Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (322) 322
Patent (50) 50
Publication (23) 23
Data Set (12) 12
Book Chapter (2) 2
Book / eBook (1) 1
Book Review (1) 1
Conference Proceeding (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (84) 84
index medicus (68) 68
peptides (61) 61
crohn's disease (47) 47
hygiene (46) 46
antimicrobial peptides (44) 44
chemistry (44) 44
human necessities (43) 43
medical or veterinary science (43) 43
metallurgy (43) 43
preparations for medical, dental, or toilet purposes (43) 43
gastroenterology & hepatology (41) 41
organic chemistry (38) 38
inflammatory-bowel-disease (37) 37
defensins (36) 36
ulcerative-colitis (36) 36
inflammatory bowel disease (33) 33
animals (29) 29
innate immunity (29) 29
crohns-disease (28) 28
microbiology (28) 28
female (25) 25
human beta-defensin-2 (24) 24
male (24) 24
ulcerative colitis (24) 24
gastroenterology and hepatology (23) 23
paneth cells (23) 23
general tagging of cross-sectional technologies spanning over several sections of the ipc (22) 22
general tagging of new technological developments (22) 22
intestinal epithelial-cells (22) 22
technical subjects covered by former uspc cross-reference art collections [xracs] and digests (22) 22
technologies for adaptation to climate change (22) 22
technologies or applications for mitigation or adaptation againstclimate change (22) 22
biochemistry (20) 20
immunology (20) 20
expression (19) 19
inflammation (19) 19
adult (18) 18
mice (18) 18
research (18) 18
bacteria (17) 17
crohn disease - metabolism (17) 17
investigating or analysing materials by determining theirchemical or physical properties (17) 17
measuring (17) 17
physics (17) 17
testing (17) 17
beer (16) 16
crohn disease - genetics (16) 16
crohn disease - immunology (16) 16
enzymology (16) 16
middle aged (16) 16
mutation or genetic engineering (16) 16
specific therapeutic activity of chemical compounds ormedicinal preparations (16) 16
spirits (16) 16
vinegar (16) 16
wine (16) 16
alpha-defensins (14) 14
beta-defensins - metabolism (14) 14
colon (14) 14
medicine (14) 14
paneth cells - metabolism (14) 14
crohn’s disease (13) 13
intestine (13) 13
multidisciplinary sciences (13) 13
beta-defensins - genetics (12) 12
digestive system (12) 12
escherichia-coli (12) 12
gene expression (12) 12
genetic aspects (12) 12
ileal crohns-disease (12) 12
ileum - metabolism (12) 12
paneth cell (12) 12
aged (11) 11
antimicrobial activity (11) 11
crohn disease - pathology (11) 11
health aspects (11) 11
intestinal mucosa - metabolism (11) 11
intestinal mucosa - microbiology (11) 11
microbiota (11) 11
small intestine (11) 11
alpha-defensins - metabolism (10) 10
article (10) 10
beta-defensins (10) 10
coli nissle 1917 (10) 10
colon - metabolism (10) 10
compositions thereof (10) 10
crohn disease - microbiology (10) 10
culture media (10) 10
foods or foodstuffs (10) 10
foods, foodstuffs, or non-alcoholic beverages, not covered bysubclasses a23b - a23j (10) 10
inflammatory bowel diseases (10) 10
microorganisms or enzymes (10) 10
nf-kappa-b (10) 10
nod2 (10) 10
preservation of foods or foodstuffs, in general (10) 10
propagating, preserving or maintaining microorganisms (10) 10
research article (10) 10
their preparation or treatment, e.g. cooking, modification ofnutritive qualities, physical treatment (10) 10
their treatment, not covered by other classes (10) 10
adolescent (9) 9
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (366) 366
German (26) 26
French (19) 19
Chinese (5) 5
Korean (5) 5
Spanish (4) 4
Dutch (1) 1
Japanese (1) 1
Portuguese (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Intestinal barrier in inflammatory bowel disease
by Lena Antoni Sabine Nuding Jan Wehkamp Eduard F Stange
世界胃肠病学杂志：英文版（电子版）, ISSN 1007-9327, 2014, Volume 20, Issue 5, pp. 1165 - 1179
A complex mucosal barrier protects as the first line of defense the surface of the healthy intestinal tract from adhesion and invasion by luminal... 
Antimicrobial | peptide | Mucus | barrier | lay | Intestinal | Inflammatory bowel disease | Paneth cell | Goblet cell | Intestinal barrier | Mucus layer | Crohn's disease | Antimicrobial peptide | Ulcerative colitis | EPITHELIAL TIGHT JUNCTIONS | INVASIVE ESCHERICHIA-COLI | ULCERATIVE-COLITIS | CELL ALPHA-DEFENSINS | ANTIMICROBIAL PEPTIDES | ILEAL CROHNS-DISEASE | 2 MUCUS LAYERS | HOST-DEFENSE | PANETH CELLS | GASTROENTEROLOGY & HEPATOLOGY | INNATE IMMUNITY | Intestinal Mucosa - metabolism | Colitis, Ulcerative - metabolism | Humans | Crohn Disease - metabolism | Colitis, Ulcerative - pathology | Intestinal Mucosa - microbiology | Permeability | Dysbiosis | Colitis, Ulcerative - immunology | Crohn Disease - immunology | Host-Pathogen Interactions | Animals | Colitis, Ulcerative - microbiology | Crohn Disease - pathology | Intestinal Mucosa - immunology | Crohn Disease - microbiology | Intestinal Mucosa - pathology | Topic Highlight | Crohn’s disease
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text NF-κB- and AP-1-Mediated Induction of Human Beta Defensin-2 in Intestinal Epithelial Cells by Escherichia coli Nissle 1917: a Novel Effect of a Probiotic Bacterium
by Jan Wehkamp and Jürgen Harder and Kai Wehkamp and Birte Wehkamp-von Meissner and Miriam Schlee and Corinne Enders and Ulrich Sonnenborn and Sabine Nuding and Stig Bengmark and Klaus Fellermann and Jens Michael Schröder and Eduard F. Stange
Infection and Immunity, ISSN 0019-9567, 10/2004, Volume 72, Issue 10, pp. 5750 - 5758
Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
INFECTIOUS DISEASES | INFLAMMATORY-BOWEL-DISEASE | CROHNS-DISEASE | HUMAN BETA-DEFENSIN-2 | LACTIC-ACID BACTERIA | ULCERATIVE-COLITIS | HOST-DEFENSE | ANTIMICROBIAL PEPTIDES | PANETH CELLS | IMMUNOLOGY | STRAIN NISSLE-1917 | INNATE IMMUNITY | Host Response and Inflammation
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial
by Hueber, Wolfgang and Sands, Bruce E and Lewitzky, Steve and Vandemeulebroecke, Marc and Reinisch, Walter and Higgins, Peter D R and Wehkamp, Jan and Feagan, Brian G and Yao, Michael D and Karczewski, Marek and Karczewski, Jacek and Pezous, Nicole and Bek, Stephan and Bruin, Gerard and Mellgard, Bjoern and Berger, Claudia and Londei, Marco and Bertolino, Arthur P and Tougas, Gervais and Travis, Simon P L and Secukinumab Crohns Dis Study Grp and Secukinumab in Crohn's Disease Study Group and for the Secukinumab in Crohn's Disease Study Group
Gut, ISSN 0017-5749, 12/2012, Volume 61, Issue 12, pp. 1693 - 1700
Objective The authors tested whether the anti-interleukin (IL)-17A monoclonal antibody secukinumab was safe and effective for the treatment of active Crohn's... 
IMMUNITY | NECROSIS-FACTOR | INFLAMMATORY-BOWEL-DISEASE | COLITIS | SUSCEPTIBILITY LOCI | IL-23 | GASTROENTEROLOGY & HEPATOLOGY | CHRONIC MUCOCUTANEOUS CANDIDIASIS | CERTOLIZUMAB PEGOL | CLINICAL-RESPONSE | GENOME-WIDE ASSOCIATION | Biomarkers - metabolism | Severity of Illness Index | Crohn Disease - genetics | Double-Blind Method | Drug Administration Schedule | Humans | Leukocyte L1 Antigen Complex - metabolism | Middle Aged | Interleukin-17 - genetics | Antibodies, Monoclonal - therapeutic use | Male | Genetic Markers | Young Adult | Interleukin-17 - antagonists & inhibitors | Crohn Disease - drug therapy | Treatment Failure | Adolescent | Bayes Theorem | Anti-Inflammatory Agents - therapeutic use | Adult | Female | Aged | Polymorphism, Single Nucleotide | Infusions, Intravenous | Safety and security measures | Patient outcomes | Monoclonal antibodies | Dosage and administration | Crohn's disease | Research | Drug therapy | Hypothesis testing | Biomedical research | Psoriasis | Cytokines | Pathogenesis | Genomes | Inflammation | Patients | Crohns disease | Inflammatory bowel disease | Studies | Prescription drugs | Hypotheses | Gangrene | Pharmaceutical industry
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Microbiome and chronic inflammatory bowel diseases
by Wehkamp, Jan and Wehkamp, Jan and Frick, Julia-Stefanie and Frick, Julia-Stefanie
Journal of Molecular Medicine, ISSN 0946-2716, 1/2017, Volume 95, Issue 1, pp. 21 - 28
It is nowadays generally accepted that the microbiome is a central driver of chronic inflammatory bowel diseases based on observations from human patients as... 
Human Genetics | Microbiota | Inflammatory bowel diseases | Biomedicine | Antimicrobial peptides | Internal Medicine | Molecular Medicine | Paneth cells | Endotoxin | LPS | MEDICINE, RESEARCH & EXPERIMENTAL | CROHNS-DISEASE | INTESTINAL MICROBIOTA | FECAL MICROBIOTA | ULCERATIVE-COLITIS | ALPHA-DEFENSINS | GUT MICROBIOTA | COLI NISSLE 1917 | RECURRENT CLOSTRIDIUM-DIFFICILE | HUMAN BETA-DEFENSIN-2 | GENETICS & HEREDITY | Paneth cells Inflammatory bowel diseases | CELL POLARIZATION | Intestinal Mucosa - metabolism | Signal Transduction | Humans | Gastrointestinal Microbiome | Adaptation, Biological | Lipopolysaccharides - metabolism | Intestinal Mucosa - microbiology | Antimicrobial Cationic Peptides - metabolism | Inflammatory Bowel Diseases - metabolism | Lipopolysaccharides - immunology | Antimicrobial Cationic Peptides - therapeutic use | Host-Pathogen Interactions - immunology | Animals | Intestinal Mucosa - immunology | Inflammatory Bowel Diseases - etiology | Inflammatory Bowel Diseases - therapy | Intestinal Mucosa - pathology | Genetic aspects | Microbiota (Symbiotic organisms) | Analysis | Animal models | Peptides | Mucosa | Microbiomes | Antiinfectives and antibacterials | Diseases | Microorganisms | Defensins | Intestine | Bowel disease | Rodents | Genetic factors
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Crohn's Disease - New Therapies
by Klag, Thomas and Wehkamp, Jan
Deutsche Medizinische Wochenschrift, ISSN 0012-0472, 07/2018, Volume 113, Issue 13, pp. 953 - 959
defensins | anti-TNF-antibody | anti-integrin-antibody | Crohn's disease | ulcerative colitis | probiotics
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Chronisch entzündliche Darmerkrankungen: Neue Therapieformen
by Klag, Thomas and Wehkamp, Jan
DMW - Deutsche Medizinische Wochenschrift, ISSN 0012-0472, 07/2018, Volume 113, Issue 13, pp. 953 - 959
Abstract New promising treatment options for chronic inflammatory bowel diseases, confirm the expanded pathophysiological understanding in terms of the... 
Dossier
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text NOD2/CARD15 Mediates Induction of the Antimicrobial Peptide Human Beta-defensin-2
by Eske Voss and Jan Wehkamp and Kai Wehkamp and Eduard F. Stange and Jens M. Schröder and Jürgen Harder
Journal of Biological Chemistry, ISSN 0021-9258, 01/2006, Volume 281, Issue 4, pp. 2005 - 2011
Production of inducible antimicrobial peptides offers a first and rapid defense response of epithelial cells against invading microbes. Human beta-defensin-2... 
HUMAN BETA-DEFENSINS | CROHNS-DISEASE | HUMAN BETA-DEFENSIN-2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | INNATE IMMUNE-RESPONSE | TOLL-LIKE RECEPTORS | STAPHYLOCOCCUS-AUREUS | NF-KAPPA-B | INTESTINAL EPITHELIAL-CELLS | ANTIINFLAMMATORY SESQUITERPENE LACTONE | CAG PATHOGENICITY ISLAND | Epithelial Cells - metabolism | Frameshift Mutation | Luciferases - metabolism | Anti-Infective Agents - pharmacology | Humans | Peptidoglycan - chemistry | Crohn Disease - metabolism | NF-kappa B - metabolism | Transcription Factor AP-1 - metabolism | Transfection | Binding Sites | Genes, Reporter | RNA - metabolism | Cell Line | Promoter Regions, Genetic | Biotinylation | Mutagenesis, Site-Directed | Enzyme-Linked Immunosorbent Assay | Peptides - chemistry | Antimicrobial Cationic Peptides - chemistry | Down-Regulation | Antimicrobial Cationic Peptides - pharmacology | Nod2 Signaling Adaptor Protein | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Keratinocytes - metabolism | beta-Defensins - pharmacology | Ligands | Mutation | Sesquiterpenes - pharmacology | Intracellular Signaling Peptides and Proteins - physiology | DNA, Complementary - metabolism | RNA, Small Interfering - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text Breakdown of antimicrobial host defense barrier as trigger of chronic inflammatory bowel diseases
by Wehkamp, Jan
Journal of Translational Medicine, ISSN 1479-5876, 12/2011, Volume 9, Issue S2, pp. I14 - I14
  Secretory cells like the Paneth cell of the small intestinal crypt as well as mucin producing goblet cells seem to be of major importance in the initial... 
Medical research | Small intestine | Bowel disease
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text Recent advances and emerging therapies in the non-surgical management of ulcerative colitis [version 1; peer review: 3 approved]
by Wehkamp, Jan and Stange, Eduard F
F1000Research, ISSN 2046-1402, 2018, Volume 7, p. 1207
The so-called "biologicals" (monoclonal antibodies to various inflammatory targets like tumor necrosis factor or integrins) have revolutionized the treatment... 
Therapy | Small molecules | Biologicals | Ulcerative colitis | Drugs | Inflammatory bowel diseases | Clinical trials | Histology | Inflammation | Gene expression | Patients | Marketing | Inflammatory bowel disease | Intestine | Monoclonal antibodies | Tumor necrosis factor-TNF | Remission | Colon | Endoscopy | Pharmaceutical industry | Azathioprine | Integrins
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Induction of Human β-Defensin 2 by the Probiotic Escherichia coli Nissle 1917 Is Mediated through Flagellin
by Miriam Schlee and Jan Wehkamp and Artur Altenhoefer and Tobias A. Oelschlaeger and Eduard F. Stange and Klaus Fellermann
Infection and Immunity, ISSN 0019-9567, 05/2007, Volume 75, Issue 5, pp. 2399 - 2407
Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit... 
Caco-2 Cells | Anti-Infective Agents - metabolism | Humans | Culture Media, Conditioned - chemistry | Gene Expression Regulation | Escherichia coli - immunology | Probiotics | Escherichia coli - genetics | Gene Deletion | Flagellin - chemistry | Flagellin - genetics | Flagellin - metabolism | beta-Defensins - biosynthesis | Escherichia coli - classification | Host Response and Inflammation
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text Intestinal bacterial translocation in rats with cirrhosis is related to compromised paneth cell antimicrobial host defense
by Teltschik, Zora and Wiest, Reiner and Beisner, Julia and Nuding, Sabine and Hofmann, Claudia and Schoelmerich, Juergen and Bevins, Charles L and Stange, Eduard F and Wehkamp, Jan
Hepatology, ISSN 0270-9139, 04/2012, Volume 55, Issue 4, pp. 1154 - 1163
Liver cirrhosis is associated with bacterial translocation (BT) and endotoxemia. Most translocating bacteria belong to the common intestinal microbiota,... 
PERITONITIS | LIVER-CIRRHOSIS | NOD2 GENE | OVERGROWTH | IN-VIVO | CHRONIC PORTAL-HYPERTENSION | ALPHA-DEFENSINS | TRANSIT-TIME | GASTROENTEROLOGY & HEPATOLOGY | ILEAL CROHNS-DISEASE | EXPRESSION | Hypertension, Portal - physiopathology | Portal Vein - physiopathology | Paneth Cells - pathology | Male | Cecum - microbiology | Rats, Inbred Strains | Liver Cirrhosis - chemically induced | Hypertension, Portal - etiology | Liver Cirrhosis - metabolism | beta-Defensins - metabolism | Bifidobacterium - physiology | Escherichia coli - physiology | Disease Models, Animal | Paneth Cells - metabolism | Bacterial Translocation - physiology | Bacteroides fragilis - physiology | Carbon Tetrachloride - adverse effects | Rats | Protein Precursors - metabolism | Animals | Intestines - microbiology | Liver Cirrhosis - pathology | Ligation - adverse effects | Ileum - microbiology | Enterococcus faecalis - physiology | Antimicrobial agents | Liver cirrhosis | Small intestine | Rodents
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text From intestinal stem cells to inflammatory bowel diseases
by Michael Gersemann Eduard Friedrich Stange Jan Wehkamp
世界胃肠病学杂志：英文版, ISSN 1007-9327, 2011, Volume 17, Issue 27, pp. 3198 - 3203
The pathogenesis of both entities of inflammatory bowel disease （IBD）, namely Crohn＇s disease （CD） and ulcerative colitis （UC）, is still complex and under... 
溃疡性结肠炎 | 鸡传染性法氏囊病 | 细胞分化 | 干细胞 | 微生物菌群 | 发展中国家 | 杯状细胞 | 肠道疾病 | Hath1 | Inflammatory bowel disease | Goblet cells | Paneth cells | TCF4 | Cell differentiation | KLF4 | ULCERATIVE-COLITIS | COLON | ANTIMICROBIAL PEPTIDES | ILEAL CROHNS-DISEASE | ALPHA-DEFENSIN EXPRESSION | DIFFERENTIATION | LAYER | GASTROENTEROLOGY & HEPATOLOGY | MUCUS | INNATE IMMUNITY | Transcription Factor 4 | Humans | Inflammatory Bowel Diseases - diagnosis | Paneth Cells - pathology | Stem Cells - cytology | Transcription Factors - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Colitis, Ulcerative - diagnosis | Kruppel-Like Transcription Factors - metabolism | Inflammatory Bowel Diseases - pathology | Crohn Disease - diagnosis | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | alpha-Defensins - metabolism | Cell Differentiation | Goblet Cells - cytology | Intestinal Mucosa - pathology | Intestines - cytology | Topic Highlight
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Antimicrobial peptides and gut microbiota in homeostasis and pathology
by Ostaff, Maureen J and Stange, Eduard Friedrich and Wehkamp, Jan
EMBO Molecular Medicine, ISSN 1757-4676, 10/2013, Volume 5, Issue 10, pp. 1465 - 1483
We survive because we adapted to a world of microorganisms. All our epithelial surfaces participate in keeping up an effective barrier against microbes while... 
microbiota | intestinal homeostasis | epithelial differentiation | defensin | antimicrobial peptides | Epithelial differentiation | Microbiota | Intestinal homeostasis | Defensin | Antimicrobial peptides | MEDICINE, RESEARCH & EXPERIMENTAL | CLOSTRIDIUM-DIFFICILE INFECTION | ACTIVATED RECEPTOR-GAMMA | COLI NISSLE 1917 | ILEAL CROHNS-DISEASE | ALPHA-DEFENSIN EXPRESSION | INTESTINAL EPITHELIAL-CELLS | COLONIC MUCUS BARRIER | INFLAMMATORY-BOWEL-DISEASE | TOLL-LIKE RECEPTORS | SINGLE-NUCLEOTIDE POLYMORPHISMS | Intestinal Mucosa - metabolism | Anti-Infective Agents - pharmacology | Colitis, Ulcerative - metabolism | Humans | Antimicrobial Cationic Peptides - pharmacology | Bacteria - drug effects | Crohn Disease - metabolism | Gastrointestinal Tract - microbiology | Intestinal Mucosa - microbiology | Colonic Neoplasms - metabolism | Animals | Colitis, Ulcerative - etiology | Intestinal Mucosa - immunology | Colonic Neoplasms - pathology | T-Lymphocytes - immunology | Crohn Disease - etiology | Peptides | Homeostasis | Review
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text Human α-Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets
by Hiutung Chu and Marzena Pazgier and Grace Jung and Sean-Paul Nuccio and Patricia A. Castillo and Maarten F. de Jong and Maria G. Winter and Sebastian E. Winter and Jan Wehkamp and Bo Shen and Nita H. Salzman and Mark A. Underwood and Renee M. Tsolis and Glenn M. Young and Wuyuan Lu and Robert I. Lehrer and Andreas J. Bäumler and Charles L. Bevins
Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6093, pp. 477 - 481
Defensins are antimicrobial peptides that contribute broadly to innate immunity, including protection of mucosal tissues. Human α-defensin (HD) 6 is highly... 
Molecules | Epithelial cells | Transgenic animals | Biosensing techniques | Humans | REPORTS | Cell lines | Bacteria | Mice | Monomers | Vehicles | HD5 | MICE | PANETH CELLS | MULTIDISCIPLINARY SCIENCES | Intestine, Small - ultrastructure | Protein Multimerization | Immunity, Mucosal | env Gene Products, Human Immunodeficiency Virus - metabolism | Nanostructures | Salmonella Infections, Animal - immunology | Adhesins, Bacterial - metabolism | Salmonella typhimurium - ultrastructure | Macromolecular Substances - chemistry | Peptides - metabolism | Paneth Cells - immunology | Intestinal Mucosa - immunology | Protein Structure, Quaternary | Macromolecular Substances - immunology | alpha-Defensins - metabolism | Yersinia enterocolitica - immunology | Intestine, Small - immunology | Paneth Cells - metabolism | Cell Line | Microscopy, Electron, Scanning | alpha-Defensins - chemistry | Intestinal Mucosa - ultrastructure | Peptides - chemistry | Salmonella typhimurium - immunology | Salmonella typhimurium - pathogenicity | Yersinia enterocolitica - pathogenicity | Intestine, Small - microbiology | Models, Molecular | Mice, Transgenic | Intestinal Mucosa - microbiology | Immunity, Innate | Animals | alpha-Defensins - immunology | Salmonella Infections, Animal - microbiology | Protein Binding | Bacterial Proteins - metabolism | Macromolecular Substances - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
15. Full Text Reduced Paneth Cell α-Defensins in Ileal Crohn's Disease
by Jan Wehkamp and Nita H. Salzman and Edith Porter and Sabine Nuding and Michael Weichenthal and Robert E. Petras and Bo Shen and Elke Schaeffeler and Matthias Schwab and Rose Linzmeier and Ryan W. Feathers and Hiutung Chu and Heriberto Lima, Jr and Klaus Fellermann and Tomas Ganz and Eduard F. Stange and Charles L. Bevins
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2005, Volume 102, Issue 50, pp. 18129 - 18134
The pathogenesis of Crohn's disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and... 
Biological Sciences | Inflammatory bowel diseases | Microbiota | Messenger RNA | Ileitis | Antimicrobials | Mucosa | Bacteria | Biopsies | Inflammation | Ileum | Inflammatory bowel disease | Innate immunity | Intestine | MICROFLORA | intestine | bacteria | MULTIDISCIPLINARY SCIENCES | INNATE | MECHANISMS | HUMAN INTESTINAL DEFENSIN | inflammatory bowel disease | INFLAMMATORY-BOWEL-DISEASE | PEPTIDES | innate immunity | GENE | MUTATIONS | EXPRESSION | Immunohistochemistry | Paneth Cells - metabolism | Humans | Crohn Disease - metabolism | Immunoblotting | Mice, Transgenic | Reverse Transcriptase Polymerase Chain Reaction | Crohn Disease - immunology | Animals | Analysis of Variance | Ileitis - immunology | Crohn Disease - microbiology | alpha-Defensins - metabolism | Ileitis - metabolism | Ileitis - microbiology | Mice | Ohio | Ileum - microbiology
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights