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Annals of Neurology, ISSN 0364-5134, 06/2015, Volume 77, Issue 6, pp. 1007 - 26
OBJECTIVE: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, leading to memory impairment in up to 65% of patients. Memory... 
Journal Article
Annals of Neurology, ISSN 0364-5134, 06/2015, Volume 77, Issue 6, pp. 1007 - 1026
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 508, Issue 1, pp. 118 - 122
Treatment of BRAF(V600E) mutant melanoma by small molecule drugs that target the BRAF or MEK kinases can be effective, but resistance develops invariably(1,2).... 
GROWTH-FACTOR RECEPTOR | BRAF INHIBITOR | RAF INHIBITION | CELLS | MULTIDISCIPLINARY SCIENCES | IMPROVED SURVIVAL | DIFFERENTIATION | C-JUN | CANCER | EXPRESSION | EGFR | Receptor, Epidermal Growth Factor - genetics | Humans | Receptor Protein-Tyrosine Kinases - biosynthesis | Cellular Senescence - drug effects | Melanoma - enzymology | Antineoplastic Agents - administration & dosage | Receptor, Platelet-Derived Growth Factor beta - genetics | Indoles - administration & dosage | Mitogen-Activated Protein Kinase Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Flow Cytometry | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | SOXE Transcription Factors - deficiency | Proto-Oncogene Proteins B-raf - metabolism | Receptor, Platelet-Derived Growth Factor beta - metabolism | Receptor, Epidermal Growth Factor - biosynthesis | Gene Library | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Protein Kinase Inhibitors - administration & dosage | Transforming Growth Factor beta - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Receptor Protein-Tyrosine Kinases - genetics | Signal Transduction - drug effects | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | RNA, Small Interfering | Transforming Growth Factor beta - metabolism | Receptor, Platelet-Derived Growth Factor beta - biosynthesis | Sulfonamides - administration & dosage | Drug Resistance, Neoplasm - drug effects | SOXE Transcription Factors - genetics | Proteins | Biopsy | Rodents | Genes | Melanoma | Mutation | Kinases | Drug resistance | Patients | Tumors | Index Medicus
Journal Article
Nederlands Tijdschrift voor Geneeskunde, ISSN 0028-2162, 2017, Volume 161, Issue 46
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0149405 - e0149405
Journal Article
Cureus, ISSN 2168-8184, 04/2018, Volume 10, Issue 4, p. e2465
In radiotherapy treatment planning, tumor delineation based on diffusion-weighted imaging (DWI) by magnetic resonance imaging (MRI) is a promising technique.... 
Pathology | Laryngeal cancer | Histopathology | Medical imaging | Nuclear magnetic resonance--NMR | Thyroid gland | Larynx | Radiation therapy | Tumors
Journal Article
Journal Article
Journal Article
Cell Reports, ISSN 2211-1247, 09/2015, Volume 12, Issue 12, pp. 1978 - 1985
Most ( ) mutant melanomas are sensitive to selective BRAF inhibitors, but mutant colon cancers are intrinsically resistant to these drugs because of feedback... 
COLON-CANCER | SHP2 PTPN11 | LUNG-CANCER | MEK INHIBITION | BRAF(V600E) INHIBITION | GROWTH | PROTEIN-TYROSINE PHOSPHATASES | RAF INHIBITORS | MUTATIONS | NOONAN-SYNDROME | CELL BIOLOGY | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | RNA, Small Interfering - genetics | Receptor, Epidermal Growth Factor - genetics | ras Proteins - genetics | Colonic Neoplasms - genetics | Colonic Neoplasms - drug therapy | Humans | Gene Expression Regulation, Neoplastic | Genomic Library | ras Proteins - metabolism | Colonic Neoplasms - metabolism | MAP Kinase Signaling System | Receptor, Epidermal Growth Factor - metabolism | Melanoma - genetics | Indoles - pharmacology | Lentivirus - genetics | Antineoplastic Agents - pharmacology | Proto-Oncogene Proteins B-raf - metabolism | Melanoma - metabolism | Transduction, Genetic | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Melanoma - pathology | Sulfonamides - pharmacology | Xenograft Model Antitumor Assays | Drug Resistance, Neoplasm - genetics | Animals | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Melanoma - drug therapy | Cell Line, Tumor | Mice, Inbred NOD | High-Throughput Nucleotide Sequencing | Mice | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Genetic Vectors | Drug Resistance, Neoplasm - drug effects | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Nederlands Tijdschrift voor Geneeskunde, ISSN 0028-2162, 2014, Volume 158, Issue 14
Journal Article
Journal of pathology, ISSN 0022-3417, 2013, Volume 230, Issue 3, pp. 270 - 276
Journal Article
International journal of cancer, ISSN 0020-7136, 2015, Volume 136, Issue 6, pp. 1434 - 1444
The multikinase inhibitor sorafenib is under clinical investigation for the treatment of many solid tumors, but in most cases, the molecular target responsible... 
AMP‐activated protein kinase | metformin | salicylate | sorafenib | non‐small cell lung cancer | Salicylate | Metformin | AMP-activated protein kinase | Sorafenib | Non-small cell lung cancer | non-small cell lung cancer | DRUG | PROTEIN-KINASE | CHEMOTHERAPY | CELL LUNG-CANCER | LKB1-AMPK PATHWAY | DIABETIC-PATIENTS | BREAST-CANCER | IN-VITRO | METABOLISM | ONCOLOGY | GROWTH | Niacinamide - analogs & derivatives | Lung Neoplasms - drug therapy | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Reactive Oxygen Species - metabolism | Humans | Lung Neoplasms - pathology | Lung Neoplasms - congenital | TOR Serine-Threonine Kinases - antagonists & inhibitors | Female | Antineoplastic Agents - pharmacology | Carcinoma, Non-Small-Cell Lung - pathology | Metformin - pharmacology | Proto-Oncogene Proteins - genetics | Drug Synergism | Xenograft Model Antitumor Assays | AMP-Activated Protein Kinases - physiology | Animals | Calcium-Calmodulin-Dependent Protein Kinase Kinase - antagonists & inhibitors | Cell Line, Tumor | Signal Transduction - physiology | Calcium-Calmodulin-Dependent Protein Kinase Kinase - physiology | Mice | Mice, Inbred BALB C | Phenylurea Compounds - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Mutation | Niacinamide - pharmacology | Clinical trials | Kinases | Disease control | Lung cancer | Index Medicus | Cancer Therapy
Journal Article