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by Loos, Ruth J F and Lindgren, Cecilia M and Li, Shengxu and Wheeler, Eleanor and Zhao, Jing Hua and Prokopenko, Inga and Inouye, Michael and Freathy, Rachel M and Attwood, Antony P and Beckmann, Jacques S and Berndt, Sonja I and Bergmann, Sven and Bennett, Amanda J and Bingham, Sheila A and Bochud, Murielle and Brown, Morris and Cauchi, Stéphane and Connell, John M and Cooper, Cyrus and Smith, George Davey and Day, Ian and Dina, Christian and De, Subhajyoti and Dermitzakis, Emmanouil T and Doney, Alex S F and Elliott, Katherine S and Elliott, Paul and Evans, David M and Sadaf Farooqi, I and Froguel, Philippe and Ghori, Jilur and Groves, Christopher J and Gwilliam, Rhian and Hadley, David and Hall, Alistair S and Hattersley, Andrew T and Hebebrand, Johannes and Heid, Iris M and Herrera, Blanca and Hinney, Anke and Hunt, Sarah E and Jarvelin, Marjo-Riitta and Johnson, Toby and Jolley, Jennifer D M and Karpe, Fredrik and Keniry, Andrew and Khaw, Kay-Tee and Luben, Robert N and Mangino, Massimo and Marchini, Jonathan and McArdle, Wendy L and McGinnis, Ralph and Meyre, David and Munroe, Patricia B and Morris, Andrew D and Ness, Andrew R and Neville, Matthew J and Nica, Alexandra C and Ong, Ken K and O'Rahilly, Stephen and Owen, Katharine R and Palmer, Colin N A and Papadakis, Konstantinos and Potter, Simon and Pouta, Anneli and Qi, Lu and Randall, Joshua C and Rayner, Nigel W and Ring, Susan M and Sandhu, Manjinder S and Scherag, André and Sims, Matthew A and Song, Kijoung and Soranzo, Nicole and Speliotes, Elizabeth K and Syddall, Holly E and Teichmann, Sarah A and Timpson, Nicholas J and Tobias, Jonathan H and Uda, Manuela and Ganz Vogel, Carla I and Wallace, Chris and Waterworth, Dawn M and Weedon, Michael N and Willer, Cristen J and Wraight, Vicki L and Yuan, Xin and Zeggini, Eleftheria and Hirschhorn, Joel N and Strachan, David P and Ouwehand, Willem H and Caulfield, Mark J and Samani, Nilesh J and Frayling, Timothy M and Vollenweider, Peter and Waeber, Gerard and Mooser, Vincent and Deloukas, Panos and McCarthy, Mark I and Wareham, Nicholas J and ... and Diabetes Genetics Initiative and The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial and FUSION and The Wellcome Trust Case Control Consortium and KORA and The SardiNIA Study and Nurses' Health Study and SardiNIA Study and Prostate Lung Colorectal Ovarian and Wellcome Trust Case Control Consor and Wellcome Trust Case Control Consortium and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial
Nature genetics, ISSN 1546-1718, 2008, Volume 40, Issue 6, pp. 768 - 775
... (0.13 Z-score units; P = 1.5 x 10(-8)). In case-control analyses (n = 10,583), the odds for severe childhood obesity reached 1.30 (P = 8.0 x 10(-11... 
FTO GENE | GENETICS & HEREDITY | MELANOCORTIN-4 RECEPTOR GENE | EARLY-ONSET OBESITY | FRAMESHIFT MUTATION | DOMINANT | ADULT OBESITY | EXPRESSION | CHILDHOOD | DEFICIENCY | GENOME-WIDE ASSOCIATION | Meta-Analysis as Topic | Humans | Middle Aged | Alpha-Ketoglutarate-Dependent Dioxygenase FTO | Male | Body Weight - genetics | Obesity - genetics | Case-Control Studies | Genetic Variation | Proteins | Adult | Female | Child | Body Mass Index | Genetic Predisposition to Disease | Cross-Sectional Studies | Receptor, Melanocortin, Type 4 - genetics | Adiposity - genetics | Linkage Disequilibrium | Obesity - pathology | Randomized Controlled Trials as Topic | Obesity - epidemiology | Adolescent | Alleles | Aged | Polymorphism, Single Nucleotide | Chromosomes, Human, Pair 18 - genetics | Genome, Human | Quantitative Trait Loci | Cohort Studies | Obesity | Body mass index | Genetic variation | Physiological aspects | Genetic aspects | Diagnosis | Research | Risk factors | Medical research | Biomedical research | Body fat | Health services | Genetics | Birth weight | Adults | Progeny | Integration | Pedigree | Data processing | Melanocortin MC4 receptors | Single-nucleotide polymorphism | Children | Mutation | Population levels | Clinical Medicine | Näringslära | Hälsovetenskap | Endokrinologi och diabetes | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin | Nutrition and Dietetics | Endocrinology and Diabetes | Health Sciences
Journal Article
The Journal of clinical investigation, ISSN 0021-9738, 2015, Volume 125, Issue 4, pp. 1739 - 1751
.... The presence of a nonsynonymous variant of N-acetyltransferase 2 (NAT2) [rs1208 (803A>G, K268R)] was strongly associated with decreased insulin sensitivity that was independent of BMI... 
Glycated Hemoglobin A - analysis | United States - epidemiology | Hypertriglyceridemia - genetics | Lipolysis - drug effects | Prospective Studies | Adipogenesis - drug effects | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Male | Arylamine N-Acetyltransferase - deficiency | Mutation, Missense | Hyperglycemia - genetics | Adipogenesis - physiology | Young Adult | Insulin Resistance - physiology | Adult | Female | Lipolysis - physiology | Child | Isoenzymes - physiology | European Continental Ancestry Group - genetics | Genome-Wide Association Study | Hispanic Americans - genetics | Gene Frequency | Europe - epidemiology | Isoenzymes - deficiency | 3T3-L1 Cells | Mice, Knockout | Hypertriglyceridemia - enzymology | Point Mutation | Animals | Coronary Disease - enzymology | Coronary Disease - genetics | Taiwan - epidemiology | Adolescent | Glucose - metabolism | Hyperglycemia - enzymology | Arylamine N-Acetyltransferase - genetics | Mice | Polymorphism, Single Nucleotide | Arylamine N-Acetyltransferase - physiology | Prevention | Insulin resistance | Genetic aspects | Health aspects | Transferases | Studies | Medical research | Rodents | Glucose | Grants | Diabetes | Laboratory animals | Insulin | Meta-analysis | Index Medicus | Abridged Index Medicus | Genetics | Cardiology | Metabolism | Endocrinology | Clinical Medicine | Endokrinologi och diabetes | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | Endocrinology and Diabetes
Journal Article
by Perry, John R. B and Voight, Benjamin F and Yengo, Loïc and Amin, Najaf and Dupuis, Josée and Ganser, Martha and Grallert, Harald and Navarro, Pau and Li, Man and Qi, Lu and Steinthorsdottir, Valgerdur and Scott, Robert A and Almgren, Peter and Arking, Dan E and Aulchenko, Yurii and Balkau, Beverley and Benediktsson, Rafn and Bergman, Richard N and Boerwinkle, Eric and Bonnycastle, Lori and Burtt, Noël P and Campbell, Harry and Charpentier, Guillaume and Collins, Francis S and Gieger, Christian and Green, Todd and Hadjadj, Samy and Hattersley, Andrew T and Herder, Christian and Hofman, Albert and Johnson, Andrew D and Kottgen, Anna and Kraft, Peter and Labrune, Yann and Langenberg, Claudia and Manning, Alisa K and Mohlke, Karen L and Morris, Andrew P and Oostra, Ben and Pankow, James and Petersen, Ann-Kristin and Pramstaller, Peter P and Prokopenko, Inga and Rathmann, Wolfgang and Rayner, William and Roden, Michael and Rudan, Igor and Rybin, Denis and Scott, Laura J and Sigurdsson, Gunnar and Sladek, Rob and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Tuomilehto, Jaakko and Uitterlinden, Andre G and Vivequin, Sidonie and Weedon, Michael N and Wright, Alan F and Hu, Frank B and Illig, Thomas and Kao, Linda and Meigs, James B and Wilson, James F and Stefansson, Kari and van Duijn, Cornelia and Altschuler, David and Morris, Andrew D and Boehnke, Michael and McCarthy, Mark I and Froguel, Philippe and Palmer, Colin N. A and Wareham, Nicholas J and Groop, Leif and Frayling, Timothy M and Cauchi, Stéphane and GIANT Consortium and MAGIC and DIAGRAM Consortium
PLoS genetics, ISSN 1553-7404, 2012, Volume 8, Issue 5, p. e1002741
Journal Article
by Burton, Paul R and Clayton, David G and Cardon, Lon R and Craddock, Nick and Deloukas, Panos and Duncanson, Audrey and Kwiatkowski, Dominic P and McCarthy, Mark I and Ouwehand, Willem H and Samani, Nilesh J and Todd, John A and Donnelly, Peter and Barrett, Jeffrey C and Davison, Dan and Easton, Doug and Evans, David M and Leung, Hin-Tak and Marchini, Jonathan L and Morris, Andrew P and Spencer, Chris C.A and Tobin, Martin D and Attwood, Antony P and Boorman, James P and Cant, Barbara and Everson, Ursula and Hussey, Judith M and Jolley, Jennifer D and Knight, Alexandra S and Koch, Kerstin and Meech, Elizabeth and Nutland, Sarah and Prowse, Christopher V and Stevens, Helen E and Taylor, Niall C and Walters, Graham R and Walker, Neil M and Watkins, Nicholas A and Winzer, Thilo and Jones, Richard W and McArdle, Wendy L and Ring, Susan M and Strachan, David P and Pembrey, Marcus and Breen, Gerome and Clair, David St and Caesar, Sian and Gordon-Smith, Katharine and Jones, Lisa and Fraser, Christine and Green, Elaine K and Grozeva, Detelina and Hamshere, Marian L and Holmans, Peter A and Jones, Ian R and Kirov, George and Moskivina, Valentina and Nikolov, Ivan and O'Donovan, Michael C and Owen, Michael J and Collier, David A and Elkin, Amanda and Farmer, Anne and Williamson, Richard and McGuffin, Peter and Young, Allan H and Ferrier, I. Nicol and Ball, Stephen G and Balmforth, Anthony J and Barrett, Jennifer H and Bishop, Timothy D and Iles, Mark M and Maqbool, Azhar and Yuldasheva, Nadira and Hall, Alistair S and Braund, Peter S and Dixon, Richard J and Mangino, Massimo and Stevens, Suzanne and Thompson, John R and Bredin, Francesca and Tremelling, Mark and Parkes, Miles and Drummond, Hazel and Lees, Charles W and Nimmo, Elaine R and Satsangi, Jack and Fisher, Sheila A and Forbes, Alastair and Lewis, Cathryn M and Onnie, Clive M and Prescott, Natalie J and Sanderson, Jeremy and Matthew, Christopher G and Barbour, Jamie and Mohiuddin, M. Khalid and Todhunter, Catherine E and Mansfield, John C and Ahmad, Tariq and Cummings, Fraser R and Jewell, Derek P and ... and Wellcome Trust Case Control Consortium and The Australo-Anglo-American Spondylitis Consortium (TASC) and Breast Cancer Susceptibility Collaboration (UK) and Biologics in RA Genetics and Genomics Study Syndicate (BRAGGS) Steering Committee and Australo-Anglo-American Spondylitis Consortium (TASC)
Nature genetics, ISSN 1546-1718, 2007, Volume 39, Issue 11, pp. 1329 - 1337
Journal Article
by Lindgren, Cecilia and Heid, Iris and Randall, Joshua and Lamina, Claudia and Steinthorsdottir, Valgerdur and Qi, Lu and Speliotes, Elizabeth and Thorleifsson, Gudmar and Willer, Cristen and Herrera, Blanca and Jackson, Anne and Lim, Noha and Scheet, Paul and Soranzo, Nicole and Amin, Najaf and Aulchenko, Yurii and Chambers, John and ng, Alexander and Luan, J and Lyon, Helen and Rivadeneira Ramirez, Fernando and Sanna, Serena and Timpson, Nicholas and Zillikens, Carola and Jing, H.Z and Almgren, Peter and Bandinelli, Stefania and Bennett, Amanda and Bergman, Richard and Bonnycastle, Lori and Bumpstead, Suzannah and Chanock, Stephen and Cherkas, Lynn and Chines, Peter and Coin, Lachlan and Cooper, Charles and Crawford, Gabe and Doering, Angela and Dominiczak, Anna and Doney, Alex and Ebrahim, Shanil and Elliott, Paul and Erdos, Michael and Estrada Gil, Karol and Ferrucci, Luigi and Fischer, Guido and Forouhi, Nita and Gieger, Christian and Grallert, Harald and Groves, Christopher and Grundy, Scott and Guiducci, Candace and Hadley, David and Hamsten, Anders and Havulinna, Aki and Hofman, Albert and Holle, Rolf and Holloway, John and Illig, Thomas and Isomaa, Bo and Jacobs, Leonie and Jameson, Karen and Jousilahti, Pekka and Karpe, Freik and Kuusisto, Johanna and Laitinen, Jaana and Lathrop, Mark and Lawlor, Debbie and Mangino, Massimo and McArdle, Wendy and Meitinger, Thomas and Morken, Mario and Morris, Anew and Munroe, Patricia and Narisu, Narisu and Nordström, Anna and Oostra, Ben and Palmer, Colin and Payne, Felicity and Peden, John and Prokopenko, Inga and Renström, Frida and Ruokonen, Aimo and Salomaa, Veikko and Sandhu, Manjinder and Scott, Laura and Scuteri, Angelo and Silander, Kaisa and Song, Kijoung and Yuan, Xin and Stringham, Heather and Swift, Amy and Tuomi, Tiinamaija and Uda, Manuela and Vollenweider, Peter and Waeber, Gérard and Wallace, Chris and Walters, Bragi and Weedon, Michael and Witteman, Jacqueline and ... and Wellcome Trust Case Control Consor and GIANT Consortium and PROCARDIS Consortia and Wellcome Trust Case Control Consortium and Giant Consortium and Procardis Consortia and The Wellcome Trust Case Control Consortium
PLoS genetics, ISSN 1553-7390, 06/2009, Volume 5, Issue 6, p. e1000508
Journal Article
by Voight, Benjamin F and Scott, Laura J and Steinthorsdottir, Valgerdur and Morris, Andrew P and Dina, Christian and Welch, Ryan P and Zeggini, Eleftheria and Huth, Cornelia and Aulchenko, Yurii S and Thorleifsson, Gudmar and McCulloch, Laura J and Ferreira, Teresa and Grallert, Harald and Amin, Najaf and Wu, Guanming and Willer, Cristen J and Raychaudhuri, Soumya and McCarroll, Steve A and Langenberg, Claudia and Hofmann, Oliver M and Dupuis, Josée and Qi, Lu and Segrè, Ayellet V and van Hoek, Mandy and Navarro, Pau and Ardlie, Kristin and Balkau, Beverley and Benediktsson, Rafn and Bennett, Amanda J and Blagieva, Roza and Boerwinkle, Eric and Bonnycastle, Lori L and Boström, Kristina Bengtsson and Bravenboer, Bert and Bumpstead, Suzannah and Burtt, Noisël P and Charpentier, Guillaume and Chines, Peter S and Cornelis, Marilyn and Couper, David J and Crawford, Gabe and Doney, Alex S F and Elliott, Katherine S and Elliott, Amanda L and Erdos, Michael R and Fox, Caroline S and Franklin, Christopher S and Ganser, Martha and Gieger, Christian and Grarup, Niels and Green, Todd and Griffin, Simon and Groves, Christopher J and Guiducci, Candace and Hadjadj, Samy and Hassanali, Neelam and Herder, Christian and Isomaa, Bo and Jackson, Anne U and Johnson, Paul R V and Jørgensen, Torben and Kao, Wen H L and Klopp, Norman and Kong, Augustine and Kraft, Peter and Kuusisto, Johanna and Lauritzen, Torsten and Li, Man and Lieverse, Aloysius and Lindgren, Cecilia M and Lyssenko, Valeriya and Marre, Michel and Meitinger, Thomas and Midthjell, Kristian and Morken, Mario A and Narisu, Narisu and Nilsson, Peter and Owen, Katharine R and Payne, Felicity and Perry, John R B and Petersen, Ann-Kristin and Platou, Carl and Proença, Christine and Prokopenko, Inga and Rathmann, Wolfgang and Rayner, N William and Robertson, Neil R and Rocheleau, Ghislain and Roden, Michael and Sampson, Michael J and Saxena, Richa and Shields, Beverley M and Shrader, Peter and Sigurdsson, Gunnar and Sparsø, Thomas and Strassburger, Klaus and Stringham, Heather M and Sun, Qi and Swift, Amy J and Thorand, Barbara and ... and The GIANT Consortium and The MAGIC investigators and GIANT Consortium and MAGIC Investigators and MAGIC investigators
Nature genetics, ISSN 1546-1718, 2010, Volume 42, Issue 7, pp. 579 - 589
Journal Article