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Blood, ISSN 0006-4971, 11/2019, Volume 134, Issue Supplement_1, pp. 3705 - 3705
While hematopoietic stem and progenitor cells (HSPCs) were thought to rely mainly on glycolysis for energy supply, emerging evidence suggests that defects in... 
Journal Article
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 03/2018, Volume 24, Issue 3, p. S431
Journal Article
Blood, ISSN 0006-4971, 12/2014, Volume 124, Issue 21, pp. 227 - 227
Reticular Dysgenesis (RD) is one of the most serious forms of severe combined immune deficiency (SCID). It is characterized by complete absence of circulating... 
Journal Article
Biology of Blood and Marrow Transplantation, ISSN 1083-8791, 03/2018, Volume 24, Issue 3, pp. S431 - S431
Journal Article
Blood, ISSN 0006-4971, 12/2015, Volume 126, Issue 23, pp. 3434 - 3434
Abstract Monoallelic gain of function (GOF) mutations in the human Signal Transducer and Activator of Transcription 1 (STAT1) manifest in immunodeficiency and... 
Journal Article
Blood, ISSN 0006-4971, 11/2012, Volume 120, Issue 21, pp. 2142 - 2142
Abstract Abstract 2142 Reticular dysgenesis (RD) is one of the most severe forms of combined immunodeficiency characterized by severe congenital neutropenia... 
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 5, pp. 1629 - 1640.e2
Background Gain-of-function (GOF) mutations in the human signal transducer and activator of transcription 1 (STAT1) manifest in immunodeficiency and... 
Allergy and Immunology | IFN-γ | autoimmunity | follicular T helper cell | TH1 cell | STAT1 gain of function | TH17 cell | T helper cell polarization | ruxolitinib | T | 17 cell | 1 cell | T(H)1 cell | IMMUNOLOGY | CHRONIC MUCOCUTANEOUS CANDIDIASIS | DEFICIENCY | INBORN-ERRORS | IMMUNE DYSREGULATION | IFN-gamma | ALLERGY | T(H)17 cell | DNA | DISEASE | IL-17 IMMUNITY | DIFFERENTIATION | BINDING | IMMUNODEFICIENCY | Th1 Cells - drug effects | Purpura, Thrombocytopenic, Idiopathic - genetics | Candidiasis, Chronic Mucocutaneous - genetics | Humans | Candidiasis, Chronic Mucocutaneous - immunology | Anemia, Hemolytic, Autoimmune - genetics | STAT1 Transcription Factor - genetics | Th1 Cells - immunology | STAT1 Transcription Factor - immunology | Janus Kinases - antagonists & inhibitors | Th17 Cells - drug effects | Purpura, Thrombocytopenic, Idiopathic - immunology | Anemia, Hemolytic, Autoimmune - immunology | Th17 Cells - immunology | Female | Protein Kinase Inhibitors - pharmacology | Mutation | Child | Autoimmunity - drug effects | Cytokines - immunology | Pyrazoles - pharmacology | Autoimmunity | Medical colleges | Immunodeficiency | Stem cells | Bone marrow | Genetic aspects | Transplantation | Interferon | Genetic transcription | Cell differentiation | Polarization | Phosphorylation | Candidiasis | Inhibitor drugs | Transcription | Syngeneic grafts | Differentiation (biology) | Helper cells | Bone marrow transplantation | Stem cell transplantation | Infections | Lymphocytes T | Dephosphorylation | Kinases | Immunology | Lymphocytes | Janus kinase | Remission | Drug therapy | Stat1 protein | Chronic mucocutaneous candidiasis | Functional analysis | Disease control | Patients | Hemopoiesis | Inhibitors | Kinetics | Autoimmune diseases
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 2558 - 2558
Abstract Hematopoietic stem cell (HSC) differentiation is accompanied by a metabolic shift from glycolysis to oxidative phosphorylation (OXPHOS) to meet the... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 06/2010, Volume 107, Issue 26, p. 11976
  Bacteroides is an abundant genus of bacteria of the human intestinal microbiota. Bacteroides species synthesize a large number of capsular polysaccharides... 
Proteins | Carbohydrates | Digestive system | Biosynthesis | Gene loci | Gram-negative bacteria | Gene expression | Bacteriology
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2014, Volume 111, Issue 24, pp. 8889 - 8894
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 5092 - 5092
Abstract The thymus is a primary lymphoid organ that plays a critical role in the development of adaptive T cell immunity and central tolerance. Bone... 
Journal Article
The Journal of Allergy and Clinical Immunology, ISSN 0091-6749, 05/2019, Volume 143, Issue 5, pp. 1952 - 1956.e6
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2010, Volume 107, Issue 26, pp. 11976 - 11980
Journal Article
The Journal of allergy and clinical immunology, ISSN 0091-6749, 11/2018, Volume 142, Issue 5, pp. 1665 - 1669
Treatment of the autoimmune and immune-dysregulatory features of patients with STAT1 GOF or STAT3 GOF disease remains challenging. Jakinibs have been used to... 
Ruxolitinib | Tofacitinib | STAT1 | Tocilizumab | HLH | STAT3 | Jakinib
Journal Article
Journal of Clinical Immunology, ISSN 0271-9142, 10/2019, Volume 39, Issue 7, pp. 653 - 667
Journal Article
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