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Diabetes, ISSN 0012-1797, 07/2013, Volume 62, Issue 7, pp. 2157 - 2163
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 04/2013, Volume 123, Issue 4, pp. 1750 - 1762
Type 2 diabetes (T2D) has emerged as a major threat to human health in most parts of the world. Therapeutic strategies aimed at improving pancreatic beta cell... 
TRANSCRIPTION FACTORS | MEDICINE, RESEARCH & EXPERIMENTAL | REGULATOR | SIGNALING PATHWAYS | SUBSTRATE-2 | INSULIN-RESISTANCE | PROTEIN-COUPLED RECEPTORS | MECHANISMS | DIFFERENTIATION | SECRETION | EXPRESSION | Cell Proliferation | Gene Expression - drug effects | Receptors, G-Protein-Coupled - metabolism | Muscarinic Agonists - pharmacology | Male | Receptor, Muscarinic M3 - physiology | Insulin Receptor Substrate Proteins - metabolism | Receptors, G-Protein-Coupled - agonists | Molecular Targeted Therapy | MAP Kinase Signaling System | Clozapine - pharmacology | Insulin-Secreting Cells - metabolism | Diabetes Mellitus, Experimental - prevention & control | Protein Engineering | Female | Drug Evaluation, Preclinical | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Insulin Receptor Substrate Proteins - genetics | Insulin-Secreting Cells - physiology | Recombinant Proteins - metabolism | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Insulin Receptor Substrate Proteins - physiology | Mice, Inbred C57BL | Mice, Transgenic | Recombinant Proteins - agonists | Recombinant Proteins - genetics | Clozapine - analogs & derivatives | Hypoglycemic Agents - pharmacology | Animals | Insulin-Secreting Cells - drug effects | Cell Line, Tumor | Diabetes Mellitus, Experimental - pathology | Mice | Receptors, G-Protein-Coupled - genetics | Receptor, Muscarinic M3 - agonists
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 02/2019, Volume 294, Issue 7, pp. 2407 - 2421
Journal Article
2007, Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease
Web Resource
2007, Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease
Web Resource
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7564, pp. 170 - 171
Understanding how cellular nutrient sensing and homeostasis affect an organism's lifespan and susceptibility to cancer and degenerative diseases is clinically... 
Life spans (Biology) | Physiological aspects | Cellular signal transduction | Research | Insulin | Enzymes | Obesity | Cardiovascular disease | Kinases | Metabolism | Mammals | Proteins | Signal transduction | Insects | Insulin resistance | Diabetes | Cancer
Journal Article
Proceedings of the National Academy of Sciences, USA, ISSN 0027-8424, 08/2016, Volume 113, Issue 31, pp. 8795 - 8795
Insulin receptor substrate-1 (IRS-1) is a signaling adaptor protein that interfaces with many pathways activated in lung cancer. It has been assumed that IRS-1... 
Journal Article
Nature, ISSN 0028-0836, 08/2015, Volume 524, Issue 7564, pp. 170 - 171
Journal Article
Diabetes, ISSN 0012-1797, 2001, Volume 50, Issue 1, pp. S140 - S145
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2014, Volume 443, Issue 2, p. 689
acents Hyperactivation of mTORC1 due to loss of TSC1 induces glucose intolerance in vivo. acents IRS1.sup.Ser307 phosphorylation is not involved in... 
Glucose metabolism | Insulin resistance | Glucose | Dextrose
Journal Article