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medical and health sciences (13) 13
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neoplasms - drug therapy (2) 2
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by Gad, Helge and Gad, Helge and Koolmeister, Tobias and Koolmeister, Tobias and Jemth, Ann-Sofie and Jemth, Ann-Sofie and Eshtad, Saeed and Eshtad, Saeed and Jacques, Sylvain A and Jacques, Sylvain A and Ström, Cecilia E and Ström, Cecilia E and Svensson, Linda M and Svensson, Linda M and Schultz, Niklas and Schultz, Niklas and Lundbäck, Thomas and Lundbäck, Thomas and Einarsdottir, Berglind Osk and Einarsdottir, Berglind Osk and Saleh, Aljona and Saleh, Aljona and Göktürk, Camilla and Göktürk, Camilla and Baranczewski, Pawel and Baranczewski, Pawel and Svensson, Richard and Svensson, Richard and Berntsson, Ronnie P-A and Berntsson, Ronnie P.-A and Gustafsson, Robert and Gustafsson, Robert and Strömberg, Kia and Strömberg, Kia and Sanjiv, Kumar and Sanjiv, Kumar and Jacques-Cordonnier, Marie-Caroline and Jacques-Cordonnier, Marie-Caroline and Desroses, Matthieu and Desroses, Matthieu and Gustavsson, Anna-Lena and Gustavsson, Anna-Lena and Olofsson, Roger and Olofsson, Roger and Johansson, Fredrik and Johansson, Fredrik and Homan, Evert J and Homan, Evert J and Loseva, Olga and Loseva, Olga and Bräutigam, Lars and Bräutigam, Lars and Johansson, Lars and Johansson, Lars and Höglund, Andreas and Höglund, Andreas and Hagenkort, Anna and Hagenkort, Anna and Pham, Therese and Pham, Therese and Altun, Mikael and Altun, Mikael and Gaugaz, Fabienne Z and Gaugaz, Fabienne Z and Vikingsson, Svante and Vikingsson, Svante and Evers, Bastiaan and Evers, Bastiaan and Henriksson, Martin and Henriksson, Martin and Vallin, Karl S A and Vallin, Karl S.A and Wallner, Olov A and Wallner, Olov A and Hammarström, Lars G.J and Hammarström, Lars G J and Wiita, Elisee and Wiita, Elisee and Almlöf, Ingrid and Almlöf, Ingrid and Kalderén, Christina and Kalderén, Christina and Axelsson, Hanna and Axelsson, Hanna and Djureinovic, Tatjana and Djureinovic, Tatjana and Puigvert, Jordi Carreras and Puigvert, Jordi Carreras and Häggblad, Maria and Häggblad, Maria and Jeppsson, Fredrik and Jeppsson, Fredrik and Martens, Ulf and Martens, Ulf and Lundin, Cecilia and Lundin, Cecilia and Lundgren, B and Lundgren, Bo and Granelli, Ingrid and Granelli, Ingrid and ... and Institutionen för medicin och hälsa and Avdelningen för läkemedelsforskning and Linköpings universitet and Hälsouniversitetet
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, pp. 215 - 221
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
TARGET | CELLS | OXIDATIVE STRESS | REPAIR | HMTH1 | PROTEIN | MULTIDISCIPLINARY SCIENCES | DNA-SYNTHESIS | MUTAGENIC SUBSTRATE | CELLULAR SENESCENCE | 8-OXOGUANINE | Neoplasms - metabolism | Humans | Molecular Conformation | Male | Molecular Targeted Therapy | Pyrimidines - chemistry | Pyrophosphatases - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | DNA Repair Enzymes - metabolism | Oxidation-Reduction - drug effects | Female | Deoxyguanine Nucleotides - metabolism | Cell Death - drug effects | DNA Repair Enzymes - antagonists & inhibitors | DNA Repair Enzymes - chemistry | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Cell Survival - drug effects | Catalytic Domain | Reproducibility of Results | Crystallization | Enzyme Inhibitors - pharmacology | Models, Molecular | Pyrimidines - pharmacology | Nucleotides - metabolism | Enzyme Inhibitors - therapeutic use | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | Pyrimidines - therapeutic use | Pyrimidines - pharmacokinetics | Mice | DNA Damage | Neoplasms - pathology | Phosphoric Monoester Hydrolases - metabolism | Phosphoric Monoester Hydrolases - chemistry | Prevention | Deoxyribonucleotides | DNA damage | Cancer cells | Physiological aspects | Research | Binding proteins | Cancer | Cytotoxicity | Kinases | Cancer therapies | Defects | Proteins | Genotype & phenotype | Mutagenesis | Rodents | Cell cycle | Mutation | Deoxyribonucleic acid--DNA | Tumors | Apoptosis | Index Medicus | Medical and Health Sciences | MEDICINE | Medicin och hälsovetenskap | MEDICIN
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3872 - 16
The glycolytic PFKFB3 enzyme is widely overexpressed in cancer cells and an emerging anticancer target. Here, we identify PFKFB3 as a critical factor in... 
RIBONUCLEOTIDE REDUCTASE | THERMAL SHIFT ASSAY | IN-VITRO | REPAIR | GLUCOSE-METABOLISM | DNTP POOLS | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | 6-PHOSPHOFRUCTO-2-KINASE PFKFB3 | GENOME INTEGRITY | DOUBLE-STRAND BREAKS | Sulfones - therapeutic use | Humans | Antineoplastic Agents - therapeutic use | Sulfones - pharmacology | Biphenyl Compounds - therapeutic use | DNA Breaks, Double-Stranded - radiation effects | Hydroxybenzoates - pharmacology | Neoplasms - therapy | Biphenyl Compounds - pharmacology | Dideoxynucleotides - metabolism | Antineoplastic Agents - pharmacology | Hydroxybenzoates - therapeutic use | Recombinational DNA Repair - drug effects | Radiation, Ionizing | Cell Survival - drug effects | Chemoradiotherapy - methods | Enzyme Inhibitors - pharmacology | Phosphofructokinase-2 - antagonists & inhibitors | Radiation Tolerance - genetics | Cell Survival - radiation effects | Enzyme Inhibitors - therapeutic use | Radiation Tolerance - drug effects | Phosphofructokinase-2 - metabolism | Phosphofructokinase-2 - genetics | Cell Line, Tumor | Recombinational DNA Repair - radiation effects | RNA, Small Interfering - metabolism | Cell survival | Target recognition | DNA damage | Homologous recombination | Homology | Pharmacology | DNA repair | Damage localization | Recruitment | Proteins | Ionizing radiation | Inhibitors | Radiosensitization | Enzymatic activity | Transformed cells | Glycolysis | Repair | Deoxyribonucleic acid--DNA | Cancer | Reductase | Index Medicus | Biological Sciences | Basic Medicine | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Medicinska och farmaceutiska grundvetenskaper | Cell and Molecular Biology | Natural Sciences | Cellbiologi | Cell- och molekylärbiologi | Cell Biology
Journal Article
Nature Medicine, ISSN 1078-8956, 02/2017, Volume 23, Issue 2, pp. 256 - 263
The cytostatic deoxycytidine analog cytarabine (ara-C) is the most active agent available against acute myelogenous leukemia (AML). Together with... 
MEDICINE, RESEARCH & EXPERIMENTAL | CYTOSINE-ARABINOSIDE | CELLS | ARA-C SENSITIVITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | CELL BIOLOGY | IN-VITRO | DNA | CHRONIC LYMPHOCYTIC-LEUKEMIA | MUTATIONS | EXPRESSION | Cytarabine - pharmacology | Prognosis | Apoptosis - drug effects | Cytarabine - therapeutic use | Humans | Leukemia, Myeloid, Acute - metabolism | SAM Domain and HD Domain-Containing Protein 1 | Child, Preschool | Infant | Male | Viral Regulatory and Accessory Proteins - pharmacology | Molecular Targeted Therapy | Monomeric GTP-Binding Proteins - drug effects | Antineoplastic Combined Chemotherapy Protocols - pharmacology | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Antimetabolites, Antineoplastic - pharmacology | Female | Child | Disease Models, Animal | Arabinofuranosylcytosine Triphosphate - metabolism | Antimetabolites, Antineoplastic - therapeutic use | Animals | Monomeric GTP-Binding Proteins - metabolism | Adolescent | Aged | Mice | In Vitro Techniques | Cellular proteins | Molecular targeted therapy | Care and treatment | Cytarabine | Patient outcomes | Drug interactions | Innovations | Development and progression | Genetic aspects | Blood diseases | Health aspects | Biomarkers | Cytotoxicity | Chemotherapy | Gene expression | Leukemia | Index Medicus | Biological Sciences | Clinical Medicine | Naturvetenskap | Medical and Health Sciences | Hematology | Hematologi | Medicin och hälsovetenskap | Biologiska vetenskaper | Natural Sciences | Klinisk medicin
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2017, Volume 60, Issue 5, pp. 2148 - 2154
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 05/2017, Volume 60, Issue 10, pp. 4279 - 4292
Journal Article
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2016, Volume 59, Issue 3, pp. 1140 - 1148
Journal Article
Science, ISSN 0036-8075, 11/2018, Volume 362, Issue 6416, pp. 834 - 839
The onset of inflammation is associated with reactive oxygen species and oxidative damage to macromolecules like 7,8-dihydro-8-oxoguanine (8-oxoG) in DNA.... 
CELLS | SITE | BASE MODIFICATIONS | OXIDATIVE DNA-DAMAGE | SPECIFICITY | REPAIR ENZYME | DEMETHYLATION | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | 8-OXOGUANINE-DNA GLYCOSYLASE | DEFICIENCY | Gene Expression - drug effects | Guanine - analogs & derivatives | Humans | Guanine - antagonists & inhibitors | NF-kappa B - metabolism | DNA Repair - genetics | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Guanine - metabolism | Inflammation - drug therapy | Mice, Mutant Strains | Enzyme Inhibitors - chemistry | HEK293 Cells | DNA Glycosylases - metabolism | Promoter Regions, Genetic | DNA Repair - drug effects | Jurkat Cells | Enzyme Inhibitors - pharmacology | Gene Knockout Techniques | Enzyme Inhibitors - therapeutic use | Tumor Necrosis Factor-alpha - pharmacology | Animals | NF-kappa B - genetics | Anti-Inflammatory Agents, Non-Steroidal - therapeutic use | DNA Glycosylases - antagonists & inhibitors | Inflammation - genetics | Mice | Care and treatment | Physiological aspects | Genetic research | DNA glycosylases | Inflammation | DNA repair | Methods | Chromatin | Reactive oxygen species | Genes | DNA damage | DNA glycosylase | Base excision repair | Guanine | Lipopolysaccharides | Oxidation resistance | Tumor necrosis factor-TNF | Inhibition | Repair | Deoxyribonucleic acid--DNA | Binding | Macromolecules | Leukocytes (neutrophilic) | Gene expression | Substrates | Immune systems | Inhibitors | Lungs | OGG1 protein | Tumor necrosis factor | Tumors | Index Medicus | Medical Biotechnology | Biological Sciences | Naturvetenskap | Medical and Health Sciences | Medicin och hälsovetenskap | Biologiska vetenskaper | Medicinsk bioteknologi | Natural Sciences | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)
Journal Article
Cancer Research, ISSN 0008-5472, 02/2017, Volume 77, Issue 4, pp. 937 - 948
Journal Article
Nature, ISSN 0028-0836, 04/2017, Volume 544, Issue 7651, p. 508
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 7495, p. 215
Cancers have dysfunctional redox regulation resulting in reactive oxygen species production, damaging both DNA and free dNTPs. The MTH1 protein sanitizes... 
Medical and Health Sciences | Medicin och hälsovetenskap
Journal Article