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by Bohula, Erin A and Scirica, Benjamin M and Inzucchi, Silvio E and McGuire, Darren K and Keech, Anthony C and Smith, Steven R and Kanevsky, Estella and Murphy, Sabina A and Leiter, Lawrence A and Dwyer, Jamie P and Corbalan, Ramon and Hamm, Christian and Kaplan, Lee and Nicolau, Jose Carlos and Ophuis, Ton Oude and Ray, Kausik K and Ruda, Mikhail and Spinar, Jindrich and Patel, Tushar and Miao, Wenfeng and Perdomo, Carlos and Francis, Bruce and Dhadda, Shobha and Bonaca, Marc P and Sabatine, Marc S and Scirica, Benjamin M and Inzucchi, Silvio and Keech, Anthony and McGuire, Darren K and Smith, Steven R and Satlin, Andrew and Brown, Conville and Budaj, Andrzej and Corbalan, Ramon and Dwyer, Jamie and Garcia-Castillo, Armando and Gupta, Milan and Hamm, Christian and Kaplan, Lee and Leiter, Lawrence A and Nicolau, Jose Carlos and Oude Ophuis, Ton and Ray, Kauski and Ruda, Mikhail and Spinar, Jindrich and Weissman, Neil and White, Harvey D and Amerena, J and Arstall, M and Jayasinghe, R and Lee, A and Lehman, R and Moses, R and Proietto, J and Purnell, P and Waites, J and Blombery, P and Cross, D and Worthley, M and d'Emden, M and Selvanayagam, J and Oqueli, RE and Whelan, A and Garrahy, P and de Looze, F and Horowitz, J and Suranyi, M and Le May, M and Pandey, AS and Vizel, S and Labonte, R and Beaudry, Y and Fortin, C and Bell, A and Kouz, S and St-Amour, É and Bata, I and St Maurice, F and Chehayeb, R and Constance, C and Wong, G and Hess, A and Liutkus, J and Poirier, P and Teitelbaum, I and Berlingieri, J and Cha, J and Heffernan, M and Twum-Barima, D and Pandith, V and Ajala, B and Jain, A and Ross, S and Bajaj, H and Khandwala, H and Yared, Z and Gupta, N and Bédard, J and Wharton, S and Blouin, F and ... and CAMELLIA-TIMI 61 Steering Committee Investigators and CAMELLIA-TIMI61 Steering Comm
The Lancet, ISSN 0140-6736, 11/2018, Volume 392, Issue 10161, pp. 2269 - 2279
There is a direct relationship between bodyweight and risk of diabetes. Lorcaserin, a selective serotonin 2C receptor agonist that suppresses appetite, has... 
LIFE-STYLE INTERVENTION | MEDICINE, GENERAL & INTERNAL | THERAPY | LIRAGLUTIDE | REDUCTION | CARDIOVASCULAR OUTCOMES | WEIGHT-LOSS | BARIATRIC SURGERY | FOLLOW-UP | ASSOCIATION | Glycated Hemoglobin A - analysis | Hypoglycemic Agents - therapeutic use | Overweight - complications | Atherosclerosis - drug therapy | Double-Blind Method | Obesity - complications | Humans | Middle Aged | Diabetes Mellitus, Type 2 - prevention & control | Prediabetic State - prevention & control | Body Weight - drug effects | Atherosclerosis - complications | Male | Prediabetic State - complications | Weight Loss - drug effects | Appetite Depressants - therapeutic use | Prediabetic State - drug therapy | Remission Induction | Diabetes Mellitus, Type 2 - blood | Benzazepines - therapeutic use | Female | Aged | Diabetes Mellitus, Type 2 - drug therapy | Diabetes Mellitus, Type 2 - complications | Type 2 diabetes | Prevention | Clinical trials | Obesity | Analysis | Diabetic retinopathy | Heart attacks | Body weight | Cardiovascular disease | Diabetic neuropathy | Body weight loss | Evidence-based medicine | Risk factors | Body mass index | Randomization | Hyperglycemia | Vascular diseases | Motivation | Atherosclerosis | Hemoglobin | Remission | Diabetes mellitus (non-insulin dependent) | Appetite | Hypertension | Serotonin | Complications | Diabetes mellitus | Weight loss | Health risks | FDA approval | Hypoglycemia | Metabolism | Risk analysis | Patients | Disease control | Disease prevention | Weight control | Statistical models | Arteriosclerosis | Coronary vessels | Microvasculature | Lifestyles | Gastrointestinal surgery | Diabetes | Health risk assessment | Long-term effects
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 11/2018, Volume 379, Issue 22, pp. 2097 - 2107
Among patients who had had an acute coronary syndrome, the risk of death from coronary heart disease, nonfatal myocardial infarction, stroke, or unstable... 
MEDICINE, GENERAL & INTERNAL | MANAGEMENT | MYOCARDIAL-INFARCTION | TASK-FORCE | EFFICACY | SAFETY | LDL | REDUCING LIPIDS | PCSK9 | MONOCLONAL-ANTIBODY | ASSOCIATION | Double-Blind Method | Follow-Up Studies | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Hypercholesterolemia - drug therapy | Anticholesteremic Agents - adverse effects | Acute Coronary Syndrome - blood | Acute Coronary Syndrome - drug therapy | Acute Coronary Syndrome - complications | Anticholesteremic Agents - therapeutic use | Proprotein Convertase 9 - antagonists & inhibitors | Cardiovascular Diseases - epidemiology | Adult | Cholesterol, LDL - blood | Female | Hypercholesterolemia - complications | Aged | Acute coronary syndrome | Diagnosis | Myocardial infarction | Fees & charges | Lipoproteins (low density) | Heart attacks | Lipids | Cardiovascular disease | Angina | Apolipoprotein B | Ischemia | Heart diseases | Drug dosages | Statins | Cerebral infarction | Stroke | Subtilisin | Angina pectoris | Patients | Low density lipoprotein | Coronary artery disease | Cholesterol | Kexin | Monoclonal antibodies | Full text | Acute coronary syndromes | Cardiovascular diseases | Health risk assessment | Pharmaceuticals | Life Sciences | Human health and pathology | Cardiology and cardiovascular system | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Klinisk medicin | Medicin och hälsovetenskap
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 06/2015, Volume 372, Issue 25, pp. 2387 - 2397
In this trial, patients with an acute coronary syndrome within the previous 10 days were randomly assigned to simvastatin plus either ezetimibe or placebo. At... 
no | CHOLESTEROL ABSORPTION | CARDIAC OUTCOMES | MEDICINE, GENERAL & INTERNAL | MYOCARDIAL-INFARCTION | EFFICACY | CARDIOVASCULAR OUTCOMES | CLINICAL-TRIALS | SIMVASTATIN | PRIMARY PREVENTION | IMPROVE-IT | ATORVASTATIN | Simvastatin - therapeutic use | Double-Blind Method | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Azetidines - adverse effects | Ezetimibe | Kaplan-Meier Estimate | Male | Anticholesteremic Agents - adverse effects | Acute Coronary Syndrome - drug therapy | Anticholesteremic Agents - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Azetidines - therapeutic use | Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use | Triglycerides - blood | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Cholesterol, LDL - blood | Female | Aged | Drug Therapy, Combination | Usage | Simvastatin | Analysis | Practice guidelines (Medicine) | Dosage and administration | Drug therapy, Combination | Acute coronary syndrome | Drug therapy | Myocardial infarction | Cerebral infarction | Lipoproteins (low density) | Stroke | Angina | Cholesterol | Intestine | Gallbladder | Acute coronary syndromes | Cardiovascular diseases | Statins | Pharmaceuticals | Cancer | Life Sciences | Human health and pathology | Cardiology and cardiovascular system
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 09/2017, Volume 377, Issue 12, pp. 1119 - 1131
Patients with myocardial infarction and a high-sensitivity CRP level of 2 mg or more per liter were assigned to one of three canakinumab doses or placebo. The... 
no | C-REACTIVE PROTEIN | MEDICINE, GENERAL & INTERNAL | HEART-DISEASE | MYOCARDIAL-INFARCTION | STATIN THERAPY | CLONAL HEMATOPOIESIS | INFLAMMATION | CARDIOVASCULAR-DISEASE | INTERLEUKIN-1-BETA INHIBITION | RISK | CORONARY-ARTERY-DISEASE | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Male | Secondary Prevention | Infection - etiology | Incidence | Dose-Response Relationship, Drug | Anti-Inflammatory Agents - adverse effects | C-Reactive Protein - metabolism | Lipids - blood | Cardiovascular Diseases - epidemiology | Cardiovascular Diseases - mortality | Anti-Inflammatory Agents - administration & dosage | Female | Neutropenia - chemically induced | Interleukin-1beta - antagonists & inhibitors | Stroke - prevention & control | Atherosclerosis - drug therapy | Double-Blind Method | Interleukin-1beta - immunology | Atherosclerosis - blood | Myocardial Infarction - drug therapy | Antibodies, Monoclonal - administration & dosage | Aged | Myocardial Infarction - prevention & control | Myocardial infarction | Cerebral infarction | Stroke | Heart attacks | C-reactive protein | Cytokines | Clinical trials | Cardiovascular disease | Innate immunity | Inflammation | Angina | Angina pectoris | Thrombosis | Cholesterol | Disease prevention | Proteins | Arteriosclerosis | Atherosclerosis | Cardiovascular diseases | Health risk assessment | Drug therapy | Drug dosages | Klinisk medicin | Clinical Medicine
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 02/2019, Volume 73, Issue 4, pp. 387 - 396
Journal Article
Journal of the American College of Cardiology, ISSN 0735-1097, 09/2019, Volume 74, Issue 9, pp. 1167 - 1176
textabstractrisk of major adverse cardiovascular events (MACEs) and death. The impact of lipid lowering by proprotein convertase subtilisin–kexin type 9... 
major adverse cardiac events | alirocumab | acute coronary syndrome | cerebrovascular disease | peripheral artery disease | death | CARDIAC & CARDIOVASCULAR SYSTEMS | MANAGEMENT | CHOLESTEROL | OUTPATIENTS | RISK | PCSK9 INHIBITION | CARDIOVASCULAR EVENT RATES | ARTERY-DISEASE | INSIGHTS | Cardiovascular Diseases - etiology | Dyslipidemias - drug therapy | Vascular Diseases - prevention & control | Antibodies, Monoclonal, Humanized - therapeutic use | Double-Blind Method | Dyslipidemias - complications | Risk Assessment | Vascular Diseases - etiology | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Male | Treatment Outcome | Vascular Diseases - epidemiology | Acute Coronary Syndrome - complications | Cardiovascular Diseases - epidemiology | Female | Aged | Care and treatment | Coronary heart disease | Patient outcomes | Analysis | Myocardial infarction | Therapy | Heart attacks | Dyslipidemia | Cardiovascular disease | Lipids | Angina | Incidence | Confidence intervals | Reduction | Ischemia | Atherosclerosis | Cardiology | Heart diseases | Statins | Cerebral infarction | Evaluation | Stroke | Medical treatment | Mortality | Health risks | Risk reduction | Subtilisin | Angina pectoris | Coronary artery disease | Kexin | Arteriosclerosis | Coronary vessels | Death | Diabetes | Acute coronary syndromes | Risk management | Cardiovascular diseases | Health risk assessment | Kardiologi | Clinical Medicine | Cardiac and Cardiovascular Systems | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
Journal Article