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MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 04/2019, Volume 95, Issue 4, pp. 349 - 360
Membrane-bound adenylyl cyclase (AC) isoforms have distinct regulatory mechanisms that contribute to their signaling specificity and physiologic roles.... 
PROTEIN-KINASE-A | LIPID MODIFICATIONS | G-BETA-GAMMA | INHIBITION | PHOSPHORYLATION | ALPHA | PHARMACOLOGY & PHARMACY | SUBUNITS | ISOFORM | IDENTIFICATION | CAMP
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 09/2018, Volume 94, Issue 3, pp. 963 - 972
Functional characterization of adenylyl cyclase (AC) isoforms has proven challenging in mammalian cells because of the endogenous expression of multiple AC... 
ACTIVATION | G(S)-COUPLED RECEPTORS | ISOFORMS | LIPID RAFTS | CRISPR-CAS9 SYSTEM | ESCHERICHIA-COLI | FORSKOLIN | PHARMACOLOGY & PHARMACY | CAPACITATIVE CA2+ ENTRY | DIFFERENTIAL REGULATION | EXPRESSION
Journal Article
Organic Letters, ISSN 1523-7060, 02/2015, Volume 17, Issue 4, pp. 892 - 895
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 03/2015, Volume 352, Issue 3, pp. 480 - 493
G protein-coupled receptors (GPCRs) often activate multiple signaling pathways, and ligands may evoke functional responses through individual pathways. These... 
ACTIVATION | AFFINITY | PHARMACOLOGY | ARRESTIN | PROTEIN-COUPLED-RECEPTORS | FUNCTIONAL SELECTIVITY | PHARMACOLOGY & PHARMACY | BETA-GAMMA-SUBUNITS | ADENYLATE-CYCLASE | ARIPIPRAZOLE
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2008, Volume 582, Issue 29, pp. 3985 - 3990
MINT‐6797156, MINT‐6797142: A2AR (uniprotkb:P29274) physically interacts (MI:0218) with A2AR (uniprotkb:P29274) by bimolecular fluorescence complementation... 
G protein-coupled receptor | Higher-order oligomer | Fluorescence (Forster) resonance energy transfer | Adenosine A2A receptor | Bimolecular fluorescence complementation | Neuronal cell | receptor | Adenosine A
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 09/2015, Volume 763, p. 223
Heterologous sensitization of adenylyl cyclase (also referred to as superactivation, sensitization, or supersensitization of adenylyl cyclase) is a cellular... 
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2019, Volume 162, pp. 568 - 585
Adenylyl cyclases type 1 (AC1) and 8 (AC8) are group 1 transmembrane adenylyl cyclases (AC) that are stimulated by Ca /calmodulin. Studies have shown that mice... 
1,3,4-Oxadiazole | Adenylyl cyclase inhibitors | Chronic pain treatment | Molecular modeling | CHEMISTRY, MEDICINAL | ISOFORMS | MEMORY | MOUSE | KNOCKOUT | TYPE-1 | INSIGHTS
Journal Article
EUROPEAN JOURNAL OF PHARMACOLOGY, ISSN 0014-2999, 09/2015, Volume 763, Issue Pt B, pp. 223 - 232
Journal Article
Journal of Chemical Information and Modeling, ISSN 1549-9596, 02/2017, Volume 57, Issue 2, p. 322
  Adenylyl cyclase 2 (AC2) is one of nine membrane-bound isoforms of adenylyl cyclase that converts ATP into cyclic AMP (cAMP), an important second messenger... 
Inhibitor drugs | Research & development--R&D | Pancreatic cancer | Small intestine | Adenosine triphosphatase | Tumors
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2019, Volume 162, p. 568
Adenylyl cyclases type 1 (AC1) and 8 (AC8) are group 1 transmembrane adenylyl cyclases (AC) that are stimulated by Ca.sup.2+/calmodulin. Studies have shown... 
Journal Article
ChemMedChem, ISSN 1860-7179, 08/2015, Volume 10, Issue 8, pp. 1351 - 1364
Journal Article
Current Opinion in Insect Science, ISSN 2214-5745, 12/2018, Volume 30, pp. 99 - 106
The pressing need for new pest control products with novel modes of action has spawned interest in small molecules and peptides targeting arthropod GPCRs.... 
EXPRESSION ANALYSIS | PHARMACOLOGICAL CHARACTERIZATION | MOSQUITO AEDES-AEGYPTI | PROTEIN-COUPLED RECEPTORS | ANOPHELES-GAMBIAE | ENTOMOLOGY | DISCOVERY | BIOLOGY | RESISTANCE | ECOLOGY | OCTOPAMINE RECEPTOR | DOPAMINE-RECEPTORS | ANTAGONISTS | Protein research | Research | Vector control | Biogenic amines
Journal Article
Psychopharmacology, ISSN 0033-3158, 03/2015, Volume 232, Issue 5, p. 917
  (-)-Stepholidine is a tetrahydroberberine alkaloid that is known to interact with dopamine receptors and has also been proposed as a novel antipsychotic... 
Care and treatment | Antipsychotic drugs | Schizophrenia | Dosage and administration | Research | Diagnosis | G proteins | Risk factors | Dopamine receptors | Antagonist drugs | Psychopharmacology | Dopamine
Journal Article
ChemMedChem, ISSN 1860-7179, 11/2016, Volume 11, Issue 22, pp. 2534 - 2546
Bordetella pertussis adenylate cyclase toxin (ACT) and Bacillus anthracis edema factor (EF) are key virulence factors with adenylate cyclase (AC) activity that... 
Journal Article
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