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Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0181585 - e0181585
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 05/2013, Volume 9, Issue 5, pp. 319 - 325
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2017, Volume 12, Issue 8, pp. e0177802 - e0177802
Triple negative breast cancers (TNBCs) have high recurrence and metastasis rates. Acquisition of a mesenchymal morphology and phenotype in addition to driving... 
EPITHELIAL-MESENCHYMAL TRANSITION | SHAPE | KINOME | MULTIDISCIPLINARY SCIENCES | GROWTH | EMT | EXPRESSION | PROGRESSION | Small Molecule Libraries - pharmacology | Epithelial Cells - drug effects | Humans | Mesoderm - drug effects | Small Molecule Libraries - therapeutic use | Epithelial Cells - pathology | Molecular Targeted Therapy | Triple Negative Breast Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Cell Movement - drug effects | Phenotype | Animals | Protein Kinase Inhibitors - therapeutic use | Cell Transdifferentiation - drug effects | Triple Negative Breast Neoplasms - pathology | Cell Line, Tumor | Mice | Protein Kinase Inhibitors - pharmacology | Mesoderm - pathology | Triple Negative Breast Neoplasms - enzymology | Drug Screening Assays, Antitumor | Prevention | Care and treatment | Enzyme inhibitors | Development and progression | Breast cancer | Genetic aspects | Metastasis | Health aspects | Phosphotransferases | Biotechnology | Target recognition | Transcription | Mesenchyme | Genomics | Cytology | Oncology | Kinases | Cell morphology | Metastases | Genotype & phenotype | Pathways | Growth factors | Hematology | Gene expression | Medical screening | Polymerase chain reaction | Medicine | Survival analysis | Inhibitors | Pharmacy | Cell lines | Stem cells | Breast | Target acquisition | Cell migration | Cancer | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2017, Volume 7, Issue 1, pp. 1 - 12
The human genome encodes two active Vaccinia-related protein kinases (VRK), VRK1 and VRK2. These proteins have been implicated in a number of cellular... 
IN-VITRO | DESIGN | PHOSPHORYLATION | STABILITY | DNA | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | SELECTIVITY | EXPRESSION | RATIONAL PROTEIN CRYSTALLIZATION | FAMILY | Genomes | DNA probes | Vaccinia | Tumors | Index Medicus
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 08/2019, Volume 15, Issue 8, pp. 822 - 822
Here, we report the fragment-based discovery of BI-9321, a potent, selective and cellular active antagonist of the NSD3-PWWP1 domain. The human NSD3 protein is... 
DESIGN | PROTEIN | ASSAY | CHROMATIN | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING | Cell proliferation | Myeloid leukemia | Leukemia | Lung cancer | Breast cancer | Myc protein | Gene expression | Domains | Organic chemistry | Lysine | Chromosome 8 | Breast | Acute myeloid leukemia | Viability | Binding sites
Journal Article
eLife, ISSN 2050-084X, 04/2018, Volume 7
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 9, pp. 4772 - 4778
We describe the design of a set of inhibitors to investigate the relationship between cyclin G associated kinase (GAK) and epidermal growth factor receptor... 
CHEMISTRY, MEDICINAL | MUTATIONS | 4-ANILINOQUINOLINES | EXPRESSION
Journal Article
Cancer Research, ISSN 0008-5472, 07/2016, Volume 76, Issue 14 Supplement, pp. 684 - 684
Journal Article
Journal Article
ChemMedChem, ISSN 1860-7179, 01/2018, Volume 13, Issue 1, pp. 48 - 66
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2019, Volume 62, Issue 5, pp. 2830 - 2836
We describe SGC-GAK-1 (11), a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK), together with a structurally related negative... 
MULTIPLE ROLES | REGULATOR | CHEMISTRY, MEDICINAL | INHIBITORS | IDENTIFICATION
Journal Article