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by Lambert, Jean-Charles and Ibrahim-Verbaas, Carla A and Harold, Denise and Naj, Adam C and Sims, Rebecca and Bellenguez, Céline and Jun, Gyungah and DeStefano, Anita L and Bis, Joshua C and Beecham, Gary W and Grenier-Boley, Benjamin and Russo, Giancarlo and Thornton-Wells, Tricia A and Jones, Nicola and Smith, Albert V and Chouraki, Vincent and Thomas, Charlene and Ikram, M. Arfan and Zelenika, Diana and Vardarajan, Badri N and Kamatani, Yoichiro and Lin, Chiao-Feng and Gerrish, Amy and Schmidt, Helena and Kunkle, Brian and Fiévet, Nathalie and Amouyel, Philippe and Pasquier, Florence and Deramecourt, Vincent and De Bruijn, Renee F.A.G and Amin, Najaf and Hofman, Albert and Van Duijn, Cornelia M and Dunstan, Melanie L and Hollingworth, Paul and Owen, Michael J and O'Donovan, Michael C and Jones, Lesley and Holmans, Peter A and Moskvina, Valentina and Williams, Julie and Baldwin, Clinton and Farrer, Lindsay A and Choi, Seung-Hoan and Lunetta, Kathryn L and Fitzpatrick, Annette L and Harris, Tamara B and Psaty, Bruce M and Gilbert, John R and Hamilton-Nelson, Kara L and Martin, Eden R and Kunkle, Brian and Haines, Jonathan L and Gudnason, Vilmundur and Jonsson, Palmi V and Eiriksdottir, Gudny and Bihoreau, Marie-Thérèse and Lathrop, Mark and Valladares, Otto and Cantwell, Laura B and Wang, Li-San and Schellenberg, Gerard D and Ruiz, Agustin and Boada, Mercè and Reitz, Christiane and Mayeux, Richard and Ramirez, Alfredo and Maier, Wolfgang and Hanon, Olivier and Kukull, Walter A and Buxbaum, Joseph D and Campion, Dominique and Wallon, David and Hannequin, Didier and Crane, Paul K and Larson, Eric B and Becker, Tim and Cruchaga, Carlos and Goate, Alison M and Craig, David and Johnston, Janet A and Mc-Guinness, Bernadette and Todd, Stephen and Passmore, Peter and Berr, Claudine and Ritchie, Karen and Lopez, Oscar L and De Jager, Philip L and Evans, Denis and Lovestone, Simon and Proitsi, Petroula and Powell, John F and Letenneur, Luc and Barberger-Gateau, Pascale and Dufouil, Carole and Dartigues, Jean-François and Morón, Francisco J and Rubinsztein, David C and St. George-Hyslop, Peter and Sleegers, Kristel and ... and EADI and CHARGE and ADGC and GERAD and Cohorts for Heart and Aging Research in Genomic Epidemiology and Genetic and Environmental Risk in Alzheimer's Disease and Alzheimer's Disease Genetic Consortium and European Alzheimer's Disease Initiative (EADI) and Alzheimer's Disease Genetic Consortium (ADGC) and Genetic and Environmental Risk in Alzheimer's Disease (GERAD) and Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) and Stockholms universitet and Centrum för forskning om äldre och åldrande (ARC), (tills m KI) and Samhällsvetenskapliga fakulteten
Nature Genetics, ISSN 1061-4036, 12/2013, Volume 45, Issue 12, pp. 1452 - 1458
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 134, Issue 2, pp. 295 - 305
Journal Article
by Thorsson, Vesteinn and Thorsson, Vésteinn and Gibbs, Richard A and Gibbs, David L and Brown, Scott D and Wolf, Gregory and Wolf, Denise and Bortone, Dante S and Ou Yang, Tai-Hsien and Porta-Pardo, Eduard and Gao, Galen F and Gao, Jianjiong and Plaisier, Christopher L and Eddy, James A and Ziv, Elad and Culhane, Aedin C and Paull, Evan O and Sivakumar, I.K. Ashok and Gentles, Andrew J and Malhotra, Raunaq and Farshidfar, Farshad and Colaprico, Antonio and Parker, Joel S and Mose, Lisle E and Vo, Nam Sy and Liu, Wenbin and Liu, Jianfang and Liu, Jia and Liu, Yuexin and Liu, Xiuping and Rader, Janet and Dhankani, Varsha and Reynolds, Sheila and Reynolds, Sheila M and Bowlby, Reanne and Califano, Andrea and Cherniack, Andrew D and Anastassiou, Dimitris and Bedognetti, Davide and Mokrab, Younes and Newman, Aaron M and Rao, Arvind and Chen, Amy and Chen, Chu and Chen, Ken and Krasnitz, Alexander and Hu, Jianhong and Hu, Hai and Malta, Tathiane M and Noushmehr, Houtan and Pedamallu, Chandra Sekhar and Bullman, Susan and Ojesina, Akinyemi I and Lamb, Andrew and Zhou, Wanding and Shen, Hui and Choueiri, Toni K and Weinstein, John N and Guinney, Justin and Saltz, Joel and Holt, Robert and Holt, Robert A and Rabkin, Charles S and Caesar-Johnson, Samantha J and Demchok, John A and Felau, Ina and Kasapi, Melpomeni and Ferguson, Martin L and Hutter, Carolyn M and Sofia, Heidi J and Tarnuzzer, Roy and Wang, Jioajiao and Wang, Min and Wang, Linghua and Wang, Zhining and Wang, Timothy and Wang, Jing and Yang, Ju Dong and Yang, Hannah and Yang, Liming and Yang, Ian and Zenklusen, Jean C and Zhang, Jiashan (Julia) and Zhang, Jiexin and Zhang, Lizhi and Zhang, Wei and Zhang, Hongzheng and Zhang, Hailei and Zhang, Hongxin and Chudamani, Sudha and Lolla, Laxmi and Naresh, Rashi and Pihl, Todd and Sun, Yichao and Sun, Qiang and Wan, Yunhu and Wu, Ye and Cho, Juok and DeFreitas, Timothy and Frazer, Scott and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network
Immunity, ISSN 1074-7613, 08/2019, Volume 51, Issue 2, pp. 411 - 412
Journal Article
by Medina-Gomez, Carolina and Kemp, John P and Trajanoska, Katerina and Luan, Jian’an and Chesi, Alessandra and Ahluwalia, Tarunveer S and Mook-Kanamori, Dennis O and Ham, Annelies and Hartwig, Fernando P and Evans, David M and Evans, Daniel S and Joro, Raimo and Nedeljkovic, Ivana and Zheng, Hou-Feng and Zhu, Kun and Atalay, Mustafa and Liu, Yongmei and Liu, Ching-Ti and Nethander, Maria and Broer, Linda and Porleifsson, Gudmar and Mullin, Benjamin H and Handelman, Samuel K and Nalls, Mike A and Jessen, Leon E and Heppe, Denise H.M and Richards, J. Brent and Wang, Carol and Chawes, Bo and Schraut, Katharina E and Amin, Najaf and Wareham, Nick and Karasik, David and Van der Velde, Nathalie and Ikram, M. Arfan and Zemel, Babette S and Zhou, Yanhua and Carlsson, Christian J and McGuigan, Fiona E and Boer, Cindy G and Bønnelykke, Klaus and Ralston, Stuart H and Robbins, John A and Walsh, John P and Zillikens, M. Carola and Langenberg, Claudia and Li-Gao, Ruifang and Williams, Frances M.K and Williams, Graham R and Harris, Tamara B and Akesson, Kristina and Jackson, Rebecca D and Sigurdsson, Gunnar and den Heijer, Martin and van der Eerden, Bram C.J and van de Peppel, Jeroen and Spector, Timothy D and Pennell, Craig and Horta, Bernardo L and Felix, Janine F and Zhao, Jing Hua and Wilson, James F and Wilson, Scott G and de Mutsert, Renée and Bisgaard, Hans and Styrkársdóttir, Unnur and Jaddoe, Vincent W and Orwoll, Eric and Lakka, Timo A and Scott, Robert and Grant, Struan F.A and Lorentzon, Mattias and van Duijn, Cornelia M and Stefansson, Kari and Psaty, Bruce M and Kiel, Douglas P and Ohlsson, Claes and Ntzani, Evangelia and van Wijnen, Andre J and Forgetta, Vincenzo and Ghanbari, Mohsen and Logan, John G and Bassett, J.H. Duncan and Croucher, Peter I and Evangelou, Evangelos and Uitterlinden, Andre G and Ackert-Bicknell, Cheryl L and Tobias, Jonathan H and Rivadeneira, Fernando and Göteborgs universitet and Gothenburg University and Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition and Core Facilities, Bioinformatics and Sahlgrenska Academy and Centre for Bone and Arthritis Research and Sahlgrenska akademin and Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
The American Journal of Human Genetics, ISSN 0002-9297, 01/2018, Volume 102, Issue 1, pp. 88 - 102
Journal Article
Nature, ISSN 0028-0836, 07/2016, Volume 535, Issue 7610, pp. 148 - 152
The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor... 
TARGET | POTENT | PTPN11 | PROTOONCOGENE | MULTIDISCIPLINARY SCIENCES | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | Pyrimidines - chemistry | Piperidines - pharmacology | Inhibitory Concentration 50 | Female | Allosteric Regulation - drug effects | Piperidines - chemistry | Reproducibility of Results | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Models, Molecular | Neoplasms - enzymology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Pyrimidines - pharmacology | Receptor Protein-Tyrosine Kinases - metabolism | Neoplasms - drug therapy | Xenograft Model Antitumor Assays | Animals | MAP Kinase Signaling System - drug effects | Mice, Nude | Piperidines - therapeutic use | Pyrimidines - therapeutic use | Protein Stability - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Neoplasms - pathology | Protein Structure, Tertiary - drug effects | Phosphatases | Observations | Health aspects | Phosphotransferases | Protein-protein interactions | Signal transduction | Cell growth | Peptides | Kinases | Phosphatase | Drug dosages | Cancer | BASIC BIOLOGICAL SCIENCES
Journal Article