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Science, ISSN 0036-8075, 3/2008, Volume 319, Issue 5868, pp. 1391 - 1394
Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The... 
Carotenoids | Virulence | Pigments | Squalene | Ligands | Reports | Biosynthesis | Infections | Diphosphates | Cholesterols | Staphylococcus aureus | TARGET | SQUALENE SYNTHASE INHIBITOR | MULTIDISCIPLINARY SCIENCES | Organothiophosphorus Compounds - therapeutic use | Virulence - drug effects | Polyisoprenyl Phosphates - chemistry | Sesquiterpenes - metabolism | Humans | Bacterial Proteins - chemistry | Molecular Sequence Data | Crystallography, X-Ray | Enzyme Inhibitors - chemical synthesis | Organothiophosphorus Compounds - pharmacology | Farnesyl-Diphosphate Farnesyltransferase - chemistry | Anti-Bacterial Agents - therapeutic use | Anti-Bacterial Agents - chemistry | Staphylococcal Infections - microbiology | Organothiophosphorus Compounds - chemical synthesis | Staphylococcus aureus - metabolism | Amino Acid Sequence | Bacterial Proteins - antagonists & inhibitors | Cell Line | Staphylococcal Infections - drug therapy | Sesquiterpenes - chemistry | Enzyme Inhibitors - metabolism | Organothiophosphorus Compounds - metabolism | Protein Structure, Secondary | Farnesyl-Diphosphate Farnesyltransferase - isolation & purification | Enzyme Inhibitors - pharmacology | Polyisoprenyl Phosphates - metabolism | Staphylococcus aureus - pathogenicity | Farnesyl-Diphosphate Farnesyltransferase - metabolism | Anti-Bacterial Agents - chemical synthesis | Animals | Farnesyl-Diphosphate Farnesyltransferase - antagonists & inhibitors | Xanthophylls - biosynthesis | Bacterial Proteins - metabolism | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Mice | Cholesterol - biosynthesis | Staphylococcus aureus - drug effects | Staphylococcus aureus - growth & development | Bacterial Proteins - isolation & purification | Prevention | Physiological aspects | Staphylococcus aureus infections | Anticholesteremic agents | Enzymes | Inhibitor drugs | Rodents | Bacteria | Biochemistry | Drug resistance | Cholesterol | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2010, Volume 107, Issue 50, pp. 21337 - 21342
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2007, Volume 104, Issue 24, pp. 10022 - 10027
Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS), resulting in decreased... 
Enzymes | Yeasts | Electronic structure | Molecular structure | Terpenoids | Diphosphonates | Ligands | Biosynthesis | Diphosphates | Binding sites | Undecaprenyl diphosphate synthase | Geranylgeranyl diphosphate synthase | X-ray structure | Cell wall | FARNESYL DIPHOSPHATE SYNTHASE | POTENTIAL ROUTE | INHIBITION | MECHANISM | ISOPRENOID BIOSYNTHESIS | STRUCTURAL BASIS | NITROGEN-CONTAINING BISPHOSPHONATES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | GERANYLGERANYL PYROPHOSPHATE SYNTHASE | DRUGS | Diphosphates - metabolism | Polyisoprenyl Phosphates - chemistry | Sesquiterpenes - metabolism | Models, Chemical | Stereoisomerism | Alkyl and Aryl Transferases - antagonists & inhibitors | Substrate Specificity | Crystallography, X-Ray | Isoenzymes - chemistry | Isoenzymes - metabolism | Transferases - metabolism | Farnesyltranstransferase - antagonists & inhibitors | Molecular Structure | Transferases - antagonists & inhibitors | Diterpenes - metabolism | Binding Sites | Dimerization | Diterpenes - chemistry | Alkyl and Aryl Transferases - chemistry | Sesquiterpenes - chemistry | Protein Structure, Secondary | Models, Molecular | Transferases - chemistry | Diphosphonates - metabolism | Polyisoprenyl Phosphates - metabolism | Farnesyltranstransferase - chemistry | Diphosphates - chemistry | Diphosphonates - chemistry | Hydrophobic and Hydrophilic Interactions | Saccharomyces cerevisiae - enzymology | Isoenzymes - antagonists & inhibitors | Usage | Research | X-ray spectroscopy | Plant cell walls | Guanosine triphosphatase | Biochemistry | Inhibitor drugs | Drug therapy | Index Medicus | Biological Sciences | undecaprenyl diphosphate synthase | x-ray structure | geranylgeranyl diphosphate synthase | cell wall
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2010, Volume 107, Issue 19, pp. 8617 - 8622
TcaR and IcaR are a weak and a strong negative regulator of transcription of the ica locus, respectively, and their presence prevents the... 
Molecules | Biofilms | Antibiotics | DNA | Operons | Dimers | Salicylates | Binding sites | Regulator genes | Crystal structure | Biofilm | Repressor | DNA binding | Multiple drug resistance | Transcription regulation | multiple drug resistance | transcription regulation | repressor | CRYSTAL-STRUCTURE | ICAADBC TRANSCRIPTION | MULTIDISCIPLINARY SCIENCES | ESCHERICHIA-COLI | INTERCELLULAR ADHESIN SYNTHESIS | OPERON EXPRESSION | biofilm | DNA-BINDING MECHANISM | MARR FAMILY | TRANSCRIPTIONAL REPRESSOR | BIOFILM FORMATION | ELECTRON-DENSITY | Apoproteins - chemistry | Staphylococcus epidermidis - physiology | Transcription, Genetic - drug effects | Staphylococcus epidermidis - drug effects | DNA, Bacterial - metabolism | Humans | Bacterial Proteins - chemistry | Biofilms - growth & development | Molecular Sequence Data | Crystallography, X-Ray | Salicylates - chemistry | Anti-Bacterial Agents - chemistry | Base Sequence | Protein Binding - drug effects | Electrophoretic Mobility Shift Assay | Operator Regions, Genetic | Repressor Proteins - metabolism | Biofilms - drug effects | Protein Structure, Secondary | Penicillin G - chemistry | Staphylococcus epidermidis - chemistry | Models, Molecular | Anti-Bacterial Agents - metabolism | Penicillin G - pharmacology | Staphylococcus epidermidis - genetics | Bacterial Proteins - metabolism | Ligands | Structural Homology, Protein | Penicillin G - metabolism | Drug resistance in microorganisms | Physiological aspects | Research | Microbial mats | Properties | DNA-ligand interactions | Staphylococcus | Staphylococcus infections | Effects | Comparative analysis | Deoxyribonucleic acid--DNA | Index Medicus | hexamers | Salicylic acid | Conserved sequence | Repressors | Transcription | Antibiotic resistance | Aminoglycoside antibiotics | Antimicrobial agents | Promoters | b-Lactam antibiotics | Biological Sciences
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, pp. e0120601 - e0120601
Journal Article
Frontiers in Microbiology, ISSN 1664-302X, 12/2017, Volume 8, pp. 2441 - 2441
Journal Article
American Journal of Surgery, The, ISSN 0002-9610, 2013, Volume 206, Issue 5, pp. 771 - 777
Journal Article