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The Journal of Nuclear Medicine, ISSN 0161-5505, 08/2017, Volume 58, Issue 8, p. 1330
The methylguanidine derivative 11C-GMOM (11C-labeled N-(2-chloro-3-thiomethylphenyl)-N'-(3-methoxyphenyl)-N'-methylguanidine) has been used successfully to... 
Spleen | Nuclear medicine | Brain | Dosimeters | Medical imaging | Glutamic acid receptors (ionotropic) | Radiation | Positron emission | Organs | N-Methyl-D-aspartic acid receptors | Glutamic acid receptors | Radiation dosage | Mathematical analysis | Tomography | Ligands | Dosimetry | Positron emission tomography
Journal Article
Drug Discovery Today, ISSN 1359-6446, 12/2019, Volume 24, Issue 12, pp. 2258 - 2272
The transforming growth factor β (TGFβ) family of cytokines achieves homeostasis through a careful balance and crosstalk with complex signalling pathways.... 
Journal Article
2017, ISBN 2889452379
The discovery and development of a biological active molecule with therapeutic properties is an ever increasing complex task, highly unpredictable at the early... 
magnetic resonance imaging (MRI) | computerized tomography(CT) | positron emission tomography (PET) | pharmacology | single photon emission computed tomography (SPECT) | imaging | medical imaging | ultrasound
eBook
European Journal of Organic Chemistry, ISSN 1434-193X, 09/2017, Volume 2017, Issue 34, pp. 5154 - 5162
Here we present a new Michael addition reaction utilizing carbon-11 labeled acrylic esters and amides. Subsequently, reactions of these synthons with... 
Michael addition | Schiff bases | Carbonylation | Radiochemistry | Amino acids | Positron emission tomography | Physical and Theoretical Chemistry | Organic Chemistry | Tracers (Biology) | Glutamine
Journal Article
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 02/2017, Volume 2017, Issue 5, p. 1019
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 03/2017, Volume 58, Issue 3, p. 479
In this study, the performance of various methods for generating quantitative parametric images of dynamic 11C-phenytoin PET studies was evaluated. Methods:... 
Noise levels | Medical imaging | Basis functions | Bias | Nonlinear analysis | Positron emission | Tomography | Regression analysis | Spectral analysis | Phenytoin | Veins & arteries | Image acquisition
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 03/2017, Volume 58, Issue 3, pp. 479 - 483
In this study, the performance of various methods for generating quantitative parametric images of dynamic C-11-phenytoin PET studies was evaluated. Methods:... 
P-GLYCOPROTEIN FUNCTION | test-retest variability | NEURORECEPTOR | parametric kinetic modeling | POSITRON-EMISSION-TOMOGRAPHY | VOLUMES | QUANTIFICATION | KINETICS | EPILEPSY | C-11-phenytoin | PET quantification | BLOOD-BRAIN-BARRIER | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 09/2018, Volume 64, p. 47
Introduction Fluorine-18 labeled positron emission tomography (PET) tracers were developed to obtain more insight into the function of P-glycoprotein (P-gp) in... 
Deuterium | Stability | Fluorine | Glycoprotein | Positron emission | Radioisotopes | Fluorine isotopes | Radioactive half-life | Steric hindrance | Glycoproteins | Metabolism | Cyclotrons | Analogs | Synthesis | Radiochemistry | Tomography | Verapamil | Deuteration | P-Glycoprotein | Isotopes | Positron emission tomography | Pharmaceuticals | Tracers
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 07/2018, Volume 64-65, pp. 47 - 56
INTRODUCTION: Fluorine-18 labeled positron emission tomography (PET) tracers were developed to obtain more insight into the function of P-glycoprotein (P-gp)... 
b_open_article_in_toll_access_journal
Journal Article
ISSN 1477-0520, 1/2017, Volume 15, Issue 3, pp. 57 - 575
A rapid method for the synthesis of carbon-11 radiolabeled phenylalanine was developed using a chiral phase-transfer catalyst and a sub-nanomolar quantity of [... 
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 06/2016, Volume 57, Issue 6, p. 861
  Quantitative assessment of ^sup 11^C-erlotinib uptake may be useful in selecting non-small cell lung cancer (NSCLC) patients for erlotinib therapy. The... 
Prescription drugs | Chemotherapy | Metabolites | Lung cancer | Pharmacology | Mutation
Journal Article
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 05/2015, Volume 56, Issue Supplement 3
Journal Article
European Journal of Organic Chemistry, ISSN 1434-193X, 02/2017, Volume 2017, Issue 5, pp. 1019 - 1024
The first 11C-labeled unmodified (“native”) peptide is described by alkylation of a tetrapeptide Schiff base, which was achieved by an automated five-step... 
Peptides | Radiochemistry | Asymmetric catalysis | Diastereoselectivity | Physical and Theoretical Chemistry | Isotopic labeling | Organic Chemistry
Journal Article
The Journal of Nuclear Medicine, ISSN 0161-5505, 09/2015, Volume 56, Issue 9, p. 1372
  The overexpression of P-glycoprotein (Pgp) is thought to be an important mechanism of pharmacoresistance in epilepsy. Recently, ...C-phenytoin has been... 
Plasma | Nuclear medicine | Medical imaging | Epilepsy | Protein expression | Pharmacology | Glycoproteins
Journal Article
Journal of Nuclear Medicine, ISSN 0161-5505, 03/2017, Volume 58, Issue 3, pp. 479 - 483
In this study, the performance of various methods for generating quantitative parametric images of dynamic 11C-phenytoin PET studies was evaluated. Methods:... 
Parametric kinetic modeling | 11C-phenytoin | Radiology Nuclear Medicine and imaging | PET quantification | Test-retest variability
Journal Article
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