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by Abbosh, Christopher and Birkbak, Nicolai J and Wilson, Gareth A and Jamal-Hanjani, Mariam and Constantin, Tudor and Salari, Raheleh and Le Quesne, John and Moore, David A and Veeriah, Selvaraju and Rosenthal, Rachel and Marafioti, Teresa and Kirkizlar, Eser and Watkins, Thomas B. K and McGranahan, Nicholas and Ward, Sophia and Martinson, Luke and Riley, Joan and Fraioli, Francesco and Al Bakir, Maise and Grönroos, Eva and Zambrana, Francisco and Endozo, Raymondo and Bi, Wenya Linda and Fennessy, Fiona M and Sponer, Nicole and Johnson, Diana and Laycock, Joanne and Shafi, Seema and Czyzewska-Khan, Justyna and Rowan, Andrew and Chambers, Tim and Matthews, Nik and Turajlic, Samra and Hiley, Crispin and Lee, Siow Ming and Forster, Martin D and Ahmad, Tanya and Falzon, Mary and Borg, Elaine and Lawrence, David and Hayward, Martin and Kolvekar, Shyam and Panagiotopoulos, Nikolaos and Janes, Sam M and Thakrar, Ricky and Ahmed, Asia and Blackhall, Fiona and Summers, Yvonne and Hafez, Dina and Naik, Ashwini and Ganguly, Apratim and Kareht, Stephanie and Shah, Rajesh and Joseph, Leena and Quinn, Anne Marie and Crosbie, Phil A and Naidu, Babu and Middleton, Gary and Langman, Gerald and Trotter, Simon and Nicolson, Marianne and Remmen, Hardy and Kerr, Keith and Chetty, Mahendran and Gomersall, Lesley and Fennell, Dean A and Nakas, Apostolos and Rathinam, Sridhar and Anand, Girija and Khan, Sajid and Russell, Peter and Ezhil, Veni and Ismail, Babikir and Irvin-Sellers, Melanie and Prakash, Vineet and Lester, Jason F and Kornaszewska, Malgorzata and Attanoos, Richard and Adams, Haydn and Davies, Helen and Oukrif, Dahmane and Akarca, Ayse U and Hartley, John A and Lowe, Helen L and Lock, Sara and Iles, Natasha and Bell, Harriet and Ngai, Yenting and Elgar, Greg and Szallasi, Zoltan and Schwarz, Roland F and Herrero, Javier and Stewart, Aengus and Quezada, Sergio A and Peggs, Karl S and Van Loo, Peter and Dive, Caroline and Lin, C. Jimmy and Rabinowitz, Matthew and Aerts, Hugo J. W. L and ... and TRACERx Consortium and The PEACE Consortium and TRACERx consortium and PEACE consortium and The PEACE consortium and The TRACERx consortium
Nature, ISSN 0028-0836, 04/2017, Volume 545, Issue 7655, pp. 446 - 451
Journal Article
Nature, ISSN 0028-0836, 01/2018, Volume 553, Issue 7689, pp. 467 - 472
Chromosomal instability is a hallmark of cancer that results from ongoing errors in chromosome segregation during mitosis. Although chromosomal instability is... 
BREAST-CANCER | MIGRATION | CELLS | ANEUPLOIDY | ACTIVATION | EVOLUTION | PROGNOSIS | PATHWAY | MULTIDISCIPLINARY SCIENCES | SENSITIVITY | EXPRESSION | Breast Neoplasms - secondary | DNA, Neoplasm - metabolism | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - pathology | Humans | Brain Neoplasms - pathology | NF-kappa B - metabolism | Cytosol - enzymology | Brain Neoplasms - secondary | Inflammation - metabolism | Female | Membrane Proteins - metabolism | Nucleotidyltransferases - metabolism | Cell Line | Micronuclei, Chromosome-Defective | Chromosome Segregation | Brain Neoplasms - genetics | Head and Neck Neoplasms - pathology | Xenograft Model Antitumor Assays | Chromosomal Instability - genetics | Neoplasm Metastasis - genetics | Animals | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Inflammation - genetics | Cytosol - metabolism | Head and Neck Neoplasms - genetics | Mesoderm - metabolism | Mice | Complications and side effects | Development and progression | Genetic aspects | Metastasis | Chromosomal instability syndromes | Genetic suppression | Mitosis | Activation | Genomes | Cytosol | Metastases | Genomic instability | Stimulators | Signal transduction | Cyclic GMP | Chromosomes | Deoxyribonucleic acid--DNA | NF-κB protein | Stability | AMP | Organs | Breast cancer | Survival analysis | Signaling | Medical prognosis | Micronuclei | Interferon | Cancer | Tumors
Journal Article
Science, ISSN 0036-8075, 03/2016, Volume 351, Issue 6280, pp. 1463 - 1469
Journal Article
Nature genetics, ISSN 1061-4036, 2015, Volume 47, Issue 8, pp. 864 - 871
Journal Article
by Jamal-Hanjani, Mariam and Wilson, Gareth A and McGranahan, Nicholas and Birkbak, Nicolai J and Watkins, Thomas B.K and Veeriah, Selvaraju and Shafi, Seema and Johnson, Diana H and Mitter, Richard and Rosenthal, Rachel and Salm, Max and Horswell, Stuart and Escudero, Mickael and Matthews, Nik and Rowan, Andrew and Chambers, Tim and Moore, David A and Turajlic, Samra and Xu, Hang and Lee, Siow-Ming and Forster, Martin D and Ahmad, Tanya and Hiley, Crispin T and Abbosh, Christopher and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Lawrence, David and Hayward, Martin and Kolvekar, Shyam and Panagiotopoulos, Nikolaos and Janes, Sam M and Thakrar, Ricky and Ahmed, Asia and Blackhall, Fiona and Summers, Yvonne and Shah, Rajesh and Joseph, Leena and Quinn, Anne M and Crosbie, Phil A and Naidu, Babu and Middleton, Gary and Langman, Gerald and Trotter, Simon and Nicolson, Marianne and Remmen, Hardy and Kerr, Keith and Chetty, Mahendran and Gomersall, Lesley and Fennell, Dean A and Nakas, Apostolos and Rathinam, Sridhar and Anand, Girija and Khan, Sajid and Russell, Peter and Ezhil, Veni and Ismail, Babikir and Irvin-Sellers, Melanie and Prakash, Vineet and Lester, Jason F and Kornaszewska, Malgorzata and Attanoos, Richard and Adams, Haydn and Davies, Helen and Dentro, Stefan and Taniere, Philippe and O’Sullivan, Brendan and Lowe, Helen L and Hartley, John A and Iles, Natasha and Bell, Harriet and Ngai, Yenting and Shaw, Jacqui A and Herrero, Javier and Szallasi, Zoltan and Schwarz, Roland F and Stewart, Aengus and Quezada, Sergio A and Le Quesne, John and Van Loo, Peter and Dive, Caroline and Hackshaw, Allan and Swanton, Charles and TRACERx Consortium
The New England Journal of Medicine, ISSN 0028-4793, 06/2017, Volume 376, Issue 22, pp. 2109 - 2121
Journal Article
Nature Genetics, ISSN 1061-4036, 12/2017, Volume 49, Issue 12, pp. 1693 - 1704
A widespread approach to modern cancer therapy is to identify a single oncogenic driver gene and target its mutant-protein product (for example, EGFR-inhibitor... 
HETEROGENEITY | CELLS | ACTIVATION | CIRCULATING TUMOR DNA | MET AMPLIFICATION | GENETICS & HEREDITY | ACQUIRED-RESISTANCE | MUTATIONS | INHIBITOR | EXPRESSION | AZD9291 | Carcinoma, Non-Small-Cell Lung - pathology | Lung Neoplasms - genetics | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Cell Proliferation - genetics | Class I Phosphatidylinositol 3-Kinases - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Humans | Kaplan-Meier Estimate | Lung Neoplasms - pathology | beta Catenin - genetics | Wnt Signaling Pathway - drug effects | Wnt Signaling Pathway - genetics | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Gene Expression Regulation, Neoplastic - drug effects | Mutation | Cyclin-Dependent Kinases - genetics | Neoplasm Staging | Clonal Evolution | Care and treatment | Gene mutations | Lung cancer | Development and progression | Genetic aspects | Drug resistance | Health aspects | Therapy | Cell survival | Genomic analysis | Wnt protein | Epidermal growth factor receptors | Genes | Biological evolution | Genomes | Metastasis | Kinases | Patients | Cyclin-dependent kinase 4 | Clinical outcomes | Metastases | Datasets | Alterations | Inhibitors | Genetic testing | Deoxyribonucleic acid--DNA | Cancer | Fibroblast growth factor receptors | Tumors
Journal Article
Journal Article