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The New England Journal of Medicine, ISSN 0028-4793, 02/2016, Volume 374, Issue 6, pp. 511 - 522
Journal Article
Blood, ISSN 0006-4971, 11/2018, Volume 132, Issue Supplement 1, pp. 3750 - 3750
Abstract INTRODUCTION Immune thrombotic thrombocytopenic purpura (iTTP) is an acute, multisystem thrombotic microangiopathy mediated by immunoglobulin G (IgG)... 
Journal Article
Blood, ISSN 0006-4971, 12/2016, Volume 128, Issue 22, pp. 1365 - 1365
Abstract Background: Acute immune-mediated Thrombotic Thrombocytopenic Purpura (TTP) is a life-threatening disorder caused by acquired antibodies to the Von... 
Journal Article
Journal Article
Expert Opinion on Orphan Drugs, ISSN 2167-8707, 10/2018, Volume 6, Issue 10, pp. 577 - 584
Introduction: Thrombotic thrombocytopenic purpura (TTP) is an acute life-threatening condition, associated with a low platelet count, hemolytic anemia,... 
Caplacizumab | anti ADAMTS 13 auto antibodies | immune TTP | ADAMTS 13 | thrombocytopenia | SAFETY | MICROANGIOPATHIES REFERENCE CENTER | HEMOLYTIC UREMIC SYNDROME | IGG ANTIBODIES | VON-WILLEBRAND-FACTOR | PLASMA-EXCHANGE | PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY | ADAMTS13 | RITUXIMAB | PHARMACOLOGY & PHARMACY | ANTI-ADAMTS13 AUTOANTIBODIES
Journal Article
Journal Article
Journal Article
BLOOD, ISSN 0006-4971, 04/2019, Volume 133, Issue 15, pp. 1644 - 1651
Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra-rare thrombomi-croangiopathy caused by an inherited deficiency of a disintegrin and... 
IN-VITRO | MANAGEMENT | CLEAVING PROTEASE ADAMTS13 | IGG ANTIBODIES | MUTATIONS | HEMATOLOGY | VON-WILLEBRAND-FACTOR | FRESH-FROZEN PLASMA | UPSHAW-SCHULMAN SYNDROME | DEFICIENCY | REGISTRY
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 02/2016, Volume 374, Issue 6, p. 511
The study examines the potential of caplacizumab, an anti-von Willebrand factor humanized single-variable-domain immunoglobulin, in the treatment of acquired... 
Thrombocytopenic purpura | Complications and side effects | Care and treatment | Immunoglobulins | Placebos | Dosage and administration | Research
Journal Article
Blood, ISSN 0006-4971, 11/2013, Volume 122, Issue 21, pp. 1073 - 1073
Abstract Increasing understanding of abnormalities within the alternative complement pathway in atypical hemolytic uremic syndrome (aHUS) is changing the way... 
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2014, Volume 73, Issue Suppl 1, pp. A81 - A82
Background and Aims Thrombotic Thrombocytopenic Purpura (TTP) is due to deficiency or dysfunction of the metalloproteinase ADAMTS13, which cleaves von... 
Journal Article
by Wong, Hanna and Wong, Danny J.N and Wong, Rachel and Wong, D.J.N and Wong, Gabriela and Harris, Meredith and Harris, Stephen and Harris, Catherine and Harris, Rebecca and Harris, Steve K and Harris, S.K and Moonesinghe, S. Ramani and Moonesinghe, S.R and Bedford, James and Boney, Oliver and Chazapis, Maria and Drake, Sharon and Drake, Jeremy and Farmer, Nicola and Farmer, Laura and Gilhooly, David and Goodwin, Naomi and Goodwin, James and Lourtie, Jose and Wagstaff, Duncan and Wagstaff, Adrian and Grocott, Jeanette and Grocott, Mike and Sneyd, Robert and Batchelor, Anna and Brett, Stephen and Brett, Michael and Plowright, Catherine and Shrestha, Suman and Shawyer, Richard and Ahmed, Dabeeruddeen and Ahmed, Raheel and Ahmed, Mohamed and Ahmed, Sameer and Ahmed, Muneeba and Ahmed, Sajjad and Ahmed, Shafi and Ahmed, Zaid and Khondoker, Mizan and Nathanson, Mike and Cripps, Paul and Research & Audit Federation of Trainees (RAFT) and Anaesthetic Audit and Research Matrix of Yorkshire (AARMY) and Intensive Care & Anaesthesia Research Network of North East Trainees (INCARNNET) and Merseyside Anaesthetic Group for Improving Quality (MAGIQ) and Midlands East Research by Critical Care and Anaesthetic Trainees (MERCAT) and North West Research and Audit Group (NWRAG) and Oxford Critical Care Anaesthetic Research Enterprise (OxCCARE) and Pan-London Peri-operative Audit & Research Network (PLAN) and Scottish East Quality Improvement & Research Academy (SEQuoIA) and SESSA Quality Improvement and Research Network (SQUARES) and Severn Trainees Anaesthetic Research (STAR) and South West Anaesthetic Research Matrix (SWARM) and South Yorkshire Hospitals Audit and Research Collaboration (SHARC) and Southcoast Peri-operative Audit and Research Collaboration (SPARC) and Welsh Anaesthetic Audit Research & Engagement Network (WAAREN) and West Midlands Trainee Research Anaesthesia & Intensive Care Network (WMTRAIN) and Rawat, Shilpa and Sathe, Sonia and Campbell, Matthew and Campbell, Bridget and Campbell, Debbie and Campbell, Alison and Campbell, Marta and Campbell, Euan and Campbell, Rachel and Campbell, Brian and Anandarajah, Janakan and Ball, Nicola and Bandara, Lalindra and Barnes, Dennis and Barnes, Elizabeth and Barnes, Veronica and Chapman, Susie and Chapman, Andy and Chapman, Roddy and Chapman, Catherine and Connor, Lynda and Cook, Amanda and Cook, Prof Tim and Cook, Angela and Ebejer, Amanda and Evans, Sandra and Evans, Alison and Evans, Samantha and Evans, Peter and Evans, Hywel and Evans, Gail and Evans, James and Evans, Jackie and Evans, Lucy and Evans, Elizabeth and Gallagher, Maire and Gallagher, Kate and Gallagher, Susan and ... and SNAP-2 EPICCS Collaborators and NHS Shetland and University Hospital of North Midlands NHS Trust and Gateshead Health NHS Foundation Trust and St George's Healthcare NHS Trust and Cardiff and Vale University Health Board and South Eastern Health and Social Care Trust and Frimley Health NHS Foundation Trust and Cwm Taf University Health Board and Trainee Research Networks and Colchester Hospital University NHS Foundation Trust and Barts Health NHS Trust and Oxford University Hospitals NHS Foundation Trust and Royal Bournemouth & Christchurch Hospitals NHS Foundation Trust and Royal Cornwall Hospitals NHS Trust and Isle of Wight NHS Trust and County Durham and Darlington NHS Foundation Trust and Sheffield Teaching Hospitals NHS Foundation Trust and University Hospitals of Morecambe Bay NHS Foundation Trust and Northern Health and Social Care Trust and Surrey and Sussex Healthcare NHS Trust and Chelsea and Westminster Hospital NHS Foundation Trust and Croydon Health Services NHS Trust and Airedale NHS Foundation Trust and Weston Area Health NHS Trust and Northern Lincolnshire and Goole Hospitals NHS Foundation Trust and Royal Wolverhampton Hospitals NHS Trust and Abertawe Bro Morgannwg University Health Board and Northumbria Healthcare NHS Foundation Trust and Brighton and Sussex University Hospitals NHS Trust and NHS Lothian and Lewisham and Greenwich NHS Trust and Homerton University Hospital NHS Foundation Trust and East Kent Hospitals University NHS Foundation Trust and Milton Keynes University Hospital NHS Foundation Trust and Great Western Hospitals NHS Foundation Trust and Lancashire Teaching Hospitals NHS Foundation Trust and City Hospitals Sunderland NHS Foundation Trust and Northampton General Hospital NHS Trust and North Tees and Hartlepool NHS Trust and Hywel Dda Health Board and Royal Devon and Exeter NHS Foundation Trust and Dorset County Hospital NHS Foundation Trust and Dudley Group NHS Foundation Trust and Liverpool Women's NHS Foundation Trust and Bedford Hospital NHS Trust and Royal National Orthopaedic Hospital NHS Trust and Medway NHS Foundation Trust and University Hospitals Birmingham NHS Foundation Trust and Gloucestershire Hospitals NHS Foundation Trust and Pennine Acute NHS Trust and Northern Devon Healthcare NHS Trust and Betsi Cadwaladr University Health Board and Epsom and St Helier University Hospitals NHS Trust and Ipswich Hospital NHS Trust and Chesterfield Royal Hospital NHS Foundation Trust and NHS Greater Glasgow & Clyde and Western Sussex Hospitals NHS Foundation Trust and NHS Lanarkshire and Blackpool Teaching Hospitals NHS Foundation Trust and Central Manchester University Hospitals NHS Foundation Trust and Buckinghamshire Healthcare NHS Trust and Hillingdon Hospitals NHS Foundation Trust and Salford Royal NHS Foundation Trust and Tameside Hospital NHS Foundation Trust and Walsall Healthcare NHS Trust and York Teaching Hospital NHS Foundation Trust and Burton Hospitals NHS Foundation Trust and Mid Essex Hospital Services NHS Trust and Birmingham Women's NHS Foundation Trust and Dartford and Gravesham NHS Trust and Kingston Hospital NHS Foundation Trust and NHS Tayside and Salisbury NHS Foundation Trust and Study Steering Group and Royal Berkshire NHS Foundation Trust and Mid Yorkshire Hospitals NHS Trust and Robert Jones and Agnes Hunt Orthopaedic Hospital Foundation Trust and East Sussex Healthcare NHS Trust and King's College Hospital NHS Foundation Trust and Aintree University Hospitals NHS Foundation Trust and NHS Highland and West Herts Hospitals NHS Trust and Worcestershire Acute Hospitals NHS Trust and Guy's and St Thomas' NHS Foundation Trust and Hull and East Yorkshire Hospitals NHS Trust and Shrewsbury and Telford Hospital NHS Trust and Hampshire Hospitals NHS Foundation Trust and Torbay and South Devon NHS Foundation Trust and SNAP-2: EPICCS collaborators and Derby Hospitals NHS Foundation Trust and North West Anglia NHS Foundation Trust and Plymouth Hospitals NHS Trust and Wye Valley NHS Trust and Leeds Teaching Hospitals NHS Trust and NHS Fife and South Tees Hospitals NHS Foundation Trust and University Hospitals Coventry and Warwickshire NHS Trust and Christie Hospital NHS Foundation Trust and Royal Free London NHS Foundation Trust and Wrightington, Wigan and Leigh NHS Foundation Trust and United Lincolnshire Hospitals NHS Trust and Bradford Teaching Hospitals NHS Foundation Trust and Newcastle upon Tyne Hospitals NHS Foundation Trust and Queen Elizabeth Hospital NHS Foundation Trust and Royal Marsden NHS Foundation Trust and Whittington Hospital NHS Trust and Portsmouth Hospitals NHS Trust and University College London Hospitals NHS Foundation Trust and University Hospitals of Leicester NHS Trust and Ashford & St Peters NHS Foundation Trust and Royal United Hospitals Bath NHS Trust and Royal Surrey County Hospital NHS Foundation Trust and East and North Hertfordshire NHS Trust and Kettering General Hospital NHS Foundation Trust and Rotherham NHS Foundation Trust and St Helens and Knowsley Teaching Hospitals NHS Trust and University Hospital Southampton NHS Foundation Trust and Health Services Research Centre, National Institute of Academic Anaesthesia and East Lancashire Hospitals NHS Trust and Warrington & Halton Hospitals NHS Foundation Trust and Calderdale and Huddersfield NHS Foundation Trust and Countess of Chester NHS Foundation Trust and University Hospitals Bristol NHS Foundation Trust and Harrogate and District NHS Foundation Trust and NHS Scotland Special Board and South Tyneside NHS Foundation Trust and Barnsley Hospital NHS Foundation Trust and Sandwell and West Birmingham Hospitals NHS Trust and North Cumbria University Hospitals NHS Trust and Aneurin Bevan Health Board and Barking, Havering and Redbridge University Hospitals NHS Trust and Bolton Hospital NHS Foundation Trust and Luton and Dunstable University Hospital NHS Foundation Trust and NHS Ayrshire & Arran and Queen Victoria Hospital NHS Foundation Trust and University Hospital of South Manchester NHS Foundation Trust and Wirral University Teaching Hospital NHS Foundation Trust and James Paget University Hospitals NHS Foundation Trust and North Bristol NHS Trust and Western Health and Social Care Trust and NHS Dumfries & Galloway and Imperial College Healthcare NHS Trust and South Warwickshire NHS Foundation Trust and Princess Alexandra Hospital NHS Trust and Poole Hospital NHS Foundation Trust and North Middlesex University Hospital NHS Trust and Belfast Health and Social Care Trust and Mid Cheshire Hospitals NHS Foundation Trust and Royal Orthopaedic Hospital NHS Foundation Trust and Taunton and Somerset NHS Foundation Trust and Yeovil District Hospital NHS Foundation Trust and Cambridge University Hospitals NHS Foundation Trust and Heart Of England NHS Foundation Trust and Net Solving Limited and Papworth Hospital NHS Foundation Trust and Basildon and Thurrock University Hospitals NHS Foundation Trust and Norfolk and Norwich University Hospitals NHS Foundation Trust and Southport and Ormskirk Hospital NHS Trust and Stockport NHS Foundation Trust and Royal Liverpool and Broadgreen University Hospitals NHS Trust and Nottingham University Hospitals NHS Trust and West Suffolk NHS Foundation Trust and Doncaster and Bassetlaw Hospitals NHS Foundation Trust
British Journal of Anaesthesia, ISSN 0007-0912, 10/2018, Volume 121, Issue 4, pp. 730 - 738
Cancellation of planned surgery impacts substantially on patients and health systems. This study describes the incidence and reasons for cancellation of... 
operating room management | Health Services Research | medical resource utilisation | surgery | NEED | VALIDATION | ANESTHESIOLOGY | CRITICAL-CARE | CANCELLATIONS | ELECTIVE SURGERY
Journal Article