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1. Full Text IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA
by Pichlmair, Andreas and Lassnig, Caroline and Eberle, Carol-Ann and Górna, Maria W and Baumann, Christoph L and Burkard, Thomas R and Búrckstúmmer, Tilmann and Stefanovic, Adrijana and Krieger, Sigurd and Bennett, Keiryn L and Rúlicke, Thomas and Weber, Friedemann and Colinge, Jacques and Múller, Mathias and Superti-Furga, Giulio
Nature Immunology, ISSN 1529-2908, 05/2011, Volume 12, Issue 7, pp. 624 - 630
Antiviral innate immunity relies on the recognition of microbial structures. One such structure is viral RNA that carries a triphosphate group on its 5'... 
STRAINS | DOUBLE-STRANDED-RNA | MASS-SPECTROMETRY DATA | INFLUENZA-A VIRUS | INNATE IMMUNE-RESPONSE | RIG-I | NETWORKS | IMMUNOLOGY | IDENTIFICATION | FAMILY | PROTEOMICS | Arginine - immunology | Humans | Mice, Inbred C57BL | Male | Viruses - immunology | Arginine - chemistry | Carrier Proteins - genetics | Animals | Arginine - genetics | HEK293 Cells | Carrier Proteins - chemistry | Female | RNA, Viral - immunology | Mice | HeLa Cells | Carrier Proteins - immunology | Proteins | Physiological aspects | Interferon | Research | RNA | Gene expression
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2. Full Text Engineering of cell factories for the production of natural products
by Weber, Tilmann
NATURAL PRODUCT REPORTS, ISSN 0265-0568, 9/2019, Volume 36, Issue 9, pp. 1231 - 1232
The Natural Product Reports themed issue on Engineering of cell factories for the production of natural products is introduced by the Guest Editor, Tilmann... 
CHEMISTRY, ORGANIC | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | Industrial engineering | Natural products | Manufacturing engineering
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3. Full Text In silico tools for the analysis of antibiotic biosynthetic pathways
by Weber, Tilmann
International Journal of Medical Microbiology, ISSN 1438-4221, 2014, Volume 304, Issue 3, pp. 230 - 235
Abstract Natural products of bacteria and fungi are the most important source for antimicrobial drug leads. For decades, such compounds were exclusively found... 
Infectious Disease | Medical Education | Polyketide | Non-ribsomal peptide synthetase | NRPS | Antibiotics | Secondary metabolite | Database | Bioinformatics | Genome mining | SEARCH | NONRIBOSOMAL PEPTIDE SYNTHETASES | NATURAL-PRODUCTS | GENE CLUSTERS | MICROBIOLOGY | POLYKETIDE SYNTHASES | PREDICTION | SUBSTRATE-SPECIFICITY | VIROLOGY | ADENYLATION DOMAINS | PROGRAM | Bacteria - metabolism | Computational Biology - methods | Anti-Bacterial Agents - biosynthesis | Biosynthetic Pathways - genetics | Bacteria - genetics | Humans | Genomics
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4. Full Text Viral immune modulators perturb the human molecular network by common and unique strategies
by Pichlmair, Andreas and Kandasamy, Kumaran and Alvisi, Gualtiero and Mulhern, Orla and Sacco, Roberto and Habjan, Matthias and Binder, Marco and Stefanovic, Adrijana and Eberle, Carol-Ann and Goncalves, Adriana and Bürckstümmer, Tilmann and Müller, André C and Fauster, Astrid and Holze, Cathleen and Lindsten, Kristina and Goodbourn, Stephen and Kochs, Georg and Weber, Friedemann and Bartenschlager, Ralf and Bowie, Andrew G and Bennett, Keiryn L and Colinge, Jacques and Superti-Furga, Giulio
Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 486 - 490
Viruses must enter host cells to replicate, assemble and propagate. Because of the restricted size of their genomes, viruses have had to evolve efficient ways... 
PATHWAYS | RESPONSES | ACTIVATION | PROTEIN | SCREEN | MULTIDISCIPLINARY SCIENCES | INNATE | SYSTEMS | EVASION | EXPRESSION | REVEALS | Endopeptidases - metabolism | Heterogeneous-Nuclear Ribonucleoprotein U - metabolism | Reproducibility of Results | Signal Transduction | Humans | Viruses - metabolism | Viral Proteins - immunology | Substrate Specificity | Viral Proteins - genetics | Viruses - immunology | Phosphatidylinositol 3-Kinases - metabolism | Open Reading Frames - genetics | Viral Proteins - metabolism | Host-Pathogen Interactions - immunology | Immunity, Innate - immunology | Mass Spectrometry | HEK293 Cells | Protein-Serine-Threonine Kinases - metabolism | Host-Pathogen Interactions - physiology | Virus diseases | Immune response | Perturbation (Mathematics) | Molecular dynamics | Physiological aspects | Development and progression | Research | Health aspects | Proteins | Influenza | Cell cycle | Viruses | Infections | Genomes | Mass spectrometry | Viral infections | Deoxyribonucleic acid--DNA
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5. Full Text The evolution of genome mining in microbes - a review
by Ziemert, Nadine and Alanjary, Mohammad and Weber, Tilmann
Natural Product Reports, ISSN 0265-0568, 7/2016, Volume 33, Issue 8, pp. 988 - 15
Covering: 2006 to 2016 The computational mining of genomes has become an important part in the discovery of novel natural products as drug leads. Thousands of... 
CHEMISTRY, MEDICINAL | NATURAL-PRODUCT DISCOVERY | NONRIBOSOMAL PEPTIDE SYNTHETASES | POLYKETIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTIBIOTIC-RESISTANCE | CHEMISTRY, ORGANIC | INFORMATIC SEARCH ALGORITHM | SECONDARY-METABOLITE BIOSYNTHESIS | STREPTOMYCES-COELICOLOR A3 | BIOSYNTHETIC GENE CLUSTERS | POSTTRANSLATIONALLY MODIFIED PEPTIDES | IN-SILICO PREDICTION
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6. Full Text The evolution of genome mining in microbes - a review
by Ziemert, Nadine and Alanjary, Mohammad and Weber, Tilmann
Natural product reports, ISSN 0265-0568, 08/2016, Volume 33, Issue 8, pp. 988 - 1005
Covering: 2006 to 2016The computational mining of genomes has become an important part in the discovery of novel natural products as drug leads. Thousands of... 
Biological Evolution | Biological Products - chemistry | Genome, Bacterial | Multigene Family | Biological Products - metabolism | Molecular Structure | High-Throughput Nucleotide Sequencing - methods | Drug Discovery
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7. Full Text CRISPR/Cas-based genome engineering in natural product discovery
by Tong, Y and Weber, T and Lee, SY
NATURAL PRODUCT REPORTS, ISSN 0265-0568, 09/2019, Volume 36, Issue 9, pp. 1262 - 1280
This review briefly introduces and summarizes current knowledge about the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated... 
PAM RECOGNITION | CHEMISTRY, MEDICINAL | SEQUENCE-SPECIFIC CONTROL | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | ANTI-CRISPR | EFFICIENT TARGETED MUTAGENESIS | CHLAMYDOMONAS-REINHARDTII | STRUCTURAL BASIS | DNA | GENE DISRUPTION | RNA-GUIDED ENDONUCLEASE | Fungi | CRISPR | Natural products | Editing | Beauveria | Genomes | Molecular biology
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8. Full Text Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes
by Weber, Tilmann and Charusanti, Pep and Musiol-Kroll, Ewa Maria and Jiang, Xinglin and Tong, Yaojun and Kim, Hyun Uk and Lee, Sang Yup
Trends in Biotechnology, ISSN 0167-7799, 2014, Volume 33, Issue 1, pp. 15 - 26
Highlights • Actinomycetes are rich sources of diverse bioactive compounds. • Various genome-mining tools have been developed for actinomycetes. • Several... 
Internal Medicine | secondary metabolites | actinomycetes | metabolic engineering | antibiotics | Metabolic engineering | Secondary metabolites | Actinomycetes | Antibiotics | COMBINATORIAL BIOSYNTHESIS | MODULAR POLYKETIDE SYNTHASES | DIRECT CLONING | NONRIBOSOMAL PEPTIDE | IN-VITRO | BIOSYNTHETIC GENE-CLUSTER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | STREPTOMYCES-COELICOLOR | SACCHAROPOLYSPORA-ERYTHRAEA | HOMOLOGOUS RECOMBINATION | HETEROLOGOUS EXPRESSION | Genome, Bacterial | Metabolic Engineering - methods | Multigene Family | Actinobacteria - metabolism | Data Mining | Anti-Bacterial Agents - biosynthesis | Gene Expression Regulation, Bacterial | Genomics | Enzymes | Genes | Biosynthesis | Genomes | Derivatives | Metabolism | Fatty acids | Bacteriology | Metabolites | Mutagenesis | Bacteria | Software | Factories | Methods
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9. Full Text Omics and multi-omics approaches to study the biosynthesis of secondary metabolites in microorganisms
by Palazzotto, Emilia and Weber, Tilmann
Current Opinion in Microbiology, ISSN 1369-5274, 10/2018, Volume 45, pp. 109 - 116
Natural products produced by microorganisms represent the main source of bioactive molecules. The development of high-throughput (omics) techniques have... 
NONRIBOSOMAL PEPTIDE | COMPLETE GENOME SEQUENCE | NATURAL-PRODUCT DIVERSITY | STREPTOMYCES-COELICOLOR | POLYKETIDE | GENE CLUSTERS | MICROBIOLOGY | STRAIN | DISCOVERY | PREDICTION | REVEALS | Metabolomics | Bacteria - metabolism | Bacteria - chemistry | Genomics | Bacterial Proteins - chemistry | Bacterial Proteins - genetics | Biological Products - metabolism | Bacterial Proteins - metabolism | Bacteria - genetics | Secondary Metabolism | Physiological aspects | Microorganisms | Plant metabolites
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10. Full Text Improved lanthipeptide detection and prediction for antiSMASH
by Blin, Kai and Kazempour, Daniyal and Wohlleben, Wolfgang and Weber, Tilmann
PLoS ONE, ISSN 1932-6203, 02/2014, Volume 9, Issue 2, p. e89420
Lanthipeptides are a class of ribosomally synthesised and post-translationally modified peptide (RiPP) natural products from the bacterial secondary... 
STREPTOCOCCUS-PYOGENES | NISIN | ORGANIZATION | BIOSYNTHETIC GENE-CLUSTER | ACTAGARDINE | MULTIDISCIPLINARY SCIENCES | MICROBISPORICIN | PURIFICATION | SEQUENCE | IDENTIFICATION | PEPTIDE | Peptide Fragments - analysis | Amino Acid Sequence | Anti-Bacterial Agents - analysis | Bacteriocins - genetics | Multigene Family | Bacteriocins - analysis | Molecular Sequence Data | Protein Processing, Post-Translational | Software | Physiological aspects | Enzymes | Amino acids | Peptides | Metabolites | Biotechnology | Infections | Biosynthesis | Genomes | Kinases | Lantibiotics | Molecular weight | Proteolysis | Post-translation | Clusters | Antibacterial activity | Cleavage | Bacteria | Automation | Protein sorting signals | Gene clusters | Cloning | Metabolism | Medicine | Antibiotics | Natural products
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11. Full Text antiSMASH 2.0-a versatile platform for genome mining of secondary metabolite producers
by Blin, Kai and Medema, Marnix H and Kazempour, Daniyal and Fischbach, Michael A and Breitling, Rainer and Takano, Eriko and Weber, Tilmann
Nucleic Acids Research, ISSN 0305-1048, 07/2013, Volume 41, Issue W1, pp. W204 - W212
Microbial secondary metabolites are a potent source of antibiotics and other pharmaceuticals. Genome mining of their biosynthetic gene clusters has become a... 
PATHWAYS | DATABASE | SPECIFICITY | BIOSYNTHESIS | ANNOTATION | SEQUENCE | POLYKETIDE | GENE CLUSTERS | IDENTIFICATION | IN-SILICO PREDICTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | Bacteria - metabolism | Genome, Bacterial | Biosynthetic Pathways - genetics | Genome, Fungal | Genomics | Data Mining | Software | Internet | Fungi - metabolism | Bacteria - genetics | Fungi - genetics
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