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Science, ISSN 0036-8075, 04/2017, Volume 356, Issue 6336, pp. eaal3755 - eaal3755
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 967 - 18
Overexpression of ATP-binding cassette (ABC) transporters is often linked to multidrug resistance (MDR) in cancer chemotherapies. P-glycoprotein (P-gp) is one... 
APOPTOSIS | IN-VITRO | TRANSPORTERS | MULTIDISCIPLINARY SCIENCES | MECHANISMS | ACUTE MYELOID-LEUKEMIA | DRUG-RESISTANCE | OVARIAN-CANCER | ALAMAR BLUE | EXPRESSION | CALCEIN-AM | Cell culture | Cell survival | Tumor cells | Multidrug resistance | Drug resistance | Drug development | Spheroids | Chemotherapy | Computer applications | P-Glycoprotein | Prostate cancer | Prostate | ABC transporter | Index Medicus
Journal Article
Lancet Infectious Diseases, The, ISSN 1473-3099, 2017, Volume 17, Issue 6, pp. 626 - 635
Summary Background DSM265 is a novel antimalarial that inhibits plasmodial dihydroorotate dehydrogenase, an enzyme essential for pyrimidine biosynthesis. We... 
Infectious Disease | VIVAX MALARIA | CLEARANCE | INFECTIOUS DISEASES | MULTICENTER | COMBINATION THERAPY | QUANTITATIVE PCR | RESISTANCE | INFECTION | PIPERAQUINE | PLASMODIUM-FALCIPARUM MALARIA | FERROQUINE | Malaria, Falciparum - drug therapy | Triazoles - administration & dosage | Antimalarials - pharmacokinetics | Double-Blind Method | Pyrimidines - administration & dosage | Humans | Middle Aged | Half-Life | Antimalarials - therapeutic use | New Zealand | Plasmodium falciparum | Mefloquine - therapeutic use | Antimalarials - administration & dosage | Enzyme Inhibitors - pharmacokinetics | Pyrimidines - therapeutic use | Enzyme Inhibitors - chemistry | Adolescent | Pyrimidines - pharmacokinetics | Adult | Oxidoreductases Acting on CH-CH Group Donors | Triazoles - pharmacokinetics | Australia | Triazoles - therapeutic use | Drugs | Physiological aspects | Enzymes | Pyrimidines | Safety and security measures | Clinical trials | Malaria | Dehydrogenases | Plasmodia | Erythrocytes | Selectivity | Biochemistry | Drug resistance | Drug development | Dosage | Incidence | Food industry | New combinations | Inhibition | Pharmaceutical industry | Drug dosages | Active control | Public health | Half life | Atovaquone | Mortality | Immunodeficiency | Parasite resistance | Bioavailability | Studies | Polymerase chain reaction | Chemotherapy | Disease transmission | Inhibitors | Cytochrome bc1 | Human beings | Antimalarial agents | Minimum inhibitory concentration | Added value | Antiprotozoal agents | Dihydroorotate dehydrogenase | Bednets | Animal models | Chloroquine | Artemisinin | Infections | Biosynthesis | Spacecraft components | Mathematical models | Gametocytes | Safety | Effectiveness | Pharmacology | Antimalarial activity | Strategy
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 05/2019, Volume 62, Issue 10, pp. 5217 - 5241
Despite advances in targeted anticancer therapies, there are still no small-molecule-based therapies available that specifically target colorectal cancer (CRC)... 
SITE | POTENT | CHEMISTRY, MEDICINAL | TUMOR-SUPPRESSOR APC | MUTATION | FUTURE | MODEL | BINDING | ASEF
Journal Article
Cell, ISSN 0092-8674, 2010, Volume 142, Issue 1, pp. 39 - 51
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 02/2015, Volume 200, pp. 201 - 211
Lung cancer is one of the most lethal forms of cancer and current chemotherapeutic strategies lack broad specificity and efficacy. Recently, β-lapachone... 
Prodrug therapy | β-Lapachone | Polymeric micelles | Non-small cell lung cancer | Cancer nanomedicine | INDUCED DNA-DAMAGE | NAD(P)H-QUINONE OXIDOREDUCTASE-1 NQO1 | DRUG-DELIVERY | MITOMYCIN-C | PROGRAMMED NECROSIS | TUMOR-CELLS | CHEMISTRY, MULTIDISCIPLINARY | beta-Lapachone | REPAIR | METABOLISM | DT-DIAPHORASE | NANOTHERAPEUTICS | PHARMACOLOGY & PHARMACY | Hemolysis - drug effects | Prodrugs - administration & dosage | Lung Neoplasms - drug therapy | Nanoparticles - chemistry | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Polyethylene Glycols - chemistry | Antineoplastic Agents - therapeutic use | Prodrugs - chemistry | Antineoplastic Agents - administration & dosage | Nanoparticles - therapeutic use | Micelles | Female | Antineoplastic Agents - pharmacology | Naphthoquinones - administration & dosage | Lactates - chemistry | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Non-Small-Cell Lung - metabolism | Naphthoquinones - therapeutic use | Esterases - metabolism | Naphthoquinones - pharmacology | Antineoplastic Agents - chemistry | Mice, SCID | Comet Assay | Erythrocytes - drug effects | Animals | Tumor Burden - drug effects | Cell Line, Tumor | NAD(P)H Dehydrogenase (Quinone) - metabolism | Naphthoquinones - chemistry | Nanoparticles - administration & dosage | Prodrugs - therapeutic use | Carcinoma, Non-Small-Cell Lung - drug therapy | Prodrugs - pharmacology | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 42, pp. 17010 - 17015
Journal Article
Carcinogenesis, ISSN 0143-3334, 10/2013, Volume 34, Issue 10, pp. 2361 - 2369
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2012, Volume 109, Issue 42, pp. 17016 - 17021
Journal Article