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2008, ISBN 9781402066986, xix, 448
21 case studies illustrate transdisciplinary, problem-driven researchWill appeal to those who initiate, steer or evaluate researchTies together science and... 
Interdisciplinary research | Interdisciplinary approach to knowledge | Science: General Issues | Aufsatzsammlung | Interdisziplinäre Forschung | Environment, general | Interdisciplinary Studies | Environmental Health | Health Promotion and Disease Prevention | Environment | Methodology of the Social Sciences | Social Policy
Book
Neuroradiology, ISSN 0028-3940, 8/2012, Volume 54, Issue 8, pp. 829 - 837
Journal Article
Nature Medicine, ISSN 1078-8956, 11/2015, Volume 21, Issue 11, pp. 1318 - 1325
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7466, pp. 232 - 236
KRAS and BRAF activating mutations drive tumorigenesis through constitutive activation of the MAPK pathway. As these tumours represent an area of high unmet... 
PATHWAYS | WILD-TYPE | ACTIVATION | PI3K | MULTIDISCIPLINARY SCIENCES | C-RAF | MAP KINASE KINASE-1 | B-RAF | MUTATIONS | TUMOR-GROWTH INHIBITION | RAF PROTEINS | Niacinamide - analogs & derivatives | Humans | Crystallography, X-Ray | Azetidines - pharmacology | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Piperidines - pharmacology | Phosphorylation - drug effects | Proto-Oncogene Proteins B-raf - metabolism | Genes, ras - genetics | Allosteric Regulation - drug effects | Cell Survival - drug effects | HCT116 Cells | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Clinical Trials as Topic | Imidazoles - pharmacology | Enzyme Activation - drug effects | Phosphoserine - metabolism | Mitogen-Activated Protein Kinase Kinases - chemistry | MAP Kinase Signaling System - drug effects | Proto-Oncogene Proteins B-raf - genetics | Feedback, Physiological - drug effects | Protein Kinase Inhibitors - pharmacology | Niacinamide - pharmacology | Neoplasms - pathology | Oncogene Protein p21(ras) - genetics | Gene mutations | Cancer cells | Cellular control mechanisms | Physiological aspects | Properties | Phosphotransferases | Mitogen-activated protein kinases | Studies | Phosphorylation | Hydrogen bonds | Melanoma | Kinases | Tumors | Cancer
Journal Article
Journal Article
Science, ISSN 0036-8075, 3/2009, Volume 323, Issue 5921, pp. 1610 - 1614
The interface between antibody and antigen is often depicted as a lock and key, suggesting that an antibody surface can accommodate only one antigen. Here, we... 
Antigens | Cell growth | DNA | Medical treatment | Antibodies | Amino acids | Reports | Breast cancer | Genetic mutation | Binding sites | Tumors | BREAST-CANCER | ANGSTROM RESOLUTION | COMPLEX | SOMATIC HYPERMUTATION | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | RECEPTOR | DIVERSITY | MOLECULAR-BASIS | ENDOTHELIAL GROWTH-FACTOR | XENOGRAFTS | Antibody Specificity | Complementarity Determining Regions - genetics | Epitopes - metabolism | Humans | Receptor, ErbB-2 - chemistry | Receptor, ErbB-2 - metabolism | Antibodies, Monoclonal - therapeutic use | Crystallography, X-Ray | Vascular Endothelial Growth Factor A - metabolism | Antibodies, Bispecific - genetics | Epitopes - immunology | Vascular Endothelial Growth Factor A - chemistry | Antibodies, Monoclonal, Humanized | Thermodynamics | Receptor, ErbB-2 - immunology | Antibodies, Monoclonal - chemistry | Antibodies, Monoclonal - immunology | Protein Structure, Tertiary | Binding Sites, Antibody - genetics | Models, Molecular | Antibody Affinity | Vascular Endothelial Growth Factor A - immunology | Antibodies, Bispecific - immunology | Xenograft Model Antitumor Assays | Antibodies, Bispecific - therapeutic use | Antibodies, Monoclonal - genetics | Animals | Genetic Engineering | Mutagenesis | Complementarity Determining Regions - immunology | Antibodies, Bispecific - chemistry | Protein Conformation | Cell Proliferation - drug effects | Mice | Neoplasms, Experimental - drug therapy | Trastuzumab | Viral antibodies | Therapeutics | Research | Properties | Vascular endothelial growth factor | Homeopathy | Materia medica and therapeutics | Proteins | Biotechnology | Cellular biology | Index Medicus
Journal Article