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1. Full Text Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
by Soler Artigas, María and Loth, Daan W and Wain, Louise V and Gharib, Sina A and Obeidat, Ma'en and Tang, Wenbo and Zhai, Guangju and Zhao, Jing Hua and Smith, Albert Vernon and Huffman, Jennifer E and Albrecht, Eva and Jackson, Catherine M and Evans, David M and Cadby, Gemma and Fornage, Myriam and Manichaikul, Ani and Lopez, Lorna M and Johnson, Toby and Alich, Melinda C and Aspelund, Thor and Barroso, Inês and Campbell, Harry and Cassano, Patricia A and Couper, David J and Eiriksdottir, Gudny and Franceschini, Nora and Garcia, Melissa and Gieger, Christian and Gislason, Gauti Kjartan and Grkovic, Ivica and Hammond, Christopher J and Hancock, Dana B and Harris, Tamara B and Ramasamy, Adaikalavan and Heckbert, Susan R and Heliövaara, Markku and Homuth, Georg and Hysi, Pirro G and James, Alan L and Jankovic, Stipan and Joubert, Bonnie R and Karrasch, Stefan and Klopp, Norman and Koch, Beate and Kritchevsky, Stephen B and Launer, Lenore J and Postma, Dirkje S and Vonk, Judith M and Wijmenga, Cisca and Boezen, Henika and GIANT Consortium and Int Lung Canc Consortium and International Lung Cancer Consortium and GIANT consortium and The International Lung Cancer Consortium and Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Institute of Medicine, School of Public Health and Community Medicine and Sahlgrenska Academy
Nature genetics, ISSN 1061-4036, 11/2011, Volume 43, Issue 11, pp. 1082 - 1090
GENETIC-VARIATION | POPULATION | OBSTRUCTIVE PULMONARY-DISEASE | METAANALYSIS | PROTEIN | POLYMORPHISMS | VARIANTS | RISK | EXPRESSION | UMCG Approved | BLOOD-PRESSURE | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | Biological and medical sciences | Genetics of eukaryotes. Biological and molecular evolution | Genome-Wide Association Study | Humans | European Continental Ancestry Group | Pulmonary Disease, Chronic Obstructive - physiopathology | Respiratory Function Tests | Child | Pulmonary Disease, Chronic Obstructive - genetics | Studies | Airway management | Genealogy | Heart attacks | Lungs | Smooth muscle | Genomes | Muscular system | Meta-analysis | Index Medicus | Medicinsk genetik | Medical Genetics | Lungmedicin och allergi | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Respiratory Medicine and Allergy | Public Health, Global Health, Social Medicine and Epidemiology
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2. Full Text Blood Pressure Loci Identified with a Gene-Centric Array
by Johnson, Toby and Gaunt, Tom R and Newhouse, Stephen J and Padmanabhan, Sandosh and Tomaszewski, Maciej and Kumari, Meena and Morris, Richard W and Tzoulaki, Ioanna and O'Brien, Eoin T and Poulter, Neil R and Sever, Peter and Shields, Denis C and Thom, Simon and Wannamethee, Sasiwarang G and Whincup, Peter H and Brown, Morris J and Connell, John M and Dobson, Richard J and Howard, Philip J and Mein, Charles A and Onipinla, Abiodun and Shaw-Hawkins, Sue and Zhang, Yun and Smith, George Davey and Day, Ian N.M and Lawlor, Debbie A and Goodall, Alison H and Fowkes, F. Gerald and Abecasis, Gonçalo R and Elliott, Paul and Gateva, Vesela and Braund, Peter S and Burton, Paul R and Nelson, Christopher P and Tobin, Martin D and van der Harst, Pim and Glorioso, Nicola and Neuvrith, Hani and Salvi, Erika and Staessen, Jan A and Stucchi, Andrea and Devos, Nabila and Jeunemaitre, Xavier and Plouin, Pierre-François and Tichet, Jean and Juhanson, Peeter and Org, Elin and Putku, Margus and Sõber, Siim and Veldre, Gudrun and Viigimaa, Margus and Levinsson, Anna and Rosengren, Annika and Thelle, Dag S and Hastie, Claire E and Hedner, Thomas and Lee, Wai K and Melander, Olle and Wahlstrand, Björn and Hardy, Rebecca and Wong, Andrew and Cooper, Jackie A and Palmen, Jutta and Chen, Li and Stewart, Alexandre F.R and Wells, George A and Westra, Harm-Jan and Wolfs, Marcel G.M and Clarke, Robert and Franzosi, Maria Grazia and Goel, Anuj and Hamsten, Anders and Lathrop, Mark and Peden, John F and Seedorf, Udo and Watkins, Hugh and Ouwehand, Willem H and Sambrook, Jennifer and Stephens, Jonathan and Casas, Juan-Pablo and Drenos, Fotios and Holmes, Michael V and Kivimaki, Mika and Shah, Sonia and Shah, Tina and Talmud, Philippa J and Whittaker, John and Wallace, Chris and Delles, Christian and Laan, Maris and Kuh, Diana and Humphries, Steve E and Nyberg, Fredrik and Cusi, Daniele and Roberts, Robert and Newton-Cheh, Christopher and Franke, Lude and Stanton, Alice V and Dominiczak, Anna F and Farrall, Martin and ... and The Global BPgen Consortium and The Cardiogenics Consortium and Global BPgen Consortium and Cardiogenics Consortium and Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa and Institute of Medicine and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin and Institute of Medicine, School of Public Health and Community Medicine and Sahlgrenska Academy and Sahlgrenska akademin and Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin and Institute of Medicine, Department of Emergeny and Cardiovascular Medicine and Institute of Medicine, Department of Internal Medicine and Institutionen för medicin
American journal of human genetics, ISSN 0002-9297, 12/2011, Volume 89, Issue 6, pp. 688 - 700
COMMON VARIANTS | POPULATION | QUANTITATIVE-TRAIT LOCI | LINKAGE DISEQUILIBRIUM | METAANALYSIS | ANGIOTENSINOGEN | CARDIOVASCULAR-DISEASE | SUSCEPTIBILITY LOCI | ESSENTIAL-HYPERTENSION | UMCG Approved | GENOME-WIDE ASSOCIATION | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Fundamental and applied biological sciences. Psychology | General aspects. Genetic counseling | Medical genetics | Biological and medical sciences | Molecular and cellular biology | Genetics of eukaryotes. Biological and molecular evolution | Medical sciences | Haplotypes | Genome-Wide Association Study | Oligonucleotide Array Sequence Analysis | Plasma Membrane Calcium-Transporting ATPases - genetics | Blood Pressure - genetics | Gene Frequency | Humans | Middle Aged | Male | Gene Expression Profiling | Genetic Loci | Sequence Analysis, DNA | Case-Control Studies | Linkage Disequilibrium | Methylenetetrahydrofolate Reductase (NADPH2) - genetics | Receptors, Atrial Natriuretic Factor - genetics | Adult | Female | Aged | Polymorphism, Single Nucleotide | Hypertension - genetics | Measurement | Hypertension | Causes of | Blood pressure | Genetic aspects | Research | Single nucleotide polymorphisms | Cardiovascular diseases | Genetic regulation | Risk factors | Genotype & phenotype | Cardiovascular disease | Chromatin | Gene loci | Gene expression | Index Medicus | Kardiologi | Medicinsk genetik | Medical Genetics | Cardiac and Cardiovascular Systems | Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi | Public Health, Global Health, Social Medicine and Epidemiology
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3. Full Text Secretory Phospholipase A2-IIA and Cardiovascular Disease: A Mendelian Randomization Study
by Holmes, Michael V and Simon, Tabassome and Exeter, Holly J and Folkersen, Lasse and Asselbergs, Folkert W and Guardiola, Montse and Cooper, Jackie A and Palmen, Jutta and Hubacek, Jaroslav A and Carruthers, Kathryn F and Horne, Benjamin D and Brunisholz, Kimberly D and Mega, Jessica L and van Iperen, Erik P. A and Li, Mingyao and Leusink, Maarten and Trompet, Stella and Verschuren, Jeffrey J. W and Hovingh, G. Kees and Dehghan, Abbas and Nelson, Christopher P and Kotti, Salma and Danchin, Nicolas and Scholz, Markus and Haase, Christiane L and Rothenbacher, Dietrich and Swerdlow, Daniel I and Kuchenbaecker, Karoline B and Staines-Urias, Eleonora and Goel, Anuj and van 't Hooft, Ferdinand and Gertow, Karl and de Faire, Ulf and Panayiotou, Anie G and Tremoli, Elena and Baldassarre, Damiano and Veglia, Fabrizio and Holdt, Lesca M and Beutner, Frank and Gansevoort, Ron T and Navis, Gerjan J and Mateo Leach, Irene and Breitling, Lutz P and Brenner, Hermann and Thiery, Joachim and Dallmeier, Dhayana and Franco-Cereceda, Anders and Boer, Jolanda M. A and Stephens, Jeffrey W and Hofker, Marten H and Tedgui, Alain and Hofman, Albert and Uitterlinden, Ané G and Adamkova, Vera and Pitha, Jan and Onland-Moret, N. Charlotte and Cramer, Maarten J and Nathoe, Henik M and Spiering, Wilko and Klungel, Olaf H and Kumari, Meena and Whincup, Peter H and Morrow, David A and Braund, Peter S and Hall, Alistair S and Olsson, Anders G and Doevendans, Pieter A and Trip, Mieke D and Tobin, Martin D and Hamsten, Anders and Watkins, Hugh and Koenig, Wolfgang and Nicolaides, Anew N and Teupser, Daniel and Day, Ian N. M and Carlquist, John F and Gaunt, Tom R and Ford, Ian and Sattar, Naveed and Tsimikas, Sotirios and Schwartz, Gregory G and Lawlor, Debbie A and Morris, Richard W and Sandhu, Manjinder S and Poledne, Rudolf and Maitland-van der Zee, Anke H and Khaw, Kay-Tee and Keating, Brendan J and van der Harst, Pim and Price, Jackie F and Mehta, Shamir R and Yusuf, Salim and Witteman, Jaqueline C. M and Franco, Oscar H and Jukema, J. Wouter and de Knijff, Peter and Tybjaerg-Hansen, Anne and Rader, Daniel J and Farrall, Martin and Samani, Nilesh J and ...
Journal of the American College of Cardiology, ISSN 0735-1097, 2013, Volume 62, Issue 21, pp. 1966 - 1976
drug development | epidemiology | genetics | cardiovascular diseases | Mendelian randomization | Cardiology. Vascular system | Heart | Biological and medical sciences | Medical sciences | LDL-C, low-density lipoprotein cholesterol | ACS, acute coronary syndrome(s) | CI, confidence interval | SNP, single-nucleotide polymorphism | OR, odds ratio | MI, myocardial infarction | sPLA2, secretory phospholipase A2 | Clinical Research | RCT, randomized clinical trial | MVE, major vascular events
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4. Full Text HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
by Swerdlow, Daniel I, Dr and Preiss, David, Dr and Kuchenbaecker, Karoline B, MSc and Holmes, Michael V, PhD and Engmann, Jorgen E L, MSc and Shah, Tina, PhD and Sofat, Reecha, MD and Stender, Stefan, MD and Johnson, Paul C D, PhD and Scott, Robert A, PhD and Leusink, Maarten, MSc and Verweij, Niek, MD and Sharp, Stephen J, MSc and Guo, Yiran, PhD and Giambartolomei, Claudia, MSc and Chung, Christina, MSc and Peasey, Anne, PhD and Amuzu, Antoinette, MSc and Li, KaWah, MSc and Palmen, Jutta, MSc and Howard, Philip, MSc and Cooper, Jackie A, MSc and Drenos, Fotios, PhD and Li, Yun R, BSc and Lowe, Gordon, Prof and Gallacher, John, PhD and Stewart, Marlene C W, PhD and Tzoulaki, Ioanna, PhD and Buxbaum, Sarah G, PhD and van der A, Daphne L, PhD and Forouhi, Nita G, MRCP and Onland-Moret, N Charlotte, PhD and van der Schouw, Yvonne T, Prof and Schnabel, Renate B, MD and Hubacek, Jaroslav A, PhD and Kubinova, Ruzena, MD and Baceviciene, Migle, MD and Tamosiunas, Abdonas, Prof and Pajak, Andrzej, Prof and Topor-Madry, Romanvan, MD and Stepaniak, Urszula, PhD and Malyutina, Sofia, Prof and Baldassarre, Damiano, PhD and Sennblad, Bengt, PhD and Tremoli, Elena, Prof and de Faire, Ulf, Prof and Veglia, Fabrizio, PhD and Ford, Ian, Prof and Jukema, J Wouter, Prof and Westendorp, Rudi G J, Prof and de Borst, Gert Jan, MD and de Jong, Pim A, MD and Algra, Ale, Prof and Spiering, Wilko, MD and der Zee, Anke H Maitland-van, PhD and Klungel, Olaf H, PharmD and de Boer, Anthonius, Prof and Doevendans, Pieter A, Prof and Eaton, Charles B, Prof and Robinson, Jennifer G, Prof and Duggan, David, PhD and Kjekshus, John, Prof and Downs, John R, MD and Gotto, Antonio M, MD and Keech, Anthony C, MD and Marchioli, Roberto, MD and Tognoni, Gianni, MD and Sever, Peter S, Prof and Poulter, Neil R, Prof and Waters, David D, MD and Pedersen, Terje R, MD and Amarenco, Pierre, MD and Nakamura, Haruo, MD and McMurray, John J V, Prof and Lewsey, James D, PhD and Chasman, Daniel I, PhD and Ridker, Paul M, MD and Maggioni, Aldo P, Prof and Tavazzi, Luigi, Prof and Ray, Kausik K, Prof and Seshasai, Sreenivasa Rao Kondapally, MD and Manson, JoAnn E, Prof and Price, Jackie F, MD and Whincup, Peter H, Prof and Morris, Richard W, Prof and Lawlor, Debbie A, Prof and Smith, George Davey, Prof and Ben-Shlomo, Yoav, Prof and Schreiner, Pamela J, Prof and Fornage, Myriam, Prof and Siscovick, David S, Prof and Cushman, Mary, MD and Kumari, Meena, PhD and Wareham, Nick J, Prof and Verschuren, W M Monique, PhD and Redline, Susan, Prof and Patel, Sanjay R, MD and Whittaker, John C, Prof and Hamsten, Anders, Prof and Delaney, Joseph A, PhD and ... and DIAGRAM Consortium, MAGIC Consortium, InterAct Consortium and MAGIC Consortium and InterAct Consortium and DIAGRAM Consortium
The Lancet (British edition), ISSN 0140-6736, 01/2015, Volume 385, Issue 9965, pp. 351 - 361
Internal Medicine | LDL CHOLESTEROL | HIGH-DOSE ATORVASTATIN | METAANALYSIS | STATIN THERAPY | ASSOCIATION ANALYSES | DISEASE | PREVENTION | BODY-MASS INDEX | RISK | MENDELIAN RANDOMIZATION | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Body Mass Index | Genetic Testing | Cholesterol, HDL - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Middle Aged | Risk Factors | Male | Body Weight - genetics | Randomized Controlled Trials as Topic | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Cholesterol, LDL - metabolism | Polymorphism, Single Nucleotide - genetics | Female | Aged | Hydroxymethylglutaryl CoA Reductases - genetics | Type 2 diabetes | Genetic research | Enzymes | Thiols | Diabetes | Low density lipoprotein | Statins | Cholesterol | Risk factors | Index Medicus | Abridged Index Medicus | Medicin och hälsovetenskap
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5. Full Text The UK10K project identifies rare variants in health and disease
by Walter, Klaudia and Min, Josine L and Huang, Jie and Crooks, Lucy and Memari, Yasin and McCarthy, Shane and Perry, John and Xu, Changjiang and Futema, Marta and Lawson, Daniel and Iotchkova, Valentina and Schiffels, Stephan and Henicks, Auey E and Danecek, Petr and Li, Rui and Floyd, James and Wain, Louise and Barroso, Inês and Humphries, Steve and Hurles, Matthew and Zeggini, Eleftheria and Barrett, Jeffrey and Plagnol, Vincent and Richards, Brent and Greenwood, Celia and Timpson, Nicholas and Durbin, Richard and Bala, Senduran and Clapham, Peter and Coates, Guy and Cox, Tony and Daly, Allan and Du, Yuanping and Edkins, Ted and Ellis, Peter and Flicek, Paul and Guo, Xiaosen and Guo, Xueqin and Huang, Liren and Jackson, David K and Joyce, Chris and Keane, Thomas and Kolb-Kokocinski, Anja and Langford, Cordelia and Li, Yingrui and Liang, Jieqin and Lin, Hong and Liu, Ryan and Maslen, John and Muddyman, Dawn and Quail, Michael A and Stalker, Jim and Sun, Jianping and Tian, Jing and Wang, Guangbiao and Wang, Jun and Wang, Yu and Wong, Kim and Zhang, Pingbo and Birney, Ewan and Boustred, Chris and Chen, Lu and Clement, Gail and Cocca, Massimiliano and Smith, Davey and Day, Ian N.M and Day-Williams, Aaron and Down, Thomas and Dunham, David and Evans, David M and Gaunt, Tom and Geihs, Matthias and Hart, Deborah and Howie, Bryan and Hubbard, Tim and Hysi, Pirro and Jamshidi, Yalda and Karczewski, Konrad and Kemp, John and Lachance, Genevieve and Lek, Monkol and Lopes, Margarida and MacArthur, Daniel G and Marchini, Jonathan and Mangino, Massimo and Mathieson, Iain and Metrustry, Sarah and Moayyeri, Alireza and Northstone, Kate and Panoutsopoulou, Kalliope and Paternoster, Lavinia and Quaye, Lydia and Ring, Susan and Ritchie, Graham R.S and Shihab, Hashem A and Shin, So-Youn and Small, Kerrin and Artigas, M.S and Soranzo, Nicole and Southam, Lorraine and ... and UCLEB Consortium and UK10K Consortium and The UK10K Consortium
Nature (London), ISSN 0028-0836, 10/2015, Volume 526, Issue 7571, pp. 82 - 89
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Genetics, Population | Receptors, LDL - genetics | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Disease - genetics | Health | Genomics | Humans | Molecular Sequence Annotation | Male | United Kingdom | Sequence Analysis, DNA | Genome, Human - genetics | Adiponectin - blood | Exome - genetics | Reference Standards | Genetics, Medical | Alleles | Triglycerides - blood | Female | Lipid Metabolism - genetics | Genetic Variation - genetics | Cohort Studies | Genetic research | Research | Genetic variation | Identification and classification | Health aspects | Population genetics | Proteins | Studies | Haplotypes | Obesity | Genealogy | Disease | Quality | Population | Genomes | Mutation | Index Medicus
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6. Full Text C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis
by Kaptoge, Stephen and Di Angelantonio, Emanuele and Lowe, Gordon and Pepys, Mark B and Thompson, Simon G and Collins, Rory and Danesh, John and Tipping, Robert W and Ford, C. E and Pressel, S. L and Walldius, G and Jungner, I and Folsom, Aaron R and Chambless, L.E and Ballantyne, C. M and Panagiotakos, Demosthenes B and Pitsavos, C and Chrysohoou, C and Stefanadis, Christodoulos and Knuiman, Matthew W and Goldbourt, Uri and Benderly, M and Tanne, David and Whincup, P.H and Wannamethee, S.G and Morris, Richard W and Kiechl, S and Willeit, J and Mayr, A and Schett, G and Wald, N and Ebrahim, S and Lawlor, D.A and Yarnell, J.W and Gallacher, J and Casiglia, Edoardo and Tikhonoff, Valerie and Nietert, Paul J and Sutherland, Susan E and Bachman, D. L and Keil, J. E and Cushman, M and Psaty, Bruce M and Tracy, R and Tybjaerg-Hansen, A and Nordestgaard, B. G and Zacho, J and Frikke-Schmidt, R and Giampaoli, S and Palmieri, L and Panico, S and Vanuzzo, D and Pilotto, L and de la Camara, A. Gomez and Gerique, J. A. Gomez and Simons, Laura and McCallum, J and Friedlander, Yechiel and Fowkes, F. Gerry R and Lee, A and Taylor, Clare J and Guralnik, Jack M and Phillips, Caroline L and Wallace, Robert B and Blazer, Dan G and Khaw, Kay-Tee and Brenner, H and Raum, E and Mueller, Heiko and Rothenbacher, Dietrich and Jansson, J-H and Wennberg, Patrik and Nissinen, A and Donfrancesco, C and Salomaa, Veikko and Harald, K and Jousilahti, P and Vartiainen, E and Woodward, M and D'Agostino, Ralph B., Sr and Wolf, P. A and Vasan, Ramachanan S and Benjamin, Emelia J and Bladbjerg, E.M and Jorgensen, T and Moller, L and Jespersen, J and Dankner, Rachel and Chetrit, A and Lubin, F and Rosengren, Annika and Wilhelmsen, Lars and Lappas, G and Eriksson, HG and Bjorkelund, Cecilia and Lissner, L and Bengtsson, C and Cremer, Peter and Nagel, Dorothea and Tilvis, Reijo S and ... and The Emerging Risk Factors Collaboration and Emerging Risk Factors Collaboration
The Lancet (British edition), ISSN 0140-6736, 2010, Volume 375, Issue 9709, pp. 132 - 140
Internal Medicine | Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Cardiology. Vascular system | Heart | Neurology | General aspects | Biological and medical sciences | Vascular diseases and vascular malformations of the nervous system | Medical sciences | Coronary heart disease | Blood Pressure | Diabetes Mellitus - blood | Cholesterol - blood | Humans | Middle Aged | Lung Diseases - mortality | Male | Motor Activity | Coronary Disease - mortality | Neoplasms - blood | Lung Diseases - blood | Interleukin-6 - blood | Female | Leukocyte Count | Stroke - mortality | C-Reactive Protein - analysis | Databases, Factual | Body Mass Index | Coronary Disease - blood | Stroke - prevention & control | Risk Assessment | Smoking - blood | Risk Factors | Neoplasms - mortality | Biomarkers - blood | Stroke - blood | Regression Analysis | Coronary Disease - prevention & control | Serum Albumin | Alcohol Drinking - blood | Alcohol Drinking - epidemiology | Smoking - epidemiology | Diabetes Mellitus - epidemiology | Fibrinogen - analysis | Sex Factors | Triglycerides - blood | Proteins | Mortality | Cardiovascular disease | Statistical methods | Blood pressure | Risk factors | Statins | Inflammatory diseases | Meta-analysis | Index Medicus | Abridged Index Medicus
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