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by Arce Vargas, Frederick and Furness, Andrew J.S and Solomon, Isabelle and Joshi, Kroopa and Mekkaoui, Leila and Lesko, Marta H and Miranda Rota, Enrique and Dahan, Rony and Georgiou, Andrew and Sledzinska, Anna and Ben Aissa, Assma and Franz, Dafne and Werner Sunderland, Mariana and Wong, Yien Ning Sophia and Henry, Jake Y and O’Brien, Tim and Nicol, David and Challacombe, Ben and Beers, Stephen A and Spain, Lavinia and Wotherspoon, Andrew and Francis, Nicholas and Smith, Amy and Smith, Sean and Smith, Myles and Smith, Elaine and Strauss, Dirk and Hayes, Andrew and Soultati, Aspasia and Stares, Mark and Lynch, Joanna and Fotiadis, Nicos and Fernando, Archana and Hazell, Steve and Chandra, Ashish and Pickering, Lisa and Rudman, Sarah and Chowdhury, Simon and Swanton, Charles and Jamal-Hanjani, Mariam and Veeriah, Selvaraju and Shafi, Seema and Czyzewska-Khan, Justyna and Johnson, Benjamin and Johnson, Diana and Laycock, Joanne and Bosshard-Carter, Leticia and Goh, Gerald and Rosenthal, Rachel and Gorman, Pat and Murugaesu, Nirupa and Hynds, Robert E and Wilson, Gareth and Birkbak, Nicolai J and Watkins, Thomas B.K and McGranahan, Nicholas and Horswell, Stuart and Mitter, Richard and Escudero, Mickael and Stewart, Aengus and Van Loo, Peter and Rowan, Andrew and Xu, Hang and Turajlic, Samra and Hiley, Crispin and Abbosh, Christopher and Goldman, Jacki and Stone, Richard Kevin and Denner, Tamara and Matthews, Nik and Matthews, Sue and Elgar, Greg and Ward, Sophia and Biggs, Jennifer and Costa, Marta and Begum, Sharmin and Phillimore, Ben and Chambers, Tim and Nye, Emma and Graca, Sofia and Al Bakir, Maise and Hartley, John A and Lowe, Helen L and Herrero, Javier and Lawrence, David and Hayward, Martin and Panagiotopoulos, Nikolaos and Kolvekar, Shyam and Falzon, Mary and Borg, Elaine and Simeon, Celia and Hector, Gemma and Aranda, Marie and Novelli, Marco and Oukrif, Dahmane and Janes, Sam M and Thakrar, Ricky and Forster, Martin and Ahmad, Tanya and Lee, Siow Ming and ... and Melanoma TRACERx Consortium and Renal TRACERx Consortium and Lung TRACERx Consortium
Immunity, ISSN 1074-7613, 04/2017, Volume 46, Issue 4, pp. 577 - 586
CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as a target for cancer immunotherapy. However, anti-CD25 antibodies... 
regulatory T cells | tumor immunotherapy | anti-CD25 | Treg depletion | inhibitory Fc receptor | CD25 | tumor microenvironment | Fc gamma receptors | anti-PD-1 | EFFECTOR | RESPONSES | LYMPHOCYTE-ASSOCIATED ANTIGEN-4 | CANCER-PATIENTS | MELANOMA | MONOCLONAL-ANTIBODY | ANTI-CTLA-4 ANTIBODIES | IMMUNOLOGY | ANTITUMOR-ACTIVITY | COMBINATION | GAMMA-RS | T-Lymphocytes, Regulatory - metabolism | Immunotherapy - methods | Humans | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Lymphocyte Depletion | Receptors, IgG - metabolism | T-Lymphocytes, Regulatory - immunology | Neoplasms - therapy | Flow Cytometry | Immunoglobulin Fc Fragments - immunology | Antibodies, Monoclonal - immunology | Interleukin-2 Receptor alpha Subunit - immunology | Kaplan-Meier Estimate | Programmed Cell Death 1 Receptor - metabolism | Receptors, IgG - immunology | Protein Binding - immunology | Animals | Neoplasms - immunology | K562 Cells | Cell Line, Tumor | Mice | Antibodies, Monoclonal - metabolism | Programmed Cell Death 1 Receptor - immunology | Neoplasms - pathology | Viral antibodies | Cell death | Analysis | Immunotherapy | Antibodies | T cells | Cancer | Fc receptors | Beer | Immunoglobulins | Lymphatic system | Immune response | Cytokines | Melanoma | Light emitting diodes | Lymphocytes T | Anticancer properties | Depletion | Lymphocytes | Tumors | Immune system | Report
Journal Article
by Arce Vargas, Frederick and Furness, Andrew J.S and Litchfield, Kevin and Joshi, Kroopa and Rosenthal, Rachel and Ghorani, Ehsan and Solomon, Isabelle and Lesko, Marta H and Ruef, Nora and Roddie, Claire and Henry, Jake Y and Spain, Lavinia and Ben Aissa, Assma and Georgiou, Andrew and Wong, Yien Ning Sophia and Smith, Myles and Smith, Elaine and Smith, Sean and Strauss, Dirk and Hayes, Andrew and Nicol, David and O'Brien, Tim and Mårtensson, Linda and Ljungars, Anne and Teige, Ingrid and Frendéus, Björn and Harrington, Kevin and Melcher, Alan and Wotherspoon, Andrew and Francis, Nicholas and Challacombe, Ben and Fernando, Archana and Hazell, Steve and Chandra, Ashish and Pickering, Lisa and Lynch, Joanna and Rudman, Sarah and Chowdhury, Simon and Harrison-Phipps, Karen and Varia, Mary and Horsfield, Catherine and Polson, Alexander and Stamp, Gordon and O'Donnell, Marie and Drake, William and Hill, Jennifer and Hill, Peter and Hrouda, David and Mayer, Eric and Olsburgh, Jonathan and Kooiman, Gordon and O'Connor, Kevin and Stewart, Grant and Stewart, Aengus and Aitchison, Michael and Tran, Maxine and Fotiadis, Nicos and Verma, Hema and Lopez, Jose and Lester, Jason and Morgan, Fiona and Kornaszewska, Malgorzata and Attanoos, Richard and Adams, Haydn and Davies, Helen and Fennell, Dean and Shaw, Emily and Shaw, Jacqui and Shaw, Penny and Le Quesne, John and Nakas, Apostolos and Rathinam, Sridhar and Monteiro, William and Marshall, Hilary and Nelson, Louise and Bennett, Jonathan and Riley, Joan and Primrose, Lindsay and Martinson, Luke and Anand, Girija and Khan, Sajid and Nicolson, Marianne and Kerr, Keith and Kerr, Amy and Palmer, Shirley and Remmen, Hardy and Miller, Joy and Buchan, Keith and Chetty, Mahendran and Gomersall, Lesley and Lock, Sara and Naidu, Babu and Langman, Gerald and Trotter, Simon and Bellamy, Mary and Bancroft, Hollie and Kadiri, Salma and Webb, Joanne and Middleton, Gary and Djearaman, Madava and ... and TRACERx Renal and TRACERx Melanoma and TRACERx Lung Consortia and TRACERx Lung consortia
Cancer Cell, ISSN 1535-6108, 04/2018, Volume 33, Issue 4, pp. 649 - 663.e4
Journal Article
by Rosenthal, Rachel and Cadieux, Elizabeth Larose and Salgado, Roberto and Bakir, Maise Al and Moore, David A and Hiley, Crispin T and Lund, Tom and Tanić, Miljana and Reading, James L and Joshi, Kroopa and Henry, Jake Y and Ghorani, Ehsan and Wilson, Gareth A and Birkbak, Nicolai J and Jamal-Hanjani, Mariam and Veeriah, Selvaraju and Szallasi, Zoltan and Loi, Sherene and Hellmann, Matthew D and Feber, Andrew and Chain, Benny and Herrero, Javier and Quezada, Sergio A and Demeulemeester, Jonas and Van Loo, Peter and Beck, Stephan and McGranahan, Nicholas and Swanton, Charles and Swanton, Charles and Jamal-Hanjani, Mariam and Veeriah, Selvaraju and Czyzewska-Khan, Justyna and Johnson, Diana and Laycock, Joanne and Rosenthal, Rachel and Gorman, Pat and Hynds, Robert E and Wilson, Gareth and Birkbak, Nicolai J and Watkins, Thomas B. K and McGranahan, Nicholas and Escudero, Mickael and Stewart, Aengus and Van Loo, Peter and Rowan, Andrew and Hiley, Crispin T and Abbosh, Christopher and Goldman, Jacki and Stone, Richard Kevin and Denner, Tamara and Ward, Sophia and Nye, Emma and Joshi, Kroopa and Ben Aissa, Assma and Wong, Yien Ning Sophia and Georgiou, Andy and Quezada, Sergio and Hartley, John A and Lowe, Helen L and Herrero, Javier and Lawrence, David and Hayward, Martin and Panagiotopoulos, Nikolaos and Falzon, Mary and Borg, Elaine and Marafioti, Teresa and Janes, Sam M and Forster, Martin and Ahmad, Tanya and Lee, Siow Ming and Papadatos-Pastos, Dionysis and Carnell, Dawn and Mendes, Ruheena and George, Jeremy and Ahmed, Asia and Taylor, Magali and Choudhary, Junaid and Summers, Yvonne and Califano, Raffaele and Taylor, Paul and Shah, Rajesh and Krysiak, Piotr and Rammohan, Kendadai and Fontaine, Eustace and Booton, Richard and Evison, Matthew and Crosbie, Phil and Moss, Stuart and Joseph, Leena and Bishop, Paul and Quinn, Anne Marie and Doran, Helen and Leek, Angela and Harrison, Phil and Moore, Katrina and Waddington, Rachael and Novasio, Juliette and Blackhall, Fiona and Rogan, Jane and Smith, Elaine and ... and TRACERx Consortium and TRACERx consortium and The TRACERx consortium
Nature, ISSN 0028-0836, 03/2019, Volume 567, Issue 7749, pp. 479 - 485
Journal Article
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 11/2018, Volume 215, Issue 11, pp. 2748 - 2759
Despite the advances in cancer immunotherapy, only a fraction of patients with bladder cancer exhibit responses to checkpoint blockade, highlighting a need to... 
MEDICINE, RESEARCH & EXPERIMENTAL | CTLA-4 BLOCKADE | MULTICENTER | THERAPY | PEMBROLIZUMAB | INFILTRATING LYMPHOCYTES | PD-1 BLOCKADE | METASTATIC UROTHELIAL CARCINOMA | IMMUNOLOGY | SINGLE-ARM | CANCER | CD8(+) T-CELLS | 314 | 307
Journal Article
by Thomas, Hannah S and Weiser, Thomas G and Drake, Thomas M and Knight, Stephen R and Fairfield, Cameron and Ademuyiwa, Adesoji O and Aguilera, Maria Lorena and Alexander, Philip and Al‐Saqqa, Sara W and Borda‐Luque, Giuliano and Costas‐Chavarri, Ainhoa and Ntirenganya, Faustin and Fitzgerald, J Edward and Fergusson, Stuart J and Glasbey, James and Ingabire, J.C. Allen and Ismaïl, Lawani and Salem, Hosni Khairy and Kojo, Anyomih Theophilus Teddy and Lapitan, Marie Carmela and Lilford, Richard and Mihaljevic, Andre L and Morton, Dion and Mutabazi, Alphonse Zeta and Nepogodiev, Dmitri and Adisa, Adewale O and Ots, Riinu and Pata, Francesco and Pinkney, Thomas and Poškus, Tomas and Qureshi, Ahmad Uzair and Medina, Antonio Ramos‐De and Rayne, Sarah and Shaw, Catherine A and Shu, Sebastian and Spence, Richard and Smart, Neil and Tabiri, Stephen and Bhangu, Aneel and Harrison, Ewen M and Harrison, Ewen M and Verjee, Azmina and Runigamugabo, Emmy and Ademuyiwa, Adesoji O and Adisa, Adewale O and Aguilera, Maria Lorena and Altamini, Afnan and Alexander, Philip and Al‐Saqqa, Sara W and Borda‐Luque, Giuliano and Cornick, Jen and Costas‐Chavarri, Ainhoa and Drake, Thomas M and Fergusson, Stuart J and Fitzgerald, J Edward and Glasbey, James and Ingabire, J.C. Allen and Ismaïl, Lawani and Jaffry, Zahra and Salem, Hosni Khairy and Khatri, Chetan and Kirby, Andrew and Kojo, Anyomih Theophilus Teddy and Lapitan, Marie Carmela and Lilford, Richard and Mihaljevic, Andre L and Mohan, Midhun and Morton, Dion and Mutabazi, Alphonse Zeta and Nepogodiev, Dmitri and Ntirenganya, Faustin and Ots, Riinu and Pata, Francesco and Pinkney, Thomas and Poškus, Tomas and Qureshi, Ahmad Uzair and Medina, Antonio Ramos‐De and Rayne, Sarah and Recinos, Gustavo and Søreide, Kjetil and Shaw, Catherine A and Shu, Sebastian and Spence, Richard and Smart, Neil and Tabiri, Stephen and Harrison, Ewen M and Bhangu, Aneel and Khatri, Chetan and Gobin, Neel and Freitas, Ana Vega and Hall, Nigel and Kim, Sung‐Hee and Negida, Ahmed and Khairy, Hosni and Jaffry, Zahra and Chapman, Stephen J and Arnaud, Alexis P and Tabiri, Stephen and Recinos, Gustavo and Manipal, Cutting Edge and ... and GlobalSurg Collaborative
British Journal of Surgery, ISSN 0007-1323, 01/2019, Volume 106, Issue 2, pp. e103 - e112
Journal Article