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Bioinformatics, ISSN 1367-4803, 09/2018, Volume 34, Issue 17, pp. i997 - i1004
Abstract Motivation Signal-transduction networks are often aberrated in cancer cells, and new anti-cancer drugs that specifically target oncogenes involved in... 
COLON-CANCER | BRAF(V600E) INHIBITION | PREDICT | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | ACQUIRED-RESISTANCE | Eccb 2018 | European Conference on Computational Biology Proceedings
Journal Article
BIOINFORMATICS, ISSN 1367-4803, 07/2019, Volume 35, Issue 14, pp. I510 - I519
Motivation Cell lines and patient-derived xenografts (PDXs) have been used extensively to understand the molecular underpinnings of cancer. While core... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | XENOGRAFTS
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 02/2017, Volume 114, Issue 8, p. 1316
  The DNA-binding sites of estrogen receptor [alpha] (ER[alpha]) show great plasticity under the control of hormones and endocrine therapy. Tamoxifen is a... 
Morphology | Estrogen | Endocrine therapy | Breast cancer | Binding sites | Risk factors | Deoxyribonucleic acid--DNA
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2016, Volume 6
Mining large datasets using machine learning approaches often leads to models that are hard to interpret and not amenable to the generation of hypotheses that... 
Journal Article
Nature Protocols, ISSN 1754-2189, 04/2015, Volume 10, Issue 4, pp. 644 - 644
Journal Article
ISSN 1756-994X, 2018
Background Mutations in KRAS are frequent in human cancer, yet effective targeted therapeutics for these cancers are still lacking. Attempts to drug the MEK... 
Colon (Anatomy)--Cancer | Genomics | Molecular biology | Mutation (Biology)
Journal Article
Cancer Research, ISSN 0008-5472, 12/2002, Volume 62, Issue 23, pp. 7110 - 7117
In similar to70% of the families with a high frequency of early-onset breast and/or ovarian cancer, BRCA1 or BRCA2 germline mutations cannot be identified with... 
ONCOLOGY | CANCER FAMILIES | GERMLINE MUTATIONS | PATTERNS | RISK | PROGRESSION | FEATURES | REVEALS | Breast Neoplasms - classification | Nucleic Acid Hybridization | Reproducibility of Results | Breast Neoplasms - genetics | Breast Neoplasms - pathology | Humans | Chromosome Aberrations | Germ-Line Mutation | Female | Genes, BRCA1 | Index Medicus
Journal Article
Chinese journal of cancer, ISSN 1000-467X, 09/2015, Volume 34, Issue 10, p. 439
A central challenge in cancer research is to create models that bridge the gap between the molecular level on which interventions can be designed and the... 
Neoplastic Processes | Mutation | Signal Transduction | Genomics | Humans | Neoplasms
Journal Article
Plos one, ISSN 1932-6203, 02/2014, Volume 9, Issue 2
Introduction: Despite continuous efforts, not a single predictor of breast cancer chemotherapy resistance has made it into the clinic yet. However, it has... 
Journal Article
Breast Cancer Research, ISSN 1465-542X, 10/2015, Volume 17
Introduction: In triple negative breast cancers (TNBC) the initial response to chemotherapy is often favorable, but relapse and chemotherapy resistance... 
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Breast cancer research : BCR, ISSN 1465-5411, 2015, Volume 17, Issue 1
INTRODUCTION: In triple negative breast cancers (TNBC) the initial response to chemotherapy is often favorable, but relapse and chemotherapy resistance... 
Journal Article
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