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PLoS Medicine, ISSN 1549-1277, 2006, Volume 3, Issue 7, pp. 1140 - 1151
The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid... 
Recombinant Fusion Proteins - adverse effects | Humans | Myeloproliferative Disorders - pathology | Mutation, Missense | Primary Myelofibrosis - pathology | Receptors, Cytokine - physiology | Janus Kinases - physiology | Bone Marrow Transplantation | Hematopoiesis - physiology | Myeloid Cells - drug effects | Transcription, Genetic | Colony-Forming Units Assay | Phosphorylation - drug effects | mRNA Cleavage and Polyadenylation Factors - genetics | Hematologic Neoplasms - physiopathology | Disease Models, Animal | Cells, Cultured - drug effects | Bone Marrow Cells - pathology | Hematopoiesis - genetics | Signal Transduction - genetics | Thrombocytosis - etiology | Sequence Analysis, DNA | Cell Division - drug effects | mRNA Cleavage and Polyadenylation Factors - physiology | Receptor, Platelet-Derived Growth Factor alpha - physiology | Hematologic Neoplasms - drug therapy | Mice | Mice, Inbred BALB C | Myeloid Cells - pathology | Protein Processing, Post-Translational - genetics | Myeloproliferative Disorders - genetics | Oncogene Proteins, Fusion - physiology | STAT Transcription Factors - physiology | Protein Processing, Post-Translational - drug effects | Cells, Cultured - pathology | Bone Marrow Cells - drug effects | Spleen - pathology | Thrombocytosis - pathology | Gene Expression Regulation | Janus Kinases - antagonists & inhibitors | Point Mutation | Megakaryocytes - pathology | Primary Myelofibrosis - genetics | Animals | Oncogene Proteins, Fusion - genetics | Protein Kinase Inhibitors - therapeutic use | Receptor, Platelet-Derived Growth Factor alpha - genetics | Myeloproliferative Disorders - etiology | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | Genetic Vectors | Megakaryocytes - drug effects | Cytokines - pharmacology | Amino Acid Substitution | Thrombocytosis - genetics | Genetic aspects | Myelofibrosis | Research | Hematology | Gene Therapy | Genomics | Genetics | Oncology | Cancer Biology | Hematology (including Blood Transfusion)
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2005, Volume 102, Issue 52, pp. 18962 - 18967
Journal Article
Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program, ISSN 1520-4391, 2006, pp. 233 - 510
The identification of JAK2V617F mutations in polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis (MF) represents an important advance in... 
Animals | Janus Kinases - genetics | Signal Transduction | Humans | Janus Kinase 2 - metabolism | Janus Kinase 2 - genetics | STAT Transcription Factors - metabolism | Myeloproliferative Disorders - etiology | Janus Kinases - metabolism | Mice
Journal Article
Journal of the American College of Surgeons, ISSN 1072-7515, 10/2018, Volume 227, Issue 4, pp. S208 - S208
Journal Article
Journal of the American College of Surgeons, ISSN 1072-7515, 10/2019, Volume 229, Issue 4, pp. e215 - e216
Journal Article
Cell, ISSN 0092-8674, 07/2016, Volume 166, Issue 2, pp. 451 - 467
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 584 - 596
We report a knockin mouse myeloproliferative neoplasm (MPN) model resembling human polycythemia vera (PV). The MPN is serially transplantable and we... 
CELLCYCLE | POLYCYTHEMIA-VERA | ACTIVATING MUTATION | ONCOLOGY | IN-VIVO | TYROSINE KINASE JAK2 | CONDITIONAL EXPRESSION | MYELODYSPLASTIC-SYNDROMES | ESSENTIAL THROMBOCYTHEMIA | VERA-LIKE DISEASE | CHRONIC MYELOMONOCYTIC LEUKEMIA | CHRONIC MYELOID-LEUKEMIA | Erythropoietin - pharmacology | Gene Expression - genetics | Cell Count | Humans | Hematocrit | Hematopoietic Stem Cells - pathology | Polycythemia Vera - genetics | Gene Expression Profiling | Myeloproliferative Disorders - pathology | Spleen - drug effects | Antigens, CD - metabolism | Bone Marrow Transplantation | Megakaryocyte-Erythroid Progenitor Cells - transplantation | Polycythemia Vera - pathology | Janus Kinase 2 - antagonists & inhibitors | Disease Models, Animal | Megakaryocyte-Erythroid Progenitor Cells - metabolism | Hematopoietic Stem Cell Transplantation | Mice, Transgenic | Myeloid Progenitor Cells - pathology | Megakaryocyte-Erythroid Progenitor Cells - drug effects | Sulfonamides - pharmacology | Megakaryocyte Progenitor Cells - metabolism | Erythroid Precursor Cells - pathology | Survival Analysis | Erythroid Precursor Cells - metabolism | Mice | Megakaryocyte Progenitor Cells - pathology | Myeloproliferative Disorders - genetics | Pyrrolidines - pharmacology | Pyrrolidines - therapeutic use | Cell Differentiation - genetics | Janus Kinase 2 - metabolism | Bone Marrow Cells - drug effects | Spleen - pathology | Hematopoietic Stem Cells - drug effects | Myeloid Progenitor Cells - metabolism | Mice, Inbred C57BL | Janus Kinase 2 - genetics | Hematopoietic Stem Cells - metabolism | Myeloproliferative Disorders - drug therapy | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Bone Marrow - pathology | Heterozygote | Protein Kinase Inhibitors - pharmacology | Amino Acid Substitution | Megakaryocyte-Erythroid Progenitor Cells - pathology | Physiological aspects | Medical colleges | Analysis | Hematopoietic stem cells | Tumors
Journal Article
Journal of Neuroscience Methods, ISSN 0165-0270, 02/2019, Volume 313, pp. 1 - 5
Animal models of optic nerve injury are often used to study central nervous system (CNS) degeneration and regeneration, and targeting the optic nerve is a... 
Optic nerve injections | Transcranial injection | Intraorbital | Optic foramen | STEM-CELLS | REGENERATION | INJURED CNS | BIOCHEMICAL RESEARCH METHODS | CELL THERAPY | MODEL | NEUROSCIENCES | NEUROPROTECTION | REPAIR | RETINA
Journal Article
Cancer Cell, ISSN 1535-6108, 2005, Volume 7, Issue 4, pp. 387 - 397
Journal Article
Annals of surgery, ISSN 0003-4932, 12/2018, p. 1
To investigate the effects of local doxycycline administration on skin scarring. Skin scarring represents a major source of morbidity for surgical patients.... 
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 05/2017, Volume 114, Issue 18, p. 4757
Fibrotic diseases are not well-understood. They represent a number of different diseases that are characterized by the development of severe organ fibrosis... 
Flow cytometry | Transcription factors | Pathways | Rodents | Transcription activation | Fibroblasts | Inhibition | Pancreas | Scleroderma | Vascular endothelial growth factor | Hypertension | Myelofibrosis | Kidneys | Lung diseases | Activator protein 1 | Organs | c-Jun protein | Cells | Pulmonary artery | 1-Phosphatidylinositol 3-kinase | Diseases | Cytometry | Pulmonary fibrosis | Fibrosis | Mice | Cancer | Kidney transplantation
Journal Article
Journal of the American College of Surgeons, ISSN 1072-7515, 10/2017, Volume 225, Issue 4, pp. S162 - S163
Journal Article
Cell, ISSN 0092-8674, 03/2015, Volume 160, Issue 6, pp. 1196 - 1208
Journal Article