Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (1277) 1277
Publication (137) 137
Patent (109) 109
Newspaper Article (88) 88
Book / eBook (71) 71
Book Chapter (53) 53
Book Review (50) 50
Dissertation (27) 27
Conference Proceeding (23) 23
Magazine Article (11) 11
Reference (5) 5
Government Document (3) 3
Video Recording (3) 3
Report (2) 2
Web Resource (2) 2
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (399) 399
index medicus (326) 326
animals (234) 234
male (216) 216
female (194) 194
adult (136) 136
biochemistry & molecular biology (122) 122
middle aged (121) 121
proteins (107) 107
research (97) 97
article (94) 94
models, molecular (92) 92
analysis (91) 91
mice (80) 80
cell biology (78) 78
aged (75) 75
crystallography, x-ray (74) 74
protein binding (71) 71
molecular sequence data (64) 64
binding sites (62) 62
protein conformation (62) 62
multidisciplinary sciences (60) 60
amino acid sequence (57) 57
physiological aspects (57) 57
rats (56) 56
ligands (52) 52
clinical neurology (49) 49
adolescent (47) 47
crystal structure (47) 47
crystal-structure (47) 47
risk factors (47) 47
surgery (45) 45
neurosciences (43) 43
performing operations (43) 43
transporting (43) 43
research article (42) 42
structure (42) 42
treatment outcome (41) 41
biology (40) 40
crystals (39) 39
usage (39) 39
biophysics (38) 38
medicine (38) 38
protein structure, tertiary (38) 38
biochemistry (37) 37
care and treatment (37) 37
immunology (37) 37
protein (37) 37
abridged index medicus (35) 35
binding (35) 35
crystallography (35) 35
health aspects (35) 35
english literature (34) 34
mutation (34) 34
studies (33) 33
crystallization (32) 32
peptides (32) 32
activation (31) 31
beta-catenin (31) 31
cancer (31) 31
cells (31) 31
science (30) 30
expression (29) 29
geochemistry & geophysics (29) 29
cardiac & cardiovascular systems (28) 28
complex (28) 28
methods (28) 28
phosphorylation (28) 28
basic biological sciences (27) 27
evolution (27) 27
general tagging of cross-sectional technologies spanning over several sections of the ipc (27) 27
general tagging of new technological developments (27) 27
psychiatry (27) 27
receptors (27) 27
signal transduction (27) 27
technical subjects covered by former uspc (27) 27
technical subjects covered by former uspc cross-reference art collections [xracs] and digests (27) 27
united states (27) 27
cell adhesion (26) 26
child (26) 26
hematology (26) 26
protein structure, secondary (26) 26
cadherins - metabolism (25) 25
cells, cultured (25) 25
diagnosis (25) 25
molecular biology (25) 25
peripheral vascular disease (25) 25
technical subjects covered by former us classification (25) 25
time factors (25) 25
chemistry (24) 24
macromolecular substances (24) 24
organic chemistry (24) 24
gene expression (23) 23
pathology (23) 23
public, environmental & occupational health (23) 23
environmental sciences (22) 22
human necessities (22) 22
in-vitro (22) 22
infectious diseases (22) 22
prevalence (22) 22
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Robarts - Stacks (27) 27
Collection Dvlpm't (Acquisitions) - Vendor file (9) 9
UofT at Mississauga - Stacks (7) 7
OISE - Stacks (6) 6
Victoria University E.J. Pratt - Stacks (6) 6
Gerstein Science - Stacks (5) 5
UTL at Downsview - May be requested (5) 5
UofT at Scarborough - Stacks (5) 5
Collection Dvlpm't (Acquisitions) - Closed Orders (4) 4
Law (Bora Laskin) - Stacks (3) 3
New College (Ivey) - Stacks (3) 3
Criminology - Stacks (2) 2
Media Commons - Audio Visual (2) 2
Online Resources - Online (2) 2
St. Michael's College (John M. Kelly) - 2nd Floor (2) 2
Trinity College (John W Graham) - Stacks (2) 2
Baycrest Hospital - Stacks (1) 1
Chemistry (A D Allen) - Stacks (1) 1
Earth Sciences (Noranda) - Stacks (1) 1
Engineering & Comp. Sci. - Stacks (1) 1
Faculty of Information - Stacks (1) 1
Innis College - Missing (1) 1
Innis College - Stacks (1) 1
Institute for Christian Studies - Stacks (1) 1
St. Michael's College (John M. Kelly) - Audio Visual (1) 1
Thomas Fisher Rare Book - May be requested at Fisher (1) 1
University College (Laidlaw) - Stacks (1) 1
UofT at Scarborough - Withdrawn (1) 1
Victoria University E.J. Pratt - Storage (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (1662) 1662
French (28) 28
German (14) 14
Finnish (4) 4
Norwegian (4) 4
Portuguese (3) 3
Spanish (2) 2
Danish (1) 1
Italian (1) 1
Korean (1) 1
Russian (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text The β-catenin destruction complex
by Stamos, Jennifer L and Weis, William I
Cold Spring Harbor Perspectives in Biology, ISSN 1943-0264, 01/2013, Volume 5, Issue 1, p. a007898
The Wnt/beta-catenin pathway is highly regulated to insure the correct temporal and spatial activation of its target genes. In the absence of a Wnt stimulus,... 
WNT SIGNALING PATHWAY | ADENOMATOUS POLYPOSIS-COLI | TRCP-UBIQUITIN LIGASE | GLYCOGEN-SYNTHASE KINASE-3 | XENOPUS EMBRYOS | PROTEIN PHOSPHATASE 2A | AXIS FORMATION | APC TUMOR-SUPPRESSOR | F-BOX PROTEIN | NEGATIVE REGULATOR | CELL BIOLOGY | Adenomatous Polyposis Coli Protein - physiology | Amino Acid Sequence | Phosphorylation | Axin Protein - physiology | Signal Transduction | Gene Expression Regulation | Molecular Sequence Data | Axin Signaling Complex - physiology | Proteasome Endopeptidase Complex - physiology | beta Catenin - metabolism | Axin Protein - metabolism | Adenomatous Polyposis Coli Protein - chemistry | Ubiquitination | Models, Biological | Proteasome Endopeptidase Complex - metabolism | Binding Sites | 065
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. The Molecular Basis of G Protein–Coupled Receptor Activation
by William I Weis and Brian K Kobilka
Annual Review of Biochemistry, ISSN 0066-4154, 01/2018, Volume 87, p. 897
G protein–coupled receptors (GPCRs) mediate the majority of cellular responses to external stimuli. Upon activation by a ligand, the receptor binds to a... 
Binding | GTP | Computer simulation | Crystallization | Pharmacology | Activation | Arrestin | Molecular chains | Intermediates | Proteins | Coupling (molecular) | Molecules | Receptors | Allosteric properties | GDP | Spectrum analysis | External stimuli | Ligands | Mathematical models | Receptor mechanisms
Journal Article
Details down arrow
3. Full Text The Molecular Basis of G Protein-Coupled Receptor Activation
by Weis, William I and Kobilka, Brian K
Annual Review of Biochemistry, ISSN 0066-4154, 6/2018, Volume 87, Issue 1, pp. 897 - 919
G protein-coupled receptors (GPCRs) mediate the majority of cellular responses to external stimuli. Upon activation by a ligand, the receptor binds to a... 
G protein-coupled receptor | energy landscape | adrenergic receptor | GPCR | 7-TM receptors | allostery | β 2 -adrenergic receptor | CRYSTALLIZING MEMBRANE-PROTEINS | STRUCTURAL INSIGHTS | BETA ADRENERGIC-RECEPTOR | DYNAMIC PROCESS | IONIC LOCK | BIOCHEMISTRY & MOLECULAR BIOLOGY | MUSCARINIC ACETYLCHOLINE-RECEPTOR | beta-adrenergic receptor | CRYO-EM STRUCTURE | CONFORMATIONAL SELECTION | Energy Metabolism | Receptors, G-Protein-Coupled - metabolism | Allosteric Regulation | Humans | Conserved Sequence | Models, Molecular | Crystallography, X-Ray | Ligands | Protein Conformation | Receptors, G-Protein-Coupled - genetics | Binding Sites | Receptors, G-Protein-Coupled - chemistry | Biological research | Cell receptors | Physiological aspects | Biochemistry | G proteins | Research | Molecular biology | Biology, Experimental | G protein–coupled receptor | β2-adrenergic receptor
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Adrenaline-activated structure of β 2-adrenoceptor stabilized by an engineered nanobody
by Ring, Aaron M and Manglik, Aashish and Kruse, Andrew C and Enos, Michael D and Weis, William I and Garcia, K. Christopher and Kobilka, Brian K
Nature, ISSN 0028-0836, 2013, Volume 502, Issue 7472, pp. 575 - 579
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Structure and biochemistry of cadherins and catenins
by Shapiro, Lawrence and Weis, William I
Cold Spring Harbor perspectives in biology, ISSN 1943-0264, 2009, Volume 1, Issue 3, pp. a003053 - a003053
Classical cadherins mediate specific adhesion at intercellular adherens junctions. Interactions between cadherin ectodomains from apposed cells mediate... 
CYTOPLASMIC DOMAIN | ALPHA-CATENIN | CRYSTAL-STRUCTURE | INTRINSICALLY UNSTRUCTURED PROTEINS | C-TERMINAL TAILS | CALCIUM-BINDING | CELL-CELL-ADHESION | P120 CATENIN | CLASSIC CADHERINS | BETA-CATENIN | CELL BIOLOGY | Protein Structure, Tertiary | Cadherins - metabolism | Humans | Cell Communication | Models, Molecular | Cytoplasm - metabolism | Cell Adhesion | Adherens Junctions - metabolism | Catenins - metabolism | Animals | Models, Biological | Biochemistry - methods | Biology - methods | Cytoskeleton - metabolism | Protein Conformation | Dimerization | 008
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Full Text Structure and mechanism of cadherins and catenins in cell-cell contacts
by Pokutta, Sabine and Weis, William I
Annual Review of Cell and Developmental Biology, ISSN 1081-0706, 2007, Volume 23, Issue 1, pp. 237 - 261
Cadherins are Ca2+-dependent cell adhesion molecules found in several kinds of cell-cell contact, including adherens junctions and desmosomes. In the presence... 
Homophilic adhesion | β-catenin | α-catenin | Desmosome | Adherens junction | beta-catenin | homophilic adhesion | TYROSINE PHOSPHORYLATION | CRYOELECTRON MICROSCOPY | CLASSICAL CADHERINS | CRYSTAL-STRUCTURE | INTRINSICALLY UNSTRUCTURED PROTEINS | alpha-catenin | DEVELOPMENTAL BIOLOGY | CELL BIOLOGY | 3-DIMENSIONAL STRUCTURE | adherens junction | HETEROPHILIC INTERACTIONS | desmosome | C-TERMINAL TAILS | Protein Structure, Tertiary | Catenins - metabolism | Animals | Cadherins - metabolism | Humans | Cadherins - chemistry | Catenins - chemistry | Cell Communication | Cadherins - genetics | Catenins - genetics
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
7. Full Text Crystal structure of the μ-opioid receptor bound to a morphinan antagonist
by Manglik, Aashish and Kruse, Andrew C and Kobilka, Tong Sun and Thian, Foon Sun and Mathiesen, Jesper M and Sunahara, Roger K and Pardo, Leonardo and Weis, William I and Kobilka, Brian K and Granier, Sébastien
Nature, ISSN 0028-0836, 05/2012, Volume 485, Issue 7398, pp. 321 - 326
Opium is one of the world's oldest drugs, and its derivatives morphine and codeine are among the most used clinical drugs to relieve severe pain. These... 
Morphinans - chemistry | Receptors, Opioid, mu - chemistry | Receptors, Opioid, mu - metabolism | Solvents - chemistry | Protein Multimerization | Models, Molecular | Crystallography, X-Ray | Receptors, Opioid, mu - antagonists & inhibitors | Animals | Morphinans - metabolism | Ligands | Protein Conformation | Mice | Binding Sites | Morphinans - pharmacology | Proteins | Crystal structure
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
8. Full Text N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor
by Zou, Yaozhong and Weis, William I and Kobilka, Brian K
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e46039
A highly crystallizable T4 lysozyme (T4L) was fused to the N-terminus of the beta(2) adrenergic receptor (beta(2)AR), a G-protein coupled receptor (GPCR) for... 
COMPLEX | ANTAGONIST | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GPCR | BETA-ADRENERGIC RECEPTOR | MUSCARINIC ACETYLCHOLINE-RECEPTOR | Protein Engineering - methods | Receptors, G-Protein-Coupled - metabolism | Humans | Molecular Sequence Data | Crystallography, X-Ray | Tritium | Recombinant Fusion Proteins - metabolism | Viral Proteins - metabolism | Receptors, Adrenergic, beta-2 - chemistry | Sf9 Cells | Bacteriophage T4 - enzymology | Binding Sites | Binding, Competitive | Protein Structure, Tertiary | Amino Acid Sequence | Protein Structure, Secondary | Muramidase - chemistry | Receptors, Adrenergic, beta-2 - genetics | Viral Proteins - chemistry | Muramidase - genetics | Crystallization | Models, Molecular | Viral Proteins - genetics | Muramidase - metabolism | Recombinant Fusion Proteins - chemistry | Receptors, Adrenergic, beta-2 - metabolism | Animals | Dihydroalprenolol - metabolism | Protein Binding | Recombinant Fusion Proteins - genetics | Dihydroalprenolol - chemistry | Protein Conformation | Receptors, G-Protein-Coupled - genetics | Mutation | Receptors, G-Protein-Coupled - chemistry | Proteins | Lysozyme | G proteins | Protein engineering | G protein-coupled receptors | Crystal lattices | Science | Catecholamines | Crystallography | Medicine | Signaling | N-Terminus | Chemical bonds | Adrenergic receptors | Physiology | Crystal structure
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. Full Text The Structure of the β-Catenin/E-Cadherin Complex and the Molecular Basis of Diverse Ligand Recognition by β-Catenin
by Huber, Andrew H and Weis, William I
Cell, ISSN 0092-8674, 2001, Volume 105, Issue 3, pp. 391 - 402
As a component of adherens junctions and the Wnt signaling pathway, β-catenin binds cadherins, Tcf family transcription factors, and the tumor suppressor APC.... 
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
10. Full Text Structural insights into μ-opioid receptor activation
by Huang, Weijiao and Manglik, Aashish and Venkatakrishnan, A.J and Laeremans, Toon and Feinberg, Evan N and Sanborn, Adrian L and Kato, Hideaki E and Livingston, Kathryn E and Thorsen, Thor S and Kling, Ralf C and Granier, Sébastien and Gmeiner, Peter and Husbands, Stephen M and Traynor, John R and Weis, William I and Steyaert, Jan and Dror, Ron O and Kobilka, Brian K
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7565, pp. 315 - 321
Activation of the μ-opioid receptor (μOR) is responsible for the efficacy of the most effective analgesics. To shed light on the structural basis for μOR... 
Allosteric Regulation | Crystallography, X-Ray | Heterotrimeric GTP-Binding Proteins - metabolism | Structure-Activity Relationship | Receptors, Opioid, mu - agonists | Receptor, Muscarinic M2 - chemistry | Receptors, Adrenergic, beta-2 - chemistry | Morphinans - metabolism | Binding Sites | Morphinans - pharmacology | Protein Structure, Tertiary | Morphinans - chemistry | Pyrroles - metabolism | Receptors, Opioid, mu - chemistry | Single-Chain Antibodies - pharmacology | Receptors, Opioid, mu - metabolism | Models, Molecular | Molecular Dynamics Simulation | Pyrroles - pharmacology | Animals | Protein Stability - drug effects | Heterotrimeric GTP-Binding Proteins - chemistry | Pyrroles - chemistry | Mice | Single-Chain Antibodies - chemistry | Life Sciences
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Full Text β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
by Weis, William I and Daniels, Danette L
Nature Structural & Molecular Biology, ISSN 1545-9993, 04/2005, Volume 12, Issue 4, pp. 364 - 371
Wnt growth factors mediate cell fate determination during embryogenesis and in the renewal of tissues in the adult. Wnts act by stabilizing cellular levels of... 
FUNCTIONAL INTERACTION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DROSOPHILA | CELL BIOLOGY | HMG BOX | IN-VITRO | BIOPHYSICS | APC | TCF COMPLEX | FACTOR LEF-1 | GENE-EXPRESSION | BINDING | Peptide Fragments - metabolism | Transcriptional Activation - genetics | beta Catenin | Cytoskeletal Proteins - genetics | Humans | Repressor Proteins - genetics | Wnt Proteins | DNA - metabolism | Transcription Factors - genetics | DNA-Binding Proteins - genetics | DNA-Binding Proteins - metabolism | Lymphoid Enhancer-Binding Factor 1 | Transcription Factors - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Animals | Trans-Activators - genetics | Protein Binding | Cytoskeletal Proteins - metabolism | Trans-Activators - metabolism | Mice | Co-Repressor Proteins | Peptide Fragments - genetics | Repressor Proteins - metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
12. Full Text Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
by Haga, Kazuko and Kruse, Andrew C and Asada, Hidetsugu and Yurugi-Kobayashi, Takami and Shiroishi, Mitsunori and Zhang, Cheng and Weis, William I and Okada, Tetsuji and Kobilka, Brian K and Haga, Tatsuya and Kobayashi, Takuya
Nature, ISSN 0028-0836, 02/2012, Volume 482, Issue 7386, pp. 547 - 551
The parasympathetic branch of the autonomic nervous system regulates the activity of multiple organ systems. Muscarinic receptors are G-protein-coupled... 
ACTIVATION | PROTEIN-COUPLED RECEPTOR | BETA-ADRENERGIC-RECEPTOR | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | BINDING-PROTEIN | RHODOPSIN | TRANSMEMBRANE DOMAIN | SCANNING MUTAGENESIS | EXPRESSION | INSIGHTS | Quinuclidinyl Benzilate - analogs & derivatives | Receptor, Muscarinic M2 - genetics | Allosteric Regulation | Humans | Crystallography, X-Ray | Acetylcholine - metabolism | Receptor, Muscarinic M2 - chemistry | Cholinergic Antagonists - pharmacology | Carrier Proteins - chemistry | Receptor, Muscarinic M2 - antagonists & inhibitors | Quinuclidinyl Benzilate - chemistry | Binding Sites | Tyrosine - chemistry | Acetylcholine - chemistry | Receptor, Muscarinic M2 - metabolism | Acetylcholine - analogs & derivatives | Models, Molecular | Acetylcholinesterase - chemistry | Quinuclidinyl Benzilate - metabolism | Cholinergic Antagonists - metabolism | Tyrosine - metabolism | Carrier Proteins - metabolism | Cholinergic Antagonists - chemistry | Ligands | Protein Conformation | Acetylcholinesterase - metabolism | Quinuclidinyl Benzilate - pharmacology | Evolution, Molecular | Physiological aspects | G proteins | Research | Muscarinic receptors | Structure | Binding proteins | Proteins | Amino acids | Binding sites | Crystal structure
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
13. Full Text Crystal structure of the β 2 adrenergic receptor-Gs protein complex
by Rasmussen, Sǒren G. F and Devree, Brian T and Zou, Yaozhong and Kruse, Andrew C and Chung, Ka Young and Kobilka, Tong Sun and Thian, Foon Sun and Chae, Pil Seok and Pardon, Els and Calinski, Diane and Mathiesen, Jesper M and Shah, Syed T. A and Lyons, Joseph A and Caffrey, Martin and Gellman, Samuel H and Steyaert, Jan and Skiniotis, Georgios and Weis, William I and Sunahara, Roger K and Kobilka, Brian K
Nature, ISSN 0028-0836, 09/2011, Volume 477, Issue 7366, pp. 549 - 557
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
14. Full Text E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch
by Nicolas Borghi and Maria Sorokina and Olga G. Shcherbakova and William I. Weis and Beth L. Pruitt and W. James Nelson and Alexander R. Dunn
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 31, pp. 12568 - 12573
Classical cadherins are transmembrane proteins at the core of intercellular adhesion complexes in cohesive metazoan tissues. The extracellular domain of... 
Intercellular junctions | Epithelial cells | Cell adhesion | Actins | Cadherins | Cytoskeleton | Cell membranes | Sensors | Cells | Endothelial cells | Morphogenesis | Signal transduction | Mechanotransduction | Mechanosensor | Mechanobiology | mechanobiology | COMPLEX | PROTEIN | ACTIN | signal transduction | mechanotransduction | MEMBRANE | MULTIDISCIPLINARY SCIENCES | ALPHA-E-CATENIN | BETA-CATENIN | morphogenesis | mechanosensor | MEDIATED ADHESIONS | VE-CADHERIN | VINCULIN | ADHERENS JUNCTIONS | Cell Line | Epithelial Cells - metabolism | Cadherins - metabolism | alpha Catenin - metabolism | Cytoskeleton - genetics | Cell Communication - physiology | Mechanotransduction, Cellular - physiology | Actomyosin - metabolism | Actomyosin - genetics | Animals | Cell Adhesion - physiology | Dogs | Cytoskeleton - metabolism | alpha Catenin - genetics | Cadherins - genetics | Epithelial Cells - cytology | Physiological aspects | Cell interaction | Research | Health aspects | Biological Sciences
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
15. Full Text Activation and allosteric modulation of a muscarinic acetylcholine receptor
by Kruse, Andrew C and Ring, Aaron M and Manglik, Aashish and Hu, Jianxin and Hu, Kelly and Eitel, Katrin and Hübner, Harald and Pardon, Els and Valant, Celine and Sexton, Patrick M and Christopoulos, Arthur and Felder, Christian C and Gmeiner, Peter and Steyaert, Jan and Weis, William I and Garcia, K. Christopher and Wess, Jürgen and Kobilka, Brian K and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Nature, ISSN 0028-0836, 2013, Volume 504, Issue 7478, pp. 101 - 106
Despite recent advances in crystallography and the availability of G-p