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gastroenterology and hepatology (21) 21
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protein-serine-threonine kinases - genetics (18) 18
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PLoS ONE, ISSN 1932-6203, 09/2013, Volume 8, Issue 9, pp. e73940 - e73940
Stem cell pluripotency, angiogenesis and epithelial-mesenchymal transition (EMT) have been shown to be significantly upregulated in pancreatic ductal... 
EPITHELIAL-MESENCHYMAL TRANSITION | GROWTH-FACTOR RECEPTOR | INTESTINAL EPITHELIUM | REPROGRAMMING FACTOR LIN28 | DUCTAL ADENOCARCINOMA | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | DOWN-REGULATION | TUMOR-GROWTH | EGF RECEPTOR | FEEDBACK LOOP | Pancreatic Neoplasms - metabolism | RNA Processing, Post-Transcriptional | Humans | Pancreatic Neoplasms - pathology | Gene Expression Regulation, Neoplastic | Gene Silencing | Protein-Serine-Threonine Kinases - genetics | MicroRNAs - metabolism | Pancreatic Neoplasms - genetics | Intracellular Signaling Peptides and Proteins - metabolism | DNA-Binding Proteins - genetics | Epithelial-Mesenchymal Transition - genetics | DNA-Binding Proteins - metabolism | Xenograft Model Antitumor Assays | Animals | Neoplastic Stem Cells - metabolism | Cell Line, Tumor | Neovascularization, Pathologic - genetics | Tumor Burden - genetics | Mice | MicroRNAs - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | MicroRNA | Analysis | Pancreatic cancer | Stem cells | Development and progression | DNA binding proteins | Metastasis | Vascular endothelial growth factor | Health aspects | Adenocarcinoma | Post-transcription | Health sciences | Animal models | Transcription factors | Mesenchyme | Veterans | Oct-4 protein | Gene regulation | c-Myc protein | Homeostasis | Myc protein | Kinases | K-Ras protein | Metastases | Angiogenesis | Allografts | KLF4 protein | Intestine | Xenografts | MiRNA | siRNA | Gene expression | Ablation | Medicine | Ribonucleic acids | MicroRNAs | Tumor suppressor genes | Poly(lactide-co-glycolide) | Snail protein | Polyps | Pluripotency | Tumors | Cancer | Index Medicus
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 351, Issue 1, pp. 151 - 161
Highlights • Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with a poor survival rate. • Doublecortin-like kinase1 (DCLK1) is upregulated in... 
Hematology, Oncology and Palliative Medicine | Epithelial–mesenchymal transition | Pluripotency factors | Angiogenic factors | XMD8-92 | DCLK1 | Epithelial-mesenchymal transition | INITIATING CELLS | DOUBLECORTIN | STATISTICS | TARGETING EZH2 | IDENTIFICATION | DCAMKL-1 | CANCER STEM-CELLS | ONCOLOGY | NANOPARTICLE-BASED DELIVERY | DEPENDENT MECHANISM | EXPRESSION | RNA-Binding Proteins - genetics | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Gene Expression - drug effects | ras Proteins - metabolism | Epithelial-Mesenchymal Transition - drug effects | MicroRNAs - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | RNA, Messenger - metabolism | Pancreatic Neoplasms - drug therapy | Antineoplastic Agents - pharmacology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Proto-Oncogene Proteins - metabolism | Benzodiazepinones - pharmacology | Pancreatic Neoplasms - pathology | RNA, Messenger - genetics | Pancreatic Neoplasms - enzymology | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Receptor, Notch1 - metabolism | Mice, SCID | Carcinoma, Pancreatic Ductal - pathology | Proto-Oncogene Proteins c-myc - metabolism | Carcinoma, Pancreatic Ductal - enzymology | Xenograft Model Antitumor Assays | Carcinoma, Pancreatic Ductal - drug therapy | Animals | Tumor Burden - drug effects | Cell Line, Tumor | Mice, Inbred NOD | Cell Proliferation - drug effects | Mice | MicroRNAs - genetics | Proto-Oncogene Proteins c-myc - genetics | Receptor, Notch1 - genetics | RNA-Binding Proteins - metabolism | Care and treatment | Pancreatic cancer | Cancer | Cell growth | Kinases | Pancreas | Stem cells | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0134212 - e0134212
Journal Article
Journal Article
2018
Although their existence was once controversial, cancer stem cells (CSCs) are now widely accepted as an important source of metastasis and drug resistance.... 
Dissertation
Molecular Cancer, ISSN 1476-4598, 05/2014, Volume 13, Issue 1, pp. 103 - 103
Background: Doublecortin-like kinase 1 (DCLK1) is emerging as a tumor specific stem cell marker in colorectal and pancreatic cancer. Previous in vitro and in... 
LRRK2-IN-1 | Kinase inhibitor | Small-molecule inhibitor | DCLK1 | Tumor stem cell | MARKER | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | DCAMKL-1 | ONCOLOGY | GENE-EXPRESSION | STEM-CELL | TUMOR-GROWTH | HOMOLOGY | Humans | Isoenzymes - chemistry | Pyrimidines - chemistry | Protein Kinase Inhibitors - chemistry | Laminin | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lentivirus - genetics | Antineoplastic Agents - pharmacology | Binding Sites | Intracellular Signaling Peptides and Proteins - genetics | Cell Survival - drug effects | Gene Expression | Proteoglycans | Isoenzymes - genetics | Benzodiazepinones - pharmacology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Pyrimidines - pharmacology | Antineoplastic Agents - chemistry | Benzodiazepinones - chemistry | Molecular Dynamics Simulation | Cell Movement - drug effects | Diffusion Chambers, Culture | Intracellular Signaling Peptides and Proteins - chemistry | Collagen | Cell Line, Tumor | Protein Binding | Cell Proliferation - drug effects | Molecular Docking Simulation | Protein Kinase Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - chemistry | Genetic Vectors | Drug Combinations | Isoenzymes - antagonists & inhibitors | Care and treatment | Gastrointestinal diseases | Oncology, Experimental | Pancreatic cancer | Research | Health aspects | Cancer | Health sciences | Phosphorylation | Colleges & universities | Kinases | Gene expression | Proteins | Rodents | Tumorigenesis | Colon | Pancreas | Binding sites | Tumors | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2015, Volume 10, Issue 2, pp. e0118933 - e0118933
Doublecortin-like kinase 1 (DCLK1) is a putative pancreatic stem cell marker and is upregulated in pancreatic cancer, colorectal cancer, and many other solid... 
EPITHELIAL-MESENCHYMAL TRANSITION | MARKER | REGENERATION | MULTIDISCIPLINARY SCIENCES | DISEASE | GROWTH | MECHANISMS | IDENTIFICATION | CANCER STEM-CELLS | Epithelial Cells - metabolism | Stromal Cells - pathology | Humans | Middle Aged | Neoplastic Cells, Circulating - metabolism | Male | Case-Control Studies | Carcinoma, Pancreatic Ductal - genetics | Protein-Serine-Threonine Kinases - blood | Adult | Female | CA-19-9 Antigen - blood | Intracellular Signaling Peptides and Proteins - genetics | Pancreatic Neoplasms - blood | Gene Expression | Pancreatic Neoplasms - pathology | Stromal Cells - metabolism | Protein-Serine-Threonine Kinases - genetics | Epithelial Cells - pathology | Pancreatic Neoplasms - genetics | Intracellular Signaling Peptides and Proteins - blood | Carcinoma, Pancreatic Ductal - pathology | Carcinoma, Pancreatic Ductal - blood | Animals | Aged | Mice | Neoplasm Staging | Adenocarcinoma | Analysis | Pancreatic cancer | Stem cells | Colorectal cancer | Diagnosis | Metastasis | Enzyme-linked immunosorbent assay | Health sciences | Animal models | Mesenchyme | Veterans | Epithelial cells | Colorectal carcinoma | Brain cancer | Stem cell transplantation | Staining | Biochemistry | Kinases | Tissues | Cancer therapies | Western blotting | Metastases | Proteins | Intestine | Surgery | Gastroenterology | Doublecortin protein | Tumorigenesis | Internal medicine | Tumor cells | Radiation therapy | Gene expression | Patients | Medicine | Serum levels | Pathology | Chemotherapy | Stromal cells | Medical prognosis | Diagnostic systems | Solid tumors | Molecular biology | Tumors | Cancer | Index Medicus
Journal Article
International Journal of Cancer, ISSN 0020-7136, 09/2018, Volume 143, Issue 5, pp. 1162 - 1175
Renal cell carcinoma (RCC) is a common and devastating disease characterized by a hypoxic microenvironment, epithelial‐mesenchymal transition and potent... 
renal cancer | cancer stem cell | monoclonal antibody therapy | DCLK1 | resistance | GENE SET | BIOMARKER | TUMOR | EPITHELIAL-MESENCHYMAL TRANSITION | ONCOLOGY | IMMUNOTHERAPY | POOR-PROGNOSIS | SUNITINIB | CARCINOMA | EXPRESSION | DOUBLECORTIN-LIKE KINASE | RNA, Small Interfering - genetics | Kidney Neoplasms - genetics | Cell Proliferation | Prognosis | Alternative Splicing | Follow-Up Studies | Neoplastic Stem Cells - drug effects | Humans | Carcinoma, Renal Cell - genetics | Drug Resistance, Neoplasm | Male | Neoplastic Stem Cells - metabolism | Cell Transformation, Neoplastic - genetics | Epithelial-Mesenchymal Transition | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Tumor Cells, Cultured | Carcinoma, Renal Cell - drug therapy | Intracellular Signaling Peptides and Proteins - genetics | Carcinoma, Renal Cell - pathology | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Survival Rate | Xenograft Model Antitumor Assays | Animals | Mice, Nude | Kidney Neoplasms - pathology | Biomarkers, Tumor - genetics | Mice | Cell Transformation, Neoplastic - drug effects | Cell Transformation, Neoplastic - pathology | Kidney Neoplasms - drug therapy | Apoptosis | Cell Movement | Immunohistochemistry | Tyrosine | Oncology, Experimental | Stem cells | Monoclonal antibodies | Development and progression | Transplantation | Research | Drug resistance | Drug approval | Cancer | TOR protein | Alternative splicing | Flow cytometry | Therapy | Mesenchyme | Syngeneic grafts | Xenotransplantation | Chemoresistance | Aldehyde dehydrogenase | Allografts | Xenografts | Doublecortin protein | Protein-tyrosine kinase receptors | Tumorigenesis | Bioinformatics | Protein-tyrosine kinase | Cell survival | Tumor cells | Markers | Gastrointestinal tract | siRNA | Survival | Kidney cancer | Hypoxia | Clear cell-type renal cell carcinoma | Tumors | Index Medicus
Journal Article
Scientific Reports, ISSN 2045-2322, 11/2016, Volume 6, Issue 1, pp. 37667 - 37667
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, pp. e0135561 - e0135561
Gastrointestinal (GI) mucosal damage is a devastating adverse effect of radiation therapy. We have recently reported that expression of Dclk1, a Tuft cell and... 
IRRADIATION | MOUSE JEJUNUM | EPITHELIUM | MULTIDISCIPLINARY SCIENCES | IN-VIVO | GROWTH | MICE | TUFT CELLS | IDENTIFICATION | MUSASHI-1 | KAPPA-B ACTIVITY | Whole-Body Irradiation | Radiation-Protective Agents - administration & dosage | Gastric Mucosa - metabolism | Stem Cells - metabolism | Mucositis - prevention & control | Dietary Supplements - analysis | Radiation Injuries, Experimental - diet therapy | Mucositis - pathology | Radiation Injuries, Experimental - prevention & control | Radiation-Protective Agents - pharmacology | Female | Protein-Serine-Threonine Kinases - metabolism | Mucositis - diet therapy | Cell Survival - drug effects | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Stem Cells - radiation effects | Gastric Mucosa - cytology | Radiation Injuries, Experimental - pathology | Gene Expression Regulation - drug effects | Pectins - administration & dosage | Pectins - pharmacology | Animals | Mucositis - etiology | Survival Analysis | Stem Cells - drug effects | Mice | Ionizing radiation | Pectin | Stem cells | Drinking water | Health sciences | Veterans | Mucosa | Stem cell transplantation | Infections | Kinases | Small intestine | Cancer therapies | Anticancer properties | Msi1 protein | Clonal deletion | Rodents | Gastroenterology | Deletion | Radiation injuries | Physiology | Drug dosages | Mucositis | Cell survival | Radiation therapy | Survival | Medicine | Regeneration | Diet | MicroRNAs | Laboratory animals | Radiation damage | Tumors | Cancer | Apoptosis | Index Medicus
Journal Article
Cancer Research, ISSN 0008-5472, 07/2018, Volume 78, Issue 13 Supplement, pp. 3611 - 3611
Journal Article
Journal Article