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1. Full Text Evidence-Based Guidelines Magnims Consensus Guidelines on the Use of Mri in Multiple Sclerosis-Establishing Disease Prognosis and Monitoring Patients
by Wattjes, M.P and Rovira, A and Miller, D and Yousry, T.A and Sormani, M.P and De Stefano, N and Tintore, M and Auger, C and Tur, C and Filippi, M and Rocca, M.A and Fazekas, F and Kappos, L and Polman, C and Barkhof, F and Montalban, X and MAGNIMS Study Grp and MAGNIMS study group
Nature Reviews Neurology, ISSN 1759-4758, 2015, Volume 11, Issue 10, pp. 597 - 606
The role of MRI in the assessment of multiple sclerosis (MS) goes far beyond the diagnostic process. MRI techniques can be used as regular monitoring to help... 
SPINAL-CORD LESIONS | BRAIN ATROPHY | PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY | LONG-TERM DISABILITY | MAGNETIZATION-TRANSFER RATIO | FOLLOW-UP | COGNITIVE IMPAIRMENT | GLATIRAMER ACETATE | INTERFERON-BETA | DIAGNOSTIC-CRITERIA | CLINICAL NEUROLOGY | Brain - drug effects | Immunotherapy - methods | Multiple Sclerosis - diagnosis | Prognosis | Humans | Brain - pathology | Magnetic Resonance Imaging - methods | Multiple Sclerosis - pathology | Evidence-Based Medicine | Consensus | Disease Progression | Multiple Sclerosis - drug therapy
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2. Full Text MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-clinical implementation in the diagnostic process
by Rovira, A and Wattjes, M.P and Tintore, M and Tur, C and Yousry, T.A and Sormani, M.P and De Stefano, N and Filippi, M and Auger, C and Rocca, M.A and Barkhof, F and Fazekas, F and Kappos, L and Polman, C and Miller, D and Montalban, X and MAGNIMS Study Grp and on behalf of the MAGNIMS study group
Nature Reviews Neurology, ISSN 1759-4758, 2015, Volume 11, Issue 8, pp. 471 - 482
The clinical use of MRI in patients with multiple sclerosis (MS) has advanced markedly over the past few years. Technical improvements and continuously... 
SPINAL-CORD LESIONS | WHITE-MATTER LESIONS | BRAIN ATROPHY | ATTENUATED INVERSION-RECOVERY | MS LESIONS | NEUROMYELITIS-OPTICA | IN-VIVO | GADOLINIUM-ENHANCED MRI | MAGNETIZATION-TRANSFER | CLINICAL NEUROLOGY | 2010 MCDONALD CRITERIA | Practice guidelines (Medicine) | Multiple sclerosis | Diagnosis | Magnetic resonance imaging | Standards
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3. Full Text Neuromuscular imaging in inherited muscle diseases
by Wattjes, M.P and Kley, R.A and Fischer, D
European Radiology, ISSN 0938-7994, 2010, Volume 20, Issue 10, pp. 2447 - 2460
Driven by increasing numbers of newly identified genetic defects and new insights into the field of inherited muscle diseases, neuromuscular imaging in general... 
Diagnostic Radiology | Congenital myopathy | Internal Medicine | Inherited muscle diseases | Muscle MRI | Neuroradiology | Muscular dystrophy | Medicine & Public Health | Myotonic dystrophy | Limb girdle muscular dystrophy | Interventional Radiology | Imaging / Radiology | Ultrasound | MYOFIBRILLAR MYOPATHIES | QUANTITATIVE-EVALUATION | DIAGNOSTIC-VALUE | MIYOSHI-MYOPATHY | HIGH-FIELD MRI | INVOLVEMENT | GIRDLE MUSCULAR-DYSTROPHY | COMPUTED-TOMOGRAPHY | ULTRASOUND | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | MYOTONIC-DYSTROPHY | Calpain - metabolism | Muscles - diagnostic imaging | Humans | Sarcoglycans - chemistry | Dysferlin | Magnetic Resonance Imaging - methods | Tomography, X-Ray Computed - methods | Male | Muscular Diseases - pathology | Muscles - pathology | Diagnostic Imaging - methods | Membrane Proteins - chemistry | Adolescent | Ultrasonography | Adult | Female | Muscle Proteins - chemistry | Muscular Diseases - congenital | Muscular Dystrophies, Limb-Girdle - diagnostic imaging | Muscular Dystrophies, Limb-Girdle - pathology | Genetic aspects | Diagnostic imaging | Genetic disorders | Algorithms | Neuro
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4. Full Text Diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy using MRI
by Wattjes, M.P and Barkhof, F
Current Opinion in Neurology, ISSN 1350-7540, 2014, Volume 27, Issue 3, pp. 260 - 270
Purpose of reviewThis review describe the role and advancements of MRI in the diagnosis and monitoring of progressive multifocal leukoencephalopathy (PML) in... 
magnetic resonance imaging | progressive multifocal leukoencephalopathy | multiple sclerosis | natalizumab | TUMEFACTIVE MULTIPLE-SCLEROSIS | JC VIRUS | GRANULE CELL NEURONOPATHY | NEUROSCIENCES | LESIONS | CLINICAL NEUROLOGY | RECONSTITUTION INFLAMMATORY SYNDROME | PATIENT | INFECTION | VIRUS ACUTE MYELITIS | PML-IRIS | Leukoencephalopathy, Progressive Multifocal - immunology | Antibodies, Monoclonal, Humanized - adverse effects | Natalizumab | Humans | Leukoencephalopathy, Progressive Multifocal - diagnosis | Magnetic Resonance Imaging | Immunosuppressive Agents - immunology | Diffusion Magnetic Resonance Imaging | Brain - pathology | Leukoencephalopathy, Progressive Multifocal - etiology | Multiple Sclerosis - immunology | Immunosuppressive Agents - adverse effects | Antibodies, Monoclonal, Humanized - immunology | Multiple Sclerosis - drug therapy
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5. Full Text PML in a Patient Treated with Dimethyl Fumarate from a Compounding Pharmacy
by van Oosten, Bob W and Killestein, Joep and Barkhof, Frederik and Polman, Chris H and Wattjes, Mike P
The New England Journal of Medicine, ISSN 0028-4793, 04/2013, Volume 368, Issue 17, pp. 1658 - 1659
Two cases of progressive multifocal leukoencephalopathy (PML) are reported in patients with psoriasis who were treated with fumarates, one with Fumaderm and... 
MEDICINE, GENERAL & INTERNAL | Psoriasis - drug therapy | Fumarates - therapeutic use | Humans | Paresis - chemically induced | Dermatologic Agents - therapeutic use | Fumarates - adverse effects | Dermatologic Agents - adverse effects | Pharmacies | Leukoencephalopathy, Progressive Multifocal - chemically induced | Magnetic Resonance Imaging | Drug Compounding | Adult | Female | Leukoencephalopathy, Progressive Multifocal - pathology | Dimethyl Fumarate | Nuclear magnetic resonance--NMR | Psoriasis | Leukoencephalopathy | Pharmacy | Progressive multifocal leukoencephalopathy
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6. Full Text Case Reports of PML in Patients Treated for Psoriasis Reply
by van Oosten, B.W and Killestein, J and Wattjes, M.P
New England Journal of Medicine, ISSN 0028-4793, 2013, Volume 369, Issue 11, pp. 1081 - 1082
MEDICINE, GENERAL & INTERNAL | MULTIPLE-SCLEROSIS | PLACEBO-CONTROLLED PHASE-3 | ORAL BG-12
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7. Full Text Diagnosis of multiple sclerosis: revision of the McDonald criteria 2017
by Aktas, O and Wattjes, M.P and Stangel, M and Hartung, H.-P
Nervenarzt, ISSN 0028-2804, 12/2018, Volume 89, Issue 12, pp. 1344 - 1354
Treatment | Magnetic resonance imaging | Cerebrospinal fluid diagnostics | Clinically isolated syndrome | Neuromyelitis optica spectrum disorders
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8. Full Text Proliferative Retinopathy in Type 1 Diabetes Is Associated With Cerebral Microbleeds, Which Is Part of Generalized Microangiopathy
by Woerdeman, J.P and van Duinkerken, E and Wattjes, M.P and Barkhof, F and Snoek, F.J and Moll, A.C and Klein, M and de Boer, M.P and IJzerman, R.G and Serne, E.H and Diamant, M
Diabetes Care, ISSN 0149-5992, 2014, Volume 37, Issue 4, pp. 1165 - 1168
OBJECTIVE We investigated whether proliferative diabetic retinopathy in type 1 diabetic patients can be generalized to cerebral small vessel disease and... 
POPULATION | BRAIN | DISEASE | ENDOCRINOLOGY & METABOLISM | Magnetic Resonance Imaging | Humans | Middle Aged | Adult | Female | Male | Diabetes Mellitus, Type 1 - complications | Diabetic Retinopathy - etiology | Diabetic Retinopathy - pathology | Cerebral Hemorrhage - etiology | Blood vessels | Physiological aspects | Research | Type 1 diabetes | Retinal diseases | Analysis
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9. Full Text Postmortem verification of MS cortical lesion detection with 3D DIR
by Seewann, A.M and Kooi, E.J and Roosendaal, S.D and Pouwels, P.J.W and Wattjes, M.P and van der Valk, P and Barkhof, F and Polman, C.H and Geurts, J.J.G
Neurology, ISSN 0028-3878, 2012, Volume 78, Issue 5, pp. 302 - 308
Objective: To assess the sensitivity and specificity of 3D double inversion recovery (DIR) MRI for detecting multiple sclerosis (MS) cortical lesions (CLs)... 
MULTIPLE-SCLEROSIS LESIONS | ATTENUATED INVERSION-RECOVERY | WHITE-MATTER | DEMYELINATION | ABNORMALITIES | COGNITIVE IMPAIRMENT | PULSE SEQUENCE | PATHOLOGY | HISTOPATHOLOGY | BRAIN | CLINICAL NEUROLOGY | Immunohistochemistry | Humans | Middle Aged | Cerebral Cortex - pathology | Imaging, Three-Dimensional - methods | Magnetic Resonance Imaging - methods | Male | Image Processing, Computer-Assisted - methods | Autopsy | Myelin Proteolipid Protein - metabolism | Aged, 80 and over | Multiple Sclerosis - pathology | Adult | Female | Aged | Postmortem Changes
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10. Full Text Progressive multifocal leukoencephalopathy after natalizumab discontinuation: Few and true?
by Wattjes, M.P and Killestein, J
Annals of Neurology, ISSN 0364-5134, 2014, Volume 75, Issue 3, pp. 462 - 462
NEUROSCIENCES | CLINICAL NEUROLOGY | Antibodies, Monoclonal, Humanized - adverse effects | Leukoencephalopathy, Progressive Multifocal - chemically induced | Humans | Female | Male | Adverse Drug Reaction Reporting Systems - trends | Leukoencephalopathy, Progressive Multifocal - diagnosis | Withholding Treatment - trends | Multiple Sclerosis - drug therapy
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11. Full Text Consensus recommendations for MS cortical lesion scoring using double inversion recovery MRI
by Geurts, J.J.G and Roosendaal, S.D and Calabrese, M and Ciccarelli, O and Agosta, F and Chard, D.T and Gass, A and Huerga, E and Moraal, B and Pareto, D and Rocca, M.A and Wattjes, M.P and Yousry, T.A and Uitdehaag, B.M.J and Barkhof, F and MAGNIMS Study Grp and MAGNIMS Study Group and On behalf of the MAGNIMS Study Group
Neurology, ISSN 0028-3878, 2011, Volume 76, Issue 5, pp. 418 - 424
Background: Different double inversion recovery (DIR) sequences are currently used in multiple sclerosis (MS) research centers to visualize cortical lesions,... 
INTRACORTICAL LESIONS | MATTER | COGNITIVE IMPAIRMENT | MULTIPLE-SCLEROSIS | DEMYELINATION | CLINICAL NEUROLOGY | Disability Evaluation | Severity of Illness Index | Predictive Value of Tests | Multiple Sclerosis - diagnosis | Reproducibility of Results | Humans | Cerebral Cortex - pathology | Magnetic Resonance Imaging - methods | Image Processing, Computer-Assisted - methods | Artifacts | Multicenter Studies as Topic - methods | Magnetic Resonance Imaging - standards | Nerve Fibers, Myelinated - pathology | Multiple Sclerosis - pathology | Multicenter Studies as Topic - standards | Observer Variation
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12. Full Text The investigation of acute optic neuritis: a review and proposed protocol
by Petzold, A.F.S and Wattjes, M.P and Costello, F and Flores-Rivera, J and Fraser, C.L and Fujihara, K and Leavitt, J and Marignier, R and Paul, F and Schippling, S and Sindic, C and Villoslada, P and Weinshenker, B and Plant, G.T
Nature Reviews Neurology, ISSN 1759-4758, 2014, Volume 10, Issue 8, pp. 447 - 458
Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course.... 
AXONAL DEGENERATION | NERVE-FIBER LAYER | MULTIPLE-SCLEROSIS | NEUROMYELITIS-OPTICA | MICROCYSTIC MACULAR EDEMA | CLINICAL-FEATURES | DIAGNOSTIC-CRITERIA | PATTERN ELECTRORETINOGRAPHY | VISUAL-FIELD LOSS | COHERENCE TOMOGRAPHY | CLINICAL NEUROLOGY | Magnetic Resonance Imaging | Medical History Taking | Optic Neuritis - diagnosis | Tomography, Optical Coherence | Humans | Practice Guidelines as Topic | Care and treatment | Optic neuritis | Clinical trials | Diagnosis | Management | Patients | Standards
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13. Full Text Visual assessment of posterior atrophy development of a MRI rating scale
by Koedam, E.L.G.E and Lehmann, M and van der Flier, W.M and Scheltens, P and Pijnenburg, Y.A.L and Fox, N.C and Barkhof, F and Wattjes, M.P
European Radiology, ISSN 0938-7994, 2011, Volume 21, Issue 12, pp. 2618 - 2625
To develop a visual rating scale for posterior atrophy (PA) assessment and to analyse whether this scale aids in the discrimination between Alzheimer’s disease... 
Medicine & Public Health | Diagnostic Radiology | MRI | Internal Medicine | Interventional Radiology | Imaging / Radiology | Ultrasound | Alzheimer | Neuroradiology | Dementia | Posterior atrophy | DIAGNOSIS | HIPPOCAMPAL ATROPHY | CONSENSUS | TEMPORAL-LOBE ATROPHY | PRESENTATIONS | CINGULATE GYRUS | DEGENERATION | ONSET ALZHEIMERS-DISEASE | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | REGIONAL ATROPHY | Alzheimer Disease - diagnosis | Cognition Disorders - diagnosis | Humans | Middle Aged | Cognition Disorders - pathology | Magnetic Resonance Imaging - methods | Atrophy - diagnosis | Female | Linear Models | Male | Alzheimer Disease - pathology | Parietal Lobe - pathology | Neuro
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14. Full Text Associations Between Cerebral Small-Vessel Disease and Alzheimer Disease Pathology as Measured by Cerebrospinal Fluid Biomarkers
by Kester, Maartje I and Goos, Jeroen D. C and Teunissen, Charlotte E and Benedictus, Marije R and Bouwman, Femke H and Wattjes, Mike P and Barkhof, Frederik and Scheltens, Philip and van der Flier, Wiesje M
JAMA Neurology, ISSN 2168-6149, 07/2014, Volume 71, Issue 7, pp. 855 - 862
IMPORTANCE: It remains unclear if and how associations between cerebral small-vessel disease and Alzheimer disease (AD) pathology lead to cognitive decline and... 
DIAGNOSIS | CLINICAL-EXPRESSION | DEMENTIA | ABNORMALITIES | ATROPHY | AMYLOID ANGIOPATHY | MARKERS | BRAIN MICROBLEEDS | WHITE-MATTER HYPERINTENSITIES | CLINICAL NEUROLOGY | IMPAIRMENT | Phosphorylation | Humans | Middle Aged | Stroke, Lacunar - blood | tau Proteins - metabolism | Cerebral Small Vessel Diseases - cerebrospinal fluid | Male | Cerebral Small Vessel Diseases - pathology | Alzheimer Disease - pathology | Cerebral Small Vessel Diseases - metabolism | Hemorrhage - cerebrospinal fluid | Amyloid beta-Peptides - metabolism | Amyloid beta-Peptides - cerebrospinal fluid | Apolipoprotein E4 - cerebrospinal fluid | Female | Biomarkers - metabolism | Peptide Fragments - metabolism | Apolipoprotein E4 - metabolism | Peptide Fragments - cerebrospinal fluid | Stroke, Lacunar - cerebrospinal fluid | Cross-Sectional Studies | Hemorrhage - blood | tau Proteins - cerebrospinal fluid | Alzheimer Disease - cerebrospinal fluid | Alzheimer Disease - metabolism | Aged | Biomarkers - cerebrospinal fluid | Hemorrhage - pathology | Genetic Carrier Screening | Stroke, Lacunar - pathology
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15. Full Text Spinal cord lesions in patients with clinically isolated syndrome A powerful tool in diagnosis and prognosis
by Sombekke, M.H and Wattjes, M.P and Balk, L.J and Nielsen, J.M and Vrenken, H and Uitdehaag, B.M.J and Polman, C.H and Barkhof, F
Neurology, ISSN 0028-3878, 2013, Volume 80, Issue 1, pp. 69 - 75
Objective: Spinal cord (SC) lesions are frequently found in multiple sclerosis (MS), but are rare in healthy aging and cerebrovascular patients.Our aimwas to... 
SPACE | DEFINITE MULTIPLE-SCLEROSIS | MRI CRITERIA | DISSEMINATION | GUIDELINES | PREDICT CONVERSION | DISABILITY | OPTIC NEURITIS | TIME | BRAIN | CLINICAL NEUROLOGY | Neuroimaging - methods | Severity of Illness Index | Predictive Value of Tests | Multiple Sclerosis - diagnosis | Prognosis | Prospective Studies | Humans | Demyelinating Diseases - complications | Magnetic Resonance Imaging - methods | Male | Neuroimaging - statistics & numerical data | Disease Progression | Multiple Sclerosis - complications | Demyelinating Diseases - diagnosis | Spinal Cord - pathology | Magnetic Resonance Imaging - statistics & numerical data | Brain - pathology | Multiple Sclerosis - pathology | Adult | Female | Demyelinating Diseases - pathology
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16. Full Text Cerebral Blood Flow Measured with 3D Pseudocontinuous Arterial Spin-labeling MR Imaging in Alzheimer Disease and Mild Cognitive Impairment: A Marker for Disease Severity
by Binnewijzend, M.A.A and Kuijer, J.P.A and Benedictus, M.R and van der Flier, W.M and Wink, A.M and Wattjes, M.P and van Berckel, B.N.M and Scheltens, P and Barkhof, F
Radiology, ISSN 0033-8419, 2013, Volume 267, Issue 1, pp. 221 - 230
Purpose: To compare quantitative cerebral blood flow (CBF) values in patients with Alzheimer disease (AD), patients with mild cognitive impairment (MCI), and... 
PERFUSION MRI | DIAGNOSIS | DEMENTIA | ABNORMALITIES | ALGORITHM | HYPOPERFUSION | OPTIMIZATION | MODEL | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | PET | PARAMETER | Severity of Illness Index | Alzheimer Disease - physiopathology | Prospective Studies | Cerebrovascular Circulation - physiology | Humans | Middle Aged | Image Interpretation, Computer-Assisted | Linear Models | Male | Spin Labels | Chi-Square Distribution | Cognitive Dysfunction - physiopathology | Analysis of Variance | Female | Magnetic Resonance Angiography - methods | Aged | Imaging, Three-Dimensional
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17. Full Text Chronic cerebrospinal venous insufficiency in multiple sclerosis: the final curtain
by Paul, Friedemann and Wattjes, Mike P
Lancet, The, ISSN 0140-6736, 2014, Volume 383, Issue 9912, pp. 106 - 108
  Despite the absence of scientific evidence, chronic cerebrospinal venous insufficiency rapidly entered the multiple sclerosis glossary and there were... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | DRAINAGE | MRI | DISEASE | Radiography | Venous Insufficiency - etiology | Multiple Sclerosis - diagnostic imaging | Azygos Vein - diagnostic imaging | Humans | Jugular Veins - diagnostic imaging | Studies | Multiple sclerosis | Hypotheses | Ultrasonic imaging | Varicose veins | Catheters | Siblings
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