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Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Cell, ISSN 0092-8674, 07/2016, Volume 166, Issue 3, pp. 740 - 754
Journal Article
Journal Article
by Biankin, Andrew V and Waddell, Nicola and Kassahn, Karin S and Gingras, Marie-Claude and Muthuswamy, Lakshmi B and Johns, Amber L and Miller, David K and Wilson, Peter J and Patch, Ann-Marie and Wu, Jianmin and Chang, David K and Cowley, Mark J and Gardiner, Brooke B and Song, Sarah and Harliwong, Ivon and Idrisoglu, Senel and Nourse, Craig and Nourbakhsh, Ehsan and Manning, Suzanne and Wani, Shivangi and Gongora, Milena and Pajic, Marina and Scarlett, Christopher J and Gill, Anthony J and Pinho, Andreia V and Rooman, Ilse and Anderson, Matthew and Holmes, Oliver and Leonard, Conrad and Taylor, Darrin and Wood, Scott and Xu, Qinying and Nones, Katia and Fink, J. Lynn and Christ, Angelika and Bruxner, Tim and Cloonan, Nicole and Kolle, Gabriel and Newell, Felicity and Pinese, Mark and Mead, R. Scott and Humphris, Jeremy L and Kaplan, Warren and Jones, Marc D and Colvin, Emily K and Nagrial, Adnan M and Humphrey, Emily S and Chou, Angela and Chin, Venessa T and Chantrill, Lorraine A and Mawson, Amanda and Samra, Jaswinder S and Kench, James G and Lovell, Jessica A and Daly, Roger J and Merrett, Neil D and Toon, Christopher and Epari, Krishna and Nguyen, Nam Q and Barbour, Andrew and Zeps, Nikolajs and Kakkar, Nipun and Zhao, Fengmei and Wu, Yuan Qing and Wang, Min and Muzny, Donna M and Fisher, William E and Brunicardi, F. Charles and Hodges, Sally E and Reid, Jeffrey G and Drummond, Jennifer and Chang, Kyle and Han, Yi and Lewis, Lora R and Dinh, Huyen and Buhay, Christian J and Beck, Timothy and Timms, Lee and Sam, Michelle and Begley, Kimberly and Brown, Andrew and Pai, Deepa and Panchal, Ami and Buchner, Nicholas and De Borja, Richard and Denroche, Robert E and Yung, Christina K and Serra, Stefano and Onetto, Nicole and Mukhopadhyay, Debabrata and Tsao, Ming-Sound and Shaw, Patricia A and Petersen, Gloria M and Gallinger, Steven and Hruban, Ralph H and Maitra, Anirban and Iacobuzio-Donahue, Christine A and Schulick, Richard D and Wolfgang, Christopher L and Morgan, Richard A and ... and Australian Pancreatic Canc Genome and Australian Pancreatic Cancer Genome Initiative
Nature, ISSN 0028-0836, 11/2012, Volume 491, Issue 7424, pp. 399 - 405
Journal Article
Bioinformatics, ISSN 1367-4803, 2016, Volume 32, Issue 17, pp. i413 - i420
Journal Article
Bioinformatics, ISSN 1367-4803, 12/2018, Volume 34, Issue 23, pp. 4079 - 4086
Abstract Motivation Intracellular signalling is realized by complex signalling networks, which are almost impossible to understand without network models,... 
ACTIVATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CANCER | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | ERK
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7670, pp. 106 - 110
Journal Article
BIOINFORMATICS, ISSN 1367-4803, 07/2019, Volume 35, Issue 14, pp. I510 - I519
Motivation Cell lines and patient-derived xenografts (PDXs) have been used extensively to understand the molecular underpinnings of cancer. While core... 
BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | XENOGRAFTS
Journal Article
Cell Reports, ISSN 2211-1247, 10/2014, Volume 7, Issue 1, pp. 86 - 93
Journal Article