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activated phosphoinositide 3-kinase δ syndrome, pik3cd gene, bronchiectasis, hematopoietic stem cell transplantation, immunodeficiency, p110δ-activating mutation causing senescent t cells, lymphadenopathy, and immunodeficiency, phosphoinositide 3-kinase inhibitor, phosphoinositide 3-kinase δ (1) 1
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by Coulter, Tanya I., MRCPI and Chandra, Anita, PhD, FRCPath and Bacon, Chris M., PhD, FRCPath and Babar, Judith, MRCP, FRCR and Curtis, James, PhD and Screaton, Nick, FRCP, FRCR and Goodlad, John R., MD, FRCPath and Farmer, George, MD and Steele, Cathal Laurence, MB and Leahy, Timothy Ronan, MRCPI and Doffinger, Rainer, PhD, FRCPath and Baxendale, Helen, PhD, FRCPath and Bernatoniene, Jolanta, PhD and Edgar, J. David M., FRCP, FRCPath and Longhurst, Hilary J., PhD, FRCPath and Ehl, Stephan, MD, PhD and Speckmann, Carsten, MD and Grimbacher, Bodo, MD, PhD and Sediva, Anna, MD, PhD and Milota, Tomas, MD and Faust, Saul N., PhD, FRCPCH and Williams, Anthony P., PhD, FRCPath and Hayman, Grant, FRCP, FRCPath and Kucuk, Zeynep Yesim, MD and Hague, Rosie, MRCP, FRCPH and French, Paul, MD, MRCS, DipFMS, FRCPath and Brooker, Richard, FRCPCH and Forsyth, Peter, FRCPath and Herriot, Richard, FRCP, FRCPath and Cancrini, Caterina, MD, PhD and Palma, Paolo, MD, PhD and Ariganello, Paola, MD and Conlon, Niall, PhD, FRCPath and Feighery, Conleth, PhD, FRCPath and Gavin, Patrick J., MD and Jones, Alison, PhD, FRCPCH and Imai, Kohsuke, MD, PhD and Ibrahim, Mohammad A.A., PhD, FRCP, FRCPath and Markelj, Gašper, MD and Abinun, Mario, MD, PhD and Rieux-Laucat, Frédéric, PhD and Latour, Sylvain, PhD and Pellier, Isabelle, MD, PhD and Fischer, Alain, MD, PhD and Touzot, Fabien, MD, PhD and Casanova, Jean-Laurent, MD, PhD and Durandy, Anne, MD, PhD and Burns, Siobhan O., MD, PhD and Savic, Sinisa, PhD, FRCPath and Kumararatne, D.S., FRCPath, DPhil (Oxon) and Moshous, Despina, MD, PhD and Kracker, Sven, PhD and Vanhaesebroeck, Bart, PhD, FMedSci and Okkenhaug, Klaus, PhD and Picard, Capucine, MD, PhD and Nejentsev, Sergey, MD, PhD and Condliffe, Alison M., PhD, FRCP and Cant, Andrew James, MD, FRCP, FRCPH
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 139, Issue 2, pp. 597 - 606.e4
Background Activated phosphoinositide 3-kinase δ syndrome (APDS) is a recently described combined immunodeficiency resulting from gain-of-function mutations in... 
Allergy and Immunology | Activated phosphoinositide 3-kinase δ syndrome | hematopoietic stem cell transplantation | phosphoinositide 3-kinase δ | immunodeficiency | phosphoinositide 3-kinase inhibitor | PIK3CD gene | bronchiectasis | p110δ-activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency | Activated phosphoinositide 3-kinase delta syndrome | IMMUNOLOGICAL FEATURES | HYPER-IGM SYNDROME | p110 delta-activating mutation causing senescent T cells | hematopoietic stem cell | COMMON VARIABLE IMMUNODEFICIENCY | PIK3CD | IMMUNOLOGY | lymphadenopathy | REFERENCE VALUES | P110-DELTA | phosphoinositide 3-kinase delta | P110 DELTA | B-CELL | ALLERGY | transplantation | MUTATIONS | Recurrence | Class I Phosphatidylinositol 3-Kinases - genetics | Herpesviridae Infections - mortality | Humans | Middle Aged | Child, Preschool | Infant | Male | Antibiotic Prophylaxis | Respiratory Tract Infections - genetics | Lymphoproliferative Disorders - therapy | Young Adult | Respiratory Tract Infections - mortality | Respiratory Tract Infections - therapy | Immunologic Deficiency Syndromes - mortality | Adult | Female | Surveys and Questionnaires | Herpesviridae Infections - genetics | Child | Immunologic Deficiency Syndromes - therapy | Hematopoietic Stem Cell Transplantation | International Cooperation | Lymphoproliferative Disorders - genetics | Mutation - genetics | Class I Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Lymphoproliferative Disorders - mortality | Animals | Herpesviridae Infections - therapy | Immunoglobulins, Intravenous - therapeutic use | Adolescent | Survival Analysis | Immunologic Deficiency Syndromes - genetics | Mice | Cohort Studies | Immune Deficiencies, Infection, and Systemic Immune Disorders | HSCT, Hematopoietic stem cell transplantation | BALF, Bronchoalveolar lavage fluid | CT, Computed tomography | APDS, Activated phosphoinositide-3 kinase δ syndrome | GOF, Gain of function | PI3K, Phosphoinositide 3-kinase | HSV, Herpes simplex virus | CMV, Cytomegalovirus | OR, Odds ratio | PPV, Pneumococcal polysaccharide vaccine | CNS, Central nervous system
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 4, pp. 990 - 990
Journal Article
Journal of Allergy and Clinical Immunology: In Practice, ISSN 2213-2198, 2016, Volume 4, Issue 6, pp. 1160 - 1166.e10
Journal Article
by Di Angelantonio, Emanuele and Thompson, Simon G and Kaptoge, Stephen and Moore, Carmel and Walker, Matthew and Armitage, Jane and Ouwehand, Willem H and Roberts, David J and Danesh, John and Donovan, Jenny and Ford, Ian and Henry, Rachel and Hunt, Beverley J and Le Huray, Bridget and Mehenny, Susan and Miflin, Gail and Green, Jane and Stredder, Mike and Watkins, Nicholas A and McDermott, Alan and Ronaldson, Clive and Thomson, Claire and Tolkien, Zoe and Williamson, Lorna and Allen, David and Sambrook, Jennifer and Hammerton, Tracey and Bruce, David and Choudry, Fizzah and Ghevaert, Cedric and Johnston, Kirstie and Kelly, Anne and King, Adam and King, Andrew and Mo, Alfred and Page, Lizanne and Richardson, Penny and Senior, Peter and Umrania, Yagnesh and Wong, Henna and Murphy, Gavin and Newland, Adrian C and Wheatley, Keith and Greaves, Michael and Turner, Ruth and Turner, Marc and Aziz, Tahir and Brain, Richard and Davies, Christine and Wakeman, Alan and Wakeman, Paula and Dent, Alison and Anthony, Ben and Bland, Desmond and Parrondo, Will and Vincent, Helen and Weatherill, Candy and Forsyth, Andrea and Butterfield, Carol and Wright, Tracey and Ellis, Karen and Poynton, Pat and Brooks, Carolyn and Martin, Emma and Littler, Lara and Williams, Lindsay and Williams, Caroline and Williams, Joanna and Blair, Donna and Ackerley, Karen and Woods, Lynn and Stanley, Sophie and Walsh, Gemma and Franklin, Gayle and Howath, Cheryl and Sharpe, Sarah and Smith, Deborah and Botham, Lauren and Alexander, Claire and Sowerbutts, Gareth and Furnival, Diane and Thake, Michael and Patel, Shilpa and Roost, Carolyn and Sowerby, Sandra and Appleton, Mary Joy and Bays, Eileen and Bowyer, Geoff and Clarkson, Steven and Halson, Stuart and Holmes, Kate and Humphries, Gareth and Parvin-Cooper, Lee and Towler, Jason and Addy, Joanne and Barrass, Patricia and Stennett, Louise and Burton, Susan and Dingwall, Hannah and Clarke, Victoria and ... and INTERVAL Trial Grp and INTERVAL Trial Group
The Lancet, ISSN 0140-6736, 11/2017, Volume 390, Issue 10110, pp. 2360 - 2371
Journal Article
by Jani, Meghna and Chinoy, Hector and Warren, Richard B and Griffiths, Christopher E. M and Plant, Darren and Fu, Bo and Morgan, Ann W and Wilson, Anthony G and Isaacs, John D and Hyrich, KimmeL and Barton, Anne and Prouse, P. J and Moitra, R. K and Shawe, D. J and Nisar, M and Fairburn, K and Nixon, J and Barnes, T and Hui, M and Coady, D and Wright, D and Morley, C and Raftery, G and Bracewell, C and Bridges, M and Armstrong, D and Chuck, A. J and Hailwood, S and Kumar, N and Ashok, D and Reece, R and O'Reilly, S. C and Ding, T and Badcock, L. J and Deighton, C. M and Raj, N and Regan, M. R and Summers, G. D and Williams, R. A and Lambert, J. R and Stevens, R and Wilkinson, C and Kelly, C. A and Hamilton, J and Heycock, C. R and Saravanan, V and Cope, A and Garrood, T and Ng, N and Kirkham, B and Green, M and Gough, A and Lawson, C and Das, D and Borbas, E and Wazir, T and Emery, P and Bingham, S and Bird, H. A and Conaghan, P.G and Pease, C. T and Wakefield, R. J and Buch, M and Bruce, I and Gorodkin, R and Ho, P and Parker, B and Smith, W and Jenkins, E and Mukhtyar, C and Gaffney, K and Macgregor, A. J and Marshall, T and Merry, P and DeSilva, C and Birrell, F. N and Crook, P. R and Szebenyi, B and Bates, D and James, D and Gillott, T and Alvi, A and Grey, C and Browning, J and McHale, J. F and Gaywood, I.C and Jones, A. C and Lanyon, P and Pande, I and Doherty, M and Gupta, A and Courtney, P. A and Srikanth, A and Abhishek, A and Das, L and Pattrick, M and Snowden, H. N and Bowden, A. P and Smith, E. E and Klimiuk, P and ... and Biology Rheumatoid Arthrit Genetic and Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate Collaborators
Arthritis & Rheumatology, ISSN 2326-5191, 08/2015, Volume 67, Issue 8, pp. 2011 - 2019
Journal Article
by Jun, Yang and Ibrahim-Verbaas, Carla and Vronskaya, M and Lambert, J.-C and Chung, J and Naj, Adam and Kunkle, Brian and Wang, L.-S and Bis, Joshua and Bellenguez, Céline and Harold, Denise and Lunetta, Kathryn and DeStefano, Anita L and Grenier-Boley, Benjamin and Sims, Rebecca and Beecham, G.W and Smith, A.V and Chouraki, Vincent and Hamilton-Nelson, Kara and Ikram, Arfan and Fiévet, Nathalie and Denning, Nicola and Martin, E.R and Schmidt, H and Kamatani, Y and Dunstan, M.L and Valladares, Otto and Laza, A.R and Zelenika, Diana and Ramirez, Alfredo and Foroud, Tatiana and Choi, Seung-Hoan and Boland, A and Becker, T and Kukull, W.A and Lee, Sven and Pasquier, Florence and Cruchaga, Carlos and Beekly, Duane and Fitzpatrick, Annette and Hanon, Olivier and Gill, M and Barber, Rachel and Gudnason, Vilmundur and Campion, D and Love, S and Bennett, David A and Amin, Najaf and Berr, Claudine and Tsolaki, Magda and Buxbaum, J.D and Lopez, O.L and Deramecourt, Vincent and Fox, N.C and Cantwell, Laura B and Tárraga, L and Dufouil, Carole and Hardy, J and Crane, L.M.A and Eiriksdottir, Gudny and Hannequin, Didier and Clarke, Robert and Evans, D and Mosley, Thomas H and Letenneur, L and Brayne, Carol and Maier, W and De Jager, P and Emilsson, Valur and Dartigues, Jean-François and Hampel, H and Kamboh, M. Ilyas and Bruijn, Renée and Tzourio, Christophe and Pastor, Pau and Larson, Eric B and Rotter, J.I and O'donovan, Michael and Montine, Thomas J and Nalls, Michael and Mead, Simon and Reiman, Eric and Jonsson, P.V and Holmes, C and St George-Hyslop, P.H and Boada, Mercè and Passmore, Peter and Wendland, Annika and Schmidt, R and Morgan, Kevin and Winslow, A.R and Powell, J.F and Carasquillo, M and Younkin, S and Jakobsdottir, Margret and Kauwe, J.S.K and Wilhelmsen, K.C and Rujescu, Dan and Nöthen, Markus M and Hofman, Albert and ... and IGAP Consortium
Molecular Psychiatry, ISSN 1359-4184, 01/2016, Volume 21, Issue 1, pp. 108 - 117
Journal Article
by Kaptoge, Stephen and Di Angelantonio, Emanuele and Moore, Carmel and Walker, Michael and Walker, Matthew and Armitage, Jane and Ouwehand, Willem H and Roberts, David J and Danesh, John and Thompson, Simon G and Donovan, Jenny and Ford, Ian and Henry, Rachel and Hunt, Beverley J and le Huray, Bridget and Mehenny, Susan and Miflin, Gail and Green, Jane and Stredder, Mike and Watkins, Nicholas A and McDermott, Alan and Ronaldson, Clive and Thomson, Claire and Tolkien, Zoe and Williamson, Lindsay and Williamson, Lorna and Allan, David and Sambrook, Jennifer and Hammerton, Tracey and Bruce, David and Choudry, Fizzah and Ghvaert, Cedric and Jonston, Kirstie and Kelly, Anne and King, Andrew and King, Adam and Mo, Alfred and Page, Lizanne and Richardson, Penny and Senior, Peter and Umrania, Yagnesh and Wong, Henna and Burchell, Brendan and Gallacher, John and Murphy, Gavin and Newland, Adrian C and Wheatley, Keith and Greaves, Michael and Turner, Ruth and Turner, Marc and Aziz, Tahir and Brain, Richard and Davies, Christine and Wakeman, Paula and Wakeman, Alan and Dent, Alison and Anthony, Ben and Bland, Desmond and Parrondo, Willem H and Vincent, Helen and Weatherill, Candy and Forsyth, Andrea and Butterfield, Carol and Wright, Tracey and Ellis, Karen and Johnston, Kristie and Poynton, Pat and Brooks, Carolyn and Martin, Emma and Littler, Lara and Blair, Donna and Ackerley, Karen and Woods, Lynn and Stanley, Sophie and Walsh, Gemma and Franklin, Gayle and Howath, Cheryl and Sharpe, Sarah and Smith, Deborah and Botham, Lauren and Williams, Caroline and Williams, Joanna and Alexander, Claire and Sowerbutts, Gareth and Furnival, Diane and Thake, Michael and Patel, Shilpa and Roost, Carolyn and Sowerby, Sandra and Appleton, Mary Joy and Bays, Eileen and Bowyer, Geoff and Clarkson, Steven and Halson, Stuart and Holmes, Kate and Humphreys, Gareth and Parvin-Cooper, Lee and Towler, Jason and Addy, Joanne and Barrass, Patrica and ... and INTERVAL Trial Grp and INTERVAL Trial Group
The Lancet Haematology, ISSN 2352-3026, 10/2019, Volume 6, Issue 10, pp. e510 - e520
The INTERVAL trial showed that, over a 2-year period, inter-donation intervals for whole blood donation can be safely reduced to meet blood shortages. We... 
HEMOGLOBIN | INTERNATIONAL FORUM | MANAGEMENT | ATTENDANCE | REMINDERS | IRON-DEFICIENCY | HEMATOLOGY | 1ST-TIME
Journal Article