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1. Full Text DNA methylation-based classification of central nervous system tumours
by Capper, David and Jones, David T. W and Sill, Martin and Hovestadt, Volker and Schrimpf, Daniel and Sturm, Dominik and Koelsche, Christian and Sahm, Felix and Chavez, Lukas and Reuss, David E and Kratz, Annekathrin and Wefers, Annika K and Huang, Kristin and Pajtler, Kristian W and Schweizer, Leonille and Stichel, Damian and Olar, Aiana and Engel, Nils W and Lindenberg, Kerstin and Harter, Patrick N and Braczynski, Anne K and Plate, Karl H and Dohmen, Hildegard and Garvalov, Boyan K and Coras, Roland and Hölsken, Annett and Hewer, Ekkehard and Bewerunge-Hudler, Melanie and Schick, Matthias and Fischer, Roger and Beschorner, Rudi and Schittenhelm, Jens and Staszewski, Ori and Wani, Khalida and Varlet, Pascale and Pages, Melanie and Temming, Petra and Lohmann, Dietmar and Selt, Florian and Witt, Henik and Milde, Till and Witt, Olaf and Aronica, Eleonora and Giangaspero, Felice and Rushing, Elisabeth and Scheurlen, Wolfram and Geisenberger, Christoph and Roiguez, Fausto J and Becker, Albert and Preusser, Matthias and Haberler, Christine and Bjerkvig, Rolf and Cryan, Jane and Farrell, Michael and Deckert, Martina and Hench, J. rgen and Frank, Stephan and Serrano, Jonathan and Kannan, Kasthuri and Tsirigos, Aristotelis and Brück, Wolfgang and Hofer, Silvia and Brehmer, Stefanie and Seiz-Rosenhagen, Marcel and Hänggi, Daniel and Hans, Volkmar and Rozsnoki, Stephanie and Hansford, Jordan R and Kohlhof, Patricia and Kristensen, Bjarne W and Lechner, Matt and Lopes, Beatriz and Mawrin, Christian and Ketter, Ralf and Kulozik, Aneas and Khatib, Ziad and Heppner, Frank and Koch, Arend and Jouvet, Anne and Keohane, Catherine and Mühleisen, Helmut and Mueller, Wolf and Pohl, Ute and Prinz, Marco and Benner, Axel and Zapatka, Marc and Gottardo, Nicholas G and ever, Pablo Hernáiz and Kramm, Christof M and Müller, Hermann L and Rutkowski, Stefan and von Hoff, Katja and Frühwald, Michael C and Gnekow, Astrid and Fleischhack, Guun and Tippelt, Stephan and Calaminus, Gabriele and Monoranu, Camelia-Maria and Perry, Arie and Jones, Chris and ...
Nature, ISSN 0028-0836, 2018, Volume 555, Issue 7697, pp. 469 - 474
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous... 
MOLECULAR CLASSIFICATION | MULTICENTER | ENTITY | GLIOMA | MULTIDISCIPLINARY SCIENCES | PILOCYTIC ASTROCYTOMA | CLASS PROBABILITY ESTIMATION | SUBGROUPS | MEDULLOBLASTOMA | EXPRESSION | BIOCONDUCTOR | Central Nervous System Neoplasms - classification | Reproducibility of Results | Central Nervous System Neoplasms - genetics | Humans | Middle Aged | Child, Preschool | Infant | Male | Unsupervised Machine Learning | Young Adult | Central Nervous System Neoplasms - pathology | DNA Methylation | Adolescent | Aged, 80 and over | Adult | Female | Aged | Central Nervous System Neoplasms - diagnosis | Child | Cohort Studies | Genetic aspects | Nucleotide sequencing | Diagnosis | Methylation | Observations | Methods | DNA sequencing | Tumors | Cancer | Analysis | DNA | Machine learning | Central nervous system | Classifiers | Brain cancer | Standardization | Clinical trials | Probability | Data processing | Nervous system | Genomes | Gene expression | Generalized linear models | Learning algorithms | Classification | Diagnostic software | DNA methylation | Diagnostic systems | Bioinformatics | Deoxyribonucleic acid--DNA
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2. Full Text DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis
by Sahm, Felix, MD and Schrimpf, Daniel, PhD and Stichel, Damian, PhD and Jones, David T W, PhD and Hielscher, Thomas, MSc and Schefzyk, Sebastian, MSc and Okonechnikov, Konstantin, PhD and Koelsche, Christian, MD and Reuss, David E, MD and Capper, David, MD and Sturm, Dominik, MD and Wirsching, Hans-Georg, MD and Berghoff, Anna Sophie, MD and Baumgarten, Peter, MD and Kratz, Annekathrin, MD and Huang, Kristin, MD and Wefers, Annika K, MD and Hovestadt, Volker, PhD and Sill, Martin, PhD and Ellis, Hayley P, BSc and Kurian, Kathreena M, Prof and Okuducu, Ali Fuat, MD and Jungk, Christine, MD and Drueschler, Katharina, MD and Schick, Matthias and Bewerunge-Hudler, Melanie, PhD and Mawrin, Christian, Prof and Seiz-Rosenhagen, Marcel, Prof and Ketter, Ralf, Prof and Simon, Matthias, Prof and Westphal, Manfred, Prof and Lamszus, Katrin, Prof and Becker, Albert, Prof and Koch, Arend, MD and Schittenhelm, Jens, Prof and Rushing, Elisabeth J, Prof and Collins, V Peter, Prof and Brehmer, Stefanie, MD and Chavez, Lukas, PhD and Platten, Michael, Prof and Hänggi, Daniel, Prof and Unterberg, Andreas, Prof and Paulus, Werner, Prof and Wick, Wolfgang, Prof and Pfister, Stefan M, Prof and Mittelbronn, Michel, Prof and Preusser, Matthias, Prof and Herold-Mende, Christel, Prof and Weller, Michael, Prof and von Deimling, Andreas, Prof
Lancet Oncology, The, ISSN 1470-2045, 2017, Volume 18, Issue 5, pp. 682 - 694
Summary Background The WHO classification of brain tumours describes 15 subtypes of meningioma. Nine of these subtypes are allotted to WHO grade I, and three... 
Hematology, Oncology and Palliative Medicine | TRAF7 | TERT PROMOTER MUTATIONS | ONCOLOGY | RECURRENT | IDH1 | GENOMIC ANALYSIS | PHASE-II | MEDULLOBLASTOMA | DEFINE | TUMORS | AGE | Neurofibromin 2 - genetics | Humans | Meningioma - classification | Transcriptome | Male | Meningioma - genetics | Smoothened Receptor - genetics | Proto-Oncogene Proteins c-akt - genetics | DNA Copy Number Variations | Neoplasm Recurrence, Local - pathology | DNA Methylation | Neoplasm Grading | DNA Mutational Analysis | Female | Retrospective Studies | Nuclear Proteins - genetics | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics | Meningeal Neoplasms - classification | Meningeal Neoplasms - genetics | Survival Rate | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Disease Progression | Disease-Free Survival | Meningioma - pathology | Sequence Analysis, RNA | Neoplasm Recurrence, Local - genetics | Meningeal Neoplasms - pathology | Genome | Kruppel-Like Transcription Factors - genetics | Genetic research | Methylation | Analysis | DNA | Meningioma
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3. Full Text Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience
by Capper, David and Stichel, Damian and Sahm, Felix and Jones, David T. W and Schrimpf, Daniel and Sill, Martin and Schmid, Simone and Hovestadt, Volker and Reuss, David E and Koelsche, Christian and Reinhardt, Annekathrin and Wefers, Annika K and Huang, Kristin and Sievers, Philipp and Ebrahimi, Azadeh and Schöler, Anne and Teichmann, Daniel and Koch, Arend and Hänggi, Daniel and Unterberg, Andreas and Platten, Michael and Wick, Wolfgang and Witt, Olaf and Milde, Till and Korshunov, Andrey and Pfister, Stefan M and von Deimling, Andreas
Acta Neuropathologica, ISSN 0001-6322, 8/2018, Volume 136, Issue 2, pp. 181 - 210
Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation... 
Copy-number variation | Pathology | Neurosciences | EPIC array | Medicine & Public Health | DNA methylation | Tumor classification | NERVOUS-SYSTEM | CRANIOPHARYNGIOMAS | INTRAOCULAR MEDULLOEPITHELIOMAS | GLIOMA | SUBGROUPS | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | MOLECULAR CLASSIFICATION | GLIOBLASTOMA | MUTATIONS | ENTITIES | MEDULLOBLASTOMA | Analysis | Genomics | DNA | Machine learning | Genomes | Methylation | Tumors | Learning algorithms | Central nervous system | Nervous system | Neurosurgery | DNA fingerprinting | Deoxyribonucleic acid--DNA | Original Paper
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4. Full Text Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations
by Reinhardt, Annekathrin and Stichel, Damian and Schrimpf, Daniel and Sahm, Felix and Korshunov, Andrey and Reuss, David E and Koelsche, Christian and Huang, Kristin and Wefers, Annika K and Hovestadt, Volker and Sill, Martin and Gramatzki, Dorothee and Felsberg, Joerg and Reifenberger, Guido and Koch, Arend and Thomale, Ulrich-W and Becker, Albert and Hans, Volkmar H and Prinz, Marco and Staszewski, Ori and Acker, Till and Dohmen, Hildegard and Hartmann, Christian and Mueller, Wolf and Tuffaha, Muin S. A and Paulus, Werner and Heß, Katharina and Brokinkel, Benjamin and Schittenhelm, Jens and Monoranu, Camelia-Maria and Kessler, Almuth Friederike and Loehr, Mario and Buslei, Rolf and Deckert, Martina and Mawrin, Christian and Kohlhof, Patricia and Hewer, Ekkehard and Olar, Adriana and Rodriguez, Fausto J and Giannini, Caterina and NageswaraRao, Amulya A and Tabori, Uri and Nunes, Nuno Miguel and Weller, Michael and Pohl, Ute and Jaunmuktane, Zane and Brandner, Sebastian and Unterberg, Andreas and Hänggi, Daniel and Platten, Michael and Pfister, Stefan M and Wick, Wolfgang and Herold-Mende, Christel and Jones, David T. W and von Deimling, Andreas and Capper, David
Acta Neuropathologica, ISSN 0001-6322, 8/2018, Volume 136, Issue 2, pp. 273 - 291
Tumors with histological features of pilocytic astrocytoma (PA), but with increased mitotic activity and additional high-grade features (particularly... 
Neurosciences | MGMT | ATRX | Methylation profile based classification | Panel sequencing | BRAF | Anaplastic pilocytic astrocytoma | Pilocytic astrocytoma with anaplasia | Pathology | CDKN2A/B | DNA copy number alterations | Medicine & Public Health | NF1 | Molecular characterization | FGFR1 | DNA METHYLATION | FREE SURVIVAL | PATHOLOGY | CLINICAL NEUROLOGY | BRAIN-TUMORS | GLIOBLASTOMA | PILOCYTIC ASTROCYTOMA | PROGRESSION | FREQUENT | MGMT PROMOTER HYPERMETHYLATION | NEUROSCIENCES | METHYLATION-BASED CLASSIFICATION | GENETIC ALTERATIONS | Medical colleges | Methylation | Gliomas | Health aspects | Analysis | Brain tumors | Glioblastoma | MAP kinase | Embedding | Glioma | DNA methylation | Microvasculature | Stochasticity | Mutation | DNA fingerprinting | Localization | Fibroblast growth factor receptor 1 | Astrocytoma | Deoxyribonucleic acid--DNA
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5. Full Text Neurogenesis from Sox2 expressing cells in the adult cerebellar cortex
by Ahlfeld, Julia and Filser, Severin and Schmidt, Felix and Wefers, Annika K and Merk, Daniel J and Glaß, Rainer and Herms, Jochen and Schüller, Ulrich
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 6137 - 7
We identified a rare undifferentiated cell population that is intermingled with the Bergmann glia of the adult murine cerebellar cortex, expresses the stem... 
NEURONS | NEURAL STEM-CELLS | CENTRAL-NERVOUS-SYSTEM | MULTIDISCIPLINARY SCIENCES | BRAIN | TRANSGENIC MICE | Adult Stem Cells - cytology | Stem Cell Niche | Cerebellar Cortex - cytology | Cerebellar Cortex - metabolism | Humans | Neurogenesis | SOXB1 Transcription Factors - metabolism | Nerve Tissue Proteins - metabolism | Adult Stem Cells - metabolism | Animals | Exercise | SOXB1 Transcription Factors - genetics | Cell Differentiation | Mice | Cerebellum | Neural stem cells | Nestin | Neuronal-glial interactions | Stem cells
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6. Full Text Canonical Wnt signaling drives tumor-like lesions from Sox2-Positive precursors of the murine olfactory epithelium
by Engel, Nils W and Neumann, Julia E and Ahlfeld, Julia and Wefers, Annika K and Merk, Daniel J and Ohli, Jasmin and Schüller, Ulrich
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, p. e0166690
Canonical Wnt signaling is known to promote proliferation of olfactory stem cells. In order to investigate the effects of a constitutive activation of Wnt... 
BETA-CATENIN GENE | PROGENITOR CELLS | STEM-CELLS | CONSTITUTIVE ACTIVATION | MULTIDISCIPLINARY SCIENCES | SMALL-INTESTINE | SINONASAL HEMANGIOPERICYTOMA | PROLIFERATION | MUTATIONS | EXPRESSION | CARCINOMA | Cell Proliferation | Wnt Signaling Pathway - physiology | Mice, Transgenic | Olfactory Mucosa - metabolism | Wnt Proteins - metabolism | Nose Neoplasms - genetics | beta Catenin - metabolism | beta Catenin - genetics | SOXB1 Transcription Factors - metabolism | Phosphorylation - genetics | Animals | Hyperplasia - genetics | Tamoxifen - pharmacology | Female | Mice | Enzyme Activation | Physiological aspects | Development and progression | Genetic engineering | Research | Epithelium | Wnt proteins | Tumors | Cell proliferation | CTNNB1 gene | Pediatrics | Phosphorylation | Wnt protein | Laboratories | Neuropathology | Pathogenesis | Hyperplasia | Stem cell transplantation | Activation | Neuroblastoma | Gene deletion | Neurogenesis | Stains & staining | Clonal deletion | Precursors | Transgenic animals | Rodents | Nose | Deletion | Lesions | Age | Immunoglobulins | Internal medicine | Transgenic mice | Embryos | Pathology | Signaling | Brain research | Stem cells | Mutation | Olfactory epithelium | Cancer | Apoptosis
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7. Full Text Molecular characterization of histopathological ependymoma variants
by Neumann, Julia E and Spohn, Michael and Obrecht, Denise and Mynarek, Martin and Thomas, Christian and Hasselblatt, Martin and Dorostkar, Mario M and Wefers, Annika K and Frank, Stephan and Monoranu, Camelia-Maria and Koch, Arend and Witt, Hendrik and Kool, Marcel and Pajtler, Kristian W and Rutkowski, Stefan and Glatzel, Markus and Schüller, Ulrich
Acta Neuropathologica, ISSN 0001-6322, 11/2019
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8. IDH-wildtype glioblastomas and grade III/IV IDH-mutant gliomas show elevated tracer uptake in fibroblast activation protein-specific PET/CT
by Röhrich, Manuel and Loktev, Anastasia and Wefers, Annika K and Altmann, Annette and Paech, Daniel and Adeberg, Sebastian and Windisch, Paul and Hielscher, Thomas and Flechsig, Paul and Floca, Ralf and Leitz, Dominik and Schuster, Julius P and Huber, Peter E and Debus, Jürgen and von Deimling, Andreas and Lindner, Thomas and Haberkorn, Uwe
European journal of nuclear medicine and molecular imaging, ISSN 1619-7070, 08/2019, Volume 46, Issue 12, pp. 2569 - 2580
Targeting fibroblast activation protein (FAP) is a new diagnostic approach allowing the visualization of tumor stroma. Here, we applied FAP-specific PET... 
Immunohistochemistry | Intravenous administration | CD26 antigen | Glioblastoma | Antibodies | Fibrosarcoma | Activation | Proteins | Computed tomography | Lutetium isotopes | Tomography | Fibroblasts | Astrocytoma | Binding | Medical imaging | Kidneys | Positron emission | Stroma | Pharmacology | Fibroblast activation protein | Magnetic resonance imaging | Glioma | Mice | Diagnostic systems | Pharmacokinetics | Tumors | Index Medicus
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9. Full Text Synaptic input as a directional cue for migrating interneuron precursors
by Wefers, Annika K and Haberlandt, Christian and Tekin, Nuriye Basdag and Fedorov, D and Timmermann, A and Van der Want, Johannes and Chaudhry, Farrukh Abbas and Steinhäuser, Christian and Schilling, K and Jabs, Ronald
ISSN 0950-1991, 2017
During CNS development, interneuron precursors have to migrate extensively before they integrate in specific microcircuits. Known regulators of neuronal... 
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10. Full Text Synaptic input as a directional cue for migrating interneuron precursors
by Wefers, Annika K and Haberlandt, Christian and Tekin, Nuriye B and Fedorov, Dmitry A and Timmermann, Aline and Van Der Want, Johannes J. L and Chaudhry, Farrukh A and Steinhäuser, Christian and Schilling, Karl and Jabs, Ronald
Development (Cambridge), ISSN 0950-1991, 11/2017, Volume 144, Issue 22, pp. 4125 - 4136
During CNS development, interneuron precursors have to migrate extensively before they integrate in specific microcircuits. Known regulators of neuronal... 
Cerebellum | Interneuron precursor cells | Mouse | Migration | Pax2 | Synapses | NEURONAL MIGRATION | PURKINJE-CELLS | GRANULE NEURONS | DENSITY-ESTIMATION | CEREBELLAR MOLECULAR LAYER | DEVELOPMENTAL BIOLOGY | POSTNATAL SUBVENTRICULAR ZONE | BANDWIDTH SELECTION | RAT CEREBELLUM | GABAERGIC INTERNEURONS | CLIMBING FIBERS | PAX2 Transcription Factor - metabolism | gamma-Aminobutyric Acid - metabolism | Mice, Inbred C57BL | Glutamates - metabolism | Male | Neural Stem Cells - cytology | Animals | Interneurons - metabolism | Synapses - metabolism | Models, Biological | Cell Shape | Cerebellum - cytology | Female | Interneurons - cytology | Electrophysiological Phenomena | Cerebellum - ultrastructure | Neural Stem Cells - metabolism | Cell Movement | Interneurons | Histogenesis | Innervation | Central nervous system | Transgenic mice | pax2 protein | Exocytosis | γ-Aminobutyric acid | Neurotransmitters | Dispersal | Rodents | Neural stem cells | Glutamatergic transmission | Cell migration
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11. Full Text PATH-16. HISTOPATHOLOGICAL EPENDYMOMA VARIANTS ARE ASSOCIATED WITH DISTINCT CLINICAL PARAMETERS AND DNA METHYLATION PATTERNS
by Neumann, Julia E and Spohn, Michael and Obrecht, Denise and Mynarek, Martin and Thomas, Christian and Hasselblatt, Martin and Dorostkar, Mario M and Wefers, Annika K and Frank, Stephan and Monoranu, Camelia-Maria and Koch, Arend and Witt, Hendrik and Kool, Marcel and Rutkowski, Stefan and Glatzel, Markus and Schüller, Ulrich
Neuro-Oncology, ISSN 1522-8517, 11/2019, Volume 21, Issue Supplement_6, pp. vi146 - vi146
Abstract According to the current WHO classification, ependymal tumors are classified as subependymomas, myxopapillary ependymomas, classic ependymomas,... 
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12. Full Text FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma
by Sievers, Philipp and Stichel, Damian and Schrimpf, Daniel and Sahm, Felix and Koelsche, Christian and Reuss, David E and Wefers, Annika K and Reinhardt, Annekathrin and Huang, Kristin and Ebrahimi, Azadeh and Hou, Yanghao and Pajtler, Kristian W and Pfister, Stefan M and Hasselblatt, Martin and Stummer, Walter and Schick, Uta and Hartmann, Christian and Hagel, Christian and Staszewski, Ori and Reifenberger, Guido and Beschorner, Rudi and Coras, Roland and Keyvani, Kathy and Kohlhof, Patricia and Diomedi-Camassei, Francesca and Herold-Mende, Christel and Giangaspero, Felice and Rushing, Elisabeth and Giannini, Caterina and Korshunov, Andrey and Jones, David T. W and von Deimling, Andreas
Acta Neuropathologica, ISSN 0001-6322, 8/2018, Volume 136, Issue 2, pp. 293 - 302
Extraventricular neurocytoma (EVN) is a rare primary brain tumor occurring in brain parenchyma outside the ventricular system. Histopathological... 
Molecular classification | Brain tumor | Pathology | Extraventricular neurocytoma | Neurosciences | Medicine & Public Health | FGFR1–TACC1 | DNA methylation profile | FGFR | Fusion | OLIGODENDROGLIOMA | SUBGROUPS | PATHOLOGY | NEUROSCIENCES | CLINICAL NEUROLOGY | NEUROEPITHELIAL TUMORS | GLIOBLASTOMA | TACC1 | DIFFERENTIATION | MUTATIONS | MEDULLOBLASTOMA | METHYLATION-BASED CLASSIFICATION | FGFR1 | GENETIC ALTERATIONS | Copy number | Brain tumors | Brain cancer | Parenchyma | Ribonucleic acid--RNA | Morphology | DNA methylation | Epigenetics | Ventricle | Fibroblast growth factor receptor 1 | Deoxyribonucleic acid--DNA | Fibroblast growth factor receptors | Tumors
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13. Full Text Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions
by Stichel, Damian and Schrimpf, Daniel and Casalini, Belén and Meyer, Jochen and Wefers, Annika K and Sievers, Philipp and Korshunov, Andrey and Koelsche, Christian and Reuss, David E and Reinhardt, Annekathrin and Ebrahimi, Azadeh and Fernández-Klett, Francisco and Kessler, Tobias and Sturm, Dominik and Ecker, Jonas and Milde, Till and Herold-Mende, Christel and Witt, Olaf and Pfister, Stefan M and Wick, Wolfgang and Jones, David T. W and von Deimling, Andreas and Sahm, Felix
Acta Neuropathologica, ISSN 0001-6322, 11/2019, Volume 138, Issue 5, pp. 827 - 835
Molecular markers have become pivotal in brain tumor diagnostics. Mutational analyses by targeted next-generation sequencing of DNA and array-based DNA... 
RNA sequencing | Molecular classification | Pathology | Neurosciences | Molecular diagnostics | Targeted treatment | Medicine & Public Health | Gene fusions | RNA | Analysis | Genes | Brain tumors | Genetic research | Methylation | Formaldehyde | Next-generation sequencing | Neuropathology | Copy number | DNA methylation | mRNA | Paraffin | Deoxyribonucleic acid--DNA | DNA sequencing
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14. Full Text A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors
by Neumann, Julia E and Wefers, Annika K and Lambo, Sander and Bianchi, Edoardo and Bockstaller, Marie and Dorostkar, Mario M and Meister, Valerie and Schindler, Pia and Korshunov, Andrey and Von Hoff, Katja and Nowak, Johannes and Warmuth-Metz, Monika and Schneider, Marlon R and Renner-Müller, Ingrid and Merk, Daniel J and Shakarami, Mehdi and Sharma, Tanvi and Chavez, Lukas and Glass, Rainer and Chan, Jennifer A and Taketo, M Mark and Neumann, Philipp and Kool, Marcel and Schüller, Ulrich
Nature Medicine, ISSN 1078-8956, 10/2017, Volume 23, Issue 10, pp. 1191 - 1202
Embryonal tumors with multilayered rosettes (ETMRs) have recently been described as a new entity of rare pediatric brain tumors with a fatal outcome. We show... 
NEURAL PROGENITORS | MEDICINE, RESEARCH & EXPERIMENTAL | MRI FINDINGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BETA-CATENIN | BRAIN-TUMORS | CELL BIOLOGY | PRIMITIVE NEUROECTODERMAL TUMORS | MOLECULAR CLASSIFICATION | SIGNALING PATHWAY | ABUNDANT NEUROPIL | CNS-PNETS | TRUE ROSETTES | Immunohistochemistry | RNA-Binding Proteins - genetics | Humans | Gene Expression Profiling | Neoplasms, Germ Cell and Embryonal - genetics | Brain Neoplasms - metabolism | Hedgehog Proteins - genetics | Antineoplastic Agents - pharmacology | Disease Models, Animal | Signal Transduction | Zinc Finger Protein GLI1 - genetics | Arsenicals - pharmacology | Down-Regulation | Brain Neoplasms - genetics | Mice, Transgenic | Neoplasms, Germ Cell and Embryonal - metabolism | Hedgehog Proteins - antagonists & inhibitors | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Xenograft Model Antitumor Assays | Oxides - pharmacology | Animals | Wnt Signaling Pathway - genetics | Cell Line, Tumor | Mice | MicroRNAs - genetics | Sonic hedgehog | Care and treatment | Tumors, Embryonal | Genetic aspects | Cellular signal transduction | Diagnosis | Gene expression | Health aspects | Brain | Inhibitor drugs | Wnt protein | Arsenic | Brain tumors | Brain cancer | MiRNA | Radial glial cells | Arsenic trioxide | Activation | mRNA | Histology | Signal transduction | Signaling | Hedgehog protein | Rodents | Neural stem cells | Models | Drug therapy | Tumors
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