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fibrosis (6) 6
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Kidney International, ISSN 0085-2538, 07/2014, Volume 86, Issue 1, pp. 75 - 85
Fibrosis is a hallmark of chronic kidney disease, for which there is currently no effective cure. The hormone relaxin is emerging as an effective antifibrotic... 
Smad2 | kidney disease | TGF-β | fibrosis | relaxin | AT2 receptor | KIDNEY-DISEASE | NITRIC-OXIDE SYNTHASE | PROTEIN-KINASE | RESONANCE ENERGY-TRANSFER | FIBROBLASTS | TGF-beta | GROWTH-FACTOR-BETA | AT RECEPTORS | IN-VIVO | UROLOGY & NEPHROLOGY | HYPERTENSIVE-RATS | HORMONE RELAXIN | Relaxin - metabolism | Kidney - pathology | Receptors, G-Protein-Coupled - metabolism | Transforming Growth Factor beta1 - antagonists & inhibitors | Humans | Protein Multimerization | Male | Receptors, Peptide - chemistry | Angiotensin II Type 2 Receptor Blockers - pharmacology | Relaxin - pharmacology | Renal Insufficiency, Chronic - drug therapy | Myofibroblasts - metabolism | Renal Insufficiency, Chronic - metabolism | Kidney - metabolism | Myofibroblasts - pathology | Receptor, Angiotensin, Type 2 - genetics | Kidney - drug effects | Cells, Cultured | Rats | Imidazoles - pharmacology | Recombinant Proteins - pharmacology | Myofibroblasts - drug effects | Rats, Sprague-Dawley | Disease Progression | Mice, Knockout | Renal Insufficiency, Chronic - pathology | Animals | MAP Kinase Signaling System - drug effects | Receptor, Angiotensin, Type 2 - metabolism | Signal Transduction - drug effects | Fibrosis | Mice | Pyridines - pharmacology | Receptor, Angiotensin, Type 2 - deficiency | Receptors, G-Protein-Coupled - chemistry | Receptors, Peptide - metabolism
Journal Article
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, ISSN 1931-857X, 09/2019, Volume 317, Issue 3, pp. E606 - E615
Posttranslational modification of nucleosomal histones is a major determinant of chromatin structure and gene activity. In the present study, we hypothesized... 
kidney | PHYSIOLOGY | histones | INHIBITION | gene regulation | unilateral ureteric obstruction | PHOSPHORYLATION | H3K9 | UROLOGY & NEPHROLOGY | mass spectrometry | fibrosis | modifications
Journal Article
American journal of physiology. Renal physiology, ISSN 1931-857X, 01/2019, Volume 316, Issue 3, pp. F517 - F529
Histone acetylation is an important modulator of gene expression in fibrosis. This study examined the effect of the pre-eminent fibrogenic cytokine TGF-b1 on... 
Journal Article
Frontiers in Pharmacology, ISSN 1663-9812, 05/2017, Volume 8, Issue MAY, p. 307
Epigenetic regulation of fibrogenesis through post-translational histone modifications (marks) may be a key determinant of progression in renal disease. In... 
Proximal tubule | Myofibroblast | Fibrosis | Epigenetics | TGF-β1 | Histone | Fibroblast | Kidney | kidney | fibrosis | fibroblast | histone | myofibroblast | epigenetics
Journal Article
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, ISSN 1046-6673, 11/2019, Volume 30, Issue 11, pp. 2191 - 2207
Background Recombinant human relaxin-2 (serelaxin), which has organ-protective actions mediated via its cognate G protein?coupled receptor relaxin family... 
Relaxin family peptide receptor 1 | AT RECEPTOR | AGONIST COMPOUND 21 | kidney disease | angiotensin receptors | BLOOD-PRESSURE | SERELAXIN | HUMAN RELAXIN-2 | ANGIOTENSIN TYPE-2 RECEPTOR | heart disease | TUBULOINTERSTITIAL FIBROSIS | SELECTIVE AGONIST | NITRIC-OXIDE | UROLOGY & NEPHROLOGY | fibrosis | Index Medicus
Journal Article
Journal Article
Methods in molecular biology (Clifton, N.J.), 2010, Volume 611, pp. 3 - 18
A number of techniques have been developed to use chemical, immunological, and molecular biology assays in histological material. Collectively termed... 
Microscopy - methods | Paraffin Embedding - methods | Animals | Histocytochemistry - methods | Humans | Tissue Fixation - methods | Fixatives - chemistry | Tissue Embedding - methods | Antigens - chemistry
Journal Article
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