor Cells - physiology | Retinal Diseases - surgery | Care and treatment | Stem cells | Physiological aspects | Eye diseases | Photoreceptors | Transplantation | Research | Embryonic stem cells | Health aspects | Biotechnology | Cell culture | Rodents | Retina | Ophthalmology | Monkeys & apes
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6. Full Text Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis
by Thompson, Eric M, MD and Hielscher, Thomas, MSc and Bouffet, Eric, Prof and Remke, Marc, MD and Luu, Betty, BSc and Gururangan, Sridharan, Prof and McLendon, Roger E, Prof and Bigner, Darell D, Prof and Lipp, Eric S, MD and Perreault, Sebastien, MD and Cho, Yoon-Jae, MD and Grant, Gerald, MD and Kim, Seung-Ki, Prof and Lee, Ji Yeoun, MD and Rao, Amulya A Nageswara, MD and Giannini, Caterina, Prof and Li, Kay Ka Wai, MD and Ng, Ho-Keung, Prof and Yao, Yu, MD and Kumabe, Toshihiro, MD and Tominaga, Teiji, Prof and Grajkowska, Wieslawa A, Prof and Perek-Polnik, Marta, Prof and Low, David C Y, MBBCh and Seow, Wan Tew, MBBS and Chang, Kenneth T E, MBBCh and Mora, Jaume, Prof and Pollack, Ian F, Prof and Hamilton, Ronald L, MD and Leary, Sarah, MD and Moore, Andrew S, PhD and Ingram, Wendy J, PhD and Hallahan, Andrew R, MBBS and Jouvet, Anne, MD and Fèvre-Montange, Michelle, PhD and Vasiljevic, Alexandre, MD and Faure-Conter, Cecile, MD and Shofuda, Tomoko, PhD and Kagawa, Naoki, MD and Hashimoto, Naoya, MD and Jabado, Nada, MD and Weil, Alexander G, MD and Gayden, Tenzin, PhD and Wataya, Takafumi, MD and Shalaby, Tarek, MD and Grotzer, Michael, Prof and Zitterbart, Karel, PhD and Sterba, Jaroslav, Prof and Kren, Leos, MD and Hortobágyi, Tibor, Prof and Klekner, Almos, PhD and László, Bognár, Prof and Pócza, Tímea, MSc and Hauser, Peter, MD and Schüller, Ulrich, MD and Jung, Shin, Prof and Jang, Woo-Youl, MD and French, Pim J, Prof and Kros, Johan M, Prof and van Veelen, Marie-Lise C, MD and Massimi, Luca, MD and Leonard, Jeffrey R, Prof and Rubin, Joshua B, MD and Vibhakar, Rajeev, MD and Chambless, Lola B, MD and Cooper, Michael K, MD and Thompson, Reid C, Prof and Faria, Claudia C, MD and Carvalho, Alice, MD and Nunes, Sofia, MD and Pimentel, José, MD and Fan, Xing, MD and Muraszko, Karin M, Prof and López-Aguilar, Enrique, MD and Lyden, David, Prof and Garzia, Livia, PhD and Shih, David J H, PhD and Kijima, Noriyuki, MD and Schneider, Christian, MD and Adamski, Jennifer, PhD and Northcott, Paul A, PhD and Kool, Marcel, PhD and Jones, David T W, PhD and Chan, Jennifer A, MD and Nikolic, Ana, MD and Garre, Maria Luisa, MD and Van Meir, Erwin G, Prof and Osuka, Satoru, MD and Olson, Jeffrey J, Prof and Jahangiri, Arman, BSc and Castro, Brandyn A, BSc and Gupta, Nalin, MD and Weiss, William A, Prof and Moxon-Emre, Iska, MSc and Mabbott, Donald J, PhD and Lassaletta, Alvaro, MD and Hawkins, Cynthia E, Prof and Tabori, Uri, MD and Drake, James, Prof and Kulkarni, Abhaya, Prof and ...
The Lancet Oncology, ISSN 1470-2045, 2016, Volume 17, Issue 4, pp. 484 - 495
Summary Background Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which... 
Hematology, Oncology and Palliative Medicine | ADJUVANT CHEMOTHERAPY | RISK MEDULLOBLASTOMA | ONCOLOGY | POSTERIOR-FOSSA TUMORS | RANDOMIZED-TRIAL | PATTERNS | OUTCOMES | MUTISM | RADIATION-THERAPY | CHILDREN | Prognosis | Humans | Brain Neoplasms - pathology | Brain Neoplasms - genetics | Child, Preschool | Infant | Male | Combined Modality Therapy | Brain Neoplasms - surgery | Disease Progression | Canada | Disease-Free Survival | Magnetic Resonance Imaging | Brain Neoplasms - classification | Medulloblastoma - pathology | Adult | Female | Medulloblastoma - surgery | Retrospective Studies | Medulloblastoma - genetics | Child | Medulloblastoma - classification | Medulloblastoma | Surgery
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7. Full Text Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis
by Torchia, Jonathon, MSc and Picard, Daniel, MSc and Lafay-Cousin, Lucie, MD and Hawkins, Cynthia E, PhD and Kim, Seung-Ki, MD and Letourneau, Louis, BSc and Ra, Young-Shin, Prof and Ho, King Ching, MSc and Chan, Tiffany Sin Yu, PhD and Sin-Chan, Patrick, MSc and Dunham, Christopher P, MD and Yip, Stephen, FRCPC and Ng, Ho-keung, MD and Lu, Jian-Qiang, FRCPC and Albrecht, Steffen, MD and Pimentel, José, PhD and Chan, Jennifer A, MD and Somers, Gino R, MBBS and Zielenska, Maria, PhD and Faria, Claudia C, PhD and Roque, Lucia, PhD and Baskin, Berivan, PhD and Birks, Diane, MS and Foreman, Nick, Prof and Strother, Douglas, MD and Klekner, Almos, PhD and Garami, Miklos, PhD and Hauser, Peter, PhD and Hortobágyi, Tibor, PhD and Bognár, Laszló, PhD and Wilson, Beverly, MD and Hukin, Juliette, FRCPC and Carret, Anne-Sophie, MD and Van Meter, Timothy E, PhD and Nakamura, Hideo, MD and Toledano, Helen, MD and Fried, Iris, MD and Fults, Daniel, MD and Wataya, Takafumi, PhD and Fryer, Chris, FRCPC and Eisenstat, David D, MD and Scheineman, Katrin, Prof and Johnston, Donna, MD and Michaud, Jean, MD and Zelcer, Shayna, MD and Hammond, Robert, MD and Ramsay, David A, MBChB and Fleming, Adam J, MD and Lulla, Rishi R, MD and Fangusaro, Jason R, MD and Sirachainan, Nongnuch, MD and Larbcharoensub, Noppadol, MD and Hongeng, Suradej, MD and Barakzai, Muhammad Abrar, MD and Montpetit, Alexandre, PhD and Stephens, Derek, MSc and Grundy, Richard G, FRCPCH and Schüller, Ulrich, MD and Nicolaides, Theodore, MD and Tihan, Tarik, PhD and Phillips, Joanna, PhD and Taylor, Michael D, PhD and Rutka, James T, MD and Dirks, Peter, PhD and Bader, Gary D, PhD and Warmuth-Metz, Monika, Prof and Rutkowski, Stefan, Prof and Pietsch, Torsten, Prof and Judkins, Alexander R, MD and Jabado, Nada, PhD and Bouffet, Eric, Prof and Huang, Annie, Dr and Medicinska fakulteten and Medicinska och farmaceutiska vetenskapsområdet and Institutionen för immunologi, genetik och patologi and Uppsala universitet and Medicinsk genetik och genomik
Lancet Oncology, The, ISSN 1470-2045, 2015, Volume 16, Issue 5, pp. 569 - 582
Summary Background Rhabdoid brain tumours, also called atypical teratoid rhabdoid tumours, are lethal childhood cancers with characteristic genetic alterations... 
Hematology, Oncology and Palliative Medicine | SURVIVAL | CELLS | FOREBRAIN | THERAPY | PROGNOSTIC-FACTORS | ONCOLOGY | GENE-EXPRESSION | MUTATIONS | HSNF5/INI1 | TERATOID/RHABDOID TUMORS | Immunohistochemistry | Basic Helix-Loop-Helix Transcription Factors - genetics | Prognosis | Genomics | Humans | Risk Factors | Gene Expression Regulation, Neoplastic | Child, Preschool | Infant | Male | Receptors, Notch - genetics | Signal Transduction - genetics | Rhabdoid Tumor - pathology | Teratoma - pathology | Rhabdoid Tumor - genetics | Receptors, Notch - biosynthesis | Basic Helix-Loop-Helix Transcription Factors - biosynthesis | Teratoma - genetics | Female | Child | Genetic research | Analysis | Tumors | Clinical Medicine | Medical and Health Sciences | Cancer and Oncology | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
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8. Full Text Minimization of Exogenous Signals in ES Cell Culture Induces Rostral Hypothalamic Differentiation
by Takafumi Wataya and Satoshi Ando and Keiko Muguruma and Hanako Ikeda and Kiichi Watanabe and Mototsugu Eiraku and Masako Kawada and Jun Takahashi and Nobuo Hashimoto and Yoshiki Sasai
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2008, Volume 105, Issue 33, pp. 11796 - 11801
Embryonic stem (ES) cells differentiate into neuroectodermal progenitors when cultured as floating aggregates in serum-free conditions. Here, we show that... 
Neurons | Stem cells | Cell aggregates | Neural stem cells | Cultured cells | Hypothalamus | Embryonic stem cells | Insulin | Cellular differentiation | Progenitor cells | Chemically defined | Patterning | Vasopressin | DIRECTED DIFFERENTIATION | FOREBRAIN | MULTIDISCIPLINARY SCIENCES | vasopressin | NEURAL PLATE | chemically defined | patterning | GENE | NEUROECTODERM | EMBRYONIC STEM-CELLS | NEURONS | RAT-BRAIN | PRECURSORS | hypothalamus | Embryonic Stem Cells - cytology | Signal Transduction | Homeodomain Proteins - metabolism | Intercellular Signaling Peptides and Proteins | Cells, Cultured | Transcription Factors - metabolism | Culture Media, Conditioned | Insulin - metabolism | Animals | Flow Cytometry | Hypothalamus - metabolism | Eye Proteins - metabolism | Hypothalamus - cytology | Gene Expression Regulation, Developmental | Biomarkers | Cell Differentiation | Mice | Proto-Oncogene Proteins c-akt - metabolism | Cell culture | Influence | Cellular signal transduction | Research | Properties | Biological Sciences
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9. Full Text The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)
by Yamagami, Keitaro and Kurogi, Ryota and Kurogi, Ai and Nishimura, Hiroyuki and Nishimura, Shinjitsu and Nishimura, Yasuaki and Nishimura, Kunihiro and Nishimura, Ataru and Onozuka, Daisuke and Ren, Nice and Kada, Akiko and Arimura, Koichi and Ido, Keisuke and Mizoguchi, Masahiro and Sakamoto, Seisaburo and Sakamoto, Tetsuya and Kayama, Takamasa and Suzuki, Nozomi and Suzuki, Michiyasu and Suzuki, Sachio and Suzuki, Hidenori and Suzuki, Ichiro and Suzuki, Susumu and Arai, Yoshinori and Arai, Hajime and Arai, Motohiro and Hagihara, Akihito and Iihara, Koji and Takigami, Masayoshi and Kamiyama, Kenji and Houkin, Kiyohiro and Nishi, Shougo and Yoshimoto, Tetsuyuki and Yoshimoto, Junpei and Kaneko, Sadao and Oka, Hirofumi and Oka, Koji and Ooyama, Hiroshi and Kamada, Kyousuke and Makino, Kenichi and Tokumitsu, Naoki and Sako, Kazuhiro and Izumi, Naoto and Nitta, Hisashi and Nitta, Kazumi and Ootaki, Masahumi and Isobe, Masanori and Nishiya, Mikio and Yamazaki, Takaaki and Mabuchi, Syouji and Mabuchi, Eiichiro and Ogasawara, Kuniaki and Kubo, Naohiko and Shimizu, Yukihiko and Saito, Hitoshi and Saito, Keiichi and Yamanome, Tatumi and Yoshino, Kimihiro and Yoshino, Atsuo and Fujitsuka, Mitsuyuki and Takami, Masaaki and Ohtaka, Hirotoshi and Hirano, Teruyuki and Shiokawa, Yosiaki and Okada, Takaharu and Kohno, Michihiro and Haraoka, Jou and Kawamura, Noriyoshi and Kawamura, Tadao and Isoshima, Akira and Yasue, Masaharu and Takayoshi Kobayashi, Mitsuhiko Hokari and Kawai, Kensuke and Maehara, Taketoshi and Noguchi, Makoto and Hoshino, Haruhiko and Hiyama, Hirofumi and Yoshida, Kensaku and Yoshida, Kazunari and Utsugi, Osamu and Takeda, Yasuaki and Takeda, Yuu and Tamaki, Kouichi and Karasudani, Hirohide and Urabe, Takao and Kobayashi, Nozomu and Kobayashi, Shiro and Nakamura, Yusaku and Nakamura, Kazuhito and Nakamura, Michio and Nakamura, Yoshinari and Koguchi, Yorio and Ono, Junichi and Suda, Sumio and Hadeishi, Hiromu and Fukutake, Toshio and Wakui, Kenji and Tanno, Hirokazu and Ishige, Naoki and Ohasi, Takashi and ... and J-ASPECT Study Collaborators
World Neurosurgery, ISSN 1878-8750, 10/2019, Volume 130, pp. e26 - e46
The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging societies.... 
Aging | Hospital mortality | Prognosis | Traumatic brain injury | Subdural hematoma | SURGERY | CARE | CLINICAL NEUROLOGY | IMPACT | CLINICAL-VARIABLES | HOSPITAL VOLUME | GENDER | COMA
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10. Full Text The use of 5-aminolevulinic acid to assist gross total resection of pediatric astroblastoma
by Agawa, Yuji and Wataya, Takafumi
Child's Nervous System, ISSN 0256-7040, 5/2018, Volume 34, Issue 5, pp. 971 - 975
Astroblastoma is an uncommon pediatric neuroepithelial tumor. The prognosis and appropriate treatment of astroblastoma were not well understood. Previous... 
Neurosciences | Astroblastoma | Medicine & Public Health | Gross total resection | Neurosurgery | 5-aminolevulinic acid | Pediatric | SURGERY | PROTON MR SPECTROSCOPY | CLINICAL NEUROLOGY | BRAIN-TUMORS | FEATURES | FLUORESCENCE-GUIDED SURGERY | PART | PEDIATRICS | CEREBRAL ASTROBLASTOMA | CLINICAL BEHAVIOR | OF-THE-LITERATURE | MEDULLOBLASTOMA | 5-ALA | Pediatrics | Care and treatment | Prognosis | Brain tumors | Diagnosis | Health aspects | Teenage girls
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11. Full Text Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals
by Eiraku, Mototsugu and Watanabe, Kiichi and Matsuo-Takasaki, Mami and Kawada, Masako and Yonemura, Shigenobu and Matsumura, Michiru and Wataya, Takafumi and Nishiyama, Ayaka and Muguruma, Keiko and Sasai, Yoshiki
Cell Stem Cell, ISSN 1934-5909, 2008, Volume 3, Issue 5, pp. 519 - 532
Here, we demonstrate self-organized formation of apico-basally polarized cortical tissues from ESCs using an efficient three-dimensional aggregation culture... 
STEMCELL | PROGENITOR CELLS | DEVELOPING NEOCORTEX | CORTEX | EMBRYONIC STEM-CELLS | TELENCEPHALON | CALCIUM WAVES | BIRTH-DATE | DIFFERENTIATION | CAJAL-RETZIUS | FATE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Immunohistochemistry | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Humans | Homeostasis | Neurons - cytology | Wnt Proteins - metabolism | Bone Morphogenetic Protein 4 - metabolism | Cerebral Cortex - cytology | Cerebral Cortex - metabolism | Fibroblast Growth Factor 8 - metabolism | Neurons - transplantation | Gene Expression Regulation, Developmental | Antigens, Differentiation - metabolism | Cell Differentiation | Neurons - metabolism | Signal Transduction | Tissue Culture Techniques | Body Patterning - physiology | Animals | Cell Cycle | Embryonic Stem Cells - transplantation | Cerebral Cortex - growth & development | Wnt3 Protein | Mice
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