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05/2012
The present invention relates to a series of 2,3,5-substituted pyridone derivatives of formula I: wherein R, R1, R2, R3 and R4 are as defined herein. This... 
METALLURGY | HYGIENE | PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES | ORGANIC CHEMISTRY | CHEMISTRY | HETEROCYCLIC COMPOUNDS | MEDICAL OR VETERINARY SCIENCE | HUMAN NECESSITIES
Patent
Tetrahedron, ISSN 0040-4020, 1990, Volume 46, Issue 12, pp. 4155 - 4160
The stereocontrolled synthesis of conformationally restricted LTD analogs 2a, b is described. Epoxidation of enone 4 affords a 2.4:1 mixture of trans-epoxide 5... 
CHEMISTRY, ORGANIC
Journal Article
Journal of Heterocyclic Chemistry, ISSN 0022-152X, 07/1979, Volume 16, Issue 5, pp. 1081 - 1082
Ring expansion by dehydration of 1,3‐dithian‐2‐ylmethanols gives 6,7‐dihydro‐5H‐1,4‐dithiepins. 
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/1985, Volume 28, Issue 6, pp. 831 - 833
Journal Article
Journal of Heterocyclic Chemistry, ISSN 0022-152X, 05/1987, Volume 24, Issue 3, pp. 561 - 563
Journal Article
Journal of Pharmaceutical Sciences, ISSN 0022-3549, 11/1989, Volume 78, Issue 11, pp. 937 - 943
A series of substituted 3,4‐dihydro‐2H‐1,4‐thiazines inhibit 5‐lipoxygenase from rat leukocytes and exhibit submicromolar IC50 values. A novel synthesis of... 
CHEMISTRY | PHARMACOLOGY & PHARMACY | Chemistry | Animals | Lipid Peroxides - pharmacology | Neutrophils - enzymology | Neutrophils - drug effects | Chemical Phenomena | Leukotriene B4 - metabolism | Rats | Thiazines - pharmacology | In Vitro Techniques | Lipoxygenase Inhibitors
Journal Article
06/1993
The present invention relates to 4-azido- DELTA 4-steroids which are useful as inhibitors of 5 alpha -reductase. The compounds are prepared by the reaction of... 
METALLURGY | STEROIDS | ORGANIC CHEMISTRY | CHEMISTRY
Patent
02/1993
The present invention relates to 4-amino- DELTA 4,6-steroids which are useful as inhibitors of 5 alpha -reductase. The compounds are prepared by the reaction... 
METALLURGY | STEROIDS | ORGANIC CHEMISTRY | CHEMISTRY
Patent
by Vos, Theo and Abajobir, Amanuel Alemu and Abate, Kalkidan Hassen and Abbafati, Cristiana and Abbas, Kaja M and Abd-Allah, Foad and Abdulkader, Rizwan Suliankatchi and Abdulle, Abdishakur M and Abebo, Teshome Abuka and Abera, Semaw Ferede and Aboyans, Victor and Abu-Raddad, Laith J and Ackerman, Ilana N and Adamu, Abdu Abdullahi and Adetokunboh, Olatunji and Afarideh, Mohsen and Afshin, Ashkan and Agarwal, Sanjay Kumar and Aggarwal, Rakesh and Agrawal, Anurag and Agrawal, Sutapa and Ahmadieh, Hamid and Ahmed, Muktar Beshir and Aichour, Ibtihel and Aichour, Amani Nidhal and Aichour, Miloud Taki Eddine and Aiyar, Sneha and Akinyemi, Rufus Olusola and Akseer, Nadia and Al Lami, Faris Hasan and Alahdab, Fares and Al-Aly, Ziyad and Alam, Khurshid and Alam, Noore and Alam, Tahiya and Alasfoor, Deena and Alene, Kefyalew Addis and Ali, Raghib and Alizadeh-Navaei, Reza and Alkerwi, Ala'a and Alla, François and Allebeck, Peter and Allen, Christine and Al-Maskari, Fatma and Al-Raddadi, Rajaa and Alsharif, Ubai and Alsowaidi, Shirina and Altirkawi, Khalid A and Amare, Azmeraw T and Amini, Erfan and Ammar, Walid and Amoako, Yaw Ampem and Andersen, Hjalte H and Antonio, Carl Abelardo T and Anwari, Palwasha and Ärnlöv, Johan and Artaman, Al and Aryal, Krishna Kumar and Asayesh, Hamid and Asgedom, Solomon W and Assadi, Reza and Atey, Tesfay Mehari and Atnafu, Niguse Tadele and Atre, Sachin R and Avila-Burgos, Leticia and Avokphako, Euripide Frinel G Arthur and Awasthi, Ashish and Bacha, Umar and Badawi, Alaa and Balakrishnan, Kalpana and Banerjee, Amitava and Bannick, Marlena S and Barac, Aleksandra and Barber, Ryan M and Barker-Collo, Suzanne L and Bärnighausen, Till and Barquera, Simon and Barregard, Lars and Barrero, Lope H and Basu, Sanjay and Battista, Bob and Battle, Katherine E and Baune, Bernhard T and Bazargan-Hejazi, Shahrzad and Beardsley, Justin and Bedi, Neeraj and Beghi, Ettore and Béjot, Yannick and Bekele, Bayu Begashaw and Bell, Michelle L and Bennett, Derrick A and Bensenor, Isabela M and Benson, Jennifer and Berhane, Adugnaw and Berhe, Derbew Fikadu and Bernabé, Eduardo and Betsu, Balem Demtsu and Beuran, Mircea and Beyene, Addisu Shunu and Bhala, Neeraj and ... and GBD 2016 Dis Injury Incidence Prev and GBD 2016 Disease and Injury Incidence and Prevalence Collaborators and Institutionen för hälsovetenskaper and Örebro universitet
The Lancet, ISSN 0140-6736, 09/2017, Volume 390, Issue 10100, pp. 1211 - 1259
As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the... 
MORTALITY | DEPRESSION | CHRONIC PAIN | CLIMATE-CHANGE | DISORDERS | FUTURE | PERSONAL HEALTH-CARE | TRENDS | MEDICINE, GENERAL & INTERNAL | Medicine, Experimental | Medical research | Mental disorders | Disease | Personal health | Mortality | Mental health | Disease control | Risk factors | Studies | Disability | Aging | Age | Public health | Injury analysis | Injuries | Chronic illnesses | Guillain-Barre syndrome | Low back pain | Gout | Disorders | Mental depression | Tropical diseases | Incidence | Ratios | Fertility | Anxiety | Alzheimer's disease | Life expectancy | Population growth | Nutrient deficiency | Neurodegenerative diseases | Violence | Anemia | Regression analysis | Firearms | Self destructive behavior | Hearing loss | Diseases | Charities | Substance use | Hospitals | Tuberculosis | Adults | Cardiovascular diseases | Bayesian analysis | Headache | Populations | Iron | Sexual assault | Demographics | Pain | Remission | Children | Heart diseases | Complications | Aggression | Migraine | Diabetes mellitus | Health risks | Estimates | Life span | Community medicine, Social medicine: 801 | Samfunnsmedisin, sosialmedisin: 801 | Epidemiology medical and dental statistics: 803 | Epidemiologi medisinsk og odontologisk statistikk: 803 | VDP | Helsefag: 800 | Health sciences: 800 | Medisinske Fag: 700 | Medical disciplines: 700 | Global Health Metrics | Clinical Medicine | Allmänmedicin | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap | General Practice
Journal Article
07/1992
The present invention relates to 4-amino- DELTA 4,6-steroids which are useful as inhibitors of 5 alpha -reductase. The compounds are prepared by the reaction... 
METALLURGY | STEROIDS | ORGANIC CHEMISTRY | CHEMISTRY
Patent
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