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1. Full Text Teaching and Evaluating Communication and Professionalism Across Pediatric Critical Care Medicine Fellowships
by Turner, David A., MD and Mink, Richard B., MD, MACM and Winkler, Margaret K., MD and Lee, K.J., MD and Ross, Sara L., MD and Schuette, Jennifer J., MD and Mason, Kathy, MD and Biagas, Katherine, MD and Storgion, Stephanie A., MD and Goodman, Denise M., MD, MS
Academic Pediatrics, ISSN 1876-2859, 2012, Volume 12, Issue 3, pp. e5 - e5
Pediatrics | Neonatal and Perinatal Medicine
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2. Full Text How Well Do Pediatric Critical Care Fellowship Programs Comply With Acgme Requirements for Teaching Professionalism and Communication?
by Turner, David A., MD and Mink, Richard B., MD, MACM and Winkler, Margaret K., MD and Lee, K.J., MD and Ross, Sara L., MD and Schuette, Jennifer J., MD and Mason, Katherine, MD and Biagas, Katherine, MD and Storgion, Stephanie A., MD and Goodman, Denise M., MD, MS
Academic Pediatrics, ISSN 1876-2859, 2012, Volume 12, Issue 3, pp. e5 - e6
Pediatrics | Neonatal and Perinatal Medicine
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3. Full Text Pediatric Off-label Use of Recombinant Factor VIIa
by Alten, Jeffrey A and Benner, Kim and Green, Kelsey and Toole, Benjamin and Tofil, Nancy M and Winkler, Margaret K
Pediatrics, ISSN 0031-4005, 03/2009, Volume 123, Issue 3, pp. 1066 - 1072
OBJECTIVE. Our goal was to report our institutional experience with recombinant factor VIIa for the treatment and/or prevention of bleeding in nonhemophiliac... 
Recombinant factor viia | Pediatrics | Transfusion | Thromboembolism | Bleeding | bleeding | thromboembolism | HEMORRHAGE | transfusion | recombinant factor VIIa | ACTIVATED FACTOR-VII | RFVIIA | CHILDREN | THERAPY | CARDIAC-SURGERY | pediatrics | CONGENITAL HEART-DISEASE | DOUBLE-BLIND | COAGULATION | TRAUMA PATIENTS | Humans | Prothrombin Time | Child, Preschool | Hemorrhage - mortality | Hospitals, Pediatric | Infant | Male | Drug Approval | Disseminated Intravascular Coagulation - mortality | Factor VIIa - adverse effects | Recombinant Proteins - adverse effects | Postoperative Hemorrhage - blood | Dose-Response Relationship, Drug | Factor VIIa - administration & dosage | Postoperative Hemorrhage - drug therapy | Female | Child | Postoperative Hemorrhage - mortality | Blood Loss, Surgical - prevention & control | Wounds and Injuries - blood | Disseminated Intravascular Coagulation - drug therapy | Wounds and Injuries - complications | Survival Rate | Hemorrhage - blood | Disseminated Intravascular Coagulation - blood | Recombinant Proteins - administration & dosage | Wounds and Injuries - mortality | Hemorrhage - drug therapy | Partial Thromboplastin Time | Adolescent | Premedication | Usage | Care and treatment | Prognosis | Mortality | Patient outcomes | Blood coagulation factors | Alabama | Hemorrhage | Diseases | Prevention | Control | Children | Health aspects | Proteins | Blood products | Medical treatment | Cells | Children & youth
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4. Full Text Oral and nasal enteral tube placement errors and complications in a pediatric intensive care unit
by Creel, Amy M and Winkler, Margaret K
Pediatric Critical Care Medicine, ISSN 1529-7535, 2007, Volume 8, Issue 2, pp. 161 - 164
Objective: To report five cases of errors in the placement of oral/nasal enteral tubes in a pediatric intensive care unit, and to review literature on... 
Critical care | Pneumothorax | Enteral tube | Pediatric | Morbidity | NASOENTERAL FEEDING TUBES | enteral tube | critical care | CONFIRMATION | CRITICALLY-ILL | CAPNOGRAPHY | pediatric | pneumothorax | CHILDREN | PEDIATRICS | PATIENT | morbidity | CRITICAL CARE MEDICINE | Humans | Nose | Adolescent | Female | Infant | Intensive Care Units, Pediatric | Male | Intubation, Gastrointestinal - adverse effects | Enteral Nutrition - instrumentation | Child | Medical Errors - prevention & control
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5. Full Text Exploring the interface between metallo-proteinase activity and growth factor and cytokine bioavailability
by Fowlkes, John L and Winkler, Margaret K
Cytokine and Growth Factor Reviews, ISSN 1359-6101, 2002, Volume 13, Issue 3, pp. 277 - 287
Metallo-proteinases are implicated in many processes involved in tissue remodeling, cell motility, morphogenesis, and cell and organ growth and... 
Metzincin | Matrix metallo-proteinase | Adamalysins | Cytokine | Growth factor | cytokine | CONVERTING-ENZYME TACE | FACTOR-BINDING PROTEIN-3 | TUMOR PROGRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-SURFACE | NECROSIS-FACTOR-ALPHA | CELL BIOLOGY | growth factor | MATRIX METALLOPROTEINASES | metzincin | LUNG BRANCHING MORPHOGENESIS | HUMAN-PREGNANCY SERUM | A PAPP-A | adamalysins | matrix metallo-proteinase | PLASMA-PROTEIN | ADAM17 Protein | Cytokines - metabolism | Humans | Epidermal Growth Factor - metabolism | Metalloendopeptidases - metabolism | ADAM Proteins | Insulin-Like Growth Factor II - metabolism | Animals | Metalloendopeptidases - pharmacology | Models, Biological | Transforming Growth Factor alpha - metabolism | Transforming Growth Factor beta - metabolism | Insulin-Like Growth Factor I - metabolism | Growth Substances - metabolism
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6. Full Text Professionalism and Communication Education in Pediatric Critical Care Medicine: The Learner Perspective
by Turner, David A., MD and Fleming, Geoffrey M., MD and Winkler, Margaret, MD and Lee, K. Jane, MD and Hamilton, Melinda F., MD and Hornik, Christoph P., MD, MPH and Petrillo-Albarano, Toni, MD and Mason, Katherine, MD and Mink, Richard, MD, MACM and Educ Pediat Intensive Care Investi and Education in Pediatric Intensive Care Investigators
Academic Pediatrics, ISSN 1876-2859, 2015, Volume 15, Issue 4, pp. 380 - 385
Abstract Objective Communication and professionalism are often challenging to teach, and the impact of the use of a given approach is not known. We undertook... 
Pediatrics | Neonatal and Perinatal Medicine | evaluation | graduate medical education | professionalism | fellowship training | competency | communication | pediatric | HIDDEN CURRICULUM | FACULTY | STYLES | PEDIATRICS | PERCEPTIONS | Attitude of Health Personnel | United States | Humans | Professionalism - education | Critical Care | Curriculum | Surveys and Questionnaires | Students, Medical | Pediatrics - education | Communication
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7. Full Text Metalloproteinase and growth factor interactions: do they play a role in pulmonary fibrosis?
by Winkler, Margaret K and Fowlkes, John L
AJP - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 07/2002, Volume 283, Issue 1, pp. 1 - L11
1  Department of Pediatrics, University of Alabama at Birmingham and Children's Hospital of Alabama, Birmingham, Alabama 35233; and 2  Department of... 
Acute respiratory distress syndrome | Bronchopulmonary dysplasia | Cytokines | Emphysema | Lung fibrosis | CONVERTING-ENZYME TACE | BRONCHOALVEOLAR LAVAGE FLUID | PHYSIOLOGY | FACTOR-BINDING PROTEIN-3 | ACUTE LUNG INJURY | DIFFUSE ALVEOLAR DAMAGE | NECROSIS-FACTOR-ALPHA | bronchopulmonary dysplasia | lung fibrosis | emphysema | RESPIRATORY-DISTRESS-SYNDROME | MATRIX METALLOPROTEINASES | RESPIRATORY SYSTEM | acute respiratory distress syndrome | TISSUE INHIBITOR | cytokines | AIRWAY SMOOTH-MUSCLE | Metalloendopeptidases - metabolism | Pulmonary Fibrosis - metabolism | Humans | Pulmonary Fibrosis - physiopathology | Growth Substances - metabolism
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8. Full Text Severe invasive community-associated methicillin-resistant Staphylococcus aureus infections in previously healthy children
by Creel, Amy M and Durham, Spencer H and Benner, Kim W and Alten, Jeffrey A and Winkler, Margaret K
Pediatric Critical Care Medicine, ISSN 1529-7535, 05/2009, Volume 10, Issue 3, pp. 323 - 327
Objective: An increase in community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections has been reported in the literature. Most... 
Necrotizing pneumonia | Vancomycin | Pediatric intensive care unit | Severe sepsis | Methicillin-resistant Staphylococcus aureus | MORTALITY | severe sepsis | methicillin-resistant Staphylococcus aureus | CLINDAMYCIN TREATMENT | DAPTOMYCIN | IN-VITRO | BACTEREMIA | PREDICTORS | pediatric intensive care unit | necrotizing pneumonia | vancomycin | PEDIATRICS | ENDOCARDITIS | INHIBITORY CONCENTRATION | TREATMENT FAILURE | CRITICAL CARE MEDICINE | Staphylococcal Infections - drug therapy | Humans | Child, Preschool | Drug Resistance, Bacterial | Medical Audit | Male | Intensive Care Units, Pediatric - statistics & numerical data | Microbial Sensitivity Tests | Anti-Bacterial Agents - therapeutic use | Staphylococcal Infections - mortality | Vancomycin - therapeutic use | Adolescent | Alabama - epidemiology | Female | Retrospective Studies | Staphylococcal Infections - microbiology | Methicillin-Resistant Staphylococcus aureus - isolation & purification | Child
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9. Full Text Are pediatric critical care medicine fellowships teaching and evaluating communication and professionalism?
by Turner, David A and Mink, Richard B and Lee, K Jane and Winkler, Margaret K and Ross, Sara L and Hornik, Christoph P and Schuette, Jennifer J and Mason, Katherine and Storgion, Stephanie A and Goodman, Denise M and Education in Pediatric Intensive Care (EPIC) Investigators, in Pediatric Intensive Care (EPIC) Investigators and EPIC Investigators and Education in Pediatric Intensive Care (EPIC) Investigators
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, ISSN 1529-7535, 2013, Volume 14, Issue 5, pp. 454 - 461
Objectives: To describe the teaching and evaluation modalities used by pediatric critical care medicine training programs in the areas of professionalism and... 
graduate medical education | professionalism | EMERGENCY-MEDICINE | CURRICULUM | fellowship training | competency | GAP ANALYSIS | EDUCATION | COMPETENCE | pediatric | evaluation | RESIDENTS | MINI-EVALUATION EXERCISE | INTERPERSONAL SKILLS | STANDARDIZED PATIENTS | FAMILY CONFERENCE | PEDIATRICS | communication | CRITICAL CARE MEDICINE | Curriculum - standards | Fellowships and Scholarships | Faculty, Medical | Cross-Sectional Studies | Humans | Critical Care | Professional Role | Pediatrics - education | Program Evaluation | Communication | Education, Medical, Graduate - methods
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10. Full Text Early developmental changes in IGF-I, IGF-II, IGF binding protein-1, and IGF binding protein-3 concentration in the cerebrospinal fluid of children
by Bunn, R. Clay and King, William D and Winkler, Margaret K and Fowlkes, John L
Pediatric Research, ISSN 0031-3998, 07/2005, Volume 58, Issue 1, pp. 89 - 93
IGF-I and IGF-II are ubiquitously expressed growth factors that have profound effects on the growth and differentiation of many cell types and tissues,... 
Insulin-Like Growth Factor II - cerebrospinal fluid | Insulin-Like Growth Factor I - cerebrospinal fluid | Age Factors | Enzyme-Linked Immunosorbent Assay | Humans | Gene Expression Regulation | Child, Preschool | Infant | Male | Insulin-Like Growth Factor Binding Protein 3 - cerebrospinal fluid | Chemistry, Clinical - methods | Insulin-Like Growth Factor Binding Protein 1 - cerebrospinal fluid | Nervous System - growth & development | Adolescent | Sex Factors | Female | Neurons - metabolism | Child | Infant, Newborn
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11. Implications for matrix metalloproteinases as modulators of pediatric lung disease
by Margaret K Winkler and Jane K Foldes and Robert C Bunn and John L Fowlkes
American Journal of Physiology, ISSN 1040-0605, 04/2003, Volume 28, Issue 4, p. L557
  Matrix metalloproteinases (MMPs) are a large family (>20) of cation-dependent proteinases believed to be important modulators of normal human lung... 
Proteins | Pediatrics | Matrix | Lungs | Disease
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12. Full Text Histamine 2 receptor antagonists vs intravenous proton pump inhibitors in a pediatric intensive care unit: A comparison of gastric pH
by Tofil, Nancy M., MD and Benner, Kim W., PharmD and Fuller, M. Paige, PharmD and Winkler, Margaret K., MD
Journal of Critical Care, ISSN 0883-9441, 2008, Volume 23, Issue 3, pp. 416 - 421
Abstract Purpose The aim of this study was to assess gastric pH in critically ill pediatric patients receiving intravenous stress ulcer medication. Materials... 
Critical Care | Gastric pH | Histamine 2 receptor antagonists | Children | Stress ulcer prophylaxis | Proton pump inhibitor | ACID SUPPRESSION | OMEPRAZOLE | STRESS-ULCER PROPHYLAXIS | RISK | PHARMACODYNAMICS | histamine 2 receptor antagonists | CRITICALLY-ILL CHILDREN | proton pump inhibitors | stress ulcer prophylaxis | THERAPY | PHARMACOKINETICS | children | gastric pH | RANITIDINE | CRITICAL CARE MEDICINE | Injections, Intravenous | Prospective Studies | Humans | Child, Preschool | Peptic Ulcer - prevention & control | Infant | Intensive Care Units, Pediatric | Male | Proton Pump Inhibitors - therapeutic use | Gastric Juice - chemistry | Histamine H2 Antagonists - therapeutic use | Respiration, Artificial | Proton Pump Inhibitors - administration & dosage | Adolescent | Female | Child | Infant, Newborn | Peptic Ulcer - etiology | Stress, Psychological - complications | Hydrogen-Ion Concentration | Ranitidine - therapeutic use | Renal Dialysis | Pediatrics | Histamine | Proton pump inhibitors | Comparative analysis | Hydrogen-ion concentration | Health aspects
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13. Full Text Implications for matrix metalloproteinases as modulators of pediatric lung disease
by Margaret K. Winkler and Jane K. Foldes and Robert C. Bunn and John L. Fowlkes
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 04/2003, Volume 284, Issue 4, pp. 557 - 565
Matrix metalloproteinases (MMPs) are a large family (>20) of cation-dependent proteinases believed to be important modulators of normal human lung development... 
Bronchoalveolar lavage | Extracellular matrix | PHYSIOLOGY | RESPIRATORY-DISTRESS | OBSTRUCTIVE PULMONARY-DISEASE | EPITHELIAL-CELLS | RESPIRATORY SYSTEM | GELATINASE-B | MATRIX-METALLOPROTEINASE-9 | TISSUE INHIBITOR | ALVEOLAR MACROPHAGES | GROWTH-FACTOR | bronchoalveolar lavage | UP-REGULATION | extracellular matrix | ACUTE ASTHMA | Bronchoalveolar Lavage Fluid | Matrix Metalloproteinase 2 - metabolism | Humans | Child, Preschool | Infant | Male | Lung Diseases - therapy | Respiratory Insufficiency - therapy | Respiration, Artificial | Lung - enzymology | Extracellular Matrix - enzymology | Matrix Metalloproteinase 9 - metabolism | Respiratory Insufficiency - enzymology | Matrix Metalloproteinase 7 - metabolism | Matrix Metalloproteinase 8 - metabolism | Adolescent | Adult | Female | Matrix Metalloproteinases - metabolism | Child | Lung Diseases - enzymology
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14. Full Text The Accreditation Council for Graduate Medical Education proposed work hour regulations
by Goodman, Denise M and Winkler, Margaret K and Fiser, Richard T and Abd-Allah, Shamel and Mathur, Mudit and Rivero, Niurka and Weiss, Irwin K and Peterson, Bradley and Cornfield, David N and Mink, Richard and Nozik Grayck, Eva and McCabe, Megan E and Schuette, Jennifer and Nares, Michael A and Totapally, Bala and Petrillo-Albarano, Toni and Wolfson, Rachel K and Moreland, Jessica G and Potter, Katherine E and Fackler, James and Garber, Nan and Burns, Jeffrey P and Shanley, Thomas P and Lieh-Lai, Mary W and Steiner, Marie and Tieves, Kelly S and Goldsmith, Matthew and Asuncion, Arsenia and Ross, Sara L. P and Howell, Joy D and Biagas, Katherine and Ognibene, Kristin and Joshi, Prashant and Rubenstein, Jeffrey S and Kocis, Keith C and Cheifetz, Ira M and Turner, David A and Doughty, Lesley and Hall, Mark W and Mason, Katherine and Penfil, Scott and Morrison, Wynne and Hoehn, K. Sarah and Watson, R. Scott and Garcia, Ricardo L and Storgion, Stephanie A and Fleming, Geoffrey M and Castillo, Leticia and Tcharmtchi, M. Hossein and Taylor, Richard P and Ul Haque, Ikram and Crain, Noreen and Baden, Harris P and Lee, K. Jane
Pediatric Critical Care Medicine, ISSN 1529-7535, 01/2011, Volume 12, Issue 1, pp. 120 - 121
PEDIATRICS | CRITICAL CARE MEDICINE | Workload - standards | Internship and Residency | United States | Humans | Critical Care | Accreditation | Pediatrics - education | Education, Medical, Graduate
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15. Full Text A pilot trial comparing cerebral perfusion pressure-targeted therapy to intracranial pressure-targeted therapy in children with severe traumatic brain injury
by Prabhakaran, Priya and Reddy, Alyssa T and Oakes, W. Jerry and King, William D and Winkler, Margaret K and Givens, Timothy G
Journal of Neurosurgery, ISSN 0022-3085, 05/2004, Volume 100, Issue 5, pp. 454 - 459
Object. The authors sought to compare cerebral perfusion pressure (CPP)- with intracranial pressure (ICP)-targeted therapy in children with severe traumatic... 
Glasgow Coma Scale | Glasgow Outcome Scale | Intracranial pressure | Cerebral edema | Cerebral perfusion pressure | Trauma | Brain injury | trauma | SURGERY | MANAGEMENT | cerebral edema | PRACTICAL SCALE | BLOOD-FLOW | COMA DATA-BANK | ADULT | CLINICAL NEUROLOGY | brain injury | intracranial pressure | SEVERE HEAD-INJURY | HYPOTENSION | HYPERTENSION | INSULTS | cerebral perfusion pressure | Prospective Studies | Humans | Child, Preschool | Brain Injuries - complications | Infant | Male | Treatment Outcome | Cerebrovascular Circulation | Combined Modality Therapy | Intracranial Pressure - physiology | Likelihood Functions | Pilot Projects | Adolescent | Female | Child | Intracranial Hypertension - etiology | Intracranial Hypertension - physiopathology | Intracranial Hypertension - therapy
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16. Full Text The use of recombinant factor VIIa in a patient with Noonan syndrome and life-threatening bleeding
by Tofil, Nancy M and Winkler, Margaret K and Watts, Raymond G and Noonan, Jacqueline
Pediatric Critical Care Medicine, ISSN 1529-7535, 05/2005, Volume 6, Issue 3, pp. 352 - 354
To present a case report of a patient with Noonan syndrome who developed life-threatening gastrointestinal bleeding shortly after cardiac surgery that was... 
Critical care | Pediatrics | Recombinant factor VIIa | Noonan syndrome | Bleeding | Recombinant Proteins - therapeutic use | Factor VII - therapeutic use | Humans | Infant | Intensive Care Units, Pediatric | Male | Cardiac Surgical Procedures - adverse effects | Postoperative Hemorrhage - drug therapy | Noonan Syndrome - complications | Noonan Syndrome - surgery | Gastrointestinal Hemorrhage - etiology | Hemostatics - therapeutic use | Gastrointestinal Hemorrhage - drug therapy | Factor VIIa
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17. Full Text A pilot trial comparing cerebral perfusion pressure—targeted therapy to intracranial pressure—targeted therapy in children with severe traumatic brain injury
by Prabhakaran, Priya and Reddy, Alyssa T and Oakes, W. Jerry and King, William D and Winkler, Margaret K and Givens, Timothy G
Journal of Neurosurgery: Pediatrics, ISSN 1933-0707, 05/2004, Volume 100, Issue 5, pp. 454 - 459
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18. Full Text The use of enteral naloxone to treat opioid-induced constipation in a pediatric intensive care unit
by Tofil, Nancy M and Benner, Kim W and Faro, Sarah Jane and Winkler, Margaret K
Pediatric Critical Care Medicine, ISSN 1529-7535, 2006, Volume 7, Issue 3, pp. 252 - 254
Objective. To describe the effects of enteral naloxone used to treat opioid-induced constipation in pediatric intensive care patients. Design: Retrospective... 
Critical care | Pediatrics | Side effects | Naloxone | Constipation | Opioids | constipation | ORAL NALOXONE | pediatrics | critical care | naloxone | side effects | opioids | CRITICAL CARE MEDICINE | Humans | Child, Preschool | Infant | Intensive Care Units, Pediatric | Male | Naloxone - therapeutic use | Chi-Square Distribution | Constipation - chemically induced | Analgesics, Opioid - adverse effects | Analysis of Variance | Narcotic Antagonists - therapeutic use | Analgesics, Opioid - administration & dosage | Adolescent | Female | Constipation - drug therapy | Retrospective Studies | Child
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19. Full Text Fatal hypermagnesemia caused by an Epsom salt enema: A case illustration
by Tofil, Nancy M and Benner, Kim W and Winkler, Margaret K
Southern Medical Journal, ISSN 0038-4348, 02/2005, Volume 98, Issue 2, pp. 253 - 256
The authors describe a case of fatal hypermagnesemia caused by an Epsom salt enema. A 7-year-old male presented with cardiac arrest and was found to have a... 
Death | Children | Epsom salt enema | Toxicity | Asystole | Hypermagnesemia | toxicity | MEDICINE, GENERAL & INTERNAL | asystole | THERAPY | death | children | EXTREME HYPERMAGNESEMIA | hypermagnesemia | SULFATE ENEMA | MAGNESIUM-CONTAINING CATHARTICS | Hyperlysinemias - etiology | Magnesium Sulfate - adverse effects | Abdominal Pain - therapy | Enema - adverse effects | Humans | Fatal Outcome | Male | Magnesium Sulfate - therapeutic use | Child | Magnesium - blood | Heart Arrest - therapy | Magnesium sulfate | Care and treatment | Risk factors | Magnesium deficiency diseases
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