PLoS Pathogens, ISSN 1553-7366, 08/2016, Volume 12, Issue 8, p. e1005809
Type I interferons (including IFN alpha beta) are innate cytokines that may contribute to pathogenesis during Mycobacterium tuberculosis (Mtb) infection. To...
OXIDIZED MITOCHONDRIAL-DNA | SYSTEMIC-LUPUS-ERYTHEMATOSUS | CYCLIC GMP-AMP | INNATE | SENSOR | MICROBIOLOGY | NLRP3 INFLAMMASOME | CYTOSOLIC SURVEILLANCE PATHWAY | VIROLOGY | IMMUNE-RESPONSES | LINEAGE | AFRICANUM | PARASITOLOGY | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Mycobacterium tuberculosis - immunology | Immunoblotting | Interferon Type I - immunology | Reverse Transcriptase Polymerase Chain Reaction | Tuberculosis - immunology | Interferon Type I - biosynthesis | Animals | Bone Marrow Cells | Tuberculosis - genetics | Mice | Macrophages - immunology | Microscopy, Fluorescence | Disease Models, Animal | Mycobacterium tuberculosis - genetics | Interferon | Genetic aspects | Tuberculosis | Research | Mycobacterium tuberculosis | DNA-ligand interactions | Cytokines | Pathogenesis | Genes | Leprosy | Mitochondrial DNA | Infections | Scholarships & fellowships | Mitochondria | Phylogenetics | Viral infections | Deoxyribonucleic acid--DNA | Deoxyribonucleic acid | DNA
OXIDIZED MITOCHONDRIAL-DNA | SYSTEMIC-LUPUS-ERYTHEMATOSUS | CYCLIC GMP-AMP | INNATE | SENSOR | MICROBIOLOGY | NLRP3 INFLAMMASOME | CYTOSOLIC SURVEILLANCE PATHWAY | VIROLOGY | IMMUNE-RESPONSES | LINEAGE | AFRICANUM | PARASITOLOGY | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Mycobacterium tuberculosis - immunology | Immunoblotting | Interferon Type I - immunology | Reverse Transcriptase Polymerase Chain Reaction | Tuberculosis - immunology | Interferon Type I - biosynthesis | Animals | Bone Marrow Cells | Tuberculosis - genetics | Mice | Macrophages - immunology | Microscopy, Fluorescence | Disease Models, Animal | Mycobacterium tuberculosis - genetics | Interferon | Genetic aspects | Tuberculosis | Research | Mycobacterium tuberculosis | DNA-ligand interactions | Cytokines | Pathogenesis | Genes | Leprosy | Mitochondrial DNA | Infections | Scholarships & fellowships | Mitochondria | Phylogenetics | Viral infections | Deoxyribonucleic acid--DNA | Deoxyribonucleic acid | DNA
Journal Article
Science, ISSN 0036-8075, 2014, Volume 343, Issue 6169, pp. 1245267 - 1245267
H2O, CO2, SO2, O-2, H-2, H2S, HCl, chlorinated hydrocarbons, NO, and other trace gases were evolved during pyrolysis of two mudstone samples acquired by the...
HYDROGEN | ANALOG | MARTIAN SOIL | MULTIDISCIPLINARY SCIENCES | DIOXIDE | SURFACE | PERCHLORATE | Exobiology | Carbon Dioxide - chemistry | Sulfides - analysis | Bays | Sulfides - chemistry | Water - analysis | Volatile Organic Compounds - analysis | Carbon Dioxide - analysis | Oxygen - analysis | Mars | Geologic Sediments - analysis | Hydrocarbons, Chlorinated - analysis | Oxygen - chemistry | Water - chemistry | Geologic Sediments - chemistry | Extraterrestrial Environment - chemistry | Rocks | Volatile organic compounds--VOCs | Space exploration | Sedimentary geology | Solar and Stellar Astrophysics | Earth and Planetary Astrophysics | Sciences of the Universe | Astrophysics | Atmospheric science | Engineering and Technology | Rymd- och flygteknik | Teknik och teknologier | Aerospace Engineering | Mechanical Engineering | Maskinteknik | Atmosfärsvetenskap
HYDROGEN | ANALOG | MARTIAN SOIL | MULTIDISCIPLINARY SCIENCES | DIOXIDE | SURFACE | PERCHLORATE | Exobiology | Carbon Dioxide - chemistry | Sulfides - analysis | Bays | Sulfides - chemistry | Water - analysis | Volatile Organic Compounds - analysis | Carbon Dioxide - analysis | Oxygen - analysis | Mars | Geologic Sediments - analysis | Hydrocarbons, Chlorinated - analysis | Oxygen - chemistry | Water - chemistry | Geologic Sediments - chemistry | Extraterrestrial Environment - chemistry | Rocks | Volatile organic compounds--VOCs | Space exploration | Sedimentary geology | Solar and Stellar Astrophysics | Earth and Planetary Astrophysics | Sciences of the Universe | Astrophysics | Atmospheric science | Engineering and Technology | Rymd- och flygteknik | Teknik och teknologier | Aerospace Engineering | Mechanical Engineering | Maskinteknik | Atmosfärsvetenskap
Journal Article
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 05/2019, Volume 321, Issue 19, pp. 1880 - 1894
IMPORTANCE Intravitreous injections of antivascular endothelial growth factor agents are effective for treating diabetic macular edema (DME) involving the...
MEDICINE, GENERAL & INTERNAL | RETINOPATHY | RANIBIZUMAB | Diabetics | Usage | Care and treatment | Laser coagulation | Blindness | Comparative analysis | Health aspects | Myocardial infarction | Cerebral infarction | Edema | Stroke | Diabetes mellitus | Visual observation | Clinical trials | Risk | Visual acuity | Diabetes mellitus (insulin dependent) | Patients | Acuity | Eye | Randomization | Lasers | Vision | Collaboration | Cooperation | Eye (anatomy) | Diabetes | Diabetes mellitus (non-insulin dependent) | Growth factors | Online First | Original Investigation | Research
MEDICINE, GENERAL & INTERNAL | RETINOPATHY | RANIBIZUMAB | Diabetics | Usage | Care and treatment | Laser coagulation | Blindness | Comparative analysis | Health aspects | Myocardial infarction | Cerebral infarction | Edema | Stroke | Diabetes mellitus | Visual observation | Clinical trials | Risk | Visual acuity | Diabetes mellitus (insulin dependent) | Patients | Acuity | Eye | Randomization | Lasers | Vision | Collaboration | Cooperation | Eye (anatomy) | Diabetes | Diabetes mellitus (non-insulin dependent) | Growth factors | Online First | Original Investigation | Research
Journal Article
Journal of Infectious Diseases, ISSN 0022-1899, 12/2016, Volume 214, Issue 12, pp. 1893 - 1896
Type I interferons (IFNs, including IFN-alpha beta) contribute to the pathogenesis of Mycobacterium tuberculosis strains that induce high IFN-alpha beta...
IFN | Tuberculosis | Type I interferon | Mycobacterium africanum | type I interferon | INFECTIOUS DISEASES | IFN-alpha beta | tuberculosis | MICROBIOLOGY | IMMUNOLOGY | Lung - microbiology | Tuberculosis, Pulmonary - microbiology | Lung - pathology | Mycobacterium - immunology | Receptors, Interferon - deficiency | Mice, Inbred C57BL | Male | Bacterial Load | Tuberculosis, Pulmonary - pathology | Mice, Knockout | Animals | Histocytochemistry | Survival Analysis | Interferon Type I - metabolism | Chronic Disease | Disease Models, Animal | Mycobacterium tuberculosis | Interferon | Research | Major and Brief Reports | IFN-αβ
IFN | Tuberculosis | Type I interferon | Mycobacterium africanum | type I interferon | INFECTIOUS DISEASES | IFN-alpha beta | tuberculosis | MICROBIOLOGY | IMMUNOLOGY | Lung - microbiology | Tuberculosis, Pulmonary - microbiology | Lung - pathology | Mycobacterium - immunology | Receptors, Interferon - deficiency | Mice, Inbred C57BL | Male | Bacterial Load | Tuberculosis, Pulmonary - pathology | Mice, Knockout | Animals | Histocytochemistry | Survival Analysis | Interferon Type I - metabolism | Chronic Disease | Disease Models, Animal | Mycobacterium tuberculosis | Interferon | Research | Major and Brief Reports | IFN-αβ
Journal Article
Blood, ISSN 0006-4971, 05/2014, Volume 123, Issue 20, pp. e110 - e122
Macrophages adopt an alternatively activated phenotype (AAMs) when activated by the interleukin-4receptor(R)alpha. AAMs can be derived either from...
IMMUNITY | CELLS | RECRUITMENT | INTERLEUKIN-4 | HOMEOSTASIS | INFLAMMATION | TOLERANCE | PROLIFERATION | HEMATOLOGY | EXPRESSION | RESIDENT MACROPHAGES | Gene Expression | Cell Proliferation | Mitochondrial Proteins - analysis | Monocytes - cytology | Mice, Inbred C57BL | Cells, Cultured | Ion Channels - genetics | Monocytes - metabolism | Gene Expression Profiling | Mitochondrial Proteins - genetics | Monocytes - immunology | Macrophages - cytology | Macrophage Activation | Macrophages - metabolism | Animals | Ion Channels - analysis | CD4 Antigens - analysis | Forkhead Transcription Factors - analysis | Mice | Uncoupling Protein 1 | Macrophages - immunology | Phagocytes, Granulocytes, and Myelopoiesis
IMMUNITY | CELLS | RECRUITMENT | INTERLEUKIN-4 | HOMEOSTASIS | INFLAMMATION | TOLERANCE | PROLIFERATION | HEMATOLOGY | EXPRESSION | RESIDENT MACROPHAGES | Gene Expression | Cell Proliferation | Mitochondrial Proteins - analysis | Monocytes - cytology | Mice, Inbred C57BL | Cells, Cultured | Ion Channels - genetics | Monocytes - metabolism | Gene Expression Profiling | Mitochondrial Proteins - genetics | Monocytes - immunology | Macrophages - cytology | Macrophage Activation | Macrophages - metabolism | Animals | Ion Channels - analysis | CD4 Antigens - analysis | Forkhead Transcription Factors - analysis | Mice | Uncoupling Protein 1 | Macrophages - immunology | Phagocytes, Granulocytes, and Myelopoiesis
Journal Article
Science, ISSN 0036-8075, 06/2017, Volume 356, Issue 6341, pp. eaah6849 - eaah6849
In 2012, NASA's Curiosity rover landed on Mars to assess its potential as a habitat for past life and investigate the paleoclimate record preserved by...
X-RAY SPECTROMETER | YELLOWKNIFE BAY | CLAY-MINERALS | ORIGIN | EVOLUTION | REFLUX DOLOMITIZATION | SEDIMENTARY | MULTIDISCIPLINARY SCIENCES | CHEMISTRY | IRON-FORMATION | CURIOSITY ROVER | Geologic Sediments - chemistry | Lakes | Mars | Oxidation-Reduction | Clastics | Climate | High resolution | Image processing | Aluminum | Deceleration | Habitats | Fluid flow | Geochemistry | Oxides | Density | Aquatic environment | Sedimentary rocks | Freshwater environments | Stratigraphy | Image resolution | Fluctuations | Anoxia | Environmental conditions | Recognition | Lithification | Metals | Mineralogy | Grain | Fresh water | Iron | Minerals | Diagenesis | Magnetite | Groundwater | Oxidation | Deposition | Age | Fractionation | Strata | Detritus | Exploration | Rivers | Nitrogen | Sediments | Imagery | Water depth | Carbon | Investigations | Flow | Climate change | Travel | Hydrologic data | Cations | Mars landing | Craters | Mars craters | Curiosity (Mars rover) | Stratification | Mars (planet) | GEOSCIENCES | Planetary Sciences
X-RAY SPECTROMETER | YELLOWKNIFE BAY | CLAY-MINERALS | ORIGIN | EVOLUTION | REFLUX DOLOMITIZATION | SEDIMENTARY | MULTIDISCIPLINARY SCIENCES | CHEMISTRY | IRON-FORMATION | CURIOSITY ROVER | Geologic Sediments - chemistry | Lakes | Mars | Oxidation-Reduction | Clastics | Climate | High resolution | Image processing | Aluminum | Deceleration | Habitats | Fluid flow | Geochemistry | Oxides | Density | Aquatic environment | Sedimentary rocks | Freshwater environments | Stratigraphy | Image resolution | Fluctuations | Anoxia | Environmental conditions | Recognition | Lithification | Metals | Mineralogy | Grain | Fresh water | Iron | Minerals | Diagenesis | Magnetite | Groundwater | Oxidation | Deposition | Age | Fractionation | Strata | Detritus | Exploration | Rivers | Nitrogen | Sediments | Imagery | Water depth | Carbon | Investigations | Flow | Climate change | Travel | Hydrologic data | Cations | Mars landing | Craters | Mars craters | Curiosity (Mars rover) | Stratification | Mars (planet) | GEOSCIENCES | Planetary Sciences
Journal Article
Astrophysical Journal, ISSN 0004-637X, 03/2019, Volume 873, Issue 2, p. 124
We use the outputs of a semianalytical model of galaxy formation run on the Millennium Simulation to investigate the prevalence of 3D compact groups (CGs) of...
galaxies: groups: general | galaxies: evolution | galaxies: statistics | galaxies: interactions | METALLICITIES | POPULATION | AGES | EVOLUTION | STAR-FORMATION RATES | MODELS | ASTRONOMY & ASTROPHYSICS | SIMULATIONS | STELLAR MASS | DATA RELEASE | KINEMATICS | Physics - Astrophysics of Galaxies
galaxies: groups: general | galaxies: evolution | galaxies: statistics | galaxies: interactions | METALLICITIES | POPULATION | AGES | EVOLUTION | STAR-FORMATION RATES | MODELS | ASTRONOMY & ASTROPHYSICS | SIMULATIONS | STELLAR MASS | DATA RELEASE | KINEMATICS | Physics - Astrophysics of Galaxies
Journal Article
PLoS Pathogens, ISSN 1553-7366, 11/2012, Volume 8, Issue 11, p. e1003000
Idiopathic chronic diarrhea (ICD) is a leading cause of morbidity amongst rhesus monkeys kept in captivity. Here, we show that exposure of affected animals to...
HOMEOSTASIS | BACTERIA | MICROBIOLOGY | PREVENTS | RESPONSES | VIROLOGY | EXPERIMENTAL COLITIS | GUT MICROBIOME | GENE-EXPRESSION | DIVERSITY | TRICHURIS-SUIS THERAPY | PARASITOLOGY | RHESUS MACAQUES | Inflammation - microbiology | Monkey Diseases - microbiology | Monkey Diseases - therapy | Colon - immunology | Diarrhea - veterinary | Male | Inflammation - immunology | Macaca mulatta | Th2 Cells - immunology | Therapy with Helminths | Intestinal Mucosa - microbiology | Th1 Cells - immunology | Monkey Diseases - immunology | Inflammation - therapy | Diarrhea - microbiology | Animals | Diarrhea - therapy | Intestinal Mucosa - immunology | Diarrhea - immunology | Female | Colon - microbiology | Chronic Disease | Cyanobacteria - immunology | Trichuris | Macaques | Worms, Intestinal and parasitic | Physiological aspects | Diarrhea | Host-parasite relationships | Research | Health aspects | Helminths | Inflammatory bowel disease | Microbiology | Genomics | Phylogenetics | Bacteria | Infections | Colon | Parasites | Autoimmune diseases | Monkeys & apes | Worms
HOMEOSTASIS | BACTERIA | MICROBIOLOGY | PREVENTS | RESPONSES | VIROLOGY | EXPERIMENTAL COLITIS | GUT MICROBIOME | GENE-EXPRESSION | DIVERSITY | TRICHURIS-SUIS THERAPY | PARASITOLOGY | RHESUS MACAQUES | Inflammation - microbiology | Monkey Diseases - microbiology | Monkey Diseases - therapy | Colon - immunology | Diarrhea - veterinary | Male | Inflammation - immunology | Macaca mulatta | Th2 Cells - immunology | Therapy with Helminths | Intestinal Mucosa - microbiology | Th1 Cells - immunology | Monkey Diseases - immunology | Inflammation - therapy | Diarrhea - microbiology | Animals | Diarrhea - therapy | Intestinal Mucosa - immunology | Diarrhea - immunology | Female | Colon - microbiology | Chronic Disease | Cyanobacteria - immunology | Trichuris | Macaques | Worms, Intestinal and parasitic | Physiological aspects | Diarrhea | Host-parasite relationships | Research | Health aspects | Helminths | Inflammatory bowel disease | Microbiology | Genomics | Phylogenetics | Bacteria | Infections | Colon | Parasites | Autoimmune diseases | Monkeys & apes | Worms
Journal Article
Science, ISSN 0036-8075, 5/2013, Volume 340, Issue 6136, pp. 1068 - 1072
Observations by the Mars Science Laboratory Mast Camera (Mastcam) in Gale crater reveal isolated outcrops of cemented pebbles (2 to 40 millimeters in diameter)...
Outcrops | RESEARCH ARTICLES | Rocks | Planetary science | Pebbles | Conglomerates | Sediments | Alluvial fans | Fluvial transport | Impact craters | Sediment transport | SYSTEM | UNIT | MERIDIANI-PLANUM | MARS | MULTIDISCIPLINARY SCIENCES | CHEMCAM INSTRUMENT SUITE | WATER | Astrogeology | Research | Observations | Mars (Planet) | Mars | Abrasion | Craters | Sand | Rock | Abrasion resistance | Spacecraft | Energetic particles | Earth Sciences | Sciences of the Universe
Outcrops | RESEARCH ARTICLES | Rocks | Planetary science | Pebbles | Conglomerates | Sediments | Alluvial fans | Fluvial transport | Impact craters | Sediment transport | SYSTEM | UNIT | MERIDIANI-PLANUM | MARS | MULTIDISCIPLINARY SCIENCES | CHEMCAM INSTRUMENT SUITE | WATER | Astrogeology | Research | Observations | Mars (Planet) | Mars | Abrasion | Craters | Sand | Rock | Abrasion resistance | Spacecraft | Energetic particles | Earth Sciences | Sciences of the Universe
Journal Article
Genetics Selection Evolution, ISSN 0999-193X, 02/2017, Volume 49, Issue 1, pp. 1 - 13
Background: Previously, we have shown that bacterial cold water disease (BCWD) resistance in rainbow trout can be improved using traditional family-based...
BAYESIAN METHODS | AGRICULTURE, DAIRY & ANIMAL SCIENCE | LINKAGE DISEQUILIBRIUM | FLAVOBACTERIUM-PSYCHROPHILUM | GENETICS & HEREDITY | RELATIONSHIP MATRIX | SALMON SALMO-SALAR | RELIABILITY | WIDE ASSOCIATION | ADMIXTURE | REFERENCE POPULATION | BEEF-CATTLE | Cold Temperature | Reproducibility of Results | Fish Diseases - microbiology | Breeding | Selection, Genetic | Oncorhynchus mykiss - genetics | Genetic Markers | Fish Diseases - genetics | Bacterial Infections - genetics | Phenotype | Animals | Pedigree | Bayes Theorem | Models, Genetic | Polymorphism, Single Nucleotide | Genomics - methods | Quantitative Trait Loci | Disease Resistance - genetics | Bacterial Infections - microbiology | Genetic aspects | Bacterial infections | Methods | Marker assisted selection | Rainbow trout | Diseases | Life Sciences
BAYESIAN METHODS | AGRICULTURE, DAIRY & ANIMAL SCIENCE | LINKAGE DISEQUILIBRIUM | FLAVOBACTERIUM-PSYCHROPHILUM | GENETICS & HEREDITY | RELATIONSHIP MATRIX | SALMON SALMO-SALAR | RELIABILITY | WIDE ASSOCIATION | ADMIXTURE | REFERENCE POPULATION | BEEF-CATTLE | Cold Temperature | Reproducibility of Results | Fish Diseases - microbiology | Breeding | Selection, Genetic | Oncorhynchus mykiss - genetics | Genetic Markers | Fish Diseases - genetics | Bacterial Infections - genetics | Phenotype | Animals | Pedigree | Bayes Theorem | Models, Genetic | Polymorphism, Single Nucleotide | Genomics - methods | Quantitative Trait Loci | Disease Resistance - genetics | Bacterial Infections - microbiology | Genetic aspects | Bacterial infections | Methods | Marker assisted selection | Rainbow trout | Diseases | Life Sciences
Journal Article