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Postȩpy higieny i medycyny doświadczalnej (Online), ISSN 0032-5449, 2015, Volume 69, pp. 1423 - 1434
Selective drugs directed at a single biological target often prove ineffective in the treatment of diseases with a complex pathomechanism, e.g. Alzheimer’s... 
potencjalne leki w chorobie Alzheimera | ligandy wielocelowe | multi-target-directed ligands | leki wielofunkcyjne | projektowanie leku | choroba alzheimera
Journal Article
Molecules, ISSN 1420-3049, 04/2016, Volume 21, Issue 4, p. 410
Cholinesterases and amyloid beta are one of the major biological targets in the search for a new and efficacious treatment of Alzheimer's disease. The study... 
Molecular modelling | Multi-target-directed ligands (mtdl) | Alzheimer's disease | Cholinesterase inhibitors | Pampa-bbb assay | β-amyloid aggregation inhibitors | SITE | multi-target-directed ligands (MTDL) | DESIGN | MONOAMINE-OXIDASE B | MULTIFACTORIAL NATURE | molecular modelling | PAMPA-BBB assay | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DIRECTED LIGANDS | CHEMISTRY, MULTIDISCIPLINARY | ISOINDOLINE-1,3-DIONE DERIVATIVES | RECEPTOR LIGANDS | cholinesterase inhibitors | ACETYLCHOLINESTERASE INHIBITORS | beta-amyloid aggregation inhibitors | HYBRIDS | Isoindoles - chemistry | Acetylcholinesterase - therapeutic use | Humans | Cholinesterase Inhibitors - chemistry | Alzheimer Disease - drug therapy | Models, Molecular | Cholinesterase Inhibitors - chemical synthesis | Isoindoles - chemical synthesis | Structure-Activity Relationship | Acetylcholinesterase - chemistry | Butyrylcholinesterase - therapeutic use | Blood-Brain Barrier - drug effects | Protein Aggregation, Pathological - drug therapy | Alzheimer Disease - pathology | Butyrylcholinesterase - chemistry | Amyloid beta-Peptides - chemical synthesis | Amyloid beta-Peptides - therapeutic use | Isoindoles - therapeutic use | Ligands | Amyloid beta-Peptides - chemistry | Cholinesterase Inhibitors - therapeutic use | Binding Sites | Protein Aggregation, Pathological - metabolism | Alzheimer’s disease
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 125, pp. 676 - 695
Journal Article
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 124, p. 63
To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1016/j.ejmech.2016.08.016... 
Drugstores | Enzyme inhibitors | Permeability | Alzheimer's disease | Pharmacy | Analysis | Development and progression
Journal Article
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 05/2018, Volume 9, Issue 5, pp. 1195 - 1214
Alzheimer’s disease (AD) is a major public health problem, which is due to its increasing prevalence and lack of effective therapy or diagnostics. The... 
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 05/2018, Volume 9, Issue 5, pp. 1074 - 1094
The multitarget approach is a promising paradigm in drug discovery, potentially leading to new treatment options for complex disorders, such as Alzheimer’s... 
Journal Article
ACS Chemical Neuroscience, 05/2018, Volume 9, Issue 5, pp. 1195 - 1214
Alzheimer's disease (AD) is a major public health problem, which is due to its increasing prevalence and lack of effective therapy or diagnostics. The... 
acetylcholinesterase inhibitors | multitarget-directed ligands | receptor antagonists | 5-HT | Alzheimer's disease | butyrylcholinesterase inhibitors | inhibition of β-amyloid aggregation | Index Medicus
Journal Article
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