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1. Full Text Current Developments in Activity-Based Protein Profiling
by Willems, Lianne I and Overkleeft, Herman S and van Kasteren, Sander I
Bioconjugate Chemistry, ISSN 1043-1802, 07/2014, Volume 25, Issue 7, pp. 1181 - 1191
Activity-based protein profiling (ABPP) has emerged as a powerful strategy to study the activity of enzymes in complex proteomes. The aim of ABPP is to... 
Topical Review | DEUBIQUITINATING ENZYME | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | TERMINAL ALKYNES | TYROSINE PHOSPHATASES | CHEMISTRY, MULTIDISCIPLINARY | ACTIVITY-BASED PROBES | CLEAVABLE LINKER | BIOORTHOGONAL REACTIONS | BETA-GLUCOSIDASE INHIBITOR | FUNCTIONAL PROTEOMIC ANALYSIS | IN-SITU | CYSTEINE PROTEASES | Protein Array Analysis | Enzyme Assays | Animals | Proteomics - methods | Humans | Enzymes - metabolism
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2. Full Text Direct One-Step Fluorescent Labeling of O‑GlcNAc-Modified Proteins in Live Cells Using Metabolic Intermediates
by Tan, Hong Yee and Eskandari, Razieh and Shen, David and Zhu, Yanping and Liu, Ta-Wei and Willems, Lianne I and Alteen, Matthew G and Madden, Zarina and Vocadlo, David J
Journal of the American Chemical Society, ISSN 0002-7863, 11/2018, Volume 140, Issue 45, pp. 15300 - 15308
The modification of proteins with O-linked N-acetylglucosamine (O-GlcNAc) by the enzyme O-GlcNAc transferase (OGT) has emerged as an important regulator of... 
CHEMICAL REPORTERS | CROSS-TALK | NUCLEAR | GLCNACYLATION | KINETIC-ANALYSIS | CYTOSOLIC PROTEINS | GLYCOSYLATION | IDENTIFICATION | STRESS | CHEMISTRY, MULTIDISCIPLINARY | TRANSFERASE | Humans | Fluorescence | Glycosylation | Molecular Structure | HeLa Cells | Acetylglucosamine - chemistry | N-Acetylglucosaminyltransferases - chemistry | N-Acetylglucosaminyltransferases - metabolism | Acetylglucosamine - metabolism
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3. Current Developments in Activity-Based Protein Profiling
by Lianne I Willems and Herman S Overkleeft and Sander I van Kasteren
Bioconjugate Chemistry, ISSN 1043-1802, 07/2014, Volume 25, Issue 7, p. 1181
  Activity-based protein profiling (ABPP) has emerged as a powerful strategy to study the activity of enzymes in complex proteomes. The aim of ABPP is to... 
Proteins | Enzymes | Chemistry | Natural products
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4. Full Text Structural and functional insight into human O-GlcNAcase
by Roth, Christian and Chan, Sherry and Offen, Wendy and Willems, Lianne and King, Dustin and Britton, Robert and Vocadlo, David and Davies, Gideon
Acta Crystallographica Section A Foundations and Advances, ISSN 2053-2733, 08/2018, Volume 74, Issue a2, pp. e42 - e42
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5. Full Text Triple Bioorthogonal Ligation Strategy for Simultaneous Labeling of Multiple Enzymatic Activities
by Willems, Lianne I and Li, Nan and Florea, Bogdan I and Ruben, Mark and van der Marel, Gijsbert A and Overkleeft, Herman S
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2012, Volume 51, Issue 18, pp. 4431 - 4434
Three at the same time: A ligation strategy combining tetrazine–norbornene cycloaddition, Staudinger–Bertozzi ligation, and copper(I)‐catalyzed click reaction... 
click chemistry | cycloadditions | bioorthogonal reactions | activity‐based profiling | tetrazines | activity-based profiling | TERMINAL ALKYNES | PROTEASOME PROBES | CHEMISTRY, MULTIDISCIPLINARY | AMINO-ACIDS | IN-VIVO | COPPER(I)-CATALYZED AZIDE-ALKYNE | INHIBITOR | PROTEINS | LIVING CELLS | Cell Line | Heptanes - chemistry | Click Chemistry | Humans | Proteasome Endopeptidase Complex - chemistry | Bridged Bicyclo Compounds - chemistry | Copper - chemistry | Cyclization | Heterocyclic Compounds, 1-Ring - chemistry | Tetrazoles - chemistry | Staining and Labeling | Molecular Structure | Catalysis | Cycloaddition | Strategy | Labels | Catalytic activity | Biological | Marking | Orthogonality | Monitoring
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6. Full Text Structural and functional insight into human O-GlcNAcase
by Roth, Christian and Chan, Sherry and Offen, Wendy A and Hemsworth, Glyn R and Willems, Lianne I and King, Dustin T and Varghese, Vimal and Britton, Robert and Vocadlo, David J and Davies, Gideon J
Nature Chemical Biology, ISSN 1552-4450, 06/2017, Volume 13, Issue 6, pp. 610 - 612
O-GlcNAc hydrolase (OGA) removes O-linked N-acetylglucosamine (O-GlcNAc) from a myriad of nucleocytoplasmic proteins. Through co-expression and assembly of OGA... 
BETA-N-ACETYLGLUCOSAMINIDASE | GLCNACYLATION | MECHANISM | SUBSTRATE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MACROMOLECULAR CRYSTALLOGRAPHY | CYTOSOLIC PROTEINS | INHIBITORS | GLYCOSYLATION | SOFTWARE | BRAIN | Protein Structure, Tertiary | beta-N-Acetylhexosaminidases - metabolism | Humans | Enzyme Inhibitors - pharmacology | Models, Molecular | beta-N-Acetylhexosaminidases - chemistry | Enzyme Activation - drug effects | Acetylglucosamine - metabolism | Protein Isoforms - chemistry | HEK293 Cells | Protein Binding | Ligands | beta-N-Acetylhexosaminidases - genetics | Binding Sites | Protein Isoforms - genetics | Proteins | Enzymes | Inhibitors | N-Acetylglucosamine | Hydrolase | Molecular structure | Fragments | Gene expression | Assembly | Structure-function relationships | Fragmentation | Hydrologic sciences
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7. Full Text Potent and selective activity-based probes for GH27 human retaining [alpha]-galactosidases
by Willems, Lianne I and Kallemeijn, Wouter W and Scheij, Saskia and Murray, Benjamin and Beenakker, Thomas J.M
Journal of the American Chemical Society, ISSN 0002-7863, 08/2014, Volume 136, Issue 33, p. 11622
Aziridines | Physiological aspects | Research | Chemical properties | Alpha galactosidases
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8. Full Text FcR[gamma]-Chain Deficiency Reduces the Development of Diet-Induced Obesity
by Lianne van Beek and Irene O C M Vroegrijk and Saeed Katiraei and Mattijs M Heemskerk and Andrea D van Dam and Sander Kooijman and Patrick C N Rensen and Frits Koning and J Sjef Verbeek and Ko Willems van Dijk and Vanessa van Harmelen
ISSN 1930-7381, 12/2015, Volume 23, Issue 12, p. 2435
  Pathogenic immunoglobulins are produced during the development of obesity and contribute to the development of insulin resistance (IR). However, the... 
Obesity | Lymphocytes | Rodents | Insulin resistance | Fatty acids
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9. Full Text Small molecule antagonists for chemokine CCR3 receptors
by Willems, Lianne I and IJzerman, Ad P
Medicinal Research Reviews, ISSN 0198-6325, 09/2010, Volume 30, Issue 5, pp. 778 - 817
The chemokine receptor CCR3 is believed to play a role in the development of allergic diseases such as asthma, atopic dermatitis, and allergic rhinitis.... 
antagonists | allergic disease | CCR3 | chemokine receptor | low‐molecular‐weight | Antagonists | Chemokine receptor | Low-molecular-weight | Allergic disease | SELECTIVE ANTAGONIST | CHEMISTRY, MEDICINAL | low-molecular-weight | DISCOVERY | BIPIPERIDINE AMIDE COMPOUNDS | RIGID CYCLIC TEMPLATES | INTERNATIONAL UNION | IN-VIVO | ASTHMA | PHARMACOLOGY & PHARMACY | PART 1 | AIRWAY HYPERRESPONSIVENESS | STABILIZED ACYCLIC SCAFFOLDS | Amino Acid Sequence | Small Molecule Libraries - chemistry | Small Molecule Libraries - pharmacology | Animals | Humans | Molecular Sequence Data | Structure-Activity Relationship | Receptors, CCR3 - chemistry | Receptors, CCR3 - antagonists & inhibitors | Patents | amides | Calcium (intracellular) | Phenylalanine | Hypersensitivity | Leukocytes (eosinophilic) | piperazine | Allergic diseases | Inflammation | Structure-activity relationships | Chemotaxis | Chemokine receptors | Asthma | Urea | Atopic dermatitis | Allergic rhinitis
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10. Full Text Gaucher disease and Fabry disease: New markers and insights in pathophysiology for two distinct glycosphingolipidoses
by Ferraz, Maria J and Kallemeijn, Wouter W and Mirzaian, Mina and Herrera Moro, Daniela and Marques, Andre and Wisse, Patrick and Boot, Rolf G and Willems, Lianne I and Overkleeft, H.S and Aerts, J.M
BBA - Molecular and Cell Biology of Lipids, ISSN 1388-1981, 05/2014, Volume 1841, Issue 5, pp. 811 - 825
Gaucher disease (GD) and Fabry disease (FD) are two relatively common inherited glycosphingolipidoses caused by deficiencies in the lysosomal glycosidases... 
Fabry disease | Gaucher disease | Galactotriaosylsphingosine | Glycosphingolipid | Lysosome | Activity-based probe | GLUCOSYLCERAMIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LYSOSOMAL STORAGE DISEASES | SUBSTRATE REDUCTION THERAPY | N-BUTYLDEOXYNOJIRIMYCIN | AGALSIDASE-BETA | CELL BIOLOGY | PLASMA CHITOTRIOSIDASE | BIOPHYSICS | CLINICAL-MANIFESTATIONS | HUMAN ALPHA-GALACTOSIDASE | ENZYME REPLACEMENT THERAPY | IN-SITU | Physiological aspects | Enzymes | Gangliosides
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11. Full Text Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation
: Glucocorticoid receptor modulation in obesity
by van den Heuvel, José K and Boon, Mariëtte R and van Hengel, Ingmar and Peschier-van der Put, Emma and van Beek, Lianne and van Harmelen, Vanessa and van Dijk, Ko Willems and Pereira, Alberto M and Hunt, Hazel and Belanoff, Joseph K and Rensen, Patrick C N and Meijer, Onno C
British Journal of Pharmacology, ISSN 0007-1188, 06/2016, Volume 173, Issue 11, pp. 1793 - 1804
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12. Full Text Acylazetine as a Dienophile in Bioorthogonal Inverse Electron-Demand Diels–Alder Ligation
by Engelsma, Sander B and Willems, Lianne I and van Paaschen, Claudia E and van Kasteren, Sander I and van der Marel, Gijsbert A and Overkleeft, Herman S and Filippov, Dmitri V
Organic Letters, ISSN 1523-7060, 05/2014, Volume 16, Issue 10, pp. 2744 - 2747
A new bioorthogonal N-acylazetine tag, suitable for tetrazine mediated inverse electron-demand Diels–Alder conjugation, is developed. The tag is small and... 
CELLS | POTENT | CYCLOADDITIONS | IN-VIVO | REACTIVITY | CHEMISTRY | CHEMISTRY, ORGANIC | PROTEASOME INHIBITOR | EPOXOMICIN | CYCLOPROPENES | PROBES | Molecular Structure | Heterocyclic Compounds, 1-Ring - chemistry | Azetidines - chemistry | Heterocyclic Compounds, 2-Ring - chemical synthesis | Heterocyclic Compounds, 2-Ring - chemistry | Electrons
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13. Full Text Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS
by Li, N and Kuo, C.L and Paniagua, G and Elst, H. van den and Verdoes, M and Willems, L.I and Linden, W.A. van der and Ruben, M and Genderen, E. van and Gubbens, J and Wezel, G.P. van and Overkleeft, H.S and Florea, B.I
Nature Protocols, ISSN 1754-2189, 2013, Volume 8, Issue 6, pp. 1155 - 1168
Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and... 
CELLS | PEPTIDES | QUANTITATIVE PROTEOMICS | MECHANISM | STRATEGY | IN-VIVO | BIOCHEMICAL RESEARCH METHODS | BETA-SUBUNITS | INHIBITORS | BORTEZOMIB | THREONINE | Molecular Probe Techniques | Fluorescence | Molecular Structure | Proteins - analysis | Proteasome Endopeptidase Complex - metabolism | Chromatography, Liquid - methods | Tandem Mass Spectrometry - methods | Protein microarrays | Research | Methods | Proteomics
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14. Full Text FcRγ-chain deficiency reduces the development of diet-induced obesity
: FcRγ-Chain Deficiency Reduces Diet-Induced Obesity
by van Beek, Lianne and Vroegrijk, Irene O.C.M and Katiraei, Saeed and Heemskerk, Mattijs M and van Dam, Andrea D and Kooijman, Sander and Rensen, Patrick C.N and Koning, Frits and Verbeek, J. Sjef and Willems van Dijk, Ko and van Harmelen, Vanessa
Obesity, ISSN 1930-7381, 12/2015, Volume 23, Issue 12, pp. 2435 - 2444
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15. Full Text Synthesis of pH-Activatable Red Fluorescent BODIPY Dyes with Distinct Functionalities
by Hoogendoorn, Sascha and Blom, Annet E. M and Willems, Lianne I and van der Marel, Gijsbert A and Overkleeft, Herman S
Organic Letters, ISSN 1523-7060, 10/2011, Volume 13, Issue 20, pp. 5656 - 5659
A series of tunable pH-dependent BODIPY dyes were synthesized and further functionalized in a Knoevenagel condensation reaction with various aldehydes. In this... 
BORONDIPYRROMETHENE | DESIGN | BORON | NEAR-INFRARED NIR | SOLID-PHASE | LIBRARY | CHEMISTRY, ORGANIC | SENSORS | RHODAMINE-101 | PROBES | Boron Compounds - chemistry | Fluorescent Dyes - chemical synthesis | Fluorescent Dyes - chemistry | Boron Compounds - chemical synthesis | Spectrometry, Fluorescence | Aldehydes - chemistry | Hydrogen-Ion Concentration
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16. Full Text Regulation of immunoproteasome function in the lung
by Keller, I.E and Vosyka, O and Takenaka, S and Kloss, A and Dahlmann, B and Willems, L.I and Verdoes, M and Overkleeft, H.S and Marcos, E and Adnot, S and Hauck, S.M and Ruppert, C and Gunther, A and Herold, S and Ohno, S and Adler, H and Eickelberg, O and Meiners, S
Scientific Reports, ISSN 2045-2322, 2015, Volume 5, Issue 1, p. 10230
Impaired immune function contributes to the development of chronic obstructive pulmonary disease (COPD). Disease progression is further exacerbated by pathogen... 
ALVEOLAR | IMMUNITY | OBSTRUCTIVE PULMONARY-DISEASE | EPITHELIAL-CELLS | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | INFECTION | ENDOPLASMIC-RETICULUM STRESS | DYSFUNCTION | IMMUNOLOGY | PROTEASOME ACTIVITY | T-Lymphocytes, Cytotoxic - immunology | Cell Line | Humans | Mice, Inbred C57BL | Rhadinovirus - immunology | Proteasome Endopeptidase Complex - genetics | Lung - virology | Animals | Cysteine Endopeptidases - metabolism | Cysteine Endopeptidases - genetics | Interferon-gamma - immunology | Tumor Virus Infections - immunology | Female | Lung - metabolism | Mice | Proteasome Endopeptidase Complex - metabolism | Adaptive Immunity - immunology | Pulmonary Disease, Chronic Obstructive - immunology | Proteasome Endopeptidase Complex - immunology | Lung - immunology | Macrophages, Alveolar - immunology | Herpesviridae Infections - immunology | Antigen presentation | Pathogens | Antiviral agents | Immune response | CD8 antigen | Lung diseases | Cytotoxicity | Lymphocytes T | Macrophages | Major histocompatibility complex | Rodents | Obstructive lung disease | Chronic obstructive pulmonary disease | Alveoli | Probes
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17. Full Text Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes
by Altun, Mikael and Kramer, Holger B and Willems, Lianne I and McDermott, Jeffrey L and Leach, Craig A and Goldenberg, Seth J and Kumar, K.G. Suresh and Konietzny, Rebecca and Fischer, Roman and Kogan, Edward and Mackeen, Mukram M and McGouran, Joanna and Khoronenkova, Svetlana V and Parsons, Jason L and Dianov, Grigory L and Nicholson, Benjamin and Kessler, Benedikt M
Chemistry & Biology, ISSN 1074-5521, 2011, Volume 18, Issue 11, pp. 1401 - 1412
Converting lead compounds into drug candidates is a crucial step in drug development, requiring early assessment of potency, selectivity, and off-target... 
PROTEIN LIGASES | CELLS | UBIQUITIN-PROTEASOME SYSTEM | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | CHEMISTRY | FUNCTIONAL PROTEOMICS | HAUSP | P53 STABILIZATION | DEUBIQUITINATING ENZYMES | USP7/HAUSP | Cell Line | Antibodies - chemistry | Humans | Enzyme Inhibitors - pharmacology | Thiophenes - pharmacology | Chromatography, High Pressure Liquid | Enzyme Activation - drug effects | Aminopyridines - chemistry | Thiocyanates - chemistry | Tandem Mass Spectrometry | RNA Interference | Aminopyridines - pharmacology | Enzyme Inhibitors - chemistry | Proteomics | Antibodies - immunology | Thiocyanates - pharmacology | Ubiquitin Thiolesterase - metabolism | Thiophenes - chemistry | Ubiquitin Thiolesterase - antagonists & inhibitors | Ubiquitin Thiolesterase - immunology | Ubiquitin-Specific Peptidase 7 | Enzymes | Chemotherapy | Sulfonamides | Proteolysis | Analysis | Physiological aspects | Lead compounds | Mass spectrometry | Cancer
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