X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (65) 65
humans (60) 60
cancer (22) 22
animals (21) 21
biochemistry & molecular biology (20) 20
biochemical research methods (19) 19
cell line, tumor (19) 19
antineoplastic agents - pharmacology (18) 18
cell biology (16) 16
oncology (16) 16
3111 biomedicine (13) 13
research (13) 13
cells (12) 12
gene expression (12) 12
identification (12) 12
proteins (12) 12
sensitivity (12) 12
kinases (11) 11
mice (11) 11
algorithms (10) 10
article (10) 10
biotechnology & applied microbiology (10) 10
drug discovery (10) 10
inhibition (10) 10
mathematical & computational biology (10) 10
breast-cancer (9) 9
cell line (9) 9
chemotherapy (9) 9
discovery (9) 9
expression (9) 9
inhibitors (9) 9
phosphorylation (9) 9
protein kinase inhibitors - pharmacology (9) 9
resistance (9) 9
3122 cancers (8) 8
activation (8) 8
antineoplastic agents - therapeutic use (8) 8
breast cancer (8) 8
female (8) 8
gene expression profiling (8) 8
guanine nucleotide exchange factors - metabolism (8) 8
mutation (8) 8
protein binding (8) 8
rhoa gtp-binding protein - metabolism (8) 8
analysis (7) 7
cell lines (7) 7
chemistry (7) 7
leukemia (7) 7
male (7) 7
models (7) 7
models, biological (7) 7
multidisciplinary sciences (7) 7
pharmacology (7) 7
pharmacology & pharmacy (7) 7
resource (7) 7
signal transduction (7) 7
transfection (7) 7
biology (6) 6
cell survival - drug effects (6) 6
cells, cultured (6) 6
drugs (6) 6
gene (6) 6
high-throughput screening assays (6) 6
machine learning (6) 6
medicine (6) 6
neoplasms - drug therapy (6) 6
pathway (6) 6
patients (6) 6
software (6) 6
actin stress fibers (5) 5
acyclic or carbocyclic compounds (5) 5
aged (5) 5
apoptosis (5) 5
cancer cells (5) 5
cdc42 (5) 5
computer applications (5) 5
cytotoxicity (5) 5
drug resistance, neoplasm - genetics (5) 5
drug synergism (5) 5
drug therapy (5) 5
genetic aspects (5) 5
genomics (5) 5
growth (5) 5
gtpase-activating proteins - metabolism (5) 5
heterocyclic compounds (5) 5
landscape (5) 5
metallurgy (5) 5
neoplasms - genetics (5) 5
organic chemistry (5) 5
predictions (5) 5
protein (5) 5
rats (5) 5
rna, small interfering - genetics (5) 5
signal transduction - drug effects (5) 5
small molecule libraries - pharmacology (5) 5
transcription (5) 5
113 computer and information sciences (4) 4
3t3 cells (4) 4
acute myeloid-leukemia (4) 4
amino acid sequence (4) 4
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7541, pp. 102 - 105
The BCR-ABL1 fusion gene is a driver oncogene in chronic myeloid leukaemia and 30-50% of cases of adult acute lymphoblastic leukaemia(1). Introduction of ABL1... 
CELLS | PONATINIB | MECHANISM | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | RESISTANCE | FOLLOW-UP | PATIENTS RECEIVING IMATINIB | BCR-ABL INHIBITOR | CHRONIC MYELOID-LEUKEMIA | T315I MUTANT | Proto-Oncogene Proteins c-abl - antagonists & inhibitors | Humans | Molecular Conformation | Imidazoles - chemistry | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Crystallography, X-Ray | Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors | Protein Kinase Inhibitors - chemistry | Angiogenesis Inhibitors - therapeutic use | Imidazoles - therapeutic use | Phosphorylation - drug effects | Fusion Proteins, bcr-abl - chemistry | Cell Line | Proto-Oncogene Proteins c-abl - genetics | Indazoles - chemistry | Crystallization | Proto-Oncogene Proteins c-abl - chemistry | Angiogenesis Inhibitors - pharmacology | Models, Molecular | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Imidazoles - pharmacology | Drug Repositioning | Indazoles - pharmacology | Drug Resistance, Neoplasm - genetics | Fusion Proteins, bcr-abl - genetics | Vascular Endothelial Growth Factor Receptor-2 - chemistry | Protein Kinase Inhibitors - therapeutic use | Fusion Proteins, bcr-abl - antagonists & inhibitors | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism | Protein Binding | Proto-Oncogene Proteins c-abl - metabolism | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Kidney Neoplasms - drug therapy | Fusion Proteins, bcr-abl - metabolism | Indazoles - therapeutic use | Angiogenesis Inhibitors - chemistry | Drug Screening Assays, Antitumor | Axitinib | Genetic aspects | Research | Gene mutations | Drug resistance | Analysis | Phosphorylation | Inhibitor drugs | Leukemia | Bone marrow | Mutation | Kinases | Drug dosages | Patients | Index Medicus
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 05/2012, Volume 366, Issue 20, pp. 1905 - 1913
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 2015, Volume 6, p. 181
Many biological or chemical agents when combined interact with each other and produce a synergistic response that cannot be predicted based on the single agent... 
Definition of synergy | Consensus agreement | Drug combinations | Interaction barometer | Bliss and Loewe models | definition of synergy | EFFICACY | consensus agreement | ENZYMATIC-HYDROLYSIS | ANTAGONISM | MODEL | drug combinations | IN-VITRO | THERAPY | interaction barometer | PHARMACOLOGY & PHARMACY | ADDITIVITY | DRUG-COMBINATION | Concensus agreement | Drug Combinations
Journal Article
by Costello, James C and Heiser, Laura M and Georgii, Elisabeth and Gönen, Mehmet and Menden, Michael P and Wang, Nicholas J and Bansal, Mukesh and Ammad-Ud-Din, Muhammad and Hintsanen, Petteri and Khan, Suleiman A and Mpindi, John-Patrick and Kallioniemi, Olli and Honkela, Antti and Aittokallio, Tero and Wennerberg, Krister and Collins, James J and Gallahan, Dan and Singer, Dinah and Saez-Rodriguez, Julio and Kaski, Samuel and Gray, Joe W and Stolovitzky, Gustavo and Abbuehl, Jean-Paul and Allen, Jeffrey and Altman, Russ B and Balcome, Shawn and Battle, Alexis and Bender, Andreas and Berger, Bonnie and Bernard, Jonathan and Bhattacharjee, Madhuchhanda and Bhuvaneshwar, Krithika and Bieberich, Andrew A and Boehm, Fred and Califano, Andrea and Chan, Christina and Chen, Beibei and Chen, Ting-Huei and Choi, Jaejoon and Coelho, Luis Pedro and Cokelaer, Thomas and Collins, James C and Creighton, Chad J and Cui, Jike and Dampier, Will and Davisson, V. Jo and De Baets, Bernard and Deshpande, Raamesh and DiCamillo, Barbara and Dundar, Murat and Duren, Zhana and Ertel, Adam and Fan, Haoyang and Fang, Hongbin and Gauba, Robinder and Gottlieb, Assaf and Grau, Michael and Gusev, Yuriy and Ha, Min Jin and Han, Leng and Harris, Michael and Henderson, Nicholas and Hejase, Hussein A and Homicsko, Krisztian and Hou, Jack P and Hwang, Woochang and IJzerman, Adriaan P and Karacali, Bilge and Keles, Sunduz and Kendziorski, Christina and Kim, Junho and Kim, Min and Kim, Youngchul and Knowles, David A and Koller, Daphne and Lee, Junehawk and Lee, Jae K and Lenselink, Eelke B and Li, Biao and Li, Bin and Li, Jun and Liang, Han and Ma, Jian and Madhavan, Subha and Mooney, Sean and Myers, Chad L and Newton, Michael A and Overington, John P and Pal, Ranadip and Peng, Jian and Pestell, Richard and Prill, Robert J and Qiu, Peng and Rajwa, Bartek and Sadanandam, Anguraj and Sambo, Francesco and Shin, Hyunjin and Song, Jiuzhou and Song, Lei and Sridhar, Arvind and ... and NCI DREAM Community
Nature Biotechnology, ISSN 1087-0156, 12/2014, Volume 32, Issue 12, pp. 1202 - 1212
Journal Article
Computational and Structural Biotechnology Journal, ISSN 2001-0370, 2015, Volume 13, Issue C, pp. 504 - 513
Rational design of multi-targeted drug combinations is a promising strategy to tackle the drug resistance problem for many complex disorders. A drug... 
High-throughput screening | Drug combination scoring | Interaction landscape | Dose–response matrix | Dose-response matrix | INHIBITION | COMBINATION THERAPY | BIOCHEMISTRY & MOLECULAR BIOLOGY | IBRUTINIB | CANCER
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 1888, pp. 205 - 217
High-throughput drug sensitivity testing provides a powerful phenotypic profiling approach to identify effective drug candidates for individual cell lines or... 
Drug polypharmacology | Target addictions | Drug–target interactions | Precision oncology | Drug sensitivity testing | Target deconvolution | Drug combinations
Journal Article
Cancer Research, ISSN 0008-5472, 05/2018, Volume 78, Issue 9, pp. 2407 - 2418
The molecular pathways that drive cancer progression and treatment resistance are highly redundant and variable between individual patients with the same... 
NETWORK | ONCOLOGY | SYNERGY | EX-VIVO PLATFORM | SENSITIVITY | INHIBITOR | MEDICINE | IDENTIFICATION | CLINICAL-RESPONSE | CANCER | REVEALS | Bcl-2 protein | Leukemia | Customizing | Crosstalk | Lymphocytes T | Drug screening | Patients | Molecular chains | Case studies | Learning algorithms | Pathways | Tacrolimus | Rewiring | Computer applications | Machine learning | Predictions | Combinatorial analysis | Cancer
Journal Article
PLoS Computational Biology, ISSN 1553-734X, 08/2017, Volume 13, Issue 8, p. e1005678
Journal Article
Journal of Cell Science, ISSN 0021-9533, 03/2004, Volume 117, Issue 8, pp. 1301 - 1312
The Rho-family proteins make up a major branch of the Ras superfamily of small GTPases. To date, 22 human genes encoding at least 25 proteins have been...