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1. Full Text T-cell immunity to infection with dengue virus in humans
by Weiskopf, Daniela and Sette, Alessandro
Frontiers in Immunology, ISSN 1664-3224, 2014, Volume 5, p. 93
Dengue virus (DENV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Up to 400 million DENV infections... 
Vaccines | HLA | T cells | Pathogenesis | Protection | DENV | UNITED-STATES | ORIGINAL ANTIGENIC SIN | vaccines | HLA-B | protection | IMMUNOLOGY | HUMAN CD8(+) | pathogenesis | RESPONSES | CYTOKINE PRODUCTION | HEMORRHAGIC-FEVER | PROTECTIVE ROLE | MOUSE MODEL | DISEASE | denv
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2. Full Text Dengue virus infection elicits highly polarized CX3CR1⁺ cytotoxic CD4⁺ T cells associated with protective immunity
by Daniela Weiskopf and Derek J. Bangs and John Sidney and Ravi V. Kolla and Aruna D. De Silva and Aravinda M. de Silva and Shane Crotty and Bjoern Peters and Alessandro Sette
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2015, Volume 112, Issue 31, pp. E4256 - E4263
Dengue virus (DENV) is a rapidly spreading pathogen with unusual pathogenesis, and correlates of protection from severe dengue disease and vaccine efficacy... 
HLA DR | CD4 | Cytotoxic | Dengue virus | T cell memory | FREQUENCIES | MULTIDISCIPLINARY SCIENCES | dengue virus | IDENTIFICATION | ANTIBODY-DEPENDENT ENHANCEMENT | EFFECTOR | HETEROGENEITY | RESPONSES | HLA-DR | MEMORY | DISEASE | CORRELATE | cytotoxic | Cell Polarity | Cell Proliferation | Species Specificity | Humans | Receptors, Chemokine - metabolism | Male | Dengue - virology | Immunity | Lymphocyte Subsets - immunology | CD4-Positive T-Lymphocytes - immunology | Phenotype | Histocompatibility Antigens Class II - immunology | Peptides - metabolism | Dengue Virus - immunology | Alleles | Protein Binding | Adult | Female | Immunologic Memory | Dengue - immunology | CX3C Chemokine Receptor 1 | Cytotoxicity, Immunologic | Biological Sciences | PNAS Plus
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3. Full Text Cytotoxic CD4 T cells: Differentiation, function, and application to dengue virus infection
by Tian, Yuan and Sette, Alessandro and Weiskopf, Daniela
Frontiers in Immunology, ISSN 1664-3224, 2016, Volume 7
Dengue virus (DENV) has spread through most tropical and subtropical areas of the world and represents a serious public health problem. The control of DENV... 
Cytotoxicity | CD4 T cells | Vaccines | Dengue virus | Protection | EFFECTOR FUNCTIONS | DENDRITIC CELLS | vaccines | dengue virus | DUAL FUNCTIONS | protection | IMMUNOLOGY | LYMPHOCYTE CLONES | CUTTING EDGE | CYTOKINE PRODUCTION | INTERFERON-GAMMA | PROTECTIVE ROLE | GENE-EXPRESSION | TRANSCRIPTION FACTOR | cytotoxicity | Virus diseases | Antiviral agents | Care and treatment | Dengue viruses | Dosage and administration | B cells | Research | T cells | Health aspects | Dengue Virus
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4. Full Text Properties of MHC Class I Presented Peptides That Enhance Immunogenicity
by Calis, Jorg J. A and Maybeno, Matt and Greenbaum, Jason A and Weiskopf, Daniela and De Silva, Aruna D and Sette, Alessandro and Keşmir, Can and Peters, Bjoern
PLoS Computational Biology, ISSN 1553-734X, 10/2013, Volume 9, Issue 10, p. e1003266
T-cells have to recognize peptides presented on MHC molecules to be activated and elicit their effector functions. Several studies demonstrate that some... 
VIRUS-INFECTION | CLEAVAGE MOTIFS | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | T-CELL REPERTOIRE | CROSS-REACTIVITY | PRECURSOR FREQUENCIES | ANTIGEN PRESENTATION | EPITOPE PREDICTION | VACCINIA VIRUS | INDEPENDENT BINDING | QUANTITATIVE-ANALYSIS | Amino Acid Sequence | Peptides - chemistry | Humans | Peptides - immunology | Histocompatibility Antigens Class I - immunology | Histocompatibility Antigens Class I - chemistry | Epitopes - immunology | Antigens, Viral - immunology | Models, Immunological | Animals | Databases, Protein | T-Lymphocytes - immunology | Mice | Physiological aspects | Immunogenetics | Major histocompatibility complex | Research | Peptides | Studies | Amino acids | Infections | Immunology
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5. Full Text Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells
by Daniela Weiskopf and Michael A. Angelo and Elzinandes L. de Azeredo and John Sidney and Jason A. Greenbaum and Anira N. Fernando and Anne Broadwater and Ravi V. Kolla and Aruna D. De Silva and Aravinda M. de Silva and Kimberly A. Mattia and Benjamin J. Doranz and Howard M. Grey and Sujan Shresta and Bjoern Peters and Alessandro Sette
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 05/2013, Volume 110, Issue 22, pp. E2046 - E2053
The role of CD8(+) T cells in dengue virus infection and subsequent disease manifestations is not fully understood. According to the original antigenic sin... 
ANTIBODY-DEPENDENT ENHANCEMENT | PATHOGENESIS | ORIGINAL ANTIGENIC SIN | POPULATION | SRI-LANKA | HEMORRHAGIC-FEVER | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | DISEASE | CLASS-I SUPERTYPES | INFECTION | Sri Lanka - epidemiology | Enzyme-Linked Immunosorbent Assay | Polyproteins - metabolism | Humans | Dengue - epidemiology | Histocompatibility Antigens Class I - immunology | Polyproteins - immunology | Monocytes - metabolism | Seroepidemiologic Studies | DNA Primers - genetics | Enzyme-Linked Immunospot Assay | Histocompatibility Antigens Class I - genetics | Histocompatibility Antigens Class I - metabolism | Dengue Virus - genetics | Flow Cytometry | Dengue Virus - immunology | Adult | CD8-Positive T-Lymphocytes - immunology | Dengue - immunology | Immunologic Memory - immunology | PNAS Plus | Biological Sciences
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6. Full Text Biology of Immune Responses to Vaccines in Elderly Persons
by Birgit Weinberger and Dietmar Herndler-Brandstetter and Angelika Schwanninger and Daniela Weiskopf and Beatrix Grubeck-Loebenstein
Clinical Infectious Diseases, ISSN 1058-4838, 4/2008, Volume 46, Issue 7, pp. 1078 - 1084
With increasing age, the human immune system undergoes characteristic changes, termed immunosenescence, which lead to increased incidence and severity of... 
T lymphocytes | Antigens | Immune response | B lymphocytes | Vaccination | Memory | Antibodies | Vaccines | Older adults | Age | Immune system | INFECTIOUS DISEASES | HEPATITIS-A | SAFETY | BONE-MARROW | OLD-AGE | MICROBIOLOGY | IMMUNOLOGY | CD8(+) T-CELLS | IMMUNOGENICITY | RISK-FACTOR | MEMORY | INFLUENZA VACCINATION | DIFFERENTIATION | Aged, 80 and over | Vaccines - immunology | Aging - immunology | Aged | Humans | Middle Aged | Physiological aspects | Demographic aspects
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7. Full Text Induction of autophagy by spermidine promotes longevity
by Tavernarakis, Nektarios and Kroemer, Guido and Herker, Eva and Madeo, Frank and Sinner, Frank and Magnes, Christoph and Laun, Peter and Knauer, Heide and Ring, Julia and Schraml, Elisabeth and Carmona-Gutierrez, Didac and Fröhlich, Kai-Uwe and Fahrenkrog, Birthe and Eisenberg, Tobias and Schroeder, Sabrina and Heeren, Gino and Breitenbach, Michael and Fussi, Heike and Weiskopf, Daniela and Hartl, Regina and Criollo, Alfredo and Megalou, Evgenia and Deszcz, Luiza and Grubeck-Loebenstein, Beatrix and Büttner, Sabrina and Minois, Nadege and Ruckenstuhl, Christoph and Schauer, Alexandra and Antonacci, Lucia
Nature Cell Biology, ISSN 1465-7392, 11/2009, Volume 11, Issue 11, pp. 1305 - 1314
Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed... 
LIFE-SPAN EXTENSION | OXIDATIVE STRESS | CAENORHABDITIS-ELEGANS | BUDDING YEAST | REGULATES APOPTOSIS | GENE-EXPRESSION | NECROTIC CELL-DEATH | MURINE SKIN | SACCHAROMYCES-CEREVISIAE | CALORIE RESTRICTION | CELL BIOLOGY | Saccharomyces cerevisiae - physiology | Drosophila melanogaster - immunology | Drosophila melanogaster - physiology | Saccharomyces cerevisiae - immunology | Longevity - drug effects | Humans | Mice, Inbred C57BL | Male | Saccharomyces cerevisiae - drug effects | Caenorhabditis elegans - immunology | Autophagy - drug effects | Drosophila melanogaster - drug effects | Necrosis | Caenorhabditis elegans - physiology | Animals | Caenorhabditis elegans - drug effects | Spermidine - pharmacology | Adult | Female | Mice | Acetylation | HeLa Cells | Histones - metabolism | Hydrogen-Ion Concentration | Autophagy (Cytology) | Chromatin | Aging | Physiological aspects | Research | Polyamines | Health aspects
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8. Full Text The aging of the immune system
by Weiskopf, Daniela and Weinberger, Birgit and Grubeck‐Loebenstein, Beatrix
Transplant International, ISSN 0934-0874, 11/2009, Volume 22, Issue 11, pp. 1041 - 1050
Summary An age‐related decline in immune functions, referred to as immunosenescence, is partially responsible for the increased prevalence and severity of... 
innate immunity | adaptive immunity | aging | Aging | Innate immunity | Adaptive immunity | SURGERY | POLYMORPHONUCLEAR LEUKOCYTES | DENDRITIC CELLS | ELDERLY INDIVIDUALS | OLD-AGE | CYTOMEGALOVIRUS-INFECTION | PROINFLAMMATORY CYTOKINE PRODUCTION | CD8(+) T-CELLS | TRANSPLANTATION | ALLOGENEIC BONE-MARROW | HEMATOPOIETIC STEM-CELLS | Neutrophils - cytology | Lymphopoiesis | Disease Susceptibility | Dendritic Cells - immunology | Humans | Vaccination | Immune System - growth & development | Macrophages - cytology | Immunity, Innate | Infection - etiology | Lymphocyte Subsets - immunology | Aging - immunology | Lymphocyte Subsets - cytology | Hematopoietic Stem Cells - cytology | Aged, 80 and over | Antibody Formation | Aged | Dendritic Cells - cytology | Myelopoiesis | Immunity, Cellular | Macrophages - immunology | Immune system
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9. Full Text Human T Cell Response to Dengue Virus Infection
by Tian, Y and Grifoni, A and Sette, A and Weiskopf, D
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 09/2019, Volume 10
DENV is a major public health problem worldwide, thus underlining the overall significance of the proposed Program. The four dengue virus (DENV) serotypes... 
ORIGINAL ANTIGENIC SIN | CD4T cell | IMMUNOLOGY | dengue | LYMPHOCYTE CLONES | vaccine | TFH CELLS | HEMORRHAGIC-FEVER | PROTECTIVE ROLE | IMMUNE-RESPONSES | MOUSE MODEL | CD4(+) | T cell epitope | CD8T cell | ANTIBODY-RESPONSES | FOLLICULAR HELPER-CELLS | CD8 T cell | CD4 T cell
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10. Full Text HLA class I alleles are associated with peptide-binding repertoires of different size, affinity and immunogenicity
by Paul, Sinu and Weiskopf, Daniela and Angelo, Michael A and Sidney, John and Peters, Bjoern and Sette, Alessandro
Journal of Immunology, ISSN 0022-1767, 12/2013, Volume 191, Issue 12, pp. 5831 - 5839
Prediction of HLA binding affinity is widely used to identify candidate T cell epitopes, and an affinity of 500 nM is routinely used as a threshold for peptide... 
IMMUNODOMINANCE | T-CELL RESPONSES | DATABASE | MHC BINDING | VACCINIA-VIRUS | SUPERTYPES | ANTIGENIC PEPTIDES | NEURAL-NETWORK | IMMUNOLOGY | PREDICTIVE TOOLS | MOLECULES | HLA-A2 Antigen - genetics | HLA-A1 Antigen - genetics | HLA-B7 Antigen - immunology | Antigen Presentation | Dengue Virus - immunology | Peptide Fragments - immunology | Inhibitory Concentration 50 | Epitopes, T-Lymphocyte - immunology | HLA-A1 Antigen - metabolism | Immunization | Peptide Fragments - metabolism | HLA-A2 Antigen - immunology | HLA-B7 Antigen - genetics | Antigens, Viral - chemistry | Mice, Transgenic | HLA-B7 Antigen - metabolism | Antigens, Viral - immunology | Peptide Fragments - chemistry | Algorithms | Animals | Alleles | Protein Binding | Genes, MHC Class I | HLA-A1 Antigen - immunology | Mice | HLA-A2 Antigen - metabolism | Epitopes, T-Lymphocyte - metabolism
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11. Full Text Cytotoxic CD4 T Cells: Differentiation, Function, and Application to Dengue Virus Infection
by Tian, Yuan and Sette, Alessandro and Weiskopf, Daniela
Frontiers in immunology, ISSN 1664-3224, 2016, Volume 7, p. 531
Dengue virus (DENV) has spread through most tropical and subtropical areas of the world and represents a serious public health problem. The control of DENV... 
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